	MeC_id	TopTF	TopGene20	TopGene100	Enrich	Enrich_MSigDB_Hallmark_2020	Enrich_GO_Biological_Process_2021	Enrich_Reactome_2016	Enrich_BioPlanet_2019	Enrich_WikiPathways_2019_Human	Enrich_KEGG_2021_Human	Enrich_GO_Molecular_Function_2021	Lisa	Lisa_topcelltype	TF_MeC_top	TF_Lisa_top	TF_MeCLisa_top	TF_MeCLisa_top_1	sc_expr_toptype
0	MeC_0	STAT1,IRF7,SP100,SP110,STAT2,ELF1	ISG15,IFI6,LY6E,MX1,ISG20,IFI44L,IFITM1,IFIT3,STAT1,MT2A,BST2,OAS1,UBE2L6,IFIT1,EPSTI1,XAF1,IRF7,MX2,SAT1,IFI16	ISG15,IFI6,LY6E,MX1,ISG20,IFI44L,IFITM1,IFIT3,STAT1,MT2A,BST2,OAS1,UBE2L6,IFIT1,EPSTI1,XAF1,IRF7,MX2,SAT1,IFI16,EIF2AK2,IFITM3,IFITM2,TRIM22,SAMD9L,IFI44,RNF213,IFI35,RSAD2,PLSCR1,PSMB9,LAP3,GBP1,TNFSF10,IFIT2,SP100,OASL,PSME2,PARP14,OAS3,SAMD9,OAS2,PARP9,DRAP1,ADAR,SP110,HERC5,TYMP,NT5C3A,PSMB8,TAP1,CMPK2,TMEM123,MYL12A,LGALS9,USP18,C19orf66,CD164,PPM1K,PSME1,GBP4,DYNLT1,CXCL10,PHF11,CD48,NMI,STAT2,SHISA5,SMCHD1,ELF1,DNAJA1,RBCK1,DDX60,DDX58,GBP2,CHMP5,DDX60L,APOL6,WARS,HLA-E,IFIH1,IFI27,HLA-C,HSH2D,CARD16,HELZ2,TNFSF13B,ANXA1,ALOX5AP,CD69,XRN1,RARRES3,PNPT1,MYD88,ZNFX1,CHST12,PSMA4,SLFN5,NUB1,C4orf3	Interferon Alpha Response; Interferon Gamma Response; cellular response to type I interferon (GO:0071357); type I interferon signaling pathway (GO:0060337); Interferon Signaling Homo sapiens R-HSA-913531	Interferon Alpha Response; Interferon Gamma Response; Inflammatory Response	cellular response to type I interferon (GO:0071357); type I interferon signaling pathway (GO:0060337); defense response to virus (GO:0051607)	Interferon Signaling Homo sapiens R-HSA-913531; Interferon alpha/beta signaling Homo sapiens R-HSA-909733; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	Interferon signaling; Interferon alpha/beta signaling; Immune system signaling by interferons, interleukins, prolactin, and growth hormones	The human immune response to tuberculosis WP4197; Type II interferon signaling (IFNG) WP619; Proteasome Degradation WP183	Influenza A; Measles; Hepatitis C	double-stranded RNA binding (GO:0003725); adenylyltransferase activity (GO:0070566); RNA binding (GO:0003723)	IRF2,STAT2,STAT1,IRF1,FOXP1,ETV6,RXRG,CDK8,TP53,RELA,MAF,IKZF1,ZNF799,BRD4,STAT5B,MYB,KLF5,STAT5A,T,MED1	Proerythroblast,Bone Marrow	IRF7,IFI16,SP100,SP110,NMI	IRF2,IRF1,FOXP1,ETV6,TP53	STAT1,STAT2	STAT1,STAT2,PML,ELF1,TRIM22,IRF9	Treg,CD8Tex
1	MeC_1	HMGB2,HMGB1,CARHSP1	TUBA1B,H2AFZ,HMGB2,STMN1,TUBB,HIST1H4C,HMGN2,HMGB1,DUT,TYMS,DEK,MKI67,TOP2A,H2AFV,PCNA,RRM2,NUSAP1,SMC4,UBE2C,ANP32B	TUBA1B,H2AFZ,HMGB2,STMN1,TUBB,HIST1H4C,HMGN2,HMGB1,DUT,TYMS,DEK,MKI67,TOP2A,H2AFV,PCNA,RRM2,NUSAP1,SMC4,UBE2C,ANP32B,TK1,CENPF,PTMA,PTTG1,CDK1,TUBB4B,CKS1B,NUCKS1,TMPO,BIRC5,MCM7,CKS2,ZWINT,ARL6IP1,RANBP1,TPX2,SLC25A5,SIVA1,ANP32E,TMEM106C,SMC2,SNRPB,CENPM,DNAJC9,NASP,ASPM,HNRNPA2B1,RAN,KIF22,PCLAF,H2AFX,IDH2,KIAA0101,COX8A,MAD2L1,CCNA2,RPA3,ASF1B,DTYMK,AURKB,DNMT1,VIM,CDKN3,MT2A,DDX39A,RRM1,PRC1,RAD21,TUBA1C,CALM2,UBE2T,CALM3,CLSPN,ATAD2,MCM5,KPNA2,LSM4,FEN1,CARHSP1,LMNB1,MCM3,CRIP1,MZT2B,GGH,EZH2,TPI1,FAM111A,CENPW,ANAPC11,USP1,TACC3,SRSF3,CENPU,BUB3,KIF20B,CCNB2,SMC1A,H2AFY,SAE1,GMNN	E2F Targets; G2-M Checkpoint; Cell Cycle, Mitotic Homo sapiens R-HSA-69278; Cell Cycle Homo sapiens R-HSA-1640170; Cell cycle	E2F Targets; G2-M Checkpoint; Myc Targets V1	DNA metabolic process (GO:0006259); mitotic spindle organization (GO:0007052); microtubule cytoskeleton organization involved in mitosis (GO:1902850)	Cell Cycle, Mitotic Homo sapiens R-HSA-69278; Cell Cycle Homo sapiens R-HSA-1640170; M Phase Homo sapiens R-HSA-68886	Cell cycle; DNA replication; Cell cycle checkpoints	Retinoblastoma Gene in Cancer WP2446; Cell Cycle WP179; Regulation of sister chromatid separation at the metaphase-anaphase transition WP4240	Cell cycle; DNA replication; Oocyte meiosis	single-stranded DNA binding (GO:0003697); damaged DNA binding (GO:0003684); RNA binding (GO:0003723)	FOXM1,MYBL2,E2F4,E2F1,RELA,RBL2,RB1,RNF2,TFDP1,FOS,FOXP1,POLR2B,MYC,GTF2B,NELFA,OGT,SCML2,ASXL1,NELFE,BRD4	U2OS,Bone	HMGB2,HMGN2,HMGB1,NASP,RAN	FOXM1,MYBL2,E2F4,E2F1,RELA		CBX3,EZH2,CBX5,YBX1,PSIP1	TMKI67
2	MeC_2	NR4A1,JUN,ID3,ATF3	HSPA1A,HSPA1B,DNAJB1,HSP90AA1,HSPB1,HSPH1,HSPE1,HSPA6,HSPD1,HSP90AB1,DNAJA1,HSPA8,CACYBP,UBC,ZFAND2A,BAG3,UBB,RGS2,PPP1R15A,SERPINH1	HSPA1A,HSPA1B,DNAJB1,HSP90AA1,HSPB1,HSPH1,HSPE1,HSPA6,HSPD1,HSP90AB1,DNAJA1,HSPA8,CACYBP,UBC,ZFAND2A,BAG3,UBB,RGS2,PPP1R15A,SERPINH1,TCP1,IER5,MRPL18,PTGES3,CLK1,DNAJB4,FKBP4,DNAJB6,AHSA1,DNAJA4,CHORDC1,DOK2,LGALS1,NR4A1,HSPA1L,DEDD2,SOD1,ANXA1,CCT4,STIP1,PLIN2,TRA2B,JUN,TSPYL2,GADD45B,TXNIP,SNX3,RPL36AL,G0S2,NEU1,CKS2,HSPA4,EIF5,NUDC,IFNG,DYNLL1,CXCL8,SLC3A2,S100A4,HSPE1-MOB4,ANKRD37,MT-CYB,SUMO2,MT-ATP6,SNAP23,TIMP1,PPP1R2,FTL,TAF7,EIF4A2,SLC25A6,HNRNPU,ID3,ST13,MAP1LC3B,SLC20A1,CDC42EP3,HLA-DPB1,NOP10,MRPS6,CCT2,MT-ND2,MT-ND4,BCAS2,MALAT1,CLEC2B,ATF3,DUSP1,HSPA5,IGLL5,PRRC2C,PFDN5,TNF,CRYAB,FXYD5,RHOB,SLC25A5,RPL26,HLA-DRA,C12orf57	Attenuation phase Homo sapiens R-HSA-3371568; response to unfolded protein (GO:0006986); HSF1-dependent transactivation Homo sapiens R-HSA-3371571; HSF1 activation Homo sapiens R-HSA-3371511; Cellular response to heat stress Homo sapiens R-HSA-3371556	Apoptosis; TNF-alpha Signaling via NF-kB; UV Response Up	response to unfolded protein (GO:0006986); 'de novo' posttranslational protein folding (GO:0051084); regulation of cellular response to heat (GO:1900034)	Attenuation phase Homo sapiens R-HSA-3371568; HSF1-dependent transactivation Homo sapiens R-HSA-3371571; HSF1 activation Homo sapiens R-HSA-3371511	Antigen processing and presentation; BDNF signaling pathway; T cell receptor regulation of apoptosis	Nuclear Receptors Meta-Pathway WP2882; Parkin-Ubiquitin Proteasomal System pathway WP2359; MAPK Signaling Pathway WP382	Antigen processing and presentation; Protein processing in endoplasmic reticulum; Legionellosis	ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389); ATPase regulator activity (GO:0060590)	HSF1,NCOA1,PPARGC1A,BRD4,AFF4,TP53,GMEB2,GTF2B,PAF1,MED1,NELFE,TAF1,REL,KAT2B,BCL3,SMAD5,CPSF3L,MAF,SUPT5H,MYH11	HCT-116,Colon	CCT4	HSF1,NCOA1,PPARGC1A,BRD4,AFF4	NR4A1	NR4A1,JUN	Th1
3	MeC_3	IRF7,IRF8,TCF4,SOX4,SPIB,IRF4,BCL11A	GZMB,JCHAIN,PLAC8,IRF7,ALOX5AP,IRF8,ITM2C,LILRA4,NPC2,GPR183,TCF4,SEC61B,SERPINF1,PLD4,UGCG,C12orf75,PPP1R14B,PTGDS,CCDC50,PLP2	GZMB,JCHAIN,PLAC8,IRF7,ALOX5AP,IRF8,ITM2C,LILRA4,NPC2,GPR183,TCF4,SEC61B,SERPINF1,PLD4,UGCG,C12orf75,PPP1R14B,PTGDS,CCDC50,PLP2,APP,TXN,TSPAN13,CLIC3,SPCS1,IL3RA,RNASET2,HERPUD1,CTSB,MPEG1,SOX4,MYL12A,RGS2,SRP14,CYB561A3,VAMP8,TYROBP,TPM2,RNASE6,SPIB,GPX1,FCER1G,IRF4,CTSC,SELL,BCL11A,MZB1,TAGLN2,SMPD3,PARK7,HSP90B1,TCL1A,LILRB4,DERL3,CD74,COMMD6,PLEK,SLC15A4,CST3,CD68,UCP2,CXCR4,CD4,PTCRA,ERP29,TGFBI,CXCR3,PSAP,LRRC26,CLEC4C,PTPRE,MAP1A,GRN,ZFP36,SCT,MAPKAPK2,TRAF4,STMN1,RGS1,CD164,PTPRS,S100A6,SLC7A5,IRF2BP2,FAM129C,CYBA,SELPLG,NUCB2,LTB,HIGD1A,DUSP5,MYL12B,LDLRAD4,CLN8,DSTN,SLC20A1,SEC61G,SSR4,DNASE1L3,GAPT	Interleukin-2 signaling pathway; neutrophil activation involved in immune response (GO:0002283); TYROBP Causal Network WP3945; neutrophil degranulation (GO:0043312); neutrophil mediated immunity (GO:0002446)	Allograft Rejection; Complement; IL-2/STAT5 Signaling	neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312); neutrophil mediated immunity (GO:0002446)	Immune System Homo sapiens R-HSA-168256	Interleukin-2 signaling pathway; Leptin influence on immune response; Immune system	TYROBP Causal Network WP3945; Development of pulmonary dendritic cells and macrophage subsets WP3892	Protein export; Protein processing in endoplasmic reticulum; Lysosome	chemokine binding (GO:0019956)	TCF4,LYL1,IKZF1,MAP2K1,SPI1,KMT2A,CD74,ETV6,RUNX1,NCOR2,EBNA3C,RELA,HMG20A,BCL6,EBF1,FOXP1,SP1,MEF2B,JUNB,NR3C1	CAL-1,Dendritic Cell	IRF7,IRF8,SOX4,ZFAT,PRKCB	LYL1,IKZF1,SPI1,ETV6,RUNX1	TCF4,NR3C1,SPIB,BCL11A,XBP1,IRF4	TCF4,NR3C1,SPIB,BCL11A,XBP1,IRF4,CREM,MYBL2,KLF6	pDC
