digraph foo {
	graph [splines=TRUE, size="15,15", bgcolor=white, ratio=fill, pad="0.5,0.5", dpi=72, fontcolor=black, rank=same, rankdir=TB];
	node [label="\N", fontsize=22, fontname=Helvetica, style="filled,bold", shape=circle, fixedsize=TRUE, fillcolor=transparent, color=black, fontcolor=black, height="0.5", width="0.75",  ];
	edge [headport=center, style=solid, penwidth=1, weight="1.0", arrowsize=2, minlen=3, color=black, dir=none, fontcolor=black, arrowhead=none, arrowtail=none, fontsize=14, labelfontsize=11];
	graph [bb="0 0 1080 1080"];
	subgraph 0 {
		graph [bb=""];
		TRAF6 [label=TRAF6, shape=ellipse, fixedsize=FALSE, fillcolor=white, height=1, width=2];
		PI3K [label=PI3K, shape=ellipse, fixedsize=FALSE, fillcolor=orangered, color=orangered, height=1, width=2];
		Ras [label=Ras, shape=ellipse, fixedsize=FALSE, fillcolor=white, height=1, width=2];
	}
	subgraph 1 {
		graph [bb=""];
		Jnk [label=Jnk, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
		p38 [label=p38, shape=ellipse, fixedsize=FALSE, fillcolor=white, height=1, width=2];
		Raf [label=Raf, shape=ellipse, fixedsize=FALSE, fillcolor=orangered, color=orangered, height=1, width=2];
		Akt [label=Akt, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
	}
	subgraph 2 {
		graph [bb=""];
		Mek [label=Mek, shape=ellipse, fixedsize=FALSE, fillcolor=white, height=1, width=2];
	}
	subgraph 3 {
		graph [rank=source,
			bb=""];
		EGF [label=EGF, style=filled, shape=ellipse, fixedsize=FALSE, fillcolor=olivedrab3, color=olivedrab3, height=1, width=2];
		TNFa [label=TNFa, style=filled, shape=ellipse, fixedsize=FALSE, fillcolor=olivedrab3, color=olivedrab3, height=1, width=2];
	}
	subgraph 4 {
		graph [rank=sink,
			bb=""];
		NFkB [label=NFkB, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
		cJun [label=cJun, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
		Hsp27 [label=Hsp27, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
		p90RSK [label=p90RSK, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
	}
	Erk [label=Erk, shape=ellipse, fixedsize=FALSE, fillcolor=lightblue, color=lightblue, height=1, width=2];
	EGF -> Ras:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	EGF -> PI3K:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	TNFa -> PI3K:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	TNFa -> TRAF6:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	TRAF6 -> p38:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	TRAF6 -> Jnk:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	TRAF6 -> NFkB:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Jnk -> cJun:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	p38 -> Hsp27:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	PI3K -> Akt:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Ras -> Raf:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Raf -> Mek:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Akt -> Mek:center [penwidth=3, weight=1, color=red, dir=forward, arrowhead=tee];
	Mek -> p90RSK:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Mek -> Erk:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
	Erk -> Hsp27:center [penwidth=3, weight=1, dir=forward, arrowhead=normal];
}
