PMID- 20435676
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20211020
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 38
IP  - Web Server issue
DP  - 2010 Jul
TI  - TranslatorX: multiple alignment of nucleotide sequences guided by amino acid 
      translations.
PG  - W7-13
LID - 10.1093/nar/gkq291 [doi]
AB  - We present TranslatorX, a web server designed to align protein-coding nucleotide 
      sequences based on their corresponding amino acid translations. Many comparisons 
      between biological sequences (nucleic acids and proteins) involve the 
      construction of multiple alignments. Alignments represent a statement regarding 
      the homology between individual nucleotides or amino acids within homologous 
      genes. As protein-coding DNA sequences evolve as triplets of nucleotides (codons) 
      and it is known that sequence similarity degrades more rapidly at the DNA than at 
      the amino acid level, alignments are generally more accurate when based on amino 
      acids than on their corresponding nucleotides. TranslatorX novelties include: (i) 
      use of all documented genetic codes and the possibility of assigning different 
      genetic codes for each sequence; (ii) a battery of different multiple alignment 
      programs; (iii) translation of ambiguous codons when possible; (iv) an innovative 
      criterion to clean nucleotide alignments with GBlocks based on protein 
      information; and (v) a rich output, including Jalview-powered graphical 
      visualization of the alignments, codon-based alignments coloured according to the 
      corresponding amino acids, measures of compositional bias and first, second and 
      third codon position specific alignments. The TranslatorX server is freely 
      available at http://translatorx.co.uk.
FAU - Abascal, Federico
AU  - Abascal F
AD  - Departamento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias 
      Naturales, CSIC, José Gutiérrez Abascal, 2, 28006 Madrid, Spain.
FAU - Zardoya, Rafael
AU  - Zardoya R
FAU - Telford, Maximilian J
AU  - Telford MJ
LA  - eng
PT  - Journal Article
DEP - 20100430
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
SB  - IM
MH  - Genetic Code
MH  - Internet
MH  - Phylogeny
MH  - Protein Biosynthesis
MH  - Sequence Alignment/*methods
MH  - *Sequence Analysis, DNA
MH  - *Sequence Analysis, Protein
MH  - *Software
PMC - PMC2896173
EDAT- 2010/05/04 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/05/04 06:00
PHST- 2010/05/04 06:00 [entrez]
PHST- 2010/05/04 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - gkq291 [pii]
AID - 10.1093/nar/gkq291 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2010 Jul;38(Web Server issue):W7-13. doi: 10.1093/nar/gkq291. 
      Epub 2010 Apr 30.