4	MeC_4	XBP1,SUB1,JUN,ATF4,PRDM1	SSR4,MZB1,XBP1,FKBP11,JCHAIN,HSP90B1,SEC11C,HERPUD1,PPIB,IGKC,PRDX4,ISG20,IGLL5,DERL3,MYDGF,SSR3,SDF2L1,SPCS2,ITM2C,SUB1	SSR4,MZB1,XBP1,FKBP11,JCHAIN,HSP90B1,SEC11C,HERPUD1,PPIB,IGKC,PRDX4,ISG20,IGLL5,DERL3,MYDGF,SSR3,SDF2L1,SPCS2,ITM2C,SUB1,HSPA5,FKBP2,SPCS3,SEC61B,BTG2,CD79A,PDIA6,PIM2,MANF,SPCS1,SERP1,RABAC1,CYBA,IGHA1,SSR2,LMAN1,ERLEC1,IGHG1,PDIA4,TMEM258,UBE2J1,TMEM59,TNFRSF17,DNAJB9,IGHG3,NUCB2,JUN,RPN2,CD38,CALR,CD27,CRELD2,HM13,TRAM1,TMED9,HLA-C,OSTC,DAD1,RPL36AL,KDELR2,TMBIM6,SEC61G,VIMP,GSTP1,OST4,TMED2,NEAT1,PLPP5,TMED10,IGLC2,LMAN2,TENT5C,P4HB,POU2AF1,ATF4,CYTIP,COPE,SELENOS,MTDH,SDC1,IGLC3,ERGIC3,CITED2,RRBP1,SELK,TXNDC15,DDOST,JSRP1,KRTCAP2,DERL1,TXNDC11,MIF,HIST1H1C,FCRL5,SLAMF7,IDH2,SEC62,GLRX,SEL1L,PRDM1	Protein processing in the endoplasmic reticulum; Protein processing in endoplasmic reticulum; Metabolism of proteins Homo sapiens R-HSA-392499; Unfolded Protein Response (UPR) Homo sapiens R-HSA-381119; Protein export	Unfolded Protein Response; mTORC1 Signaling; Protein Secretion	protein exit from endoplasmic reticulum (GO:0032527); response to endoplasmic reticulum stress (GO:0034976); ERAD pathway (GO:0036503)	Metabolism of proteins Homo sapiens R-HSA-392499; Unfolded Protein Response (UPR) Homo sapiens R-HSA-381119; SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339	Protein processing in the endoplasmic reticulum; Diabetes pathways; Protein export	Photodynamic therapy-induced unfolded protein response WP3613	Protein processing in endoplasmic reticulum; Protein export; Vibrio cholerae infection	dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579); oligosaccharyl transferase activity (GO:0004576); immunoglobulin receptor binding (GO:0034987)	XBP1,FOXP1,BRD4,TP53,RELA,MAX,TCF4,KMT2A,MYC,TCF7L1,MYB,BCL6,TAF1,TCF12,MED1,CHD2,EBF1,NOTCH1,MAZ,MEF2B	MDA-MB-231,Epithelium,Breast	SUB1,POU2AF1,ATF4,CITED2,EAF2	FOXP1,BRD4,TP53,RELA,MAX	XBP1	XBP1,JUN,PRDM1	Plasma
5	MeC_5	HMGB2,HMGB1,HMGB3,MXD3	ARL6IP1,HMGB2,UBE2C,TUBB4B,PTTG1,CENPF,TOP2A,KPNA2,CKS2,CCNB1,CDC20,TUBA1B,CCNB2,TUBA1C,BIRC5,MKI67,ASPM,HMGN2,NUSAP1,PLK1	ARL6IP1,HMGB2,UBE2C,TUBB4B,PTTG1,CENPF,TOP2A,KPNA2,CKS2,CCNB1,CDC20,TUBA1B,CCNB2,TUBA1C,BIRC5,MKI67,ASPM,HMGN2,NUSAP1,PLK1,TUBB,CDKN3,TPX2,CKS1B,CALM2,HIST1H4C,DLGAP5,STMN1,SMC4,CENPE,RAD21,AURKB,CCNA2,HMMR,NUCKS1,CDK1,TROAP,ANP32E,H2AFV,TUBA1A,NUF2,HMGB1,GTSE1,LGALS1,KIF20B,UBE2S,CENPA,CDCA8,HMGB3,CKAP2,AURKA,PRC1,CDCA3,HSP90B1,HP1BP3,DCTN3,BUB3,MAD2L1,CALM3,JPT1,KIF23,KIF2C,UBB,BUB1,DYNLL1,KIF22,SDCBP,CDC25B,RACGAP1,HN1,H2AFZ,VIM,CENPW,KIF14,PTMS,NDC80,TMPO,H2AFX,TACC3,SUN2,KNSTRN,CKAP2L,WSB1,KIFC1,DEPDC1,CKAP5,NEK2,LSM5,MXD3,MZT1,LRRFIP1,HJURP,MYL12A,NCAPG,KIF20A,CEP55,DDX39A,CDCA2,RAN,PRR11	G2-M Checkpoint; E2F Targets; Cell Cycle Homo sapiens R-HSA-1640170; Cell Cycle, Mitotic Homo sapiens R-HSA-69278; Cell cycle	G2-M Checkpoint; E2F Targets; Mitotic Spindle	mitotic spindle organization (GO:0007052); microtubule cytoskeleton organization involved in mitosis (GO:1902850); mitotic sister chromatid segregation (GO:0000070)	Cell Cycle Homo sapiens R-HSA-1640170; Cell Cycle, Mitotic Homo sapiens R-HSA-69278; M Phase Homo sapiens R-HSA-68886	Cell cycle; Aurora B signaling; M phase pathway	Regulation of sister chromatid separation at the metaphase-anaphase transition WP4240; Retinoblastoma Gene in Cancer WP2446; Cell Cycle WP179	Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation	microtubule binding (GO:0008017); tubulin binding (GO:0015631); microtubule motor activity (GO:0003777)	MYBL2,FOXM1,E2F4,E2F1,RBL2,RNF2,FOXP1,NFYA,BARX2,TFDP1,FOS,SAP30,CHD2,IRF3,SP1,SRSF3,GTF2B,HDAC1,SNRNP70,KAT5	Epithelium,Mammary Gland	HMGB2,HMGN2,HMGB1,CENPA,HMGB3	MYBL2,FOXM1,E2F4,E2F1,RBL2		KLF6,MXD3	TMKI67
6	MeC_6	ID2,FOS,CEBPD,SPI1	CST3,HLA-DPB1,HLA-DQA1,HLA-DQB1,HLA-DPA1,FCER1A,HLA-DRB1,HLA-DRA,LSP1,CLEC10A,PPA1,CD74,CD1C,GSTP1,HLA-DMA,HLA-DRB5,AREG,COTL1,CPVL,VIM	CST3,HLA-DPB1,HLA-DQA1,HLA-DQB1,HLA-DPA1,FCER1A,HLA-DRB1,HLA-DRA,LSP1,CLEC10A,PPA1,CD74,CD1C,GSTP1,HLA-DMA,HLA-DRB5,AREG,COTL1,CPVL,VIM,TUBA1B,HLA-DMB,LYZ,S100A10,GSN,TUBA1A,LGALS2,SAMHD1,RGS10,ARL4C,ANXA1,JAML,HLA-DQA2,H2AFY,ALDH2,ID2,C1orf162,GPR183,SPINT2,TIMP1,HMGN1,CD1E,ACTB,CTSH,GDI2,NAP1L1,PKIB,ACTG1,LST1,ITGB2,CSTB,PAK1,CST7,EIF3L,MYL12A,LGALS1,DDIT4,FOS,BASP1,CEBPD,CFP,CSF2RA,PABPC1,CKLF,ANXA2,TMSB10,NDRG2,SERPINB1,SNX3,RAC1,AP1S2,BID,HINT1,RGS1,RGCC,RNASE6,RBPJ,LIMD2,TMEM14C,MNDA,PLD4,SPI1,ARPC1B,RNH1,FAM49B,DBI,CNN2,GLIPR1,LRRFIP1,GABARAPL2,ENHO,PPT1,IFI30,STK17B,KCNK6,INSIG1,LCP1,PKM,PRCP,DUSP2	Viral myocarditis; Viral myocarditis; Asthma; Asthma; Ebola Virus Pathway on Host WP4217	Allograft Rejection; Epithelial Mesenchymal Transition; Apoptosis	antigen processing and presentation of exogenous peptide antigen (GO:0002478); antigen processing and presentation of peptide antigen via MHC class II (GO:0002495); antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	MHC class II antigen presentation Homo sapiens R-HSA-2132295; Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430; Generation of second messenger molecules Homo sapiens R-HSA-202433	Viral myocarditis; Asthma; Phagosome	Ebola Virus Pathway on Host WP4217; Allograft Rejection WP2328; Pathogenic Escherichia coli infection WP2272	Viral myocarditis; Asthma; Phagosome	MHC class II receptor activity (GO:0032395); MHC class II protein complex binding (GO:0023026); peptidase inhibitor activity (GO:0030414)	CIITA,SPI1,IRF1,BRD4,CEBPB,RBL2,STAT1,ZNF669,JMJD1C,RFX5,CD74,FOS,DRAP1,HMG20A,RELA,CEBPA,MEF2B,KAT2B,HOXA9,FAIRE	Raji,B Lymphocyte,Blood	ID2,BASP1,CEBPD,MNDA,SUB1	IRF1,BRD4,CEBPB,RBL2,STAT1	SPI1,CIITA,FOS	SPI1,CIITA,FOS,KLF4	M1,cDC2,M2,pDC,cDC1,Monocyte,B
7	MeC_7	BATF,FOXP3,ARID5B,CREM,IKZF2,PRDM1,REL,TSC22D3,GATA3	IL32,TNFRSF18,TNFRSF4,LTB,S100A4,BATF,IL2RA,CARD16,CTSC,FOXP3,CD7,TIGIT,SAT1,TNFRSF1B,CD27,CTLA4,UGP2,GBP2,PMAIP1,SPOCK2	IL32,TNFRSF18,TNFRSF4,LTB,S100A4,BATF,IL2RA,CARD16,CTSC,FOXP3,CD7,TIGIT,SAT1,TNFRSF1B,CD27,CTLA4,UGP2,GBP2,PMAIP1,SPOCK2,TBC1D4,ICOS,PIM2,DNPH1,TNFRSF9,GLRX,DUSP4,IL2RG,GADD45A,HLA-A,ENO1,LAIR2,STK17B,LAYN,IL1R2,ARID5B,IL2RB,CORO1B,ACP5,GBP5,UCP2,PHLDA1,RPS27L,MAGEH1,HTATIP2,PBXIP1,MIR4435-2HG,TYMP,BIRC3,CXCR6,BTG1,CD2,PKM,CD74,S100A6,SYNGR2,RTKN2,SOD1,CST7,CCR8,CCND2,SH2D2A,NAMPT,CREM,CYTIP,IKZF2,PRDM1,CASP1,UQCRB,TRAC,PARK7,REL,RGS1,STAM,AC017002.3,ARL6IP5,ARPC1B,COX17,CALM3,SELL,SERPINB9,SLAMF1,GAPDH,BTG3,NDUFA4,CFLAR,ENTPD1,NEAT1,LMNA,SUMO2,DOK2,TSC22D3,SH3BGRL,CD247,CYTOR,MYL6,GATA3,DDIT4,RHBDD2,TNFAIP3	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; IL-2/STAT5 Signaling; Apoptosis; TNF-alpha Signaling via NF-kB	IL-2/STAT5 Signaling; Apoptosis; TNF-alpha Signaling via NF-kB	regulation of T cell differentiation (GO:0045580); cytokine-mediated signaling pathway (GO:0019221); regulation of apoptotic process (GO:0042981)	Immune System Homo sapiens R-HSA-168256; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215; TNFs bind their physiological receptors Homo sapiens R-HSA-5669034	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; CD8/T cell receptor downstream pathway	Apoptosis Modulation and Signaling WP1772; Inflammatory Response Pathway WP453; Vitamin D Receptor Pathway WP2877	Cytokine-cytokine receptor interaction; Th17 cell differentiation; NOD-like receptor signaling pathway	cysteine-type endopeptidase inhibitor activity (GO:0004869); protease binding (GO:0002020); cytokine receptor activity (GO:0004896)	T,MAF,STAT5B,MYB,STAT5,RELA,CD74,BRD4,CDK9,ETS1,KMT2A,GATA3,NOTCH1,TAL1,TBX21,IRF1,IRF2,PML,STAT1,LYL1	Th1	ENO1,ARID5B,HTATIP2,PBXIP1,BTG1	T,MAF,STAT5B,MYB,RELA	GATA3,FOXP3,BATF,PRDM1,STAT3,REL	GATA3,FOXP3,BATF,PRDM1,STAT3,REL	Treg
8	MeC_8	HOPX,ID2,REL,FOS,XBP1,CEBPD,TBX21	GNLY,TYROBP,KLRB1,FCER1G,CD7,KLRD1,KLRF1,NKG7,PRF1,CTSW,IFITM2,GZMB,CMC1,HOPX,IL2RB,CD247,XCL2,PLAC8,KLRC1,SPON2	GNLY,TYROBP,KLRB1,FCER1G,CD7,KLRD1,KLRF1,NKG7,PRF1,CTSW,IFITM2,GZMB,CMC1,HOPX,IL2RB,CD247,XCL2,PLAC8,KLRC1,SPON2,TRDC,XCL1,AREG,CLIC3,FCGR3A,ID2,SRGN,CD63,JAK1,MATK,IFITM1,FGFBP2,TXK,CST7,TNFRSF18,SH2D1B,RHOC,ITGB2,IFITM3,NFKBIA,BTG1,EFHD2,CD300A,EIF3G,LAT2,IGFBP7,APMAP,GSTP1,LIMD2,FXYD5,CLIC1,REL,BIN2,RAC2,FOS,S1PR5,CXXC5,CTSD,CD160,PTGDR,AKR1C3,FAM49B,UBB,SELL,HCST,TPI1,XBP1,NCR3,HNRNPA1,GNG2,FGR,CEBPD,PFN1,DUSP2,DDIT4,PRDX5,EVL,ARHGAP9,CHST12,TMIGD2,CDC42SE1,CCL3,TTC38,IER2,CCL4,GNPTAB,GLIPR2,BST2,ZAP70,CIRBP,STK17A,SERPINB1,PRSS23,ACTG1,ATM,GZMM,CX3CR1,B3GNT7,C1orf162,TBX21	Interleukin-2 signaling pathway; Natural killer cell mediated cytotoxicity; regulation of immune response (GO:0050776); Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933; Immune System Homo sapiens R-HSA-168256	Allograft Rejection; TNF-alpha Signaling via NF-kB; IL-2/STAT5 Signaling	regulation of immune response (GO:0050776); response to interferon-gamma (GO:0034341); cytokine-mediated signaling pathway (GO:0019221)	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933; Immune System Homo sapiens R-HSA-168256; Adaptive Immune System Homo sapiens R-HSA-1280218	Interleukin-2 signaling pathway; Natural killer cell-mediated cytotoxicity; T cell receptor regulation of apoptosis	Chemokine signaling pathway WP3929; miRNAs involvement in the immune response in sepsis WP4329; Microglia Pathogen Phagocytosis Pathway WP3937	Natural killer cell mediated cytotoxicity; Th1 and Th2 cell differentiation; Chemokine signaling pathway	chemokine receptor binding (GO:0042379); non-membrane spanning protein tyrosine kinase activity (GO:0004715); CCR chemokine receptor binding (GO:0048020)	T,ZNF552,GATA3,MYB,ZNF701,CEBPA,LYL1,SPI1,KMT2A,STAT5B,RUNX1,STAT6,TAL1,LMO2,CUX1,EZH2,SMAD1,AR,DROSHA,TBX21	Th1	HOPX,ID2,NFKBIA,BTG1,REL	T,ZNF552,GATA3,MYB,ZNF701	TBX21	TBX21,FOS	MAIT,NK,CD4Teff
