Starting NMTRAN
  
 WARNINGS AND ERRORS (IF ANY) FOR PROBLEM    1
             
 (WARNING  2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
  
Note: Analytical 2nd Derivatives are constructed in FSUBS but are never used.
      You may insert $ABBR DERIV2=NO after the first $PROB to save FSUBS construction and compilation time
  
Recompiling certain components
Building NONMEM Executable
Starting nonmem execution ...
License Registered to: Uppsala University
Expiration Date:    14 MAR 2024
Current Date:       27 SEP 2023
Days until program expires : 172


 First Order Conditional Estimation with Interaction
 MONITORING OF SEARCH:


0ITERATION NO.:    0    OBJECTIVE VALUE:   25.1404693556685        NO. OF FUNC. EVALS.:   7
 CUMULATIVE NO. OF FUNC. EVALS.:        7
 NPARAMETR:  1.0000E-01  5.7500E+00  1.0000E-01  1.0000E-01  9.0000E-02  9.0000E-02  3.3836E-01
 PARAMETER:  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01
 GRADIENT:   1.4225E-05  2.1101E+00  2.2116E+00 -3.5350E-03  1.3649E-02  1.6621E+00 -1.2915E-01

0ITERATION NO.:   51    OBJECTIVE VALUE:   17.5719791951587        NO. OF FUNC. EVALS.: 579
 CUMULATIVE NO. OF FUNC. EVALS.:      586
 NPARAMETR:  1.0122E-01  5.7501E-02  1.7747E+05  4.3434E+04  9.0000E-06  9.0000E-06  9.3323E-02
 PARAMETER:  1.1209E-01 -7.9164E+00  1.2091E+01  1.3082E+01 -4.6558E+01 -6.7387E+02 -5.4403E-01
 GRADIENT:   7.1140E-07  0.0000E+00 -1.7939E-02  1.8114E-02  0.0000E+00  0.0000E+00 -2.3891E-03
 Elapsed estimation  time in seconds:     3.55
 Elapsed postprocess time in seconds:     0.02
 Elapsed finaloutput time in seconds:     0.00
Done with nonmem execution
