<?xml version='1.0' encoding='UTF-8'?>
<sbml xmlns:fbc="http://www.sbml.org/sbml/level3/version1/fbc/version2" level="3" sboTerm="SBO:0000624" version="1" xmlns="http://www.sbml.org/sbml/level3/version1/core" fbc:required="false">
  <model fbc:strict="true" id="HP">
    <listOfUnitDefinitions>
      <unitDefinition id="mmol_per_gDW_per_hr">
        <listOfUnits>
          <unit exponent="1" kind="mole" multiplier="1" scale="-3"/>
          <unit exponent="-1" kind="gram" multiplier="1" scale="0"/>
          <unit exponent="-1" kind="second" multiplier="3600" scale="0"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <fbc:listOfObjectives fbc:activeObjective="obj">
      <fbc:objective fbc:id="obj" fbc:type="maximize">
        <fbc:listOfFluxObjectives>
          <fbc:fluxObjective fbc:reaction="R_BiomassHP_published" fbc:coefficient="1"/>
        </fbc:listOfFluxObjectives>
      </fbc:objective>
    </fbc:listOfObjectives>
    <listOfParameters>
      <parameter constant="true" id="cobra_default_lb" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="-1000"/>
      <parameter constant="true" id="cobra_default_ub" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="1000"/>
      <parameter constant="true" id="cobra_0_bound" sboTerm="SBO:0000626" units="mmol_per_gDW_per_hr" value="0"/>
      <parameter constant="true" id="R_ATPM_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="0.2"/>
      <parameter constant="true" id="R_EX_ala-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.3"/>
      <parameter constant="true" id="R_EX_arg-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.15"/>
      <parameter constant="true" id="R_EX_asn-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.225"/>
      <parameter constant="true" id="R_EX_asp-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.225"/>
      <parameter constant="true" id="R_EX_cys-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.3"/>
      <parameter constant="true" id="R_EX_fe2_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_fe3_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_gal_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.29487"/>
      <parameter constant="true" id="R_EX_glc-D_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.29487"/>
      <parameter constant="true" id="R_EX_gln-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.18"/>
      <parameter constant="true" id="R_EX_glu-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.18"/>
      <parameter constant="true" id="R_EX_gly_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.45"/>
      <parameter constant="true" id="R_EX_his-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.15"/>
      <parameter constant="true" id="R_EX_ile-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.15"/>
      <parameter constant="true" id="R_EX_leu-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.15"/>
      <parameter constant="true" id="R_EX_lys-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.15"/>
      <parameter constant="true" id="R_EX_met-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.18"/>
      <parameter constant="true" id="R_EX_na1_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_o2_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-10"/>
      <parameter constant="true" id="R_EX_orot_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_phe-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.099"/>
      <parameter constant="true" id="R_EX_pheme_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_pi_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-10"/>
      <parameter constant="true" id="R_EX_pime_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_pro-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.18"/>
      <parameter constant="true" id="R_EX_ser-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.3"/>
      <parameter constant="true" id="R_EX_so4_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_thm_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-1"/>
      <parameter constant="true" id="R_EX_thr-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.225"/>
      <parameter constant="true" id="R_EX_trp-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.081"/>
      <parameter constant="true" id="R_EX_tyr-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.099"/>
      <parameter constant="true" id="R_EX_val-L_lower_bound" sboTerm="SBO:0000625" units="mmol_per_gDW_per_hr" value="-0.18"/>
    </listOfParameters>
    <listOfCompartments/>
    <listOfSpecies>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_10fthf[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_12dgr_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_13dpg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_1p3h5c[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_1pyr5c[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_23dhdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_23dhmb[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_23dhmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_25aics[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_25dhpp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_26dap-LL[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_26dap-M[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ahbut[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ahhmd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ahhmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2cpr5p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2dda7p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ddg6p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2dhp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2dmmq6[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2dr1p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2dr5p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2kmb[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2mahmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2me4p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2mecdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2obut[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ombzl[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2ommbl[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2oph[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2p4c2me[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2pg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_2shchc[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_34hpp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3dhq[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3dhsk[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3hoctaACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3hpalmACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3ig3p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3mob[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3mop[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3ophb[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3pg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3php[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_3psme[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4abut[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4abz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4adcho[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4ampm[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4c2me[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4h2oglt[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hba[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hbz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hglusa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4hpro-LT[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4mhetz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4mop[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4mpetz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4pasp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4ppan[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4ppcys[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_4r5au[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5aizc[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5aop[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5aprbu[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5apru[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5caiz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5mdr1p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5mdru1p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5mta[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5mthf[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_5mtr[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_6pgc[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_6pgl[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_8aonn[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aa[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aacoa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ac[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ac[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acac[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acac[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acald[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acald[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_accoa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acgam1p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_achms[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acmam[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acmama[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acryl[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_acser[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_actACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_actp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ad[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ad[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ade[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ade[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adn[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adn[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adphep7p-LD[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adphep-DD[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_adphep-LD[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_agm[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ahcys[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ahdt[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aicar[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_air[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_akg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_akg[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ala-B[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ala-D[c]"/>
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      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ala-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ala-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_alaala[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_alac-S[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_amet[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ametam[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_amob[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_amp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_anth[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aps[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ara5p[c]"/>
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      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_arg-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_argsuc[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_asn-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_asn-L[e]"/>
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      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_asp-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_aspsa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_atp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_btamp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_btn[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_c190cACP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cbasp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cbp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cdpdag_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cdpea[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cgly[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_chor[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cit[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cit[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_citr-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_clpn_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cmpkdo[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_co2[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_co2[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_coa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_core_lps_hp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cpppg1[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cpppg3[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ctp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cys-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cys-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cyst-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cytd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_cytd[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dad-2[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dad-2[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dadp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_damp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dann[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_datp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_db4p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dcamp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dcdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dctp[c]"/>
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      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_dcyt[e]"/>
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      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ser-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ser-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_skm5p[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_skm[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_sl26da[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_sl2a6o[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_so3[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_so4[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_so4[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_spmd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_sprm[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ssaltpp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_sucbz[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_succ[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_succ[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_succoa[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_suchms[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thf[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thm[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thm[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thmmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thmpp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thr-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thr-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thymd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_thymd[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_trdox[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_trdrd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_trnaglu[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_trp-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_trp-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_tyr-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_tyr-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_u23ga_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_u2ga_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_u2hga_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_u3aga_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_u3hga_HP[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uaagmda[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uaccg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uacgam[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uagmda[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uama[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uamag[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uamr[c]" compartment="["/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udcpdp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udcpp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udpg[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_udpgal[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ugam[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ugmd[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ugmda[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ump[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uppg1[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uppg3[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ura[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_ura[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_urea[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_urea[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uri[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_uri[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_utp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_val-L[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_val-L[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_xan[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_xan[e]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_xmp[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_xtsn[c]"/>
      <species boundaryCondition="false" constant="false" hasOnlySubstanceUnits="false" id="M_xu5p-D[c]"/>
    </listOfSpecies>
    <fbc:listOfGeneProducts>
      <fbc:geneProduct fbc:id="G_HP0056" fbc:label="HP0056"/>
      <fbc:geneProduct fbc:id="G_HP0690" fbc:label="HP0690"/>
      <fbc:geneProduct fbc:id="G_HP0950" fbc:label="HP0950"/>
      <fbc:geneProduct fbc:id="G_HP0370" fbc:label="HP0370"/>
      <fbc:geneProduct fbc:id="G_HP0557" fbc:label="HP0557"/>
      <fbc:geneProduct fbc:id="G_HP0371" fbc:label="HP0371"/>
      <fbc:geneProduct fbc:id="G_HP0903" fbc:label="HP0903"/>
      <fbc:geneProduct fbc:id="G_HP0202" fbc:label="HP0202"/>
      <fbc:geneProduct fbc:id="G_HP0779" fbc:label="HP0779"/>
      <fbc:geneProduct fbc:id="G_HP0930" fbc:label="HP0930"/>
      <fbc:geneProduct fbc:id="G_HP0808" fbc:label="HP0808"/>
      <fbc:geneProduct fbc:id="G_HP1045" fbc:label="HP1045"/>
      <fbc:geneProduct fbc:id="G_HP0587" fbc:label="HP0587"/>
      <fbc:geneProduct fbc:id="G_HP0618" fbc:label="HP0618"/>
      <fbc:geneProduct fbc:id="G_HP1180" fbc:label="HP1180"/>
      <fbc:geneProduct fbc:id="G_HP0572" fbc:label="HP0572"/>
      <fbc:geneProduct fbc:id="G_HP1112" fbc:label="HP1112"/>
      <fbc:geneProduct fbc:id="G_HP0255" fbc:label="HP0255"/>
      <fbc:geneProduct fbc:id="G_HP0859" fbc:label="HP0859"/>
      <fbc:geneProduct fbc:id="G_HP0089" fbc:label="HP0089"/>
      <fbc:geneProduct fbc:id="G_HP0106" fbc:label="HP0106"/>
      <fbc:geneProduct fbc:id="G_HP1091" fbc:label="HP1091"/>
      <fbc:geneProduct fbc:id="G_HP0738" fbc:label="HP0738"/>
      <fbc:geneProduct fbc:id="G_HP1398" fbc:label="HP1398"/>
      <fbc:geneProduct fbc:id="G_HP0941" fbc:label="HP0941"/>
      <fbc:geneProduct fbc:id="G_HP0942" fbc:label="HP0942"/>
      <fbc:geneProduct fbc:id="G_HP1104" fbc:label="HP1104"/>
      <fbc:geneProduct fbc:id="G_HP0772" fbc:label="HP0772"/>
      <fbc:geneProduct fbc:id="G_HP0976" fbc:label="HP0976"/>
      <fbc:geneProduct fbc:id="G_HP0294" fbc:label="HP0294"/>
      <fbc:geneProduct fbc:id="G_HP1483" fbc:label="HP1483"/>
      <fbc:geneProduct fbc:id="G_HP1280" fbc:label="HP1280"/>
      <fbc:geneProduct fbc:id="G_HP1282" fbc:label="HP1282"/>
      <fbc:geneProduct fbc:id="G_HP1281" fbc:label="HP1281"/>
      <fbc:geneProduct fbc:id="G_HP0598" fbc:label="HP0598"/>
      <fbc:geneProduct fbc:id="G_HP1505" fbc:label="HP1505"/>