9	MeC_9	TCF7L2,SPI1,MAFB,CEBPB,POU2F2,HES4,YBX1,CUX1,TSC22D3	FCGR3A,LST1,MS4A7,NAP1L1,AIF1,IFITM2,IFITM3,SAT1,SERPINA1,RHOC,COTL1,FCER1G,CFD,LILRB2,PSAP,STXBP2,CTSS,LYN,HCK,PECAM1	FCGR3A,LST1,MS4A7,NAP1L1,AIF1,IFITM2,IFITM3,SAT1,SERPINA1,RHOC,COTL1,FCER1G,CFD,LILRB2,PSAP,STXBP2,CTSS,LYN,HCK,PECAM1,CD68,LRRC25,CDKN1C,FTH1,PILRA,TCF7L2,MTSS1,RNASET2,FTL,BCL2A1,WARS,HMOX1,LINC01272,TNFRSF1B,S100A11,SPI1,VASP,PTPN6,MAFB,CEBPB,ASAH1,DRAP1,POU2F2,RHOB,BID,CSF1R,HES4,TUBA1A,C5AR1,TIMP1,RPS19,CD52,LILRB1,TUBA1B,CALM2,NAAA,CTSC,ABI3,EVI2B,CYTIP,LILRA5,FAM26F,SLC7A7,SIGLEC10,YBX1,FKBP1A,CSTB,MAPKAPK3,UNC119,PPDPF,NACA,LYST,LILRA1,S100A4,NFKBIZ,SPN,CUX1,TYROBP,TESC,ARPC3,IFI30,BIN2,SMIM25,ZFAND5,LYPD2,TSC22D3,RNF149,FAM110A,CD37,RAP1B,LTA4H,SLC11A1,CXCL16,SOD1,ARRB2,NPC2,CD48,DUSP1,SLC2A6,TKT	neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446); negative regulation of lymphocyte proliferation (GO:0050672); Interleukin-2 signaling pathway	Complement; Apoptosis; UV Response Up	neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446)	Immune System Homo sapiens R-HSA-168256; Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002; Hemostasis Homo sapiens R-HSA-109582	Interleukin-2 signaling pathway; Platelet activation, signaling and aggregation; Hemostasis pathway	TYROBP Causal Network WP3945; Microglia Pathogen Phagocytosis Pathway WP3937; Ferroptosis WP4313	Osteoclast differentiation; B cell receptor signaling pathway; Lysosome	protein homodimerization activity (GO:0042803); MHC class I protein binding (GO:0042288)	RUNX1,SPI1,SMAD1,STAT1,NR4A1,RARA,TAL1,NCOR1,IRF1,CD74,KMT2A,FLI1,CEBPA,PML,BRD4,LMO2,ERG,RXRG,JMJD1C,RUNX1T1	Kasumi-1,Myeloblast,Blood	HES4,TSC22D3,KLF2,KLF3,ID2	RUNX1,SMAD1,STAT1,RARA,TAL1	SPI1,NR4A1,CUX1,CEBPB,JUNB,TCF7L2	SPI1,NR4A1,CUX1,CEBPB,JUNB,TCF7L2,POU2F2,KLF4,YBX1,MAFB	M1,Monocyte,M2,cDC2
10	MeC_10	KLF6,JUNB,FOS,ATF3,FOSB,JUN,ELF1,EGR1	MT-CO3,MT-CO2,MT-CYB,MT-CO1,MT-ATP6,MT-ND3,MT-ND4,MT-ND1,MT-ND2,MT-ND5,MT-ND4L,MT-ATP8,MALAT1,KLF6,MTRNR2L12,JUNB,MT-ND6,MTRNR2L8,ZFP36L2,BTG1	MT-CO3,MT-CO2,MT-CYB,MT-CO1,MT-ATP6,MT-ND3,MT-ND4,MT-ND1,MT-ND2,MT-ND5,MT-ND4L,MT-ATP8,MALAT1,KLF6,MTRNR2L12,JUNB,MT-ND6,MTRNR2L8,ZFP36L2,BTG1,SLC2A3,NEAT1,PPP1R15A,FOS,HSP90B1,ATF3,FOSB,EMP3,ZFP36,DNAJB1,SQSTM1,IER2,CD52,IFITM1,B2M,PSMA7,INS,RGS1,HLA-B,JUN,MTDH,DUSP2,HLA-E,ZFP36L1,MTRNR2L10,MTRNR2L1,DUSP1,COX5B,TMBIM6,CCL4,UBXN1,SARAF,SEC61B,SAT1,IL32,COX7A2,CD83,H1FX,FYB,SSR4,FXYD5,ARHGEF1,ELF1,STK17B,RAN,SGK1,CXCL8,CD37,PLIN2,HLA-C,CORO1B,MZT2B,SOD2,NFKBIZ,SEC62,PNRC1,UBXN4,IQGAP1,PCBP2,CCL4L2,CLEC2B,PSMB9,ZFAND5,GADD45B,GABARAPL2,ATP6V1F,EVL,MT-RNR2,UBE2D3,DRAP1,IFI30,IER3,LGALS3,BSG,EIF3G,EGR1,RGS10,APLP2,CTSZ,H3F3B	TNF-alpha Signaling via NF-kB; T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; UV Response Up; Hypoxia	TNF-alpha Signaling via NF-kB; UV Response Up; Hypoxia	cytokine-mediated signaling pathway (GO:0019221); antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (GO:0002480); antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	Immune System Homo sapiens R-HSA-168256; ER-Phagosome pathway Homo sapiens R-HSA-1236974; Antigen processing-Cross presentation Homo sapiens R-HSA-1236975	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; BDNF signaling pathway	Proteasome Degradation WP183; TGF-beta Signaling Pathway WP366; Senescence and Autophagy in Cancer WP615	Protein processing in endoplasmic reticulum; Kaposi sarcoma-associated herpesvirus infection; Cellular senescence		TBP,TAF1,RELA,MAF,MAX,KMT2A,SPI1,MYC,NFKB2,T,MED1,CDK9,GATA3,NCOR1,STAT1,CD74,BRD4,RELB,STAT5B,TCF12	GM12878,B Lymphocyte,Blood	BTG1,FOSB	TAF1,RELA,MAF,MAX,SPI1	JUNB	JUNB,ATF3,FOS,JUN,KLF6	Epithelial,MAIT,CD8Tem
11	MeC_11	HOPX,KLF2,LITAF,ZEB2,TSC22D3,TBX21,XBP1,YBX1,RORA	GNLY,NKG7,FGFBP2,GZMB,GZMH,PRF1,FCGR3A,CST7,ITGB2,SPON2,KLRD1,PLAC8,CTSW,CCND3,PLEK,CX3CR1,CD247,ARPC2,IFITM1,S1PR5	GNLY,NKG7,FGFBP2,GZMB,GZMH,PRF1,FCGR3A,CST7,ITGB2,SPON2,KLRD1,PLAC8,CTSW,CCND3,PLEK,CX3CR1,CD247,ARPC2,IFITM1,S1PR5,FLNA,HOPX,KLF2,BIN2,EFHD2,LITAF,GZMA,TXNIP,EMP3,CALM1,KLRF1,RAP1B,ITGB1,TYROBP,AES,UCP2,ADGRG1,GZMM,ZEB2,C12orf75,CYBA,IFITM2,CTSC,S100A4,IER2,GNG2,KLRB1,ARL4C,MYL12A,LGALS1,PFN1,SYNE1,FCRL6,CD53,TTC38,PRSS23,C1orf21,PXN,TSC22D3,HLA-E,CCL4,FGR,UBB,DSTN,CLIC3,APMAP,TGFBR3,ANXA1,MT2A,FCER1G,SPN,CMC1,DDIT4,YWHAQ,CD47,ADD3,CD300A,CYTH1,NEAT1,SUN2,TPST2,SRGN,TBX21,SYNE2,SH3BP5,MSN,XBP1,YBX1,KLRG1,CFL1,ITGAL,ADRB2,TCF25,HCST,HNRNPA2B1,DOK2,SYTL3,HLA-C,PDIA3,RORA	Interleukin-2 signaling pathway; regulation of immune response (GO:0050776); Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933; Allograft Rejection; Immunoregulatory interactions between a lymphoid and a non-lymphoid cell	Allograft Rejection; Complement; Interferon Alpha Response	regulation of immune response (GO:0050776); cellular defense response (GO:0006968); neutrophil mediated immunity (GO:0002446)	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933; Adaptive Immune System Homo sapiens R-HSA-1280218; Immune System Homo sapiens R-HSA-168256	Interleukin-2 signaling pathway; Immunoregulatory interactions between a lymphoid and a non-lymphoid cell; Natural killer cell-mediated cytotoxicity	Microglia Pathogen Phagocytosis Pathway WP3937; Focal Adhesion WP306; Cells and Molecules involved in local acute inflammatory response  WP4493	Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton	cytoskeleton-nuclear membrane anchor activity (GO:0140444)	GATA3,T,KMT2A,TAL1,RUNX1,MYB,TBX21,RXRG,LMO2,MED12,JMJD1C,RUNX1T1,CEBPA,FLI1,SMAD1,ERG,STAT5B,STAT5,LYL1,TLX1	Th1	HOPX,KLF2,LITAF,AES,ZEB2	GATA3,T,TAL1,RUNX1,MYB	TBX21,IRF1	TBX21,IRF1,YBX1	NK,CD8Teff,CD8Tex,CD4Teff,CD8Tcm,CD8Tem
12	MeC_12	EOMES,JUNB,SUB1,JUN,ELF1	GZMK,CCL5,GZMA,DUSP2,CST7,CMC1,NKG7,CD74,CCL4,COTL1,SH2D1A,CD27,CXCR4,CD8A,CLDND1,RGS1,KLRG1,CD8B,SRSF7,LYAR	GZMK,CCL5,GZMA,DUSP2,CST7,CMC1,NKG7,CD74,CCL4,COTL1,SH2D1A,CD27,CXCR4,CD8A,CLDND1,RGS1,KLRG1,CD8B,SRSF7,LYAR,CD44,ITM2C,HLA-DRB1,TRAT1,GZMM,LYST,EOMES,PPP2R5C,APOBEC3G,PYHIN1,STK17A,GIMAP4,OAZ1,IL32,DNAJB1,ITM2A,FYN,BTG1,TRAC,PTPRC,CLEC2B,PPDPF,SRGN,LDHA,GPR183,CRTAM,HCST,HLA-DPB1,CD3D,CD3E,CNN2,SAMD3,PIK3R1,HLA-DPA1,TIGIT,JUNB,RARRES3,PLEK,ITGB2,RPS15A,TC2N,CTSC,RPL27A,WIPF1,RNF213,TUBA4A,RPL13A,CSTB,MYL12B,TRBC2,MT2A,CD69,GUK1,PSMB9,ARPC3,HERPUD1,IFNG,CD84,CCL4L2,ANXA2,PTP4A2,MIAT,CYBA,ALDOA,DUSP4,TERF2IP,ARL6IP1,CD2,SUB1,GABARAPL2,CALM2,GIMAP7,YPEL5,DTHD1,JUN,ELF1,ATP6V1G1,CHI3L2,PNRC1,TSPYL2	Interleukin-2 signaling pathway; Immune System Homo sapiens R-HSA-168256; Allograft Rejection; Adaptive Immune System Homo sapiens R-HSA-1280218; Immune system	Allograft Rejection; TNF-alpha Signaling via NF-kB; Interferon Gamma Response	cytokine-mediated signaling pathway (GO:0019221); cellular response to interferon-gamma (GO:0071346); T cell receptor signaling pathway (GO:0050852)	Immune System Homo sapiens R-HSA-168256; Adaptive Immune System Homo sapiens R-HSA-1280218; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427	Interleukin-2 signaling pathway; Immune system; Adaptive immune system	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863; T-Cell antigen Receptor (TCR)  Signaling Pathway WP69; T-Cell Receptor and Co-stimulatory Signaling WP2583	T cell receptor signaling pathway; Hematopoietic cell lineage; Rheumatoid arthritis		GATA3,T,KMT2A,STAT5B,MYB,SPI1,TBX21,STAT6,RUNX1,CD74,NFKB2,RAG1,CDK9,RELA,TAL1,ETS1,JUNB,NOTCH1,CREBBP,ZNF799	Th1	PYHIN1,BTG1,SUB1,JUN,ELF1	GATA3,T,STAT5B,MYB,SPI1	JUNB,ETS1	JUNB,ETS1,EOMES	CD8Tex,CD8Tcm,NK,CD4Teff,CD8Tem,CD8Teff
