<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" metaid="metaid_0000001" level="2" version="4">
  <model metaid="metaid_0000002" id="Goldbeter1990_CalciumSpike_CICR" name="Goldbeter1990_CalciumSpike_CICR">
    <notes>
      <body xmlns="http://www.w3.org/1999/xhtml">
        <p>This model is automatically converted from the Model BIOMD0000000098 by using <a href="http://sbml.org/Software/libSBML" target="_blank">libsbml</a>. According to the <a href="http://www.ebi.ac.uk/biomodels//legal.html">terms of use</a>, this generated model is not related with Model <a href="http://www.ebi.ac.uk/biomodels/models-main/publ/BIOMD0000000098.xml">BIOMD0000000098</a> any more.</p>
      </body>
    </notes>
    <annotation>
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        <rdf:Description rdf:about="#metaid_0000002">
          <dc:creator>
            <rdf:Bag>
              <rdf:li rdf:parseType="Resource">
                <vCard:N rdf:parseType="Resource">
                  <vCard:Family>Dharuri</vCard:Family>
                  <vCard:Given>Harish</vCard:Given>
                </vCard:N>
                <vCard:EMAIL>hdharuri@cds.caltech.edu</vCard:EMAIL>
                <vCard:ORG rdf:parseType="Resource">
                  <vCard:Orgname>California Institute of Technology</vCard:Orgname>
                </vCard:ORG>
              </rdf:li>
            </rdf:Bag>
          </dc:creator>
          <dcterms:created rdf:parseType="Resource">
            <dcterms:W3CDTF>2007-03-21T15:41:17Z</dcterms:W3CDTF>
          </dcterms:created>
          <dcterms:modified rdf:parseType="Resource">
            <dcterms:W3CDTF>2009-10-05T11:43:57Z</dcterms:W3CDTF>
          </dcterms:modified>
          <bqmodel:is>
            <rdf:Bag>
              <rdf:li rdf:resource="urn:miriam:biomodels.db:BIOMD0000000098"/>
            </rdf:Bag>
          </bqmodel:is>
          <bqmodel:is>
            <rdf:Bag>
              <rdf:li rdf:resource="urn:miriam:biomodels.db:MODEL4519937652"/>
            </rdf:Bag>
          </bqmodel:is>
          <bqmodel:isDescribedBy>
            <rdf:Bag>
              <rdf:li rdf:resource="urn:miriam:pubmed:2304911"/>
            </rdf:Bag>
          </bqmodel:isDescribedBy>
          <bqbiol:isVersionOf>
            <rdf:Bag>
              <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005220"/>
              <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006816"/>
            </rdf:Bag>
          </bqbiol:isVersionOf>
        </rdf:Description>
      </rdf:RDF>
    </annotation>
    <listOfUnitDefinitions>
      <unitDefinition metaid="metaid_0000031" id="substance" name="micromole">
        <listOfUnits>
          <unit kind="mole" scale="-6"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition metaid="metaid_0000032" id="uM_per_sec" name="uM_per_sec">
        <listOfUnits>
          <unit kind="mole" scale="-6"/>
          <unit kind="litre" exponent="-1"/>
          <unit kind="second" exponent="-1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition metaid="metaid_0000033" id="sec_inv" name="sec_inv">
        <listOfUnits>
          <unit kind="second" exponent="-1"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition metaid="metaid_0000034" id="uM" name="uM">
        <listOfUnits>
          <unit kind="mole" scale="-6"/>
          <unit kind="litre" exponent="-1"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment metaid="metaid_0000016" id="cytosol" name="cytosol" size="1">
        <annotation>
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              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005829"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </compartment>
      <compartment metaid="metaid_0000030" id="store" name="store" size="1">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005783"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </compartment>
    </listOfCompartments>
    <listOfSpecies>
      <species metaid="metaid_0000018" id="Z" compartment="cytosol" initialConcentration="0.15">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000018">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A29108"/>
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                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
      <species metaid="metaid_0000019" id="Y" compartment="store" initialConcentration="1.6">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A29108"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00076"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
      </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter metaid="metaid_0000003" id="v0" value="1" units="uM_per_sec"/>
      <parameter metaid="metaid_0000004" id="v1" value="7.3" units="uM_per_sec"/>
      <parameter metaid="metaid_0000005" id="beta" value="0.301" units="dimensionless"/>
      <parameter metaid="metaid_0000006" id="Vm2" value="65" units="uM_per_sec"/>
      <parameter metaid="metaid_0000007" id="n" value="2" units="dimensionless"/>
      <parameter metaid="metaid_0000008" id="K2" value="1" units="uM"/>
      <parameter metaid="metaid_0000009" id="Vm3" value="500" units="uM_per_sec"/>
      <parameter metaid="metaid_0000010" id="m" value="2" units="dimensionless"/>
      <parameter metaid="metaid_0000012" id="Kr" value="2" units="uM"/>
      <parameter metaid="metaid_0000013" id="Ka" value="0.9" units="uM"/>
      <parameter metaid="metaid_0000014" id="kf" value="1" units="sec_inv"/>
      <parameter metaid="metaid_0000015" id="k" value="10" units="sec_inv"/>
      <parameter metaid="metaid_0000035" id="p" value="4" units="dimensionless"/>
    </listOfParameters>
    <listOfReactions>
      <reaction metaid="metaid_0000020" id="R0" name="Ca influx" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000020">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0006816"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Z"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> v0 </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000021" id="R1" name="InsP3 dependent Ca influx" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0005220"/>
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              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfProducts>
          <speciesReference species="Z"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> v1 </ci>
              <ci> beta </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000022" id="R2" name="ATP driven Ca pumping into store" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000022">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0032470"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Z"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Y"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> Vm2 </ci>
                  <apply>
                    <power/>
                    <ci> Z </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
                <apply>
                  <plus/>
                  <apply>
                    <power/>
                    <ci> K2 </ci>
                    <ci> n </ci>
                  </apply>
                  <apply>
                    <power/>
                    <ci> Z </ci>
                    <ci> n </ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000023" id="R3" name="ATP driven pumping into cytosol" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000023">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0007204"/>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0048763"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Y"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Z"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> store </ci>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <ci> Vm3 </ci>
                  <apply>
                    <power/>
                    <ci> Y </ci>
                    <ci> m </ci>
                  </apply>
                  <apply>
                    <power/>
                    <ci> Z </ci>
                    <ci> p </ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <apply>
                    <plus/>
                    <apply>
                      <power/>
                      <ci> Kr </ci>
                      <ci> m </ci>
                    </apply>
                    <apply>
                      <power/>
                      <ci> Y </ci>
                      <ci> m </ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus/>
                    <apply>
                      <power/>
                      <ci> Ka </ci>
                      <ci> p </ci>
                    </apply>
                    <apply>
                      <power/>
                      <ci> Z </ci>
                      <ci> p </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000024" id="Rf" name="Ca leak" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000024">
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                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:obo.go:GO%3A0007204"/>
                </rdf:Bag>
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            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Y"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="Z"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> store </ci>
              <ci> kf </ci>
              <ci> Y </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
      <reaction metaid="metaid_0000025" id="R_eff" name="Ca efflux" reversible="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#metaid_0000025">
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                </rdf:Bag>
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          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="Z"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> cytosol </ci>
              <ci> k </ci>
              <ci> Z </ci>
            </apply>
          </math>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>