      <fbc:geneProduct fbc:id="G_HP0422" fbc:label="HP0422"/>
      <fbc:geneProduct fbc:id="G_HP1399" fbc:label="HP1399"/>
      <fbc:geneProduct fbc:id="G_HP1017" fbc:label="HP1017"/>
      <fbc:geneProduct fbc:id="G_HP1189" fbc:label="HP1189"/>
      <fbc:geneProduct fbc:id="G_HP0723" fbc:label="HP0723"/>
      <fbc:geneProduct fbc:id="G_HP0724" fbc:label="HP0724"/>
      <fbc:geneProduct fbc:id="G_HP0034" fbc:label="HP0034"/>
      <fbc:geneProduct fbc:id="G_HP1084" fbc:label="HP1084"/>
      <fbc:geneProduct fbc:id="G_HP1229" fbc:label="HP1229"/>
      <fbc:geneProduct fbc:id="G_HP0649" fbc:label="HP0649"/>
      <fbc:geneProduct fbc:id="G_HP0672" fbc:label="HP0672"/>
      <fbc:geneProduct fbc:id="G_HP1134" fbc:label="HP1134"/>
      <fbc:geneProduct fbc:id="G_HP1137" fbc:label="HP1137"/>
      <fbc:geneProduct fbc:id="G_HP0828" fbc:label="HP0828"/>
      <fbc:geneProduct fbc:id="G_HP1212" fbc:label="HP1212"/>
      <fbc:geneProduct fbc:id="G_HP1131" fbc:label="HP1131"/>
      <fbc:geneProduct fbc:id="G_HP1133" fbc:label="HP1133"/>
      <fbc:geneProduct fbc:id="G_HP1136" fbc:label="HP1136"/>
      <fbc:geneProduct fbc:id="G_HP1132" fbc:label="HP1132"/>
      <fbc:geneProduct fbc:id="G_HP1135" fbc:label="HP1135"/>
      <fbc:geneProduct fbc:id="G_HP1140" fbc:label="HP1140"/>
      <fbc:geneProduct fbc:id="G_HP1538" fbc:label="HP1538"/>
      <fbc:geneProduct fbc:id="G_HP1539" fbc:label="HP1539"/>
      <fbc:geneProduct fbc:id="G_HP1227" fbc:label="HP1227"/>
      <fbc:geneProduct fbc:id="G_HP1540" fbc:label="HP1540"/>
      <fbc:geneProduct fbc:id="G_HP1406" fbc:label="HP1406"/>
      <fbc:geneProduct fbc:id="G_HP0558" fbc:label="HP0558"/>
      <fbc:geneProduct fbc:id="G_HP0195" fbc:label="HP0195"/>
      <fbc:geneProduct fbc:id="G_HP0561" fbc:label="HP0561"/>
      <fbc:geneProduct fbc:id="G_HP1376" fbc:label="HP1376"/>
      <fbc:geneProduct fbc:id="G_HP0416" fbc:label="HP0416"/>
      <fbc:geneProduct fbc:id="G_HP0875" fbc:label="HP0875"/>
      <fbc:geneProduct fbc:id="G_HP0919" fbc:label="HP0919"/>
      <fbc:geneProduct fbc:id="G_HP1237" fbc:label="HP1237"/>
      <fbc:geneProduct fbc:id="G_HP1461" fbc:label="HP1461"/>
      <fbc:geneProduct fbc:id="G_HP0871" fbc:label="HP0871"/>
      <fbc:geneProduct fbc:id="G_HP1443" fbc:label="HP1443"/>
      <fbc:geneProduct fbc:id="G_HP0291" fbc:label="HP0291"/>
      <fbc:geneProduct fbc:id="G_HP0663" fbc:label="HP0663"/>
      <fbc:geneProduct fbc:id="G_HP0665" fbc:label="HP0665"/>
      <fbc:geneProduct fbc:id="G_HP1226" fbc:label="HP1226"/>
      <fbc:geneProduct fbc:id="G_HP0026" fbc:label="HP0026"/>
      <fbc:geneProduct fbc:id="G_HP0349" fbc:label="HP0349"/>
      <fbc:geneProduct fbc:id="G_HP0144" fbc:label="HP0144"/>
      <fbc:geneProduct fbc:id="G_HP0145" fbc:label="HP0145"/>
      <fbc:geneProduct fbc:id="G_HP0147" fbc:label="HP0147"/>
      <fbc:geneProduct fbc:id="G_HP0146" fbc:label="HP0146"/>
      <fbc:geneProduct fbc:id="G_HP0107" fbc:label="HP0107"/>
      <fbc:geneProduct fbc:id="G_HP0943" fbc:label="HP0943"/>
      <fbc:geneProduct fbc:id="G_HP0700" fbc:label="HP0700"/>
      <fbc:geneProduct fbc:id="G_HP0290" fbc:label="HP0290"/>
      <fbc:geneProduct fbc:id="G_HP0566" fbc:label="HP0566"/>
      <fbc:geneProduct fbc:id="G_HP0215" fbc:label="HP0215"/>
      <fbc:geneProduct fbc:id="G_HP0804" fbc:label="HP0804"/>
      <fbc:geneProduct fbc:id="G_HP0029" fbc:label="HP0029"/>
      <fbc:geneProduct fbc:id="G_HP0372" fbc:label="HP0372"/>
      <fbc:geneProduct fbc:id="G_HP0134" fbc:label="HP0134"/>
      <fbc:geneProduct fbc:id="G_HP1099" fbc:label="HP1099"/>
      <fbc:geneProduct fbc:id="G_HP0321" fbc:label="HP0321"/>
      <fbc:geneProduct fbc:id="G_HP0510" fbc:label="HP0510"/>
      <fbc:geneProduct fbc:id="G_HP1013" fbc:label="HP1013"/>
      <fbc:geneProduct fbc:id="G_HP1545" fbc:label="HP1545"/>
      <fbc:geneProduct fbc:id="G_HP1510" fbc:label="HP1510"/>
      <fbc:geneProduct fbc:id="G_HP1011" fbc:label="HP1011"/>
      <fbc:geneProduct fbc:id="G_HP0266" fbc:label="HP0266"/>
      <fbc:geneProduct fbc:id="G_HP0581" fbc:label="HP0581"/>
      <fbc:geneProduct fbc:id="G_HP1232" fbc:label="HP1232"/>
      <fbc:geneProduct fbc:id="G_HP1038" fbc:label="HP1038"/>
      <fbc:geneProduct fbc:id="G_HP0283" fbc:label="HP0283"/>
      <fbc:geneProduct fbc:id="G_HP0929" fbc:label="HP0929"/>
      <fbc:geneProduct fbc:id="G_HP0400" fbc:label="HP0400"/>
      <fbc:geneProduct fbc:id="G_HP1228" fbc:label="HP1228"/>
      <fbc:geneProduct fbc:id="G_HP0831" fbc:label="HP0831"/>
      <fbc:geneProduct fbc:id="G_HP1474" fbc:label="HP1474"/>
      <fbc:geneProduct fbc:id="G_HP1178" fbc:label="HP1178"/>
      <fbc:geneProduct fbc:id="G_HP0865" fbc:label="HP0865"/>
      <fbc:geneProduct fbc:id="G_HP0216" fbc:label="HP0216"/>
      <fbc:geneProduct fbc:id="G_HP0354" fbc:label="HP0354"/>
      <fbc:geneProduct fbc:id="G_HP1100" fbc:label="HP1100"/>
      <fbc:geneProduct fbc:id="G_HP0154" fbc:label="HP0154"/>
      <fbc:geneProduct fbc:id="G_HP0176" fbc:label="HP0176"/>
      <fbc:geneProduct fbc:id="G_HP1385" fbc:label="HP1385"/>
      <fbc:geneProduct fbc:id="G_HP0112" fbc:label="HP0112"/>
      <fbc:geneProduct fbc:id="G_HP0376" fbc:label="HP0376"/>
      <fbc:geneProduct fbc:id="G_HP0687" fbc:label="HP0687"/>
      <fbc:geneProduct fbc:id="G_HP0807" fbc:label="HP0807"/>
      <fbc:geneProduct fbc:id="G_HP0889" fbc:label="HP0889"/>
      <fbc:geneProduct fbc:id="G_HP1400" fbc:label="HP1400"/>
      <fbc:geneProduct fbc:id="G_HP0888" fbc:label="HP0888"/>
      <fbc:geneProduct fbc:id="G_HP0686" fbc:label="HP0686"/>
      <fbc:geneProduct fbc:id="G_HP1161" fbc:label="HP1161"/>
      <fbc:geneProduct fbc:id="G_HP0642" fbc:label="HP0642"/>
      <fbc:geneProduct fbc:id="G_HP1087" fbc:label="HP1087"/>
      <fbc:geneProduct fbc:id="G_HP1238" fbc:label="HP1238"/>
      <fbc:geneProduct fbc:id="G_HP0191" fbc:label="HP0191"/>
      <fbc:geneProduct fbc:id="G_HP0192" fbc:label="HP0192"/>
      <fbc:geneProduct fbc:id="G_HP0193" fbc:label="HP0193"/>
      <fbc:geneProduct fbc:id="G_HP1434" fbc:label="HP1434"/>
      <fbc:geneProduct fbc:id="G_HP0577" fbc:label="HP0577"/>
      <fbc:geneProduct fbc:id="G_HP1325" fbc:label="HP1325"/>
      <fbc:geneProduct fbc:id="G_HP0683" fbc:label="HP0683"/>
      <fbc:geneProduct fbc:id="G_HP0306" fbc:label="HP0306"/>
      <fbc:geneProduct fbc:id="G_HP0961" fbc:label="HP0961"/>
      <fbc:geneProduct fbc:id="G_HP1101" fbc:label="HP1101"/>
      <fbc:geneProduct fbc:id="G_HP0646" fbc:label="HP0646"/>
      <fbc:geneProduct fbc:id="G_HP1174" fbc:label="HP1174"/>
      <fbc:geneProduct fbc:id="G_HP1346" fbc:label="HP1346"/>
      <fbc:geneProduct fbc:id="G_HP0921" fbc:label="HP0921"/>
      <fbc:geneProduct fbc:id="G_HP1532" fbc:label="HP1532"/>
      <fbc:geneProduct fbc:id="G_HP0045" fbc:label="HP0045"/>
      <fbc:geneProduct fbc:id="G_HP0183" fbc:label="HP0183"/>
      <fbc:geneProduct fbc:id="G_HP0512" fbc:label="HP0512"/>
      <fbc:geneProduct fbc:id="G_HP1169" fbc:label="HP1169"/>
      <fbc:geneProduct fbc:id="G_HP1172" fbc:label="HP1172"/>
      <fbc:geneProduct fbc:id="G_HP1171" fbc:label="HP1171"/>
      <fbc:geneProduct fbc:id="G_HP1170" fbc:label="HP1170"/>
      <fbc:geneProduct fbc:id="G_HP0380" fbc:label="HP0380"/>
      <fbc:geneProduct fbc:id="G_HP0549" fbc:label="HP0549"/>
      <fbc:geneProduct fbc:id="G_HP0239" fbc:label="HP0239"/>
      <fbc:geneProduct fbc:id="G_HP0643" fbc:label="HP0643"/>
      <fbc:geneProduct fbc:id="G_HP0476" fbc:label="HP0476"/>
      <fbc:geneProduct fbc:id="G_HP1506" fbc:label="HP1506"/>
      <fbc:geneProduct fbc:id="G_HP0509" fbc:label="HP0509"/>
      <fbc:geneProduct fbc:id="G_HP0044" fbc:label="HP0044"/>
      <fbc:geneProduct fbc:id="G_HP0858" fbc:label="HP0858"/>
      <fbc:geneProduct fbc:id="G_HP0860" fbc:label="HP0860"/>
      <fbc:geneProduct fbc:id="G_HP0854" fbc:label="HP0854"/>
      <fbc:geneProduct fbc:id="G_HP0409" fbc:label="HP0409"/>
      <fbc:geneProduct fbc:id="G_HP1118" fbc:label="HP1118"/>
      <fbc:geneProduct fbc:id="G_HP0928" fbc:label="HP0928"/>
      <fbc:geneProduct fbc:id="G_HP0802" fbc:label="HP0802"/>
      <fbc:geneProduct fbc:id="G_HP0735" fbc:label="HP0735"/>
      <fbc:geneProduct fbc:id="G_HP1360" fbc:label="HP1360"/>
      <fbc:geneProduct fbc:id="G_HP0004" fbc:label="HP0004"/>
      <fbc:geneProduct fbc:id="G_HP1186" fbc:label="HP1186"/>
      <fbc:geneProduct fbc:id="G_HP0845" fbc:label="HP0845"/>
      <fbc:geneProduct fbc:id="G_HP1103" fbc:label="HP1103"/>
      <fbc:geneProduct fbc:id="G_HP0237" fbc:label="HP0237"/>
      <fbc:geneProduct fbc:id="G_HP1036" fbc:label="HP1036"/>
      <fbc:geneProduct fbc:id="G_HP1158" fbc:label="HP1158"/>
      <fbc:geneProduct fbc:id="G_HP0822" fbc:label="HP0822"/>
      <fbc:geneProduct fbc:id="G_HP1050" fbc:label="HP1050"/>
      <fbc:geneProduct fbc:id="G_HP0634" fbc:label="HP0634"/>
      <fbc:geneProduct fbc:id="G_HP0631" fbc:label="HP0631"/>
      <fbc:geneProduct fbc:id="G_HP0632" fbc:label="HP0632"/>
      <fbc:geneProduct fbc:id="G_HP0633" fbc:label="HP0633"/>
      <fbc:geneProduct fbc:id="G_HP0027" fbc:label="HP0027"/>
      <fbc:geneProduct fbc:id="G_HP1279" fbc:label="HP1279"/>
      <fbc:geneProduct fbc:id="G_HP1468" fbc:label="HP1468"/>
      <fbc:geneProduct fbc:id="G_HP0829" fbc:label="HP0829"/>
      <fbc:geneProduct fbc:id="G_HP0330" fbc:label="HP0330"/>
      <fbc:geneProduct fbc:id="G_HP0230" fbc:label="HP0230"/>
      <fbc:geneProduct fbc:id="G_HP0003" fbc:label="HP0003"/>
      <fbc:geneProduct fbc:id="G_HP1222" fbc:label="HP1222"/>
      <fbc:geneProduct fbc:id="G_HP0867" fbc:label="HP0867"/>
      <fbc:geneProduct fbc:id="G_HP0159" fbc:label="HP0159"/>
      <fbc:geneProduct fbc:id="G_HP0093" fbc:label="HP0093"/>
      <fbc:geneProduct fbc:id="G_HP1416" fbc:label="HP1416"/>
      <fbc:geneProduct fbc:id="G_HP0279" fbc:label="HP0279"/>
      <fbc:geneProduct fbc:id="G_HP0826" fbc:label="HP0826"/>
      <fbc:geneProduct fbc:id="G_HP0094" fbc:label="HP0094"/>
      <fbc:geneProduct fbc:id="G_HP0208" fbc:label="HP0208"/>
      <fbc:geneProduct fbc:id="G_HP0140" fbc:label="HP0140"/>
      <fbc:geneProduct fbc:id="G_HP0141" fbc:label="HP0141"/>
      <fbc:geneProduct fbc:id="G_HP0043" fbc:label="HP0043"/>
      <fbc:geneProduct fbc:id="G_HP0090" fbc:label="HP0090"/>
      <fbc:geneProduct fbc:id="G_HP0086" fbc:label="HP0086"/>
      <fbc:geneProduct fbc:id="G_HP0625" fbc:label="HP0625"/>
      <fbc:geneProduct fbc:id="G_HP1020" fbc:label="HP1020"/>
      <fbc:geneProduct fbc:id="G_HP0197" fbc:label="HP0197"/>
      <fbc:geneProduct fbc:id="G_HP0957" fbc:label="HP0957"/>
      <fbc:geneProduct fbc:id="G_HP1058" fbc:label="HP1058"/>
      <fbc:geneProduct fbc:id="G_HP1394" fbc:label="HP1394"/>
      <fbc:geneProduct fbc:id="G_HP0630" fbc:label="HP0630"/>
      <fbc:geneProduct fbc:id="G_HP0329" fbc:label="HP0329"/>
      <fbc:geneProduct fbc:id="G_HP0313" fbc:label="HP0313"/>
      <fbc:geneProduct fbc:id="G_HP1183" fbc:label="HP1183"/>
      <fbc:geneProduct fbc:id="G_HP1552" fbc:label="HP1552"/>
      <fbc:geneProduct fbc:id="G_HP1273" fbc:label="HP1273"/>
      <fbc:geneProduct fbc:id="G_HP1270" fbc:label="HP1270"/>
      <fbc:geneProduct fbc:id="G_HP1264" fbc:label="HP1264"/>
      <fbc:geneProduct fbc:id="G_HP1271" fbc:label="HP1271"/>
      <fbc:geneProduct fbc:id="G_HP1265" fbc:label="HP1265"/>
      <fbc:geneProduct fbc:id="G_HP1269" fbc:label="HP1269"/>
      <fbc:geneProduct fbc:id="G_HP1261" fbc:label="HP1261"/>
      <fbc:geneProduct fbc:id="G_HP1262" fbc:label="HP1262"/>
      <fbc:geneProduct fbc:id="G_HP1260" fbc:label="HP1260"/>
      <fbc:geneProduct fbc:id="G_HP1266" fbc:label="HP1266"/>
      <fbc:geneProduct fbc:id="G_HP1263" fbc:label="HP1263"/>
      <fbc:geneProduct fbc:id="G_HP1268" fbc:label="HP1268"/>
      <fbc:geneProduct fbc:id="G_HP1272" fbc:label="HP1272"/>
      <fbc:geneProduct fbc:id="G_HP1267" fbc:label="HP1267"/>
      <fbc:geneProduct fbc:id="G_HP0198" fbc:label="HP0198"/>
      <fbc:geneProduct fbc:id="G_HP1576" fbc:label="HP1576"/>
      <fbc:geneProduct fbc:id="G_HP1077" fbc:label="HP1077"/>
      <fbc:geneProduct fbc:id="G_HP1337" fbc:label="HP1337"/>
      <fbc:geneProduct fbc:id="G_HP1290" fbc:label="HP1290"/>
      <fbc:geneProduct fbc:id="G_HP1355" fbc:label="HP1355"/>
      <fbc:geneProduct fbc:id="G_HP1563" fbc:label="HP1563"/>
      <fbc:geneProduct fbc:id="G_HP0691" fbc:label="HP0691"/>
      <fbc:geneProduct fbc:id="G_HP0692" fbc:label="HP0692"/>
      <fbc:geneProduct fbc:id="G_HP0240" fbc:label="HP0240"/>
      <fbc:geneProduct fbc:id="G_HP0005" fbc:label="HP0005"/>
      <fbc:geneProduct fbc:id="G_HP0589" fbc:label="HP0589"/>
      <fbc:geneProduct fbc:id="G_HP0591" fbc:label="HP0591"/>
      <fbc:geneProduct fbc:id="G_HP0588" fbc:label="HP0588"/>
      <fbc:geneProduct fbc:id="G_HP0590" fbc:label="HP0590"/>
      <fbc:geneProduct fbc:id="G_HP0396" fbc:label="HP0396"/>
      <fbc:geneProduct fbc:id="G_HP1257" fbc:label="HP1257"/>
      <fbc:geneProduct fbc:id="G_HP0293" fbc:label="HP0293"/>
      <fbc:geneProduct fbc:id="G_HP0006" fbc:label="HP0006"/>
      <fbc:geneProduct fbc:id="G_HP0493" fbc:label="HP0493"/>
      <fbc:geneProduct fbc:id="G_HP1348" fbc:label="HP1348"/>
      <fbc:geneProduct fbc:id="G_HP1111" fbc:label="HP1111"/>
      <fbc:geneProduct fbc:id="G_HP1109" fbc:label="HP1109"/>
      <fbc:geneProduct fbc:id="G_HP1110" fbc:label="HP1110"/>
      <fbc:geneProduct fbc:id="G_HP1108" fbc:label="HP1108"/>
      <fbc:geneProduct fbc:id="G_HP0075" fbc:label="HP0075"/>
      <fbc:geneProduct fbc:id="G_HP0096" fbc:label="HP0096"/>
      <fbc:geneProduct fbc:id="G_HP0397" fbc:label="HP0397"/>
      <fbc:geneProduct fbc:id="G_HP1166" fbc:label="HP1166"/>
      <fbc:geneProduct fbc:id="G_HP1345" fbc:label="HP1345"/>
      <fbc:geneProduct fbc:id="G_HP1102" fbc:label="HP1102"/>
      <fbc:geneProduct fbc:id="G_HP0974" fbc:label="HP0974"/>
      <fbc:geneProduct fbc:id="G_HP0737" fbc:label="HP0737"/>
      <fbc:geneProduct fbc:id="G_HP1016" fbc:label="HP1016"/>
      <fbc:geneProduct fbc:id="G_HP1491" fbc:label="HP1491"/>
      <fbc:geneProduct fbc:id="G_HP1275" fbc:label="HP1275"/>
      <fbc:geneProduct fbc:id="G_HP0844" fbc:label="HP0844"/>
      <fbc:geneProduct fbc:id="G_HP0620" fbc:label="HP0620"/>
      <fbc:geneProduct fbc:id="G_HP0163" fbc:label="HP0163"/>
      <fbc:geneProduct fbc:id="G_HP1179" fbc:label="HP1179"/>
      <fbc:geneProduct fbc:id="G_HP1380" fbc:label="HP1380"/>
      <fbc:geneProduct fbc:id="G_HP0381" fbc:label="HP0381"/>
      <fbc:geneProduct fbc:id="G_HP0121" fbc:label="HP0121"/>
      <fbc:geneProduct fbc:id="G_HP1218" fbc:label="HP1218"/>
      <fbc:geneProduct fbc:id="G_HP0818" fbc:label="HP0818"/>
      <fbc:geneProduct fbc:id="G_HP0819" fbc:label="HP0819"/>
      <fbc:geneProduct fbc:id="G_HP0936" fbc:label="HP0936"/>
      <fbc:geneProduct fbc:id="G_HP0055" fbc:label="HP0055"/>
      <fbc:geneProduct fbc:id="G_HP0742" fbc:label="HP0742"/>
      <fbc:geneProduct fbc:id="G_HP0401" fbc:label="HP0401"/>
      <fbc:geneProduct fbc:id="G_HP1357" fbc:label="HP1357"/>
      <fbc:geneProduct fbc:id="G_HP0736" fbc:label="HP0736"/>
      <fbc:geneProduct fbc:id="G_HP0652" fbc:label="HP0652"/>
      <fbc:geneProduct fbc:id="G_HP1071" fbc:label="HP1071"/>
      <fbc:geneProduct fbc:id="G_HP0905" fbc:label="HP0905"/>
      <fbc:geneProduct fbc:id="G_HP1475" fbc:label="HP1475"/>
      <fbc:geneProduct fbc:id="G_HP1356" fbc:label="HP1356"/>
      <fbc:geneProduct fbc:id="G_HP1574" fbc:label="HP1574"/>
      <fbc:geneProduct fbc:id="G_HP0002" fbc:label="HP0002"/>
      <fbc:geneProduct fbc:id="G_HP0105" fbc:label="HP0105"/>
      <fbc:geneProduct fbc:id="G_HP0680" fbc:label="HP0680"/>
      <fbc:geneProduct fbc:id="G_HP0364" fbc:label="HP0364"/>
      <fbc:geneProduct fbc:id="G_HP1386" fbc:label="HP1386"/>
      <fbc:geneProduct fbc:id="G_HP0574" fbc:label="HP0574"/>
      <fbc:geneProduct fbc:id="G_HP0857" fbc:label="HP0857"/>
      <fbc:geneProduct fbc:id="G_HP0212" fbc:label="HP0212"/>
      <fbc:geneProduct fbc:id="G_HP0624" fbc:label="HP0624"/>
      <fbc:geneProduct fbc:id="G_HP1210" fbc:label="HP1210"/>
      <fbc:geneProduct fbc:id="G_HP0132" fbc:label="HP0132"/>
      <fbc:geneProduct fbc:id="G_HP0133" fbc:label="HP0133"/>
      <fbc:geneProduct fbc:id="G_HP1249" fbc:label="HP1249"/>
      <fbc:geneProduct fbc:id="G_HP0157" fbc:label="HP0157"/>
      <fbc:geneProduct fbc:id="G_HP0832" fbc:label="HP0832"/>
      <fbc:geneProduct fbc:id="G_HP0389" fbc:label="HP0389"/>
      <fbc:geneProduct fbc:id="G_HP0228" fbc:label="HP0228"/>
      <fbc:geneProduct fbc:id="G_HP1495" fbc:label="HP1495"/>
      <fbc:geneProduct fbc:id="G_HP0626" fbc:label="HP0626"/>
      <fbc:geneProduct fbc:id="G_HP0098" fbc:label="HP0098"/>
      <fbc:geneProduct fbc:id="G_HP0814" fbc:label="HP0814"/>
      <fbc:geneProduct fbc:id="G_HP1088" fbc:label="HP1088"/>
      <fbc:geneProduct fbc:id="G_HP1533" fbc:label="HP1533"/>
      <fbc:geneProduct fbc:id="G_HP0843" fbc:label="HP0843"/>
      <fbc:geneProduct fbc:id="G_HP0194" fbc:label="HP0194"/>
      <fbc:geneProduct fbc:id="G_HP1164" fbc:label="HP1164"/>
      <fbc:geneProduct fbc:id="G_HP0824" fbc:label="HP0824"/>
      <fbc:geneProduct fbc:id="G_HP1458" fbc:label="HP1458"/>
      <fbc:geneProduct fbc:id="G_HP0825" fbc:label="HP0825"/>
      <fbc:geneProduct fbc:id="G_HP1278" fbc:label="HP1278"/>
      <fbc:geneProduct fbc:id="G_HP1277" fbc:label="HP1277"/>
      <fbc:geneProduct fbc:id="G_HP0196" fbc:label="HP0196"/>
      <fbc:geneProduct fbc:id="G_HP1494" fbc:label="HP1494"/>
      <fbc:geneProduct fbc:id="G_HP1375" fbc:label="HP1375"/>
      <fbc:geneProduct fbc:id="G_HP0648" fbc:label="HP0648"/>
      <fbc:geneProduct fbc:id="G_HP1155" fbc:label="HP1155"/>
      <fbc:geneProduct fbc:id="G_HP0494" fbc:label="HP0494"/>
      <fbc:geneProduct fbc:id="G_HP0623" fbc:label="HP0623"/>
      <fbc:geneProduct fbc:id="G_HP1418" fbc:label="HP1418"/>
      <fbc:geneProduct fbc:id="G_HP1221" fbc:label="HP1221"/>
      <fbc:geneProduct fbc:id="G_HP0360" fbc:label="HP0360"/>
      <fbc:geneProduct fbc:id="G_HP0740" fbc:label="HP0740"/>
      <fbc:geneProduct fbc:id="G_HP1052" fbc:label="HP1052"/>
      <fbc:geneProduct fbc:id="G_HP0777" fbc:label="HP0777"/>
      <fbc:geneProduct fbc:id="G_HP1224" fbc:label="HP1224"/>
      <fbc:geneProduct fbc:id="G_HP0604" fbc:label="HP0604"/>
      <fbc:geneProduct fbc:id="G_HP0067" fbc:label="HP0067"/>
      <fbc:geneProduct fbc:id="G_HP0068" fbc:label="HP0068"/>
      <fbc:geneProduct fbc:id="G_HP0069" fbc:label="HP0069"/>
      <fbc:geneProduct fbc:id="G_HP0073" fbc:label="HP0073"/>
      <fbc:geneProduct fbc:id="G_HP0072" fbc:label="HP0072"/>
      <fbc:geneProduct fbc:id="G_HP0070" fbc:label="HP0070"/>
      <fbc:geneProduct fbc:id="G_HP0071" fbc:label="HP0071"/>
    </fbc:listOfGeneProducts>
    <listOfReactions>