13	MeC_13	GATA2,TSC22D1,EGR1,FOXP1,FOSB,ELF1,ID2,AHR	TPSAB1,TPSB2,CPA3,CLU,HPGDS,ANXA1,SAMSN1,SRGN,GATA2,VWA5A,HPGD,SLC18A2,LAPTM4A,GLUL,RGS2,CD69,CAPG,KIT,MS4A2,RGS1	TPSAB1,TPSB2,CPA3,CLU,HPGDS,ANXA1,SAMSN1,SRGN,GATA2,VWA5A,HPGD,SLC18A2,LAPTM4A,GLUL,RGS2,CD69,CAPG,KIT,MS4A2,RGS1,CTSG,CD9,CD63,HDC,IL1RL1,ALOX5AP,FCER1G,RGS13,RAC2,LTC4S,PLIN2,VIM,ARHGDIB,LAPTM5,CD44,PRDX6,TIMP1,NFKBIA,MAOB,CLIC1,CTSD,TSC22D1,NSMCE1,UBB,DUSP6,ACSL4,PTGS1,LMNA,SH3BGRL3,BIRC3,LMO4,BTK,EGR1,ARHGAP18,SDCBP,FOXP1,CTNNBL1,CD82,ALOX5,FOSB,NFKBIZ,NDUFA4,LAT2,S100A4,TNFSF10,FXYD5,PPP1R15A,ASAH1,TYROBP,STMN1,LAT,ELF1,ID2,PRDX1,ADCYAP1,C1ORF186,S100A6,FTH1,CD37,PTGS2,GCSAML,SOCS1,ALDH1A1,EMP3,RPL36AL,SMYD3,CNRIP1,IFITM2,SERPINB1,AREG,TAGLN2,RGS10,AHR,ARHGEF6,AKAP13,ATP6V1F,IER2,DRAP1,TPSD1,RAB27B	BDNF signaling pathway; TNF-alpha Signaling via NF-kB; Interleukin-2 signaling pathway; Interleukin-5 regulation of apoptosis; KRAS Signaling Up	TNF-alpha Signaling via NF-kB; KRAS Signaling Up; Apoptosis	lipoxygenase pathway (GO:0019372); lipoxin metabolic process (GO:2001300); lipoxin biosynthetic process (GO:2001301)	Synthesis of Lipoxins (LX) Homo sapiens R-HSA-2142700; Arachidonic acid metabolism Homo sapiens R-HSA-2142753; Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Homo sapiens R-HSA-2162123	BDNF signaling pathway; Interleukin-2 signaling pathway; Interleukin-5 regulation of apoptosis	Prostaglandin Synthesis and Regulation WP98; Eicosanoid Synthesis WP167; Nuclear Receptors Meta-Pathway WP2882	Fc epsilon RI signaling pathway; Arachidonic acid metabolism; Lysosome		SMAD1,RUNX1,TAL1,5HMC,MED12,GATA2,LMO2,ERG,RUNX1T1,LYL1,MYB,GATA1,SPI1,FOSL2,RAD21,NR3C1,CEBPB,GATA3,CEBPA,HES2	Haematopoietic Progenitor Cell,Blood	NFKBIA,TSC22D1,LMO4,EGR1,FOSB	SMAD1,RUNX1,TAL1,MED12,ERG	GATA2,LYL1,NR4A1,FOXP1	GATA2,LYL1,NR4A1,FOXP1	Mast
14	MeC_14	CARHSP1,HMGA1	DUT,PCNA,TYMS,MCM7,TK1,RRM2,STMN1,MCM5,MCM3,DEK,HIST1H4C,RANBP1,FEN1,SLBP,H2AFZ,DHFR,GINS2,PCLAF,NASP,TMEM106C	DUT,PCNA,TYMS,MCM7,TK1,RRM2,STMN1,MCM5,MCM3,DEK,HIST1H4C,RANBP1,FEN1,SLBP,H2AFZ,DHFR,GINS2,PCLAF,NASP,TMEM106C,DNMT1,HELLS,TUBB,CENPM,CLSPN,ZWINT,SIVA1,ASF1B,DNAJC9,IDH2,RPA3,ATAD2,MCM6,NAP1L1,CENPU,MCM4,MCM2,LIG1,CARHSP1,KIAA0101,CDCA7,TUBA1B,HNRNPF,RNASEH2A,GMNN,RFC2,RRM1,CDK4,PPDPF,PKMYT1,SVIP,RPA2,HPRT1,CDT1,TCF19,SNRPB,FAM111B,CRIP1,ARL6IP6,RFC4,HSPB11,H2AFY,HAT1,UNG,CENPK,RBBP7,SMC3,TMEM109,GGCT,PSIP1,CDC45,USP1,UBE2T,UHRF1,WDR76,CENPH,RAD51AP1,RBBP4,PA2G4,NUDT1,HNRNPAB,SNRNP25,SRSF2,ANXA5,WDR34,LDHB,EIF4EBP1,PGAM1,TPI1,FABP5,CKLF,SMC1A,PRDX2,GGH,CDC6,C19orf48,SMC2,COPS3,PTMA,HMGA1	E2F Targets; Retinoblastoma Gene in Cancer WP2446; Cell cycle; Cell Cycle, Mitotic Homo sapiens R-HSA-69278; Cell Cycle Homo sapiens R-HSA-1640170	E2F Targets; Myc Targets V1; G2-M Checkpoint	DNA metabolic process (GO:0006259); DNA replication (GO:0006260); DNA replication initiation (GO:0006270)	Cell Cycle, Mitotic Homo sapiens R-HSA-69278; Cell Cycle Homo sapiens R-HSA-1640170; DNA strand elongation Homo sapiens R-HSA-69190	Cell cycle; DNA replication; DNA strand elongation	Retinoblastoma Gene in Cancer WP2446; DNA Replication WP466; G1 to S cell cycle control WP45	DNA replication; Cell cycle; Mismatch repair	DNA replication origin binding (GO:0003688); single-stranded DNA binding (GO:0003697); single-stranded DNA helicase activity (GO:0017116)	E2F1,E2F4,RBL2,RB1,RELA,TFDP1,KAT2B,SAP30,E2F7,TBP,RNF2,MYH11,BRD4,PHF8,GTF2B,FOXP1,NELFA,CHD2,MXI1,HDAC1	Mesenchymal Stem Cell,Umbilical Cord	NASP,HELLS,ATAD2,CARHSP1,GMNN	E2F4,RBL2,RB1,RELA,KAT2B	TFDP1,E2F1,FOS	TFDP1,E2F1,FOS,EGR1,EZH2,CBX3,MYBL2,BRCA1,PSIP1,RBBP4	TMKI67
15	MeC_15	YBX1	RPL41,RPL26,RPL23A,RPS12,RPS15A,RPS29,RPL30,RPL32,RPL21,RPL12,RPS14,RPS18,RPS13,RPL34,RPL19,RPL35A,RPS25,RPL39,RPL31,PPDPF	RPL41,RPL26,RPL23A,RPS12,RPS15A,RPS29,RPL30,RPL32,RPL21,RPL12,RPS14,RPS18,RPS13,RPL34,RPL19,RPL35A,RPS25,RPL39,RPL31,PPDPF,RPS27A,EEF1D,RPS23,PFDN5,RPL29,RPS27,RPS10,RPL27,FTL,RPLP1,RPLP2,RPL9,RPL38,RPS3A,FTH1,RPL17,RPL37,RPL36A,UBB,RPL18A,RPS7,FAU,RPS21,RPL10A,NACA,RPL22,RPL36,RPS15,RPL28,RPL8,RPL37A,RPS4X,UBA52,RPS16,TPT1,RPS5,RPL10,RPS8,RPL15,HMGN2,RPS20,RPS24,RPS28,RPL11,RPL35,RPL24,RPS6,RPL6,RPL13,SH3BGRL3,TOMM7,RPS11,COMMD6,RPS26,RPS3,SERF2,RPS19,PNRC1,RPS9,CCL5,RPL18,PFN1,S100A4,TMA7,TMSB10,RPL27A,UBC,COX4I1,RPL7A,TMSB4X,H2AFZ,ATP5E,RPL36AL,RPL7,OAZ1,RPL14,YBX1,CST7,H3F3B,SNRPD2	Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Selenocysteine synthesis Homo sapiens R-HSA-2408557; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	Myc Targets V1; Allograft Rejection	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cytoplasmic translation (GO:0002181); cotranslational protein targeting to membrane (GO:0006613)	Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842	Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication; Translation	Cytoplasmic Ribosomal Proteins WP477	Ribosome; Coronavirus disease; Mitophagy	RNA binding (GO:0003723); ubiquitin ligase inhibitor activity (GO:1990948); ubiquitin-protein transferase inhibitor activity (GO:0055105)	BRD4,EZH2,WDR5,MYC,KAT2B,MED1,GTF2B,TP53,KAT5,FOXM1,MAFB,GTF2F1,BRD2,TAF7,NELFE,BMI1,SNAPC1,TAFII,ZNF22,GTF2E2	Proerythroblast,Fetal Liver	PFDN5,HMGN2,YBX1,NFKBIA,BTG1	BRD4,EZH2,MYC,KAT2B,MED1		IRF1,CREM,JUN,KLF6	CD8Tn,Th17
16	MeC_16	RORA,ID2,CEBPD,SATB1,BHLHE40,ZBTB16,HOPX,XBP1,MYC	KLRB1,LTB,IL7R,GZMK,S100A4,RORA,SPOCK2,NCR3,GZMA,DUSP1,S100A6,CXCR4,ID2,LAPTM5,AQP3,KLRG1,TNFAIP3,ALOX5AP,FKBP11,RGS2	KLRB1,LTB,IL7R,GZMK,S100A4,RORA,SPOCK2,NCR3,GZMA,DUSP1,S100A6,CXCR4,ID2,LAPTM5,AQP3,KLRG1,TNFAIP3,ALOX5AP,FKBP11,RGS2,DUSP2,GPR65,LYAR,NKG7,RPLP0,CXCR6,CEBPD,GYG1,IL32,GBP5,JAML,LST1,PRF1,CD69,CCR6,MT2A,SLC4A10,CTSA,SATB1,NFKBIA,LGALS3,IFNGR1,TNFRSF25,SYNE2,LAG3,YWHAQ,CTSW,LCP1,DPP4,IL2RG,CTSH,EIF4A1,LINC01871,ZFP36,CCL5,PDE4D,PBXIP1,ZFP36L1,CCL20,OSTF1,TNFAIP8,SRSF3,UCP2,ERN1,TMIGD2,ARL4C,ODF2L,EML4,SERP1,PDCD4,PIM1,MGAT4A,YWHAH,CASP1,CCDC107,PARP8,UBC,CD96,MYO1F,SESN1,BHLHE40,TTC39C,TPM3,CALM1,CNN2,DDIT4,ZBTB16,CD74,HOPX,TC2N,SLC25A6,ATF7IP2,XBP1,JAK1,CST7,MT-CO3,MYC,PHACTR2,PERP,BZW1	Interleukin-2 signaling pathway; TNF-alpha Signaling via NF-kB; cellular response to cytokine stimulus (GO:0071345); cytokine-mediated signaling pathway (GO:0019221); T cell receptor regulation of apoptosis	TNF-alpha Signaling via NF-kB; Complement; IL-2/STAT5 Signaling	cellular response to cytokine stimulus (GO:0071345); cytokine-mediated signaling pathway (GO:0019221); positive regulation of fat cell differentiation (GO:0045600)	Immune System Homo sapiens R-HSA-168256; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215; Chemokine receptors bind chemokines Homo sapiens R-HSA-380108	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Interleukin-4 regulation of apoptosis	IL-7 Signaling Pathway WP205; Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway WP2203; Apoptosis WP254	Cytokine-cytokine receptor interaction; Pathways in cancer; Kaposi sarcoma-associated herpesvirus infection	C-C chemokine binding (GO:0019957); chemokine binding (GO:0019956); cytokine receptor activity (GO:0004896)	RUNX1,T,MYB,KMT2A,TAL1,GATA3,STAT6,LMO1,CDK9,TBX21,TCF7L1,STAT5B,SMAD1,CDK7,SMARCA4,TCF12,PPARG,RXRG,HDAC6,ETS1	Jurkat E6-1,T Lymphocyte,Blood	RORA,ID2,CEBPD,SATB1,NFKBIA	RUNX1,T,MYB,TAL1,GATA3	MAF	MAF,MYC,BHLHE40	MAIT,Th17,CD8Tcm,CD8Tex
