Metadata-Version: 2.1
Name: physiofit
Version: 2.0b2
Summary: Calculate extracellular fluxes from metabolite concentrations and biomass data
Home-page: https://github.com/MetaSys-LISBP/PhysioFit
Author: Loïc Le Grégam
Author-email: legregam@insa-toulouse.fr
License: UNKNOWN
Project-URL: Bug Tracker, https://github.com/MetaSys-LISBP/PhysioFit/issues
Platform: UNKNOWN
Classifier: Programming Language :: Python :: 3
Classifier: License :: OSI Approved :: MIT License
Classifier: Operating System :: OS Independent
Requires-Python: >=3.6
Description-Content-Type: text/markdown
License-File: LICENSE
Requires-Dist: pandas
Requires-Dist: numpy
Requires-Dist: scipy
Requires-Dist: streamlit (>=1.5.0)
Requires-Dist: matplotlib
Requires-Dist: openpyxl

# PhysioFit

PhysioFit is a scientific tool designed to i) quantify exchange (production and consumption) fluxes and  ii) cell growth rate during (batch) cultivations of microorganisms. Fluxes are estimated from time-course measurements of extracellular metabolites and biomass concentrations. An important assumption is that cells are in metabolic (pseudo) steady-state.

PhysioFit includes the following features:
-	Calculation of growth rate and extracellular (uptake and production) fluxes.
-	Lag before growth (e.g. due to adaptation to a novel environment) can be taken into account and estimated.
-	Non-enzymatic degradation of some carbon sources (e.g. DHA or glutamine) can be estimated and taken into account when calculating exchange fluxes.
-	Sensitivity analyses are performed to estimate the precision of the calculated fluxes.
-	Evaluation of the goodness of fit and visual inspection of the fitted curves.