      <reaction fast="false" id="R_4HGLSD" reversible="true" name="L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_4hglusa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_e4hglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_A5PISO" reversible="true" name="arabinose-5-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ara5p[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AAtr" reversible="true" name="acrylamide transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_aa[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACACT1r" reversible="true" name="acetyl-CoA C-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0690"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACACt2" reversible="true" name="acetoacetate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acac[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACALDt" reversible="true" name="acetaldehyde reversible transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_acald[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ACCOACr" reversible="true" name="acetyl-CoA carboxylase, reversible reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0370"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0371"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0950"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0557"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACKr" reversible="true" name="acetate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_actp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0903"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACOATA" reversible="true" name="Acetyl-CoA ACP transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0202"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACONT" reversible="true" name="aconitase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_icit[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0779"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACP1_FMN" reversible="false" name="acid phosphatase (FMN)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0930"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACPS" reversible="false" name="Acyl Carrier Protein Synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pan4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0808"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACS" reversible="false" name="acetyl-CoA synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1045"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ACt2r" reversible="true" name="acetate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADCL" reversible="false" name=" 4-aminobenzoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4adcho[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0587"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADD" reversible="false" name="adenine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADEt2" reversible="false" name="adenine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ade[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADK1" reversible="true" name="adenylate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0618"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADMDCr" reversible="true" name="Adenosylmethionine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ametam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADNUC" reversible="false" name="adenosine hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADNt2" reversible="false" name="adenosine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADPT" reversible="false" name="adenine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0572"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSK" reversible="false" name="adenylyl-sulfate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_paps[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ADSL1r" reversible="true" name="adenylsuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcamp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1112"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSL2r" reversible="true" name="adenylosuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_25aics[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1112"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADSS" reversible="false" name="adenylosuccinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcamp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0255"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ADtr" reversible="true" name="acetamide transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ad[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ad[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AGMHE" reversible="false" name="ADP-D-glycero-D-manno-heptose epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adphep-DD[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adphep-LD[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0859"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AGMT" reversible="false" name="agmatinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_agm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ptrc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AHCYSNS" reversible="false" name="S-adenosylhomocysteine nucleosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rhcys[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0089"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AHSERL2" reversible="false" name="O-acetylhomoserine (thiol)-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_achms[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0106"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AICART" reversible="true" name="phosphoribosylaminoimidazolecarboxamide formyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_aicar[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fprica[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AIRC2r" reversible="true" name="phosphoribosylaminoimidazole carboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5caiz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AIRC3" reversible="true" name="phosphoribosylaminoimidazole carboxylase (mutase rxn)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aizc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5caiz[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_AKGt2r" reversible="true" name=" 2-oxoglutarate reversible transport via symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1091"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AKO" reversible="false" name="a-ketoglutarate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ALAALAr" reversible="true" name="D-alanine-D-alanine ligase (reversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0738"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAD_L" reversible="false" name="L-alanine dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1398"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAR" reversible="true" name="alanine racemase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0941"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAt2" reversible="false" name="L-alanine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0942"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALAt4" reversible="false" name="Alanine-Sodium symporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0942"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ALCD2y" reversible="true" name="alcohol dehydrogenase (ethanol, NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_etoh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1104"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMAA" reversible="false" name="N-acetylmuramoyl-L-alanine amidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acmama[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acmam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0772"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMAOTr" reversible="true" name="adenosylmethionine-8-amino-7-oxononanoate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_8aonn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dann[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0976"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMID2" reversible="false" name="amidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pac[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0294"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMID4" reversible="false" name="amidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0294"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMID5" reversible="false" name="amidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acryl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0294"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AMMQT6" reversible="false" name="S-adenosylmethione" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dmmq6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1483"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ANPRT" reversible="false" name="anthranilate phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_anth[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pran[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1280"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ANS" reversible="false" name="anthranilate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_anth[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1282"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1281"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ANS2" reversible="false" name="anthranilate synthase 2" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_anth[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1282"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1281"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_AOXSr" reversible="true" name=" 8-amino-7-oxononanoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_8aonn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0598"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_APRAUR" reversible="false" name=" 5-amino-6-(5-phosphoribosylamino)uracil reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5apru[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5aprbu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1505"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGDC" reversible="false" name="arginine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_agm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0422"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGN" reversible="false" name="arginase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1399"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ARGSL" reversible="true" name="argininosuccinate lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_argsuc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARGSS" reversible="false" name="argininosuccinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_citr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_argsuc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ARGt2r" reversible="true" name="L-arganine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1017"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASAD" reversible="true" name="aspartate-semialdehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4pasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1189"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNN" reversible="false" name="L-asparaginase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0723"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNS2" reversible="false" name="asparagine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0723"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASNabc" reversible="false" name="L-asparagine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ASNt2" reversible="false" name="L-asparagine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0724"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASP1DC" reversible="false" name="aspartate 1-decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0034"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPCT" reversible="false" name="aspartate carbamoyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cbasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1084"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPK" reversible="true" name="aspartate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4pasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1229"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPO2" reversible="false" name="L-aspartate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_iasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ASPT" reversible="false" name="L-aspartase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0649"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPTA" reversible="true" name="aspartate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0672"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ASPt2r" reversible="true" name="L-aspartate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0724"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ATPS4r" reversible="true" name="ATP synthase (four protons for one ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1212"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1131"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP1136"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1137"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1135"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1132"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1133"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0828"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1134"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BACCL" reversible="false" name="biotin-[acetyl-CoA-carboxylase] ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_btamp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1140"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BC10_new" reversible="false" name="Cytochrome bc1 complex (complex III)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ficytcc553[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_focytcc553[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1540"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP1539"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1538"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1227"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BPNT" reversible="false" name=" 3',5'-bisphosphate nucleotidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_BTS2" reversible="true" name="biotin synthase (ala-L producing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtbt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1406"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_BiomassHP_published" reversible="false" name="growth demand" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mthf[c]" stoichiometry="0.05"/>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="5e-05"/>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="0.488"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="0.001"/>
          <speciesReference constant="true" species="M_arg-L[c]" stoichiometry="0.281"/>
          <speciesReference constant="true" species="M_asn-L[c]" stoichiometry="0.229"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="0.229"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="45.7318"/>
          <speciesReference constant="true" species="M_btn[c]" stoichiometry="6e-06"/>
          <speciesReference constant="true" species="M_clpn_HP[c]" stoichiometry="0.027907"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="6e-06"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="0.126"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="0.087"/>
          <speciesReference constant="true" species="M_datp[c]" stoichiometry="0.0247"/>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="0.0254"/>
          <speciesReference constant="true" species="M_dgtp[c]" stoichiometry="0.0254"/>
          <speciesReference constant="true" species="M_dttp[c]" stoichiometry="0.0247"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1e-05"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="0.25"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="0.25"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="0.582"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="0.203"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="45.5608"/>
          <speciesReference constant="true" species="M_his-L[c]" stoichiometry="0.09"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="0.276"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="0.428"/>
          <speciesReference constant="true" species="M_lps_HP[c]" stoichiometry="0.0084"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="0.326"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="0.146"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="6e-06"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="0.00215"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="5e-05"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="0.00013"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="0.0004"/>
          <speciesReference constant="true" species="M_pe_HP[c]" stoichiometry="0.074894"/>
          <speciesReference constant="true" species="M_peptido_EC[c]" stoichiometry="0.0276"/>
          <speciesReference constant="true" species="M_pg_HP[c]" stoichiometry="0.016354"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="0.176"/>
          <speciesReference constant="true" species="M_pheme[c]" stoichiometry="6e-06"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="0.21"/>
          <speciesReference constant="true" species="M_ps_HP[c]" stoichiometry="0.003374"/>
          <speciesReference constant="true" species="M_ptrc[c]" stoichiometry="0.035"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="0.205"/>
          <speciesReference constant="true" species="M_spmd[c]" stoichiometry="0.007"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="3e-06"/>
          <speciesReference constant="true" species="M_thm[c]" stoichiometry="6e-06"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="0.241"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="0.054"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="0.131"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="0.003"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="0.136"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="0.402"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="45.5608"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="45.5608"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="45.5628"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="0.7302"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_C140SN" reversible="false" name="Fatty acid biosynthesis (n-C14:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="17"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="12"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_myrsACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="12"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_C160SN" reversible="false" name="Fatty acid biosynthesis (n-C16:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="20"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="14"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="6"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="14"/>
          <speciesReference constant="true" species="M_palmACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_C180SN" reversible="false" name="Fatty acid biosynthesis (n-C18:0)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="23"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="16"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="16"/>
          <speciesReference constant="true" species="M_ocdcaACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_C181SN" reversible="false" name="Fatty acid biosynthesis (n-C18:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="22"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="15"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="7"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="15"/>