17	MeC_17	FOS,ZEB2,CEBPB	S100A9,S100A8,LYZ,FCN1,VCAN,CTSS,S100A4,S100A6,TIMP1,PSAP,SERPINA1,TKT,THBS1,CFD,IL1B,TSPO,CD55,LST1,CSTA,COTL1	S100A9,S100A8,LYZ,FCN1,VCAN,CTSS,S100A4,S100A6,TIMP1,PSAP,SERPINA1,TKT,THBS1,CFD,IL1B,TSPO,CD55,LST1,CSTA,COTL1,S100A12,CD52,DUSP1,FGR,CFP,APOBEC3A,AP1S2,MNDA,SAMSN1,TYROBP,SLC11A1,C1orf162,EREG,SOD2,AIF1,FPR1,STXBP2,SH3BGRL3,BCL2A1,NAMPT,C5AR1,LTA4H,NCF2,SERPINB1,OAZ1,DUSP6,CD300E,FCER1G,APLP2,TNFRSF1B,CORO1A,IFI30,CD36,RETN,LYST,NEAT1,LCP1,FKBP1A,VMP1,CLEC12A,SLC25A6,H3F3A,PLBD1,PLAUR,CXCL2,RGS2,NFKBIA,TYMP,SRGN,CD48,MPEG1,PLAC8,HCK,CST3,FOS,EVI2B,TALDO1,CARD16,AQP9,CYBB,CD14,GSTP1,LILRB2,MARCO,WARS,MCEMP1,ZEB2,AC020656.1,ITGB2,CSF3R,PRELID1,CD44,CEBPB,CYBA,ATP2B1,SERP1,G0S2,PTPRE,SDCBP,SRSF5	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312); Inflammatory Response; inflammatory response (GO:0006954)	Inflammatory Response; TNF-alpha Signaling via NF-kB; Complement	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312)	Immune System Homo sapiens R-HSA-168256; Innate Immune System Homo sapiens R-HSA-168249; Hemostasis Homo sapiens R-HSA-109582	Leptin influence on immune response; Interleukin-2 signaling pathway; Phagosome	Microglia Pathogen Phagocytosis Pathway WP3937; Human Complement System WP2806; Spinal Cord Injury WP2431	Phagosome; Leishmaniasis; Lipid and atherosclerosis	RAGE receptor binding (GO:0050786); superoxide-generating NAD(P)H oxidase activity (GO:0016175); endopeptidase inhibitor activity (GO:0004866)	SMAD1,SPI1,CEBPA,RUNX1,JMJD1C,STAT1,KMT2A,IRF1,LYL1,BRD4,MYC,CEBPB,LMO2,FLI1,REST,PPARG,HDAC2,KLF1,PML,RUNX1T1	U937,Pleura	MNDA,NFKBIA,ZEB2,PFDN5,POU2F2	SMAD1,CEBPA,RUNX1,JMJD1C,STAT1	SPI1,CEBPB,FOS	SPI1,CEBPB,FOS	Monocyte
18	MeC_18	TSC22D3,POU2F2,ID3,SP100,IRF8,REL,TCF4,NR4A2,SP140,HMGB1	CD74,CD79A,MS4A1,CD37,HLA-DRA,CD52,LAPTM5,IGKC,CD79B,CD83,HLA-DRB1,BANK1,EZR,LTB,IGHM,BTG1,CD69,HLA-DQB1,CXCR4,MEF2C	CD74,CD79A,MS4A1,CD37,HLA-DRA,CD52,LAPTM5,IGKC,CD79B,CD83,HLA-DRB1,BANK1,EZR,LTB,IGHM,BTG1,CD69,HLA-DQB1,CXCR4,MEF2C,HLA-DPB1,HLA-DPA1,ARPC3,SMIM14,HLA-DQA1,ZFP36L1,LINC00926,SNX2,CYBA,ISG20,CD53,LY9,VPREB3,ADAM28,NCF1,SWAP70,TSC22D3,POU2F2,ID3,RALGPS2,SP100,IRF8,YWHAZ,CORO1A,FCMR,BIRC3,TXNIP,CD22,REL,SYPL1,ARHGAP24,SNX3,SEPT7,TNFRSF13C,BLK,HERPUD1,IGLC2,RAC2,TCL1A,PDLIM1,SYNGR2,LIMD2,IGHD,CLIC1,IFT57,CD19,HVCN1,HLA-DMA,CD24,TAGLN2,IGHA1,STK17A,LY86,PARP14,OAZ1,CD55,FCRLA,TPD52,RPS11,CD40,IGLC3,LSM7,TCEA1,EMP3,EVI2B,TCF4,PTPRCAP,PKIG,RHOH,RPLP2,HLA-DMB,NR4A2,SP140,RPS5,H3F3A,RCSD1,PARP1,FCER2,HMGB1,ORAI2	Hematopoietic cell lineage; Immune system; Intestinal immune network for IgA production; Intestinal immune network for IgA production; Antigen-activated B-cell receptor generation of second messengers	Interferon Gamma Response; Allograft Rejection; IL-2/STAT5 Signaling	antigen receptor-mediated signaling pathway (GO:0050851); antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886); antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	Immune System Homo sapiens R-HSA-168256; CD22 mediated BCR regulation Homo sapiens R-HSA-5690714; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Homo sapiens R-HSA-983695	Immune system; Intestinal immune network for IgA production; Antigen-activated B-cell receptor generation of second messengers	Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217; B Cell Receptor Signaling Pathway WP23	Hematopoietic cell lineage; Intestinal immune network for IgA production; Viral myocarditis	MHC class II protein complex binding (GO:0023026); MHC class II receptor activity (GO:0032395); CD4 receptor binding (GO:0042609)	CIITA,CD74,FOXO1,SPI1,RELA,MEF2B,CREBBP,NCOR2,BCL6,MED1,PAX5,KMT2A,SND1,BRD4,SP1,BHLHE40,NCOR1,ETV6,CDK9,EED	Raji,B Lymphocyte,Blood	BTG1,TSC22D3,ID3,SP100,IRF8	CIITA,FOXO1,SPI1,RELA,MEF2B	PAX5,MYC,FOXP1,ELF1,REL,POU2F2,BACH2,SPIB,JUND	PAX5,MYC,FOXP1,ELF1,REL,POU2F2,BACH2,SPIB,JUND,TCF4,PRDM2,JUN,SMARCB1	B,cDC1,M1
19	MeC_19	CREM,MAF,MAFB	C1QB,C1QA,APOE,C1QC,CTSD,APOC1,LGMN,PLD3,GPNMB,RNASE1,FTL,CTSB,CD14,TMEM176B,ASAH1,LIPA,ACP5,SLC40A1,PSAP,CTSL	C1QB,C1QA,APOE,C1QC,CTSD,APOC1,LGMN,PLD3,GPNMB,RNASE1,FTL,CTSB,CD14,TMEM176B,ASAH1,LIPA,ACP5,SLC40A1,PSAP,CTSL,MS4A4A,A2M,CD68,CTSC,SELENOP,CREG1,MS4A6A,MS4A7,FOLR2,DAB2,PRDX1,PLTP,FCGRT,FCGR3A,TMEM176A,SLCO2B1,CTSZ,CAPG,TREM2,CD163,GRN,HLA-E,SEPP1,HLA-DMB,ITM2B,LAPTM5,STAB1,GLUL,FUCA1,CD81,BLVRB,HMOX1,CTSS,HLA-DQA1,GM2A,CTSA,CD63,NUPR1,PMP22,TYROBP,AKR1B1,VSIG4,HLA-A,RGS1,NPC2,CREM,SDS,CD4,MSR1,ATOX1,NINJ1,ARL4C,MAF,ATP6V1F,MAFB,CFD,RNASE6,HLA-DMA,GPR34,ADAP2,LGALS3,GPX1,FCGR2A,UCP2,SDCBP,UBB,LAIR1,AIF1,MMP9,AKR1A1,PLA2G7,CD59,LY96,HEXA,FCER1G,LAMP1,CD9,TIMP2,CSF1R,CCL18	Lysosome; Lysosome; neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312)	Complement; Allograft Rejection; KRAS Signaling Up	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312)	Immune System Homo sapiens R-HSA-168256; MHC class II antigen presentation Homo sapiens R-HSA-2132295; Innate Immune System Homo sapiens R-HSA-168249	Lysosome; Phagosome; TGF-beta regulation of extracellular matrix	TYROBP Causal Network WP3945; Allograft Rejection WP2328; Microglia Pathogen Phagocytosis Pathway WP3937	Lysosome; Phagosome; Antigen processing and presentation	low-density lipoprotein particle binding (GO:0030169); MHC class II protein complex binding (GO:0023026); lipoprotein particle binding (GO:0071813)	SMAD1,SPI1,STAT1,CEBPB,IRF1,INO80,CEBPA,VDR,FAIRE,SRPK2,STAT5,JMJD1C,BRD4,GATA2,RUNX1,SPIB,CDK8,PPARG,MAX,LMO2	U937,Pleura	CREG1,MAF,MAFB,LITAF,NR4A2	SMAD1,SPI1,CEBPB,IRF1,INO80	STAT1,CREM	STAT1,CREM,JUN,NR1H3	M2,M1,Monocyte
20	MeC_20	NR3C1,JUNB,BHLHE40,TOX,STAT4,HIF1A,ARID5A,TCF7,KLF6,MAF	CXCL13,NR3C1,ITM2A,RBPJ,SRGN,ALOX5AP,JUNB,NMB,FKBP5,SH2D1A,DUSP4,TNFRSF18,CXCR4,KLRB1,UCP2,YWHAQ,BHLHE40,COTL1,CHN1,H2AFZ	CXCL13,NR3C1,ITM2A,RBPJ,SRGN,ALOX5AP,JUNB,NMB,FKBP5,SH2D1A,DUSP4,TNFRSF18,CXCR4,KLRB1,UCP2,YWHAQ,BHLHE40,COTL1,CHN1,H2AFZ,CD200,ICA1,PDCD1,NFKBIA,IGFL2,FABP5,TSHZ2,CD247,TOX,CD82,TNFRSF4,S100A11,SEPT6,CPM,STAT4,SLA,SOCS1,BTLA,HIF1A,SEC11A,RNF19A,GNG4,TRAT1,LAPTM5,AHI1,TNFAIP8,CORO1B,ARID5A,TCF7,CIRBP,TMEM173,OST4,PPP1CC,KLF6,ISCU,MAF,DBI,CD37,SMCO4,SMARCA2,PNRC1,CNIH1,IFITM1,BHLHE40-AS1,SOD1,TSPO,ACTG1,RGS2,IGFBP4,XCL1,TNFSF8,CD40LG,RNASET2,BST2,FYB1,FXYD5,LAT,AC004585.1,CCDC50,GRAMD1A,ITGB2,TMSB10,GYPC,SERF2,SRSF5,DYNLL1,HINT1,UBC,C9orf16,RILPL2,PTPRC,CTSB,EDF1,DUSP1,SKP1,CRIP1,TPI1,CD6,SLC25A6,MYL12B	Interleukin-2 signaling pathway; Allograft Rejection; T cell receptor regulation of apoptosis; cytokine-mediated signaling pathway (GO:0019221); Adaptive Immune System Homo sapiens R-HSA-1280218	Allograft Rejection; TNF-alpha Signaling via NF-kB; Hypoxia	cytokine-mediated signaling pathway (GO:0019221); regulation of immune response (GO:0050776)	Adaptive Immune System Homo sapiens R-HSA-1280218; Immune System Homo sapiens R-HSA-168256; Circadian Clock Homo sapiens R-HSA-400253	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Adaptive immune system	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863	Th1 and Th2 cell differentiation; T cell receptor signaling pathway; PD-L1 expression and PD-1 checkpoint pathway in cancer	ubiquitin protein ligase binding (GO:0031625); protein kinase binding (GO:0019901); ubiquitin-like protein ligase binding (GO:0044389)	CD74,AR,T,NR3C1,STAT3,RELA,NFKB1,STAT5B,GATA3,SPI1,CBX1,EBF1,KMT2A,RBPJ,MYB,JUNB,EBNA3,CUX1,CDK9,ETV6	B Lymphocyte	NFKBIA,TOX,STAT4,HIF1A,ARID5A	AR,T,STAT3,RELA,NFKB1	NR3C1,JUNB,BATF	NR3C1,JUNB,BATF,MAF,BHLHE40	Th1,Tfh,CD8Tex
21	MeC_21	SUB1,ARID5B	ACTG1,COTL1,SUB1,ISG20,GMFG,GYPC,CD52,LIMD2,CD27,NEAT1,LDHB,CNN2,RGS10,SAT1,UCP2,GZMK,EVI2B,CD44,CD3D,CD74	ACTG1,COTL1,SUB1,ISG20,GMFG,GYPC,CD52,LIMD2,CD27,NEAT1,LDHB,CNN2,RGS10,SAT1,UCP2,GZMK,EVI2B,CD44,CD3D,CD74,ARPC1B,GAPDH,CORO1A,ARHGDIB,GBP2,SLC25A5,PFN1,MT2A,AES,LCK,UBXN1,EEF2,ARPC3,CYTOR,PPP1CA,CAPZB,POLR1D,EVL,TRBC2,RAC2,ITM2A,SLC25A6,FYB1,ARPC2,TMSB10,ACTB,HINT1,SELL,LEPROTL1,BTF3,EIF3H,PMAIP1,NOSIP,LAT,PSMB8,COX7A2,IL32,HIGD2A,TRAF3IP3,PSME1,EIF3F,COX6B1,SEPT6,TRAC,LAPTM5,MYL6,BIN1,C9orf16,TMSB4X,DYNLL1,CLIC1,RGS1,ISG15,STK17A,PTPRCAP,OCIAD2,FKBP1A,MZT2A,MIR4435-2HG,CALM3,SH3BGRL3,ARID5B,CASP4,CD2,SLC25A3,ATP5MC2,GPR183,RARRES3,CORO1B,EIF3M,RSL24D1,EIF3E,NOP10,SRGN,GSTK1,ARPC5,GPSM3,NDUFB11,EIF3D,MCL1	Shigellosis; Interleukin-2 signaling pathway; Yersinia infection; RHO GTPases Activate WASPs and WAVEs Homo sapiens R-HSA-5663213; Regulation of actin cytoskeleton	Interferon Alpha Response; Apical Junction; Allograft Rejection	Fc receptor mediated stimulatory signaling pathway (GO:0002431); Fc-gamma receptor signaling pathway (GO:0038094); Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	RHO GTPases Activate WASPs and WAVEs Homo sapiens R-HSA-5663213; EPHB-mediated forward signaling Homo sapiens R-HSA-3928662; Immune System Homo sapiens R-HSA-168256	Shigellosis; Interleukin-2 signaling pathway; Actin cytoskeleton regulation	Pathogenic Escherichia coli infection WP2272; Translation Factors WP107; Electron Transport Chain (OXPHOS system in mitochondria) WP111	Yersinia infection; Regulation of actin cytoskeleton; Salmonella infection	translation initiation factor activity (GO:0003743); actin monomer binding (GO:0003785)	EZH2,TP53,T,CDK9,GATA3,SPI1,FLI1,BRD4,SND1,CREBBP,ETS1,MYB,TBP,STAT5B,BMI1,SPIB,BCL6,EBF1,FOXP1,GABPA	Proerythroblast,Fetal Liver	SUB1,AES,ARID5B,NPM1,IFI16	EZH2,TP53,T,GATA3,SPI1	ETS1,IRF1	ETS1,IRF1	CD8Tex,Tfh,TMKI67
