Starting NMTRAN
  
 WARNINGS AND ERRORS (IF ANY) FOR PROBLEM    1
             
 (WARNING  2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
             
 (WARNING  23) $PK DOES NOT DEFINE A SCALE PARAMETER FOR THE CENTRAL
 COMPARTMENT.  WITH THIS TRANS, IT MAY NOT BE POSSIBLE TO SEPARATELY
 OBTAIN ESTIMATES OF PARAMETERS AFFECTING CLEARANCE AND VOLUME.
  
Note: Analytical 2nd Derivatives are constructed in FSUBS but are never used.
      You may insert $ABBR DERIV2=NO after the first $PROB to save FSUBS construction and compilation time
  
Recompiling certain components
Building NONMEM Executable
Starting nonmem execution ...
License Registered to: Uppsala University
Expiration Date:    14 MAR 2024
Current Date:       27 SEP 2023
Days until program expires : 172


 First Order Conditional Estimation with Interaction
 MONITORING OF SEARCH:


0ITERATION NO.:    0    OBJECTIVE VALUE:   25.1404686874887        NO. OF FUNC. EVALS.:   6
 CUMULATIVE NO. OF FUNC. EVALS.:        6
 NPARAMETR:  5.7500E+00  1.0000E-01  1.0000E-01  9.0000E-02  9.0000E-02  3.3836E-01
 PARAMETER:  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01  1.0000E-01
 GRADIENT:   2.1101E+00  2.2116E+00 -3.5356E-03  1.3649E-02  1.6621E+00 -1.2915E-01

0ITERATION NO.:   43    OBJECTIVE VALUE:   17.5722206488840        NO. OF FUNC. EVALS.: 403
 CUMULATIVE NO. OF FUNC. EVALS.:      409
 NPARAMETR:  5.7501E-02  1.4457E+05  3.5394E+04  9.0000E-06  9.0000E-06  9.3417E-02
 PARAMETER: -7.7536E+00  1.1886E+01  1.2877E+01 -4.5829E+01 -6.6430E+02 -5.4352E-01
 GRADIENT:   0.0000E+00 -7.7412E-02  7.7308E-02  0.0000E+00  0.0000E+00 -5.4216E-03
 Elapsed estimation  time in seconds:     0.04
 Elapsed postprocess time in seconds:     0.01
 Elapsed finaloutput time in seconds:     0.00
Done with nonmem execution