          <speciesReference constant="true" species="M_octeACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_C190cSN" reversible="false" name="C190cSN" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octeACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_c190cACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_HP0416"/>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CAT" reversible="false" name="catalase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0875"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CBPS" reversible="false" name="carbamoyl-phosphate synthase (glutamine-hydrolysing)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1237"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0919"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CCP" reversible="false" name="Cytochrome c peroxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_focytcc553[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ficytcc553[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1461"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDAPPA_HP" reversible="false" name="CDP-Diacylglycerol pyrophosphatase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdag_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pa_Hp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0871"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CDPMEK" reversible="false" name=" 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2p4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1443"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHCOAL" reversible="false" name=" 6-carboxyhexanoate-CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pime[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pmcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CHORM" reversible="false" name="chorismate mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0291"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CHORS" reversible="false" name="chorismate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3psme[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0663"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CLPNS_HP" reversible="true" name="Cardiolipin Synthase (Hpi)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pg_HP[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_clpn_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CO2t" reversible="true" name="CO2 transporter via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CPPPGO" reversible="false" name="coproporphyrinogen oxidase (O2 required)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cpppg3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pppg9[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0665"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1226"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CS" reversible="false" name="citrate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0026"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CTPS1" reversible="false" name="CTP synthase (NH3)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0349"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYOO_HP" reversible="false" name="cytochrome c 553 oxidase, Hpylori" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_focytcc553[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="5.98"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ficytcc553[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1.99"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="0.005"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0147"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0146"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1227"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0144"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0145"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYSS" reversible="false" name="cysteine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acser[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0107"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYSabc" reversible="false" name="L-cysteine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_CYTDt2" reversible="false" name="cytidine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cytd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_CYTK1" reversible="true" name="cytidylate kinase (CMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DAAD" reversible="false" name="D-Amino acid dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0943"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DADK" reversible="true" name="deoxyadenylate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_damp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0618"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DADNt2" reversible="false" name="deoxyadenosine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dad-2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dad-2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DAGK_HP" reversible="false" name="Diacylglycerol kinase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_12dgr_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa_Hp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0700"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DALAt2" reversible="false" name="D-Alanine transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ala-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0942"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DAPDC" reversible="false" name="diaminopimelate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0290"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DAPE" reversible="true" name="diaminopimelate epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-LL[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0566"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DASYN_HP" reversible="true" name="CDP-Diacylglycerol synthetase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pa_Hp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cdpdag_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0215"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DB4PS" reversible="false" name=" 3,4-Dihydroxy-2-butanone-4-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_db4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0804"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DBTSr" reversible="true" name="dethiobiotin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtbt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0029"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCTPD" reversible="false" name="dCTP deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0372"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCTPD2" reversible="false" name="dCTP deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0372"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DCYTt2" reversible="false" name="deoxycytidine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcyt[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcyt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DDPA" reversible="false" name=" 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dda7p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0134"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DDPGA" reversible="true" name=" 2-dehydro-3-deoxy-phosphogluconate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_4h2oglt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1099"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DGK1" reversible="true" name="deoxyguanylate kinase (dGMP:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0321"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHDPRy" reversible="false" name="dihydrodipicolinate reductase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_23dhdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0510"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHDPS" reversible="false" name="dihydrodipicolinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1013"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHFRi" reversible="false" name="dihydrofolate reductase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DHFS" reversible="false" name="dihydrofolate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1545"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHNAOT2" reversible="false" name=" 1,4-dihydroxy-2-naphthoate octaprenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dmmq6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DHNPA" reversible="false" name="dihydroneopterin aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhnpt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ahhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gcald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1510"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORD3" reversible="true" name="dihydroorotic acid dehydrogenase (menaquinone 6)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1011"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHORTS" reversible="true" name="dihydroorotase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhor-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cbasp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0581"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0266"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPPDA" reversible="false" name="diaminohydroxyphosphoribosylaminopyrimidine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_25dhpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5apru[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1505"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPS" reversible="false" name="dihydropteroate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1232"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHPTDCs" reversible="false" name=" 4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhptd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hmfurn[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DHQD" reversible="true" name=" 3-dehydroquinate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3dhq[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3dhsk[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1038"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DHQS" reversible="false" name=" 3-dehydroquinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dda7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3dhq[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0283"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DKMPPD" reversible="false" name=" 2,3-diketo-5-methylthio-1-phosphopentane degradation reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dkmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2kmb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DMATT" reversible="false" name="dimethylallyltranstransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_grdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0929"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DMPPS" reversible="false" name=" 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0400"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DM_HMFURN" reversible="false" name="Sink needed to allow 4-hydroxy-5-methyl-3(2H)-furanone to leave system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hmfurn[c]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_DNMPPA" reversible="false" name="Dihydroneopterin monophosphate dephosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhpmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhnpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1228"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DNTPPA" reversible="false" name="Dihydroneopterin triphosphate pyrophosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahdt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1228"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DPCOAK" reversible="false" name="dephospho-CoA kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dpcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0831"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DPR" reversible="false" name=" 2-dehydropantoate 2-reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dhp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pant-R[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DSERt2" reversible="false" name="D-serine transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-D[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0942"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DTMPK" reversible="true" name="dTMP kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1474"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DURIK1" reversible="false" name="deoxyuridine kinase (ATP:Deoxyuridine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_DURIPP" reversible="true" name="deoxyuridine phosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DURIt2" reversible="false" name="deoxyuridine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_duri[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_duri[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DUTPDP" reversible="false" name="dUTP diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0865"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DXPRIi" reversible="false" name=" 1-deoxy-D-xylulose reductoisomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dxyl5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2me4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0216"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_DXPS" reversible="false" name=" 1-deoxy-D-xylulose 5-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dxyl5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0354"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_EDA" reversible="false" name=" 2-dehydro-3-deoxy-phosphogluconate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ddg6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1099"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_EDD" reversible="false" name=" 6-phosphogluconate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6pgc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ddg6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1100"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_EHGLAT" reversible="false" name="L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_e4hglu[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4h2oglt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0672"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ENO" reversible="true" name="enolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2pg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0154"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ETOHt2r" reversible="true" name="ethanol reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_etoh[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_etoh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FADOX" reversible="false" name="fadox" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FBA" reversible="true" name="fructose-bisphosphate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0176"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FBA2" reversible="true" name="D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_f1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyald[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0176"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FBP" reversible="false" name="fructose-bisphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1385"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FCLPA" reversible="true" name="L-fuculose 1-phosphate aldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fc1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lald-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0112"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FCLT" reversible="false" name="Ferrochelatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pheme[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0376"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FE2abc" reversible="false" name="iron (II) transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fe2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0687"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FEDCabc" reversible="false" name="iron (III) dicitrate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cit[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_fe3[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cit[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_fe3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP0889"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP0888"/>
            </fbc:and>
            <fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_HP0807"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP0686"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1400"/>
            </fbc:or>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FLDO" reversible="false" name="NAD(P)H-flavin oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fmnh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0642"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1161"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FMNAT" reversible="false" name="FMN adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1087"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FOLD3" reversible="false" name="dihydropteroate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahhmd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4abz[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhpt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1232"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FORAMD" reversible="false" name="formamidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frmd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1238"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FORt" reversible="true" name="formate transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_for[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FRD5" reversible="true" name="fumarate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0192"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0191"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0193"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FRDO" reversible="false" name="frdo" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fdxrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fdxox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_FTHFD" reversible="false" name="formyltetrahydrofolate deformylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1434"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FTHFLi" reversible="false" name="formate-tetrahydrofolate ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0577"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FUM" reversible="true" name="fumarase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1325"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_FUMt3" reversible="false" name="fumarate transport out via proton antiport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fum[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G1PACT" reversible="false" name="glucosamine-1-phosphate N-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gam1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0683"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G1SATi" reversible="false" name="glutamate-1-semialdehyde aminotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu1sa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5aop[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0306"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G3PD1" reversible="true" name="glycerol-3-phosphate dehydrogenase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0961"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G3PD2" reversible="true" name="glycerol-3-phosphate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0961"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_G5SADr" reversible="true" name="L-glutamate 5-semialdehyde dehydratase, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G6PDH1" reversible="false" name="glucose-6-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6pgl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_G6PDH2" reversible="false" name="glucose 6-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6pgl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1101"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALK" reversible="false" name="galactokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gal1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GALTi" reversible="false" name="galactose-1-phosphate uridylyltransferase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GALU" reversible="true" name="UTP-glucose-1-phosphate uridylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0646"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GALt2" reversible="false" name="D-galactose transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gal[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1174"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GAPD" reversible="true" name="glyceraldehyde-3-phosphate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_13dpg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_HP0921"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1346"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GARFTi" reversible="false" name="phosphoribosylglycinamide formyltransferase, irreversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gar[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GART" reversible="false" name="GAR transformylase-T" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gar[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GCALDDr" reversible="true" name="Glycolaldehyde dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gcald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GF6PTA" reversible="false" name="glutamine-fructose-6-phosphate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gam6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1532"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GFUCS" reversible="false" name="GDP-L-fucose synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpddman[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpfuc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0045"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GHMT2r" reversible="true" name="glycine hydroxymethyltransferase, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0183"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GK1" reversible="true" name="guanylate kinase (GMP:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0321"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLCt2" reversible="false" name="D-glucose transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glc-D[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1174"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNS" reversible="false" name="glutamine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0512"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLNabc" reversible="false" name="L-glutamine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP1169"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1170"/>