22	MeC_22	EGR1,PRRX1	COL1A1,COL3A1,COL1A2,LUM,DCN,SPARC,COL6A3,C1S,SFRP2,FN1,SERPINF1,BGN,COL6A2,VCAN,COL6A1,COL5A2,C1R,CTHRC1,CTSK,CCDC80	COL1A1,COL3A1,COL1A2,LUM,DCN,SPARC,COL6A3,C1S,SFRP2,FN1,SERPINF1,BGN,COL6A2,VCAN,COL6A1,COL5A2,C1R,CTHRC1,CTSK,CCDC80,POSTN,AEBP1,FSTL1,RARRES2,FBLN1,MGP,PCOLCE,MMP2,THY1,ISLR,SFRP4,CTGF,SERPING1,LGALS1,COL5A1,TIMP1,CALD1,THBS2,NNMT,EFEMP1,TAGLN,CFD,PLA2G2A,C3,FBLN2,CXCL14,FBN1,LGALS3BP,SPON2,CST3,SERPINH1,CD99,MXRA8,MXRA5,GSN,MFAP4,SULF1,IGFBP6,TIMP2,COL12A1,IGFBP4,LRP1,IGF1,IGFBP5,COL8A1,CXCL12,CDH11,TPM2,NBL1,MMP14,DPT,EGR1,PPIC,TUBA1A,INHBA,ASPN,MYL9,ZFP36L1,TPM4,CYR61,PRRX1,ITGB1,HTRA1,LY6E,SELENOM,OLFML3,MEG3,MFAP5,LAPTM4A,APOD,PPIB,TPM1,PSAP,IGFBP7,CD63,PDGFRB,COL14A1,C12orf57,S100A13,MRC2	Epithelial Mesenchymal Transition; Extracellular matrix organization Homo sapiens R-HSA-1474244; extracellular matrix organization (GO:0030198); Extracellular matrix organization; extracellular structure organization (GO:0043062)	Epithelial Mesenchymal Transition; Coagulation; Myogenesis	extracellular matrix organization (GO:0030198); extracellular structure organization (GO:0043062); external encapsulating structure organization (GO:0045229)	Extracellular matrix organization Homo sapiens R-HSA-1474244; Collagen biosynthesis and modifying enzymes Homo sapiens R-HSA-1650814; Collagen formation Homo sapiens R-HSA-1474290	Extracellular matrix organization; Collagen biosynthesis and modifying enzymes; Syndecan 1 pathway	miRNA targets in ECM and membrane receptors WP2911; Senescence and Autophagy in Cancer WP615; miR-509-3p alteration of YAP1/ECM axis WP3967	Protein digestion and absorption; Focal adhesion; ECM-receptor interaction	platelet-derived growth factor binding (GO:0048407); protease binding (GO:0002020); calcium ion binding (GO:0005509)	KLF10,CEBPB,TCF21,YAP1,JUND,PGR,PR,TCF12,FOSL2,RELA,RXRA,E2F7,SMAD3,BRD4,TEAD1,FOXM1,CEBPA,NEUROG2,FOXO1,NR3C1	A549,Epithelium,Lung	AEBP1,EGR1,PRRX1,ARID5B,ID3	KLF10,CEBPB,TCF21,YAP1,JUND		TCF4	Fibroblasts
23	MeC_23	ID1,TCF4,TSC22D1,ETS2,ID3	ACKR1,IFITM3,IGFBP7,AQP1,TM4SF1,IFI27,SPARCL1,FKBP1A,PLVAP,VWF,ENG,A2M,CRIP2,RAMP2,RNASE1,HYAL2,RAMP3,PDLIM1,CLDN5,IFITM2	ACKR1,IFITM3,IGFBP7,AQP1,TM4SF1,IFI27,SPARCL1,FKBP1A,PLVAP,VWF,ENG,A2M,CRIP2,RAMP2,RNASE1,HYAL2,RAMP3,PDLIM1,CLDN5,IFITM2,CLEC14A,HSPG2,EPAS1,PECAM1,MGP,NPDC1,PRCP,CD74,CD59,GNG11,EGFL7,CD93,ESAM,STOM,ADGRL4,HLA-E,HLA-DRB1,ID1,CAV1,GUK1,CALCRL,SPARC,COL15A1,TCF4,EMCN,TSC22D1,SRP14,CD34,TGM2,SELE,TAGLN2,ADAM15,S1PR1,PALMD,MSN,CD9,ECSCR,EMP1,ITM2B,DUSP23,ETS2,VIM,TPM3,CDC37,SLCO2A1,SPRY1,CDH5,PTPRB,ICAM2,S100A16,TSPAN7,PRSS23,APP,SOCS3,GIMAP4,ZFP36,FLT1,IGFBP4,COL4A1,SLC2A3,ICAM1,FXYD5,NEAT1,PODXL,GIMAP7,NEDD9,HLA-DRA,ID3,ITM2A,YBX3,CYYR1,PCAT19,ADAMTS9,ADIRF,HLA-DRB5,VAMP5,LDB2,MMRN2,LMNA,SWAP70	Cell adhesion molecules (CAMs); Cell adhesion molecules; extracellular structure organization (GO:0043062); external encapsulating structure organization (GO:0045229); blood vessel morphogenesis (GO:0048514)	Coagulation; Interferon Gamma Response; KRAS Signaling Up	extracellular structure organization (GO:0043062); external encapsulating structure organization (GO:0045229); blood vessel morphogenesis (GO:0048514)	Interferon Signaling Homo sapiens R-HSA-913531; Extracellular matrix organization Homo sapiens R-HSA-1474244; Interferon gamma signaling Homo sapiens R-HSA-877300	Cell adhesion molecules (CAMs); Interferon signaling; Adhesion and diapedesis of lymphocytes	Ebola Virus Pathway on Host WP4217; Spinal Cord Injury WP2431; Allograft Rejection WP2328	Cell adhesion molecules; Viral myocarditis; Hematopoietic cell lineage	calcitonin family receptor activity (GO:0097642); amyloid-beta binding (GO:0001540); MHC class II protein complex binding (GO:0023026)	TAL1,FLI1,NR2F2,GATA2,RELA,FOS,ZNF799,JUN,MAPK1,BRD4,STAT1,PROX1,GATA3,ESR1,IKZF1,STAT5A,PPARG,STAT3,LYL1,ZNF280D	Cord blood	CRIP2,PDLIM1,EPAS1,ID1,TSC22D1	TAL1,FLI1,NR2F2,GATA2,RELA	ETS1,ERG	ETS1,ERG,KLF4,TCF4,WWTR1	Endothelial
24	MeC_24	CSDE1,NR4A1,ID3,EGR3	MT2A,MT1X,MT1G,MT1E,MT1F,MT1H,MT1M,ZFP36,SQSTM1,RPSA,CD63,RPS6,GEM,GSN,CSDE1,TUBA1A,APOC2,RPS2,BTG2,IL32	MT2A,MT1X,MT1G,MT1E,MT1F,MT1H,MT1M,ZFP36,SQSTM1,RPSA,CD63,RPS6,GEM,GSN,CSDE1,TUBA1A,APOC2,RPS2,BTG2,IL32,ANGPTL4,TRBC2,SLC3A2,IFITM2,CCL20,STK17A,RPS25,ALOX5AP,HMOX1,DUSP1,MIF,RPL13A,RPL4,CLDND1,SAMSN1,PSAP,S100A9,CUTA,PRRC2C,ATP6V0B,IFITM3,NPC2,SSR4,FKBP8,RPS15A,S100A8,PLP2,MT-CYB,MTND4LP30,GLUL,NR4A1,GABARAP,CYBA,GPX4,EIF3E,ARPC1B,CCL3,SLC25A6,SLC7A5,ADM,RPL17,H3F3B,UBE2B,EIF4B,RPS11,ID3,CNN2,MARCKSL1,MT1A,UQCR11,TNF,GMFG,RASD1,EMC4,A2M,EGR3,SPCS1,SLC39A8,PIM1,GPBP1,RAB13,GAPDH,EEF1A1,UBB,ATP6V1F,FAU,MYL12B,C3,UBXN1,MMP9,BTG1,ITGB1,RPL5,YWHAB,SLC25A37,TREM1,FUS,RPL7,RPL10A,P2RY12	Translation; Translation Homo sapiens R-HSA-72766; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279; SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339	Hypoxia; TNF-alpha Signaling via NF-kB; Apoptosis	nuclear-transcribed mRNA catabolic process (GO:0000956); cellular zinc ion homeostasis (GO:0006882); cellular response to zinc ion (GO:0071294)	Translation Homo sapiens R-HSA-72766; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279	Translation; Cytoplasmic ribosomal proteins; Influenza infection	Cytoplasmic Ribosomal Proteins WP477; Zinc homeostasis WP3529; Copper homeostasis WP3286	Coronavirus disease; Ribosome; Mineral absorption	transition metal ion binding (GO:0046914); RNA binding (GO:0003723); zinc ion binding (GO:0008270)	AR,NR3C1,BRD4,NR3C2,PALB2,GTF3C1,NCOA1,RELA,PPARG,BCL3,KAT2B,CDK9,NR0B2,STAT3,CDK8,AFF4,BDP1,ELL2,MYC,TP53	DU145,Epithelium,Prostate	CSDE1	AR,NR3C1,BRD4,NR3C2,NCOA1			TMKI67,Fibroblasts,Endothelial
25	MeC_25	HOPX,ID2,ZNF683,ARID5B,HMGB1,TSC22D3,ZBTB16,BHLHE40	GNLY,GZMB,PRF1,SELL,HOPX,KLRD1,CD74,CD52,CD44,ITGB1,KLRC1,DDIT4,LGALS3,LYAR,CD63,MYL12B,RPL15,ID2,PMAIP1,FXYD5	GNLY,GZMB,PRF1,SELL,HOPX,KLRD1,CD74,CD52,CD44,ITGB1,KLRC1,DDIT4,LGALS3,LYAR,CD63,MYL12B,RPL15,ID2,PMAIP1,FXYD5,IL7R,CYTIP,HLA-A,ZNF683,XCL1,CXCR3,LGALS1,RP11-291B21.2,SOD1,MT-CO2,IFITM3,ITM2C,ISG20,GPR183,SERP1,COX7C,IFITM2,CCR7,RPS14,CTSW,RPL30,JAK1,ANXA1,ARID5B,LSP1,RPS12,DUSP4,CFLAR,HMGB1,TOB1,NDUFS5,CD247,RPL41,TSC22D3,CD82,NEAT1,SAT1,ERP29,EMB,GLIPR1,YWHAQ,CIB1,S100A11,RPS10,GAS5,RPL11,KLRC2,ZBTB16,HLA-DRA,SLA2,PGK1,S100A10,SSR4,RPL27A,H3F3A,DSTN,BHLHE40,KLRC3,CLIC3,CYCS,IL10RA,HLA-DRB5,RPS27,CD53,COX4I1,PPP1R2,LINC02446,COX5A,RPS24,HNRNPF,FCGR3A,LDHA,ALDOA,RGS2,EEF1G,NFKBIA,CCL5,CD37,ARL4C,PRDX2	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Apoptosis; TNF-alpha Signaling via NF-kB; Interferon Gamma Response	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cytoplasmic translation (GO:0002181); cotranslational protein targeting to membrane (GO:0006613)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Translation	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Apoptosis WP254	Graft-versus-host disease; Coronavirus disease; Ribosome	MHC class I protein complex binding (GO:0023024); chemokine binding (GO:0019956); cytokine receptor activity (GO:0004896)	GATA3,STAT5B,T,MYB,CEBPA,RUNX1,CD74,LANA,TAL1,SPI1,TBX21,KMT2A,LMO2,NR3C1,SMARCC1,LMNA,AR,CDK9,RELA,5HMC	Th1	HOPX,ID2,ZNF683,ARID5B,HMGB1	GATA3,STAT5B,T,MYB,CEBPA		BHLHE40	NK,CD4Teff,CD8Tex,CD8Tcm,CD8Teff
26	MeC_26	MXI1	SPP1,CSTB,PLIN2,LDHA,MIF,ENO1,TPI1,ALDOA,LSP1,GAPDH,S100A10,NUPR1,PGK1,CXCL8,GPNMB,RNASET2,BNIP3L,C15orf48,CTSD,SLC2A3	SPP1,CSTB,PLIN2,LDHA,MIF,ENO1,TPI1,ALDOA,LSP1,GAPDH,S100A10,NUPR1,PGK1,CXCL8,GPNMB,RNASET2,BNIP3L,C15orf48,CTSD,SLC2A3,VIM,PKM,FTL,HK2,PPDPF,GLUL,LGALS3,ERO1A,LGALS1,FTH1,CLEC2B,ATP6V1F,ADM,BNIP3,PGAM1,C4orf3,FAM162A,BTG1,RGCC,P4HA1,RALA,GPI,RNASE1,ALOX5AP,GUK1,CXCR4,FCGR2B,H2AFY,NDRG1,ANXA1,EIF4EBP1,APOC1,CYTIP,SGK1,LAPTM5,IL1RN,MGAT1,BCL2A1,WSB1,SDCBP,EMP3,CD68,PLAUR,HILPDA,VKORC1,BLVRB,ATP6V1G1,GSTO1,MAP1LC3B,SLC2A1,CAPG,SEC61G,ADAM8,NCF1,LIMS1,ENO2,VCAN,SLC11A1,SNHG12,SAT1,SNX10,VDAC1,UPP1,GRB2,CD9,LRRFIP1,CD300A,MPC2,ZNF385A,SLC16A3,SOD2,MXI1,FXYD5,S100A11,FABP5,SCD,C15ORF48,ASAH1,BRI3,TAGLN2	Hypoxia; Glycolysis and Gluconeogenesis WP534; pyruvate metabolic process (GO:0006090); glycolytic process (GO:0006096); Glycolysis	Hypoxia; Glycolysis; mTORC1 Signaling	pyruvate metabolic process (GO:0006090); glycolytic process (GO:0006096); glucose catabolic process to pyruvate (GO:0061718)	Glycolysis Homo sapiens R-HSA-70171; Gluconeogenesis Homo sapiens R-HSA-70263; Glucose metabolism Homo sapiens R-HSA-70326	Glycolysis and gluconeogenesis; HIF-1 transcriptional activity in hypoxia; Interleukin-2 signaling pathway	Glycolysis and Gluconeogenesis WP534; Metabolic reprogramming in colon cancer WP4290; Pathways in clear cell renal cell carcinoma WP4018	Glycolysis / Gluconeogenesis; HIF-1 signaling pathway; Central carbon metabolism in cancer	cadherin binding (GO:0045296)	HIF1A,TP53,KLF10,EPAS1,USP7,STAT1,SPI1,BRD4,SMAD1,ARNT,MYC,MAX,MED1,NFE2,JMJD1C,RUNX1,CEBPA,KLF1,BMI1,EBF1	Macrophage	ENO1,BNIP3,BTG1,PTTG1IP,ATF5	HIF1A,TP53,KLF10,EPAS1,STAT1	JUND,CEBPB,MXI1,BHLHE40	JUND,CEBPB,MXI1,BHLHE40,ATF3,KLF6	Monocyte,M2
27	MeC_27	NR2F2,HES4,ID3,EBF1,ID4,CEBPD	RGS5,NDUFA4L2,IGFBP7,ACTA2,CALD1,MYL9,PPP1R14A,TAGLN,HIGD1B,TPPP3,COL18A1,BGN,TPM2,COX4I2,COL4A1,NOTCH3,ADIRF,SPARC,THY1,ARHGDIB	RGS5,NDUFA4L2,IGFBP7,ACTA2,CALD1,MYL9,PPP1R14A,TAGLN,HIGD1B,TPPP3,COL18A1,BGN,TPM2,COX4I2,COL4A1,NOTCH3,ADIRF,SPARC,THY1,ARHGDIB,PHLDA1,FRZB,SPARCL1,EPS8,COL4A2,PDGFRB,TPM1,RGS16,MFGE8,SEPT7,MGP,MAP1B,CST3,CPE,LGALS1,NR2F2,PLXDC1,SDC2,LHFPL6,TFPI,KCNJ8,SOD3,GJA4,MEF2C,HES4,TINAGL1,MCAM,CCDC102B,CRIP1,APOE,CYTOR,FILIP1L,ASPN,SEPT4,TIMP1,CSRP2,ANGPT2,LGALS3BP,OAZ2,CHN1,COL6A2,ID3,PLAC9,MIR4435-2HG,CCL2,DKK3,CRIP2,FAM162B,PRSS23,PCOLCE,MYLK,UACA,LDHB,STOM,CYGB,CALM2,GPX3,ANXA6,ISG15,CD59,TGFB1I1,LHFP,EBF1,PTP4A3,CRISPLD2,CAV1,IFITM3,EGFL6,COL6A1,ENPEP,ID4,PDLIM1,HSPB1,CD36,CEBPD,PGF,S100A4,HLA-B,CLIC1,EDNRA	Epithelial Mesenchymal Transition; FSH regulation of apoptosis; Myogenesis; Smooth Muscle Contraction Homo sapiens R-HSA-445355; Smooth muscle contraction	Epithelial Mesenchymal Transition; Myogenesis; Apoptosis	negative regulation of endothelial cell proliferation (GO:0001937); supramolecular fiber organization (GO:0097435); muscle contraction (GO:0006936)	Smooth Muscle Contraction Homo sapiens R-HSA-445355; Extracellular matrix organization Homo sapiens R-HSA-1474244; Assembly of collagen fibrils and other multimeric structures Homo sapiens R-HSA-2022090	FSH regulation of apoptosis; Smooth muscle contraction; TSH regulation of gene expression	miRNA targets in ECM and membrane receptors WP2911; Focal Adhesion WP306; Striated Muscle Contraction Pathway WP383	Focal adhesion; Vascular smooth muscle contraction; Human papillomavirus infection	platelet-derived growth factor binding (GO:0048407)	PGR,TCF21,TP63,TFAP2A,FOXO1,TP53,KLF10,SMAD1,NEUROG2,SMC3,CHRM2,AR,NOTCH1,CTCF,GATA3,MYOD1,FOSL2,PR,SUMO1,MAML3	Stromal Cell,Endometrium	HES4,CSRP2,ID3,CRIP2,TGFB1I1	PGR,TCF21,TP63,TFAP2A,FOXO1	NR2F2	NR2F2,MYC,HIF1A	Fibroblasts,Endothelial
28	MeC_28	FOXP1,EGR1,PRDM1,ID2,YBX1	HNRNPH1,CDC42,SET,C1orf56,CDC42SE1,CTNNB1,PPP1CB,B4GALT1,CAPZA1,EIF5A,WTAP,MDM4,CALR,TRA2A,APOBEC3C,CHP1,ARPC4,TNRC6B,YWHAE,CBX6	HNRNPH1,CDC42,SET,C1orf56,CDC42SE1,CTNNB1,PPP1CB,B4GALT1,CAPZA1,EIF5A,WTAP,MDM4,CALR,TRA2A,APOBEC3C,CHP1,ARPC4,TNRC6B,YWHAE,CBX6,C6orf62,EIF2S3,SAR1A,FOXP1,LYZ,PPP3CA,SRSF6,STK17B,TSPYL1,SERPINB9,AXL,RASGEF1B,CTTN,SUMF2,GOLIM4,AC020656.1,FGD2,C16orf54,ADAM19,SRSF3,DNAJC3,IFI6,INSR,APOL2,ADAM17,ARF6,NUCKS1,PIP4K2A,TOR1AIP2,PPP2R5C,ARRDC3,RP11-138A9.2,EGR1,PRDM1,TMED4,RIN2,RASSF3,ID2,ZC3HAV1,IAH1,EIF5AL1,RBM6,WSB1,SAT1,CDC42SE2,RQCD1,SEC22B,YBX1,PSMA3-AS1,ANKRD40,RAP2B,DDX6,PHKG1,TOB1,GIGYF1,PIM2,RP11-1143G9.4,RPL23,SSR3,DOCK5,ELMSAN1,CD47,LRRC75A,PAFAH1B2,CLEC2D,SLC35F6,EIF3E,CSNK1A1,VMP1,CYBB,CNOT9,RPS25,R3HDM2,TLE3,THRAP3,NPM1,SETD5,PTP4A2,MARCH6,RIT1	RNA binding (GO:0003723); RHO GTPase Effectors Homo sapiens R-HSA-195258; S33 mutants of beta-catenin aren't phosphorylated Homo sapiens R-HSA-5358747; S45 mutants of beta-catenin aren't phosphorylated Homo sapiens R-HSA-5358751; phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Homo sapiens R-HSA-4839743		negative regulation of translation (GO:0017148)	RHO GTPase Effectors Homo sapiens R-HSA-195258; S33 mutants of beta-catenin aren't phosphorylated Homo sapiens R-HSA-5358747; S45 mutants of beta-catenin aren't phosphorylated Homo sapiens R-HSA-5358751	E-cadherin nascent AJ-like junctions pathway; Signaling events mediated by hepatocyte growth factor receptor (c-Met); Beta-catenin phosphorylation cascade			RNA binding (GO:0003723)	MAF,BRD4,GATA4,BRD2,GTF2B,TAF7,INO80,NCOA1,CTCF,RELA,PAX6,TAF1,SPI1,CDK9,FOXP1,CPSF3L,SNAPC1,PHF8,NELFE,PAF1	Osteoblast	CTNNB1,ID2,YBX1,THRAP3,NPM1	MAF,BRD4,GATA4,TAF7,INO80	FOXP1,TP53	FOXP1,TP53,EGR1,ADNP,PRDM1,SOX4	CD8Tem,Endothelial,CD8Teff,NK
29	MeC_29	FOS,HMGB2,SUB1,HIF1A,FOSB	S100A9,S100A8,S100A12,LYZ,NFKBIA,CD14,VCAN,SELL,G0S2,MNDA,FCN1,NCF1,SRGN,VIM,CSTA,FOS,CTSS,GAPDH,TSPO,ANXA1	S100A9,S100A8,S100A12,LYZ,NFKBIA,CD14,VCAN,SELL,G0S2,MNDA,FCN1,NCF1,SRGN,VIM,CSTA,FOS,CTSS,GAPDH,TSPO,ANXA1,ZFP36,RGS2,NAMPT,S100A6,SLC2A3,PLAUR,HMGB2,TKT,H3F3A,IER2,CD36,GRN,SOD2,CSF3R,APLP2,SERPINB1,PLBD1,RPS9,MS4A6A,TALDO1,IL1B,HLA-A,NEAT1,METTL9,SUB1,CTSD,SH3BGRL3,CH17-373J23.1,OAZ1,MCL1,RNASE2,FTL,CAPG,ACTG1,GCA,PTPRE,PGD,S100A4,CCL3,FPR1,BCL2A1,LAMTOR4,STXBP2,AP1S2,SAT1,NUP214,CCNI,RPS24,TNFSF13B,LAPTM5,BLOC1S6,TYMP,COX4I1,CLEC12A,CD44,CYBB,RPL34,EVI2B,AC020656.1,NDUFB1,TMEM167A,PFDN5,CYBA,CDA,HLA-C,MGST1,MT-ND3,THBS1,RBP7,RPL37A,AHNAK,S100A11,RETN,HIF1A,CD99,NFKBIZ,CCL4,ATP6V0B,CD79A,FOSB	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312); TNF-alpha Signaling via NF-kB; inflammatory response (GO:0006954)	TNF-alpha Signaling via NF-kB; Inflammatory Response; Apoptosis	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312)	Cross-presentation of particulate exogenous antigens (phagosomes) Homo sapiens R-HSA-1236973; Antigen processing-Cross presentation Homo sapiens R-HSA-1236975; Immune System Homo sapiens R-HSA-168256	Leptin influence on immune response; T cell receptor regulation of apoptosis; Phagosome	Pentose Phosphate Metabolism WP134; Spinal Cord Injury WP2431; Vitamin D Receptor Pathway WP2877	Phagosome; Lipid and atherosclerosis; Leishmaniasis	RAGE receptor binding (GO:0050786); calcium ion binding (GO:0005509); Toll-like receptor binding (GO:0035325)	CEBPA,SPI1,SMAD1,IRF1,FLI1,RUNX1,STAT1,CEBPB,JMJD1C,KMT2A,PPARG,BRD4,EZH1,LYL1,MED12,MYC,GATA2,NCOR1,EZH2,GATA3	U937,Pleura	NFKBIA,MNDA,HMGB2,SUB1,PFDN5	CEBPA,SPI1,SMAD1,IRF1,FLI1	FOS	FOS,JUND,HIF1A	Monocyte
30	MeC_30	HMGB1,HMGB2,ARID5B,TCF4,BCL11A	IGKC,IGHG1,IGHG4,IGHG3,IGHGP,IGHM,IGHG2,PTPN6,ANAPC16,CXCR4,MT-ND5,SNX3,CD37,LINC00926,SELL,CD79A,MEF2C,HMGB1,BTG1,H3F3A	IGKC,IGHG1,IGHG4,IGHG3,IGHGP,IGHM,IGHG2,PTPN6,ANAPC16,CXCR4,MT-ND5,SNX3,CD37,LINC00926,SELL,CD79A,MEF2C,HMGB1,BTG1,H3F3A,IFI16,YWHAZ,SUMO2,TMEM123,SEPT7,DRAP1,HMGB2,S100A4,TCL1A,IGHD,HVCN1,UBB,COTL1,LTB,RPS26,P2RX5,S100A11,YBX3,TUBA1B,RPS11,EFHD2,TAPBP,UBL5,PRKCB,RAP1B,HNRNPC,HINT1,SRSF5,POMP,S100A10,CAPZA2,FCER2,MYL12A,FCMR,HNRNPDL,HLA-DOB,ARID5B,AIDA,DDIT4,SNAP23,BANK1,HCLS1,TMSB10,SMAP2,PLPP5,SYF2,RIPOR2,TCF4,RCSD1,TXNIP,ETFA,CD247,BCL11A,CARD16,PRDX4,LMNA,ARHGDIB,LAMTOR4,SRP9,REEP5,RSL24D1,SRSF3,CMTM6,MS4A1,FKBP11,DBI,RHOH,TRAF3IP3,TNFRSF13C,BCLAF1,TMEM154,MARCH1,CLEC2D,MT-ND4,SMCHD1,SNRPF,SAMHD1,GNG7,ITGB1,BZW1	Immune system; Immune System Homo sapiens R-HSA-168256; CD22 mediated BCR regulation Homo sapiens R-HSA-5690714; FCGR activation Homo sapiens R-HSA-2029481; Role of phospholipids in phagocytosis Homo sapiens R-HSA-2029485	Allograft Rejection; Interferon Gamma Response; p53 Pathway	B cell activation (GO:0042113); B cell receptor signaling pathway (GO:0050853); cellular response to cytokine stimulus (GO:0071345)	Immune System Homo sapiens R-HSA-168256; CD22 mediated BCR regulation Homo sapiens R-HSA-5690714; FCGR activation Homo sapiens R-HSA-2029481	Immune system; Adaptive immune system; Innate immune system	Pathogenic Escherichia coli infection WP2272; B Cell Receptor Signaling Pathway WP23	Leukocyte transendothelial migration	RNA binding (GO:0003723); RAGE receptor binding (GO:0050786); protein kinase binding (GO:0019901)	CD74,FOXP1,FOXO1,NCOR1,MEF2B,RELA,IKZF1,CREBBP,SPI1,IRF1,KMT2A,TCF12,RARA,ZNF384,BCL6,STAT1,MED1,RAG1,TAL1,STAT3	B Lymphocyte	HMGB1,BTG1,IFI16,HMGB2,PRKCB	FOXP1,FOXO1,NCOR1,MEF2B,RELA			Plasma