            </fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1171"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1172"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUDC" reversible="false" name="Glutamate Decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4abut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0422"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUDy" reversible="true" name="glutamate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0380"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUN" reversible="false" name="glutaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLUPRT" reversible="false" name="glutamine phosphoribosyldiphosphate amidotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pram[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLUR" reversible="true" name="glutamate racemase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0549"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUTRR" reversible="false" name="glutamyl-tRNA reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glutrna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu1sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trnaglu[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0239"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUTRS" reversible="false" name="Glutamyl-tRNA synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trnaglu[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glutrna[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0643"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0476"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLUt2r" reversible="true" name="L-glutamate transport via proton symport, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1506"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYCTO1" reversible="false" name="Glycolate oxidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glyclt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0509"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GLYK" reversible="false" name="glycerol kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GLYt2" reversible="false" name="glycine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0942"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMAND" reversible="false" name="GDP-D-mannose dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpddman[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0044"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMHEPAT" reversible="false" name="D-glycero-D-manno-hepose 1-phosphate adenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmhep1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adphep-DD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0858"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMHEPK" reversible="false" name="D-glycero-D-manno-heptose 7-phosphate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmhep7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmhep17bp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0858"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMHEPPA" reversible="false" name="D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gmhep17bp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmhep1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0860"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMPR" reversible="false" name="GMP reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0854"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GMPS2" reversible="false" name="GMP synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0409"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GND" reversible="false" name="phosphogluconate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6pgc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GNNUC" reversible="false" name="gnnuc" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_rib-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GRTT" reversible="false" name="geranyltranstransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_grdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0929"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GSNt2" reversible="false" name="guanosine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gsn[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_GTMLT" reversible="false" name="g-glutamyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gthrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cgly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gluala[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1118"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPCI" reversible="false" name="GTP cyclohydrolase I" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ahdt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0928"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GTPCII" reversible="false" name="GTP cyclohydrolase II" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_25dhpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_for[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0802"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GUAPRT" reversible="false" name="guanine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0735"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_GUAt" reversible="true" name="Guanine transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gua[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2CO3D" reversible="true" name="carboxylic acid dissociation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2co3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2CO3D2" reversible="true" name="carboxylic acid dissociation" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2co3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2CO3TP" reversible="true" name="H2CO3 transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2co3[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2co3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_H2Ot" reversible="true" name="H2O transport via diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HBZOPT" reversible="false" name="Hydroxybenzoate octaprenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4hbz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3ophb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1360"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HCO3E" reversible="true" name="HCO3 equilibration reaction" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hco3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_HP0004"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1186"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HEMEti" reversible="false" name="Heme transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pheme[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pheme[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HETZK" reversible="false" name="hydroxyethylthiazole kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4mhetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4mpetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0845"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HEX1" reversible="false" name="hexokinase (D-glucose:ATP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glc-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1103"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HISabc" reversible="false" name="L-histidine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_his-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_his-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HMBS" reversible="false" name="hydroxymethylbilane synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppbng[c]" stoichiometry="4"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hmbil[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="4"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0237"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HPPK" reversible="false" name=" 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ahhmd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1036"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HPROa" reversible="false" name="L-hydroxyproline reductase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1p3h5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hpro-LT[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1158"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HPROx" reversible="false" name="L-hydroxyproline oxidase (NAD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4hpro-LT[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1p3h5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSDy" reversible="true" name="homoserine dehydrogenase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aspsa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0822"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HSERTA" reversible="true" name="homoserine O-trans-acetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_achms[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_HSK" reversible="false" name="homoserine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hom-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phom[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1050"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HXPRT" reversible="false" name="hypoxanthine phosphoribosyltransferase (Hypoxanthine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0735"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HYDA1" reversible="false" name="hyda" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0633"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0631"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0632"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0634"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_HYXNt" reversible="true" name="Hypoxanthine transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_hxan[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ICDHyr" reversible="true" name="isocitrate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_icit[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0027"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ICHORSi" reversible="false" name="Isochorismate Synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ichor[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IGPS" reversible="false" name="indole-3-glycerol-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2cpr5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1279"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ILETA" reversible="true" name="isoleucine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1468"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ILEabc" reversible="false" name="L-isoleucine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ile-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IMPC" reversible="true" name="IMP cyclohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fprica[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_IMPD" reversible="false" name="IMP dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_imp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0829"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_IPDPS" reversible="false" name=" 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0400"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KARA1i" reversible="false" name="acetohydroxy acid isomeroreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alac-S[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhmb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0330"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KARA2i" reversible="false" name="ketol-acid reductoisomerase (2-Aceto-2-hydroxybutanoate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ahbut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_23dhmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0330"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KAS14" reversible="false" name="beta-ketoacyl-ACP synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KAS15" reversible="false" name="beta-ketoacyl-ACP synthase (2)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_actACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0202"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KAS_HP" reversible="false" name=" 3-hydroxy-palmetoyl-ACP synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_myrsACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3hpalmACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_KAS_HP2" reversible="false" name=" 3-hydroxy-octadecanoyl-ACP synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_palmACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3hoctaACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0561"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1376"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0558"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0195"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KDOCT" reversible="false" name=" 3-deoxy-manno-octulosonate cytidylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kdo[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmpkdo[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0230"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_KDOPP" reversible="false" name=" 3-deoxy-manno-octulosonate-8-phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kdo8p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_kdo[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_KDOPS" reversible="false" name=" 3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ara5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_kdo8p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0003"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LDH_D1" reversible="true" name="D-lactate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1222"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LEUTA" reversible="true" name="leucine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4mop[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1468"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LEUabc" reversible="false" name="L-leucine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_leu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_LPADSS_HP" reversible="false" name="lipidA HP disaccaride synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lipidX_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u2ga_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_lipidA_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0867"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LPSSYN_HP" reversible="false" name="Formation for LPS from Core oligosaccharide-Lipid A and O-chain" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adphep-DD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_core_lps_hp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdpfuc[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_lps_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="5"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:and>
              <fbc:or>
                <fbc:geneProductRef fbc:geneProduct="G_HP1416"/>
                <fbc:geneProductRef fbc:geneProduct="G_HP0208"/>
                <fbc:geneProductRef fbc:geneProduct="G_HP0159"/>
              </fbc:or>
              <fbc:geneProductRef fbc:geneProduct="G_HP0279"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP0826"/>
              <fbc:or>
                <fbc:geneProductRef fbc:geneProduct="G_HP0094"/>
                <fbc:geneProductRef fbc:geneProduct="G_HP0093"/>
              </fbc:or>
            </fbc:and>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LYSt2r" reversible="true" name="L-lysine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lys-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_L_LACt2r" reversible="true" name="L-lactate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0141"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0140"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_LacR" reversible="true" name="lactate racemase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_lac-D[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MALS" reversible="false" name="malate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glx[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MALt2r" reversible="true" name="L-malate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0724"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MAN1PT2r" reversible="true" name="mannose-1-phosphate guanylyltransferase (GDP) reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_man1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gdpmann[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0043"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MAN6PI" reversible="true" name="mannose-6-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_man6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0043"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MCOATA" reversible="true" name="Malonyl-CoA-ACP transacylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_malACP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0090"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MDH4" reversible="false" name="Malate dehydrogenase (menaquinone 6 as acceptor)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_oaa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0086"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MDRPDr" reversible="true" name=" 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mdru1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dkmpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ME1_rev" reversible="true" name="malic enzyme" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MECDPDH" reversible="false" name=" 2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2mecdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2mb4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0625"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MECDPS" reversible="false" name=" 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2p4c2me[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2mecdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1020"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MEPCT" reversible="false" name=" 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2me4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4c2me[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1020"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METAT" reversible="false" name="methionine adenosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0197"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METB1r" reversible="true" name="metb1 (rev)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_achms[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0106"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_METabc" reversible="false" name="L-methionine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MOAT_HP" reversible="false" name="moat HP" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cmpkdo[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_lipidA_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kdolipid4_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0957"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MOHMT" reversible="false" name=" 3-methyl-2-oxobutanoate hydroxymethyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dhp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1058"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTAN" reversible="false" name="methylthioadenosine nucleosidase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mtr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0089"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFC" reversible="true" name="methenyltetrahydrofolate cyclohydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_10fthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0577"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFD" reversible="true" name="methylenetetrahydrofolate dehydrogenase (NADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_methf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0577"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_MTHFR2" reversible="false" name=" 5,10-methylenetetrahydrofolate reductase (NADH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mthf[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MTRI" reversible="true" name=" 5-methylthioribose-1-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mdr1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mdru1p[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_MTRK" reversible="false" name=" 5-methylthioribose kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5mtr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mdr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NADK" reversible="false" name="NAD kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1394"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADPHQR" reversible="false" name="NADPH Quinone Reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0630"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NADS1" reversible="false" name="NAD synthase (nh3)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dnad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0329"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NARK" reversible="false" name="nark" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no2[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0313"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NAt3_1" reversible="true" name="sodium proton antiporter (H:NA is 1:1)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:or>
            <fbc:geneProductRef fbc:geneProduct="G_HP1552"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1183"/>
          </fbc:or>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDH_1" reversible="false" name="NADH dehydrogenase (menaquinone) (complex I)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_mqn6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_mql6[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1273"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1272"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1271"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1260"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1269"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1261"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1264"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1266"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1270"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1262"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1267"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1265"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1263"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1268"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK1" reversible="true" name="nucleoside-diphosphate kinase (ATP:GDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK2" reversible="true" name="nucleoside-diphosphate kinase (ATP:UDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK3" reversible="true" name="nucleoside-diphosphate kinase (ATP:CDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK4" reversible="true" name="nucleoside-diphosphate kinase (ATP:dTDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dttp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK5" reversible="true" name="nucleoside-diphosphate kinase (ATP:dGDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dgtp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK6" reversible="true" name="nucleoside-diphosphate kinase (ATP:dUDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dutp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK7" reversible="true" name="nucleoside-diphosphate kinase (ATP:dCDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dcdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dctp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NDPK8" reversible="true" name="nucleoside-diphosphate kinase (ATP:dADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_datp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0198"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NH4t" reversible="true" name="ammonia reversible transport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_nh4[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NIabc" reversible="false" name="nickel transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ni2[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ni2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1077"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1576"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NMNAT" reversible="false" name="nicotinamide-nucleotide adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nmn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1337"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NMNTP" reversible="false" name="nmntp" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nmn[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nmn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1290"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNAT" reversible="false" name="nicotinate-nucleotide adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dnad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1337"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NNDPR" reversible="false" name="nicotinate-nucleotide diphosphorylase (carboxylating)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_quln[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nicrnt[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1355"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_NO" reversible="false" name="peroxynitrite formation (spontanous)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NO3t2" reversible="false" name="nitrate transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NO3t3" reversible="false" name="nitrate transport out via proton antiport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no3[e]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NOt" reversible="true" name="NO transport (diffusion)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_no[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NPHS" reversible="false" name="naphthoate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_sbzcoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dhna[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_NTRARz" reversible="false" name="nitrate reductase (NADPH,TRDRD)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_no2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1563"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_O2t" reversible="true" name="o2 transport (diffusion)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OCBTi" reversible="false" name="ornithine carbamoyltransferase, irreversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cbp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_citr-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_OCOAT1" reversible="false" name=" 3-oxoacid CoA-transferase (Succinyl-CoA: acetoacetate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aacoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0691"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0692"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OCTDPS" reversible="false" name="Octaprenyl pyrophosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="5"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_octdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="5"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0240"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OMBZLM" reversible="false" name=" 2-Octaprenyl-6-methoxy-benzoquinol methylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2ombzl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_amet[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2ommbl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1483"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OMPDC" reversible="false" name="orotidine-5'-phosphate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0005"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OOR3" reversible="false" name="ferredoxin oxidoreductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fdxox[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fdxrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0591"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0588"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0590"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0589"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OPHBDC" reversible="false" name="Octaprenyl-hydroxybenzoate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3ophb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2oph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0396"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_ORNTA" reversible="false" name="ornithine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ORNt2r" reversible="true" name="orntithine reversible transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orn[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1017"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OROATP" reversible="false" name="oroatp" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_ORPT" reversible="true" name="orotate phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_orot5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_orot[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1257"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_OXGDC2" reversible="false" name=" 2-oxoglutarate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ssaltpp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_P5CD" reversible="false" name=" 1-pyrroline-5-carboxylate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_P5CR" reversible="false" name="pyrroline-5-carboxylate reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1158"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PABB" reversible="false" name="pabb" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_chor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4adcho[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0293"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PANTS" reversible="false" name="pantothenate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-B[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pant-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pnto-R[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0006"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPPT3" reversible="false" name="phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_uagmda[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0493"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PAPSR" reversible="false" name="phosphoadenylyl-sulfate reductase (thioredoxin)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_paps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PASYN_HP" reversible="false" name="Phosphatidic acid synthase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_c190cACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_myrsACP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pa_Hp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1348"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PDH2" reversible="false" name="pyruvate dehydrogenase - FMN dependent" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmnh2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1108"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1109"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1110"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1111"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PEPT_HP" reversible="true" name="ethanolamine phosphotransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_12dgr_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cdpea[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGAMT" reversible="true" name="phosphoglucosamine mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gam1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gam6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0075"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGCD" reversible="false" name="phosphoglycerate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3php[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0096"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0397"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGI" reversible="true" name="glucose-6-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1166"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGK" reversible="true" name="phosphoglycerate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_13dpg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1345"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGL" reversible="false" name=" 6-phosphogluconolactonase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_6pgl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_6pgc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1102"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGM" reversible="true" name="phosphoglycerate mutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2pg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3pg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0974"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGMT" reversible="true" name="phosphoglucomutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g6p[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PGPP_HP" reversible="false" name="Phosphatidylglycerol phosphate phosphatase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pg_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0737"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PGSA_HP" reversible="true" name="Phosphatidylglycerol synthase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdag_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glyc3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pgp_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1016"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PHCD" reversible="false" name="L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_1p3h5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_e4hglu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PHCHGS" reversible="true" name="L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_1p3h5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hglusa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PHETA1" reversible="true" name="phenylalanine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phpyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0672"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PHEt2r" reversible="true" name="L-phenylalanine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phe-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PIMEtr" reversible="true" name="pimelate transport via diffusion, reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pime[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pime[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PIt2r" reversible="true" name="phosphate reversible transport via symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1491"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PMANM" reversible="true" name="phosphomannomutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_man1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_man6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1275"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PMDPHT" reversible="false" name="pyrimidine phosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aprbu[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PMPK" reversible="false" name="phosphomethylpyrimidine kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ampm[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2mahmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0844"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PNTK" reversible="false" name="pantothenate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pnto-R[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPA" reversible="false" name="inorganic diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0620"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPBNGS" reversible="false" name="porphobilinogen synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aop[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppbng[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0163"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPCDC" reversible="false" name="phosphopantothenoylcysteine decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pan4p[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPM" reversible="true" name="phosphopentomutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1179"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPM2" reversible="true" name="phosphopentomutase 2 (deoxyribose)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1179"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNCL2" reversible="false" name="phosphopantothenate-cysteine ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4ppan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ctp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4ppcys[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPND" reversible="false" name="prephenate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_34hpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1380"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPNDH" reversible="false" name="prephenate dehydratase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pphn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phpyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PPPGO" reversible="false" name="protoporphyrinogen oxidase (aerobic)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1.5"/>
          <speciesReference constant="true" species="M_pppg9[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_ppp9[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0381"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPS" reversible="false" name="phosphoenolpyruvate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0121"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PPTGS" reversible="false" name="Peptidoglycan subunit synthesis" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_peptido_EC[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PRAGSr" reversible="true" name="phosphoribosylglycinamide synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gly[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pram[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gar[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1218"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRAIS" reversible="false" name="phosphoribosylaminoimidazole synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fpram[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_air[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PRAIi" reversible="false" name="phosphoribosylanthranilate isomerase (irreversible)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pran[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2cpr5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1279"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRASCS" reversible="true" name="phosphoribosylaminoimidazolesuccinocarboxamide synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_5aizc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_asp-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_25aics[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PRFGS" reversible="false" name="phosphoribosylformylglycinamidine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fpram[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PROD2" reversible="false" name="Proline dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fad[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_1pyr5c[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fadh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROabc" reversible="false" name="L-proline transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0819"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0818"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROt2r" reversible="true" name="L-proline reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0936"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PROt4r" reversible="true" name="proline transporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_na1[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pro-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0055"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PRPPS" reversible="true" name="phosphoribosylpyrophosphate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0742"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSCVT" reversible="true" name=" 3-phosphoshikimate 1-carboxyvinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3psme[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0401"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSD_HP" reversible="false" name="Phosphatidylserine decarboxylase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pe_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1357"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSERT" reversible="false" name="phosphoserine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3php[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0736"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSP_D" reversible="false" name="phosphoserine phosphatase (D-serine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pser-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0652"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSP_L" reversible="false" name="phosphoserine phosphatase (L-serine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0652"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PSSA_HP" reversible="true" name="Phosphatidylserine synthase Hp specific" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdpdag_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ps_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1071"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PTAr" reversible="true" name="phosphotransacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_actp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0905"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PTPATi" reversible="false" name="pantetheine-phosphate adenylyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pan4p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dpcoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1475"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP1" reversible="true" name="purine-nucleoside phosphorylase (Adenosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP2" reversible="true" name="purine-nucleoside phosphorylase (Deoxyadenosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dad-2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ade[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP3" reversible="true" name="purine-nucleoside phosphorylase (Guanosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_gsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP4" reversible="true" name="purine-nucleoside phosphorylase (Deoxyguanosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dgsn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gua[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP5" reversible="true" name="purine-nucleoside phosphorylase (Inosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ins[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP6" reversible="true" name="purine-nucleoside phosphorylase (Deoxyinosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_din[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2dr1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hxan[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUNP7" reversible="true" name="purine-nucleoside phosphorylase (Xanthosine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xtsn[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_r1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1178"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PUTA3" reversible="false" name="puta3" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu5sa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nad[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_nadh[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0056"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_PYRDC" reversible="false" name="pyruvate decarboxylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acald[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_PYRt2r" reversible="true" name="pyruvate reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_QULNS" reversible="false" name="quinolinate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_iasp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_quln[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1356"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFK" reversible="false" name="riboflavin kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1087"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFSa" reversible="false" name="riboflavin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_db4p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dmlz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0002"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1574"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RBFSb" reversible="false" name="riboflavin synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dmlz[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4r5au[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ribflv[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0002"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1574"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RFAC_HP" reversible="false" name="RFAC HP" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adphep-LD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adphep7p-LD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_RFA_HP" reversible="false" name="Formation of lipidA and sugar core for Hpylori LPS" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adphep-DD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adphep-LD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_adphep7p-LD[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_kdolipid4_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_core_lps_hp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="3"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0279"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RHCCE" reversible="false" name="S-ribosylhomocysteine cleavage enzyme" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_rhcys[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dhptd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0105"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR1" reversible="false" name="ribonucleoside-diphosphate reductase (ADP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0680"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0364"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR2" reversible="false" name="ribonucleoside-diphosphate reductase (GDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dgdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0680"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0364"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR3" reversible="false" name="ribonucleoside-diphosphate reductase (CDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dcdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0680"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0364"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RNDR4" reversible="false" name="ribonucleoside-diphosphate reductase (UDP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0680"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0364"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RPE" reversible="true" name="ribulose 5-phosphate 3-epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1386"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_RPI" reversible="true" name="ribose-5-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ru5p-D[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0574"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_S7PI" reversible="false" name="sedoheptulose 7-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_s7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_gmhep7p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0857"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SADT2" reversible="false" name="Sulfate adenyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gtp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_aps[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SDPDS" reversible="false" name="succinyl-diaminopimelate desuccinylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl26da[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_26dap-LL[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0212"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SDPTA" reversible="true" name="succinyldiaminopimelate transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl26da[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl2a6o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0624"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERAT" reversible="true" name="serine O-acetyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_accoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_acser[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1210"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERD_L" reversible="false" name="L-serine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0132"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SERt2r" reversible="true" name="L-serine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0133"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHCHCS2" reversible="false" name=" 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ichor[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ssaltpp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2shchc[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmpp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SHK3Dr" reversible="true" name="shikimate dehydrogenase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3dhsk[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1249"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHKK" reversible="false" name="shikimate kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_skm5p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0157"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHSL1r" reversible="true" name="O-succinylhomoserine lyase reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_cyst-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0106"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHSL2r" reversible="true" name="O-succinylhomoserine lyase (H2S)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_hcys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0106"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SHSL4r" reversible="true" name="O-succinylhomoserine lyase (elimination), reversible" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_suchms[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0106"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SPMS" reversible="false" name="spermidine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ametam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ptrc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_spmd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0832"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SPODM" reversible="false" name="superoxide dismutase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_o2s[c]" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_o2[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0389"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SPRMS" reversible="false" name="spermine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ametam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_spmd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_5mta[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sprm[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0832"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCBZL" reversible="false" name="o-succinylbenzoate-CoA ligase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucbz[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_amp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sbzcoa[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SUCBZS" reversible="false" name="O-succinylbenzoate-CoA synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2shchc[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sucbz[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SUCCt2r" reversible="true" name="succinate transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0724"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SUCFUMt" reversible="true" name="succinate:fumarate antiporter" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_fum[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0724"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_SULR" reversible="true" name="sulfite reductase (NADPH2)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_h2s[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="3"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="5"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="3"/>
          <speciesReference constant="true" species="M_so3[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_SULabc" reversible="false" name="sulfate transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_so4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0228"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TALA" reversible="true" name="transaldolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_s7p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1495"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THDPS" reversible="false" name="tetrahydrodipicolinate succinylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_succoa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_coa[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_sl2a6o[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0626"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THMDt2" reversible="false" name="thymidine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THMabc" reversible="false" name="thiamine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thm[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thm[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_THRD_L" reversible="false" name="L-threonine deaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_2obut[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0132"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THRS" reversible="false" name="threonine synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_phom[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0098"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_THRt2r" reversible="true" name="L-threonine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thr-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_THZSN" reversible="false" name="thiazole synthesis from xylulose" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dxyl[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_4hba[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mhetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pyr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0814"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TKT1" reversible="true" name="transketolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_r5p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_s7p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1088"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TKT2" reversible="true" name="transketolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_e4p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xu5p-D[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_f6p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1088"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMDK1" reversible="false" name="thymidine kinase (ATP:thymidine)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thymd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1474"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMDSf" reversible="false" name="thymidylate synthase  (Flavin-dependent)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmnh2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_mlthf[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_dtmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_fmn[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thf[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1533"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TMPPP" reversible="false" name="thiamine-phosphate diphosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2mahmp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_4mpetz[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_thmmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0843"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TPI" reversible="true" name="triose-phosphate isomerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_dhap[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0194"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRDR" reversible="false" name="thioredoxin reductase (NADPH)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdox[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trdrd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP0824"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1458"/>
            </fbc:and>
            <fbc:and>
              <fbc:geneProductRef fbc:geneProduct="G_HP0825"/>
              <fbc:geneProductRef fbc:geneProduct="G_HP1164"/>
            </fbc:and>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPS1" reversible="false" name="tryptophan synthase (indoleglycerol phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1278"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1277"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPS2" reversible="false" name="tryptophan synthase (indole)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_indole[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ser-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1278"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1277"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPS3" reversible="false" name="tryptophan synthase (indoleglycerol phosphate)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3ig3p[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_g3p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_indole[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP1278"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP1277"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TRPt2r" reversible="true" name="L-tryptophan reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_trp-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_TYRTA" reversible="true" name="tyrosine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_34hpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0672"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_TYRt2r" reversible="true" name="L-tyrosine reversible transport via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_tyr-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_U23GAAT_HP" reversible="false" name="UDP-3-O-(3-hydroxypalmetoyl)glycosamine acyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3hoctaACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u3hga_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u23ga_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0196"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_U2GAAT" reversible="false" name="u2gaat" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_3hoctaACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u2hga_HP[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_U2GAAT2" reversible="false" name="u2gaat2" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ocdcaACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u2hga_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u2ga_HP[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UAAGDS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_26dap-M[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmd[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1494"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGAAT_HP" reversible="true" name="UDP-N-acetylglucosamine acyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_3hpalmACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ACP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u3aga_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1375"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGCVT" reversible="false" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pep[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaccg[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0648"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGDP" reversible="false" name="UDP-N-acetylglucosamine diphosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acgam1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0683"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGDP2" reversible="false" name="UDP-glucosamine diphosphorylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gam1p[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_utp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugam[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0683"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAGPT3" reversible="false" name="UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uacgam[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uagmda[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaagmda[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1155"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAMAGS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-D[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uama[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamag[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0494"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAMAS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uama[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0623"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UAPGR" reversible="false" name="UDP-N-acetylenolpyruvoylglucosamine reductase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nadph[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uaccg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_nadp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uamr[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1418"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDCPDP" reversible="false" name="undecaprenyl-diphosphatase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udcpp[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UDCPDPS" reversible="false" name="Undecaprenyl diphosphate synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_frdp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ipdp[c]" stoichiometry="8"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="8"/>
          <speciesReference constant="true" species="M_udcpdp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1221"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UDPG4E" reversible="true" name="UDPglucose 4-epimerase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_udpg[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_udpgal[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0360"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UGMDDS" reversible="false" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_alaala[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmd[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ugmda[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0740"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UHGADA_HP" reversible="false" name="UDP-3-O-acetylglucosamine deacetylase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u3aga_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ac[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u3hga_HP[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1052"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UMPK" reversible="true" name="UMP kinase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_udp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0777"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UNK2" reversible="false" name=" 2-keto-4-methylthiobutyrate transamination" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_2kmb[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_gln-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_met-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UPP3S" reversible="false" name="uroporphyrinogen-III synthase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hmbil[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uppg3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1224"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPDC1" reversible="false" name="uroporphyrinogen decarboxylase (uroporphyrinogen III)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_uppg3[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_cpppg3[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0604"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPDC2" reversible="false" name="uroporphyrinogen decarboxylase (uroporphyrinogen I)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_uppg1[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="4"/>
          <speciesReference constant="true" species="M_cpppg1[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0604"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UPPRT" reversible="false" name="uracil phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_URAt2" reversible="false" name="uracil transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ura[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_UREA" reversible="false" name="urease" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_co2[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_nh4[c]" stoichiometry="2"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:and>
            <fbc:geneProductRef fbc:geneProduct="G_HP0069"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0068"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0067"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0073"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0070"/>
            <fbc:geneProductRef fbc:geneProduct="G_HP0072"/>
          </fbc:and>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_UREAt" reversible="true" name="Urea transport via facilitate diffusion" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_urea[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_urea[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0071"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_URIDK2r" reversible="true" name="uridylate kinase (dUMP)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dump[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_dudp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1474"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_URIt2" reversible="false" name="uridine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uri[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_uri[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1180"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_USHD_HP" reversible="false" name="UDP-sugar hydrolase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_u23ga_HP[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="2"/>
          <speciesReference constant="true" species="M_lipidX_HP[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_ump[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_VALTA" reversible="true" name="valine transaminase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_3mob[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_glu-L[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP1468"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_VALabc" reversible="false" name="L-valine transport via ABC system" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_val-L[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_XANt2" reversible="false" name="xanthine transport in via proton symport" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[e]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_XPPT" reversible="false" name="xanthine phosphoribosyltransferase" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_prpp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xan[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_ppi[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_xmp[c]" stoichiometry="1"/>
        </listOfProducts>
        <fbc:geneProductAssociation>
          <fbc:geneProductRef fbc:geneProduct="G_HP0735"/>
        </fbc:geneProductAssociation>
      </reaction>
      <reaction fast="false" id="R_sink_ahcys_c" reversible="true" name="sink ahcys(c)" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_ahcys[c]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_sink_amob" reversible="true" name="sink amob" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_default_lb">
        <listOfReactants>
          <speciesReference constant="true" species="M_amob[c]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_ATPM" reversible="false" name="ATPM" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_ATPM_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_atp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h2o[c]" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="M_adp[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_h[c]" stoichiometry="1"/>
          <speciesReference constant="true" species="M_pi[c]" stoichiometry="1"/>
        </listOfProducts>
      </reaction>
      <reaction fast="false" id="R_EX_aa" reversible="false" name="EX_aa[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_aa[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ac" reversible="false" name="EX_ac[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ac[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_acac" reversible="false" name="EX_acac[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acac[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_acald" reversible="false" name="EX_acald[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_acald[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ad" reversible="false" name="EX_ad[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ad[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ade" reversible="false" name="EX_ade[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ade[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_adn" reversible="false" name="EX_adn[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_adn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_akg" reversible="false" name="EX_akg[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_akg[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ala-D" reversible="false" name="EX_ala-D[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ala-L" reversible="true" name="EX_ala-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_ala-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ala-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_arg-L" reversible="true" name="EX_arg-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_arg-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_arg-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_asn-L" reversible="true" name="EX_asn-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_asn-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asn-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_asp-L" reversible="true" name="EX_asp-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_asp-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_asp-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cit" reversible="false" name="EX_cit[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cit[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_co2" reversible="false" name="EX_co2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_co2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cys-L" reversible="true" name="EX_cys-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_cys-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cys-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_cytd" reversible="false" name="EX_cytd[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_cytd[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_dad-2" reversible="false" name="EX_dad-2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dad-2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_dcyt" reversible="false" name="EX_dcyt[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_dcyt[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_duri" reversible="false" name="EX_duri[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_duri[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_etoh" reversible="false" name="EX_etoh[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_etoh[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fe2" reversible="true" name="EX_fe2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_fe2_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fe3" reversible="true" name="EX_fe3[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_fe3_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fe3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_for" reversible="false" name="EX_for[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_for[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_fum" reversible="false" name="EX_fum[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_fum[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gal" reversible="true" name="EX_gal[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_gal_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gal[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glc-D" reversible="true" name="EX_glc-D[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_glc-D_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glc-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gln-L" reversible="true" name="EX_gln-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_gln-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gln-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_glu-L" reversible="true" name="EX_glu-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_glu-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_glu-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gly" reversible="true" name="EX_gly[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_gly_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gly[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gsn" reversible="false" name="EX_gsn[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gsn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_gua" reversible="false" name="EX_gua[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_gua[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2" reversible="false" name="EX_h2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2co3" reversible="false" name="EX_h2co3[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2co3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h2o" reversible="false" name="EX_h2o[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h2o[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_h" reversible="false" name="EX_h[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_h[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_his-L" reversible="true" name="EX_his-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_his-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_his-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_hxan" reversible="false" name="EX_hxan[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_hxan[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ile-L" reversible="true" name="EX_ile-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_ile-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ile-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_lac-L" reversible="false" name="EX_lac-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lac-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_leu-L" reversible="true" name="EX_leu-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_leu-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_leu-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_lys-L" reversible="true" name="EX_lys-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_lys-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_lys-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_mal-L" reversible="false" name="EX_mal-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_mal-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_met-L" reversible="true" name="EX_met-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_met-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_met-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_na1" reversible="true" name="EX_na1[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_na1_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_na1[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_nh4" reversible="false" name="EX_nh4[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nh4[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ni2" reversible="false" name="EX_ni2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ni2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_nmn" reversible="false" name="EX_nmn[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_nmn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no2" reversible="false" name="EX_no2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no3" reversible="false" name="EX_no3[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no3[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_no" reversible="false" name="EX_no[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_no[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_o2" reversible="true" name="EX_o2[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_o2_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_o2[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_orn" reversible="false" name="EX_orn[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_orn[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_orot" reversible="true" name="EX_orot[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_orot_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_orot[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_phe-L" reversible="true" name="EX_phe-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_phe-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_phe-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pheme" reversible="true" name="EX_pheme[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_pheme_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pheme[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pi" reversible="true" name="EX_pi[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_pi_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pi[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pime" reversible="true" name="EX_pime[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_pime_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pime[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pro-L" reversible="true" name="EX_pro-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_pro-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pro-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_pyr" reversible="false" name="EX_pyr[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_pyr[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ser-D" reversible="false" name="EX_ser-D[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-D[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ser-L" reversible="true" name="EX_ser-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_ser-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ser-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_so4" reversible="true" name="EX_so4[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_so4_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_so4[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_succ" reversible="false" name="EX_succ[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_succ[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_thm" reversible="true" name="EX_thm[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_thm_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_thm[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_thr-L" reversible="true" name="EX_thr-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_thr-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_thr-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_thymd" reversible="false" name="EX_thymd[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_thymd[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_trp-L" reversible="true" name="EX_trp-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_trp-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_trp-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_tyr-L" reversible="true" name="EX_tyr-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_tyr-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_tyr-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_ura" reversible="false" name="EX_ura[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_ura[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_urea" reversible="false" name="EX_urea[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_urea[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_uri" reversible="false" name="EX_uri[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_uri[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_val-L" reversible="true" name="EX_val-L[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="R_EX_val-L_lower_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_val-L[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
      <reaction fast="false" id="R_EX_xan" reversible="false" name="EX_xan[u]" fbc:upperFluxBound="cobra_default_ub" fbc:lowerFluxBound="cobra_0_bound">
        <listOfReactants>
          <speciesReference constant="true" species="M_xan[e]" stoichiometry="1"/>
        </listOfReactants>
      </reaction>
    </listOfReactions>
  </model>
</sbml>