31	MeC_31	DDIT3,XBP1,JUN,KLF6,HMGB2,ATF4	HSPA5,HSP90B1,CALR,PDIA3,PDIA6,MANF,PPIB,SDF2L1,HERPUD1,P4HB,PDIA4,DNAJB9,SEC61G,CDK2AP2,SERP1,SSR2,FKBP2,SEC61B,OSTC,CANX	HSPA5,HSP90B1,CALR,PDIA3,PDIA6,MANF,PPIB,SDF2L1,HERPUD1,P4HB,PDIA4,DNAJB9,SEC61G,CDK2AP2,SERP1,SSR2,FKBP2,SEC61B,OSTC,CANX,DNAJB11,TMED2,TMED9,MYDGF,SPCS2,SELK,HM13,KDELR2,TMEM258,CRELD2,SSR3,SEC11C,SLC3A2,DNAJC3,CTSD,RPL36AL,ARF1,SF3B5,TRAM1,RPN1,DDIT3,SELENOK,XBP1,NUCB2,JUN,ARF4,MTDH,VIMP,HMOX1,DUSP2,MTHFD2,SEC61A1,COPE,FTH1,SSR4,SSR1,ISG20,DERL2,KLF6,CXCL8,LMAN1,HYOU1,EDF1,WARS,TMED10,EVI2B,SARAF,RNF181,DSTN,RPN2,DDOST,CCNI,PTMA,MAP1LC3B,HNRNPC,SARS,UFM1,SURF4,EIF1,DAD1,HMGB2,IGFBP3,S100A11,ANXA5,RSL24D1,NANS,MLEC,UBXN1,SELENOS,HAX1,SQSTM1,ATF4,NUPR1,EIF2S2,ERLEC1,TRMT112,CISD2,CCDC167,MT1X,MORF4L2	Protein processing in endoplasmic reticulum; Protein processing in the endoplasmic reticulum; Metabolism of proteins Homo sapiens R-HSA-392499; Unfolded Protein Response (UPR) Homo sapiens R-HSA-381119; Diabetes pathways	mTORC1 Signaling; Unfolded Protein Response; Apoptosis	response to endoplasmic reticulum stress (GO:0034976); IRE1-mediated unfolded protein response (GO:0036498); protein exit from endoplasmic reticulum (GO:0032527)	Metabolism of proteins Homo sapiens R-HSA-392499; Unfolded Protein Response (UPR) Homo sapiens R-HSA-381119; IRE1alpha activates chaperones Homo sapiens R-HSA-381070	Protein processing in the endoplasmic reticulum; Diabetes pathways; Unfolded protein response	Photodynamic therapy-induced unfolded protein response WP3613; Ferroptosis WP4313; Selenium Metabolism and Selenoproteins WP28	Protein processing in endoplasmic reticulum; Protein export; Vibrio cholerae infection	dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579); RNA binding (GO:0003723); oligosaccharyl transferase activity (GO:0004576)	XBP1,MED1,CREB1,TP53,NFYA,HCFC1,KDM1A,DDX21,GMEB2,PAF1,BRD4,PHF8,SP1,BCL3,CREM,CHD1,E2F1,SAP30,SIN3A,AFF4	MDA-MB-231,Epithelium,Breast	DDIT3,EDF1,HMGB2,MORF4L2,CITED2	MED1,CREB1,TP53,NFYA,HCFC1	XBP1,EGR1	XBP1,EGR1,KLF6,JUN,ATF4	pDC,Plasma,TMKI67,Mast,Fibroblasts,NK,Endothelial,Epithelial
32	MeC_32	ZEB2,LITAF,TSC22D3,ZNF683,HMGB2,KLF2,KLF3,KLF6	GZMH,CD3D,CCL5,NKG7,CD52,FGFBP2,GNLY,CD8A,GZMB,IL32,CD8B,CD3G,HLA-DPB1,LGALS1,RAP1B,ITGB1,S100A4,PLEK,S100A6,CD3E	GZMH,CD3D,CCL5,NKG7,CD52,FGFBP2,GNLY,CD8A,GZMB,IL32,CD8B,CD3G,HLA-DPB1,LGALS1,RAP1B,ITGB1,S100A4,PLEK,S100A6,CD3E,TRAC,TRGC2,ZEB2,HLA-DRB1,YWHAQ,SH3BGRL3,C12orf75,CST7,CD99,LITAF,ANXA1,RPS26,TRBC2,HERPUD1,KLRD1,TOB1,DSTN,ARL6IP5,IFITM2,TSC22D3,ERP29,PPP2R5C,CTSW,ZNF683,VAMP2,CD48,KLRG1,HLA-DPA1,PATL2,RHOA,ARPC2,FCRL6,CTSC,HNRNPDL,CX3CR1,CD2,PTP4A2,SLC25A6,YWHAB,SUN2,SRP14,CLEC2D,FTL,HMGB2,LAT,PNRC1,HIGD2A,KLF2,ADGRG1,VIM,PRSS23,SYNE1,TUBA1B,EIF3H,S100A10,AHNAK,MYL12B,FLNA,PPDPF,KLF3,ARRDC3,CALR,PTPRC,TSPO,PSMB8,TPST2,KLF6,EIF3E,MALAT1,RPS3,PPIB,PSMA2,EIF3F,IDH2,TMEM59,ACTR2,ARPC5,BIN2,TMSB10,ITGB7	Interleukin-2 signaling pathway; Adaptive immune system; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427; PD-1 signaling; Adaptive Immune System Homo sapiens R-HSA-1280218	Allograft Rejection; Interferon Gamma Response; Epithelial Mesenchymal Transition	regulation of immune response (GO:0050776); T cell receptor signaling pathway (GO:0050852); positive regulation of T cell proliferation (GO:0042102)	Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427; Adaptive Immune System Homo sapiens R-HSA-1280218; Generation of second messenger molecules Homo sapiens R-HSA-202433	Interleukin-2 signaling pathway; Adaptive immune system; PD-1 signaling	Allograft Rejection WP2328; Pathogenic Escherichia coli infection WP2272; T-Cell antigen Receptor (TCR)  Signaling Pathway WP69	Hematopoietic cell lineage; Cell adhesion molecules; Salmonella infection		CIITA,T,GATA3,MYB,KMT2A,TAL1,RUNX1T1,KDM2B,TCF4,SPI1,MEIS1,RUNX1,LYL1,LMO2,TCF7L1,TBX21,ZMYM3,STAT5B,KLF10,CDK9	Raji,B Lymphocyte,Blood	ZEB2,LITAF,TSC22D3,ZNF683,YWHAB	CIITA,T,GATA3,MYB,TAL1			CD8Tex,CD8Tcm,CD8Teff,CD4Teff,NK,CD8Tem
33	MeC_33	GTF3A,YBX1	HSP90AB1,NCL,DDX21,C1QBP,HSPE1,NPM1,SERBP1,GTF3A,HSPD1,RAN,RPL22L1,NHP2,ENO1,MIF,APRT,PSME2,RSL1D1,EIF5A,PPA1,NME1	HSP90AB1,NCL,DDX21,C1QBP,HSPE1,NPM1,SERBP1,GTF3A,HSPD1,RAN,RPL22L1,NHP2,ENO1,MIF,APRT,PSME2,RSL1D1,EIF5A,PPA1,NME1,SNRPE,FABP5,YBX1,LDHA,PA2G4,CCT2,PRMT1,SRSF7,CNBP,GADD45GIP1,NME2,PRDX1,POLR2L,CCT3,TIMM13,SNU13,CCT5,APEX1,RPS26,CCT4,TXN,PHB,HNRNPDL,PSMA7,CYCS,NOP58,SLIRP,RBM3,EIF5B,CCT7,CCDC85B,GNL3,HSPA8,SOD1,CCT6A,IMPDH2,EIF4A1,SNRPD1,MIR155HG,TPI1,LSM7,PDCD5,SET,SSBP1,RSL24D1,CCT8,PRELID1,RANBP1,SNHG8,PEBP1,SYNCRIP,FBL,MRPS34,NOP16,DDX18,TOMM22,NOP56,RPS17,PAICS,MRPL4,ATP5G1,SSB,SRSF2,SRM,LDHB,HSPA9,NFKBIA,IMP4,MRTO4,MRPL3,FTL,RBM8A,SNHG15,NIFK,PSMA3,CD44,CHCHD2,WDR43,TOMM40,MRPS12	Myc Targets V1; RNA binding (GO:0003723); Myc Targets V2; T cell receptor regulation of apoptosis; positive regulation of protein localization to chromosome, telomeric region (GO:1904816)	Myc Targets V1; Myc Targets V2; mTORC1 Signaling	positive regulation of protein localization to chromosome, telomeric region (GO:1904816); positive regulation of telomerase RNA localization to Cajal body (GO:1904874); positive regulation of establishment of protein localization to telomere (GO:1904851)	Folding of actin by CCT/TriC Homo sapiens R-HSA-390450; Gene Expression Homo sapiens R-HSA-74160; Association of TriC/CCT with target proteins during biosynthesis Homo sapiens R-HSA-390471	T cell receptor regulation of apoptosis; Folding of actin by CCT/TriC; Protein metabolism	mRNA Processing WP411; Glycolysis and Gluconeogenesis WP534	Ribosome biogenesis in eukaryotes; Spliceosome; Ribosome	RNA binding (GO:0003723); snoRNA binding (GO:0030515); cadherin binding (GO:0045296)	BRD4,MYC,FOXP1,SNAPC1,MAX,KAT5,BMI1,GTF2B,PAF1,BCL3,MAFB,SCML2,TAF1,TP53,TFDP1,E2F4,E2F1,SPI1,ELF1,NRF1	Raji,B Lymphocyte,Blood	NPM1,GTF3A,RAN,ENO1,APEX1	BRD4,MYC,FOXP1,MAX,KAT5		CEBPD,YBX1	cDC1,pDC,TMKI67,Treg,B
34	MeC_34	NR4A2,FOS,EGR1,NR4A1,KLF6,ID2,CREM,ARID5B,EGR2,ELF1	CCL4,CCL4L2,IFNG,CCL3,ZFP36L1,TNF,CD69,NR4A2,CCL3L3,RGCC,CCL4L1,SLA,LTB,TIGIT,TAGAP,TNFSF9,XCL1,SDCBP,XCL2,FOS	CCL4,CCL4L2,IFNG,CCL3,ZFP36L1,TNF,CD69,NR4A2,CCL3L3,RGCC,CCL4L1,SLA,LTB,TIGIT,TAGAP,TNFSF9,XCL1,SDCBP,XCL2,FOS,LGALS1,EGR1,NR4A1,S100A10,KLF6,RHOH,RILPL2,EVI2A,PRNP,ID2,CREM,PHLDA1,HNRNPA2B1,RNF19A,MIR155HG,CCNI,STK4,ICOS,ARID5B,ALDOA,BIRC3,IFITM2,EGR2,PTGER4,ELF1,GBP2,NEU1,SARAF,PDCD1,CD7,MT-CO2,REL,PGAM1,PTPN7,EEF1B2,PKM,NFKBID,COX6C,S100A11,CCL2,NAP1L1,DEK,EIF3E,HMGN2,EVI2B,FXYD5,KMT2E,EEF2,FASLG,LAG3,RPS27L,LYST,NDFIP1,HSPB1,TRAC,SLC1A5,IFI16,RAB27A,CD2,RPS8,PPP1R2,PTPN22,IER2,COMMD6,IFITM3,PLP2,LDHA,GPX1,POLR2K,FOSB,PNRC1,TCEB1,NDUFA1,ZFAS1,CD52,GSTK1,NDUFV2,JUN,PPIG,RP3-323A16.1	T cell receptor regulation of apoptosis; TNF-alpha Signaling via NF-kB; Interleukin-2 signaling pathway; BDNF signaling pathway; Interleukin-5 regulation of apoptosis	TNF-alpha Signaling via NF-kB; Apoptosis; Allograft Rejection	cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345); cellular response to tumor necrosis factor (GO:0071356)	Chemokine receptors bind chemokines Homo sapiens R-HSA-380108	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; BDNF signaling pathway	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863; Spinal Cord Injury WP2431; Photodynamic therapy-induced AP-1 survival signaling. WP3611	Viral protein interaction with cytokine and cytokine receptor; Cytokine-cytokine receptor interaction; Rheumatoid arthritis	CCR chemokine receptor binding (GO:0048020); chemokine activity (GO:0008009); chemokine receptor binding (GO:0042379)	CDK9,T,MEF2B,STAT5B,GATA3,NCOR1,RUNX1,KMT2A,SMAD1,NCOR2,CEBPA,EBNA3C,RELA,MYB,IRF1,JMJD1C,SPI1,FOXO1,TBX21,BCL6	Th2	NR4A2,KLF6,ID2,CREM,ARID5B	T,MEF2B,STAT5B,GATA3,NCOR1	ELF1,NR4A1	ELF1,NR4A1,FOS,EGR1,REL,EGR2	CD8Tex,NK
35	MeC_35	TSC22D3,KLF6,FOS,ETS1,JUND,FOSB,ARID4B,RARA	TAGLN2,ANXA1,CRIP1,TSC22D3,MYADM,UCP2,LMNA,RGCC,VIM,CD44,AHNAK,PBXIP1,LRRFIP1,S100A10,IDS,KLF6,EZR,ATP2B1,TUBA1A,ADGRE5	TAGLN2,ANXA1,CRIP1,TSC22D3,MYADM,UCP2,LMNA,RGCC,VIM,CD44,AHNAK,PBXIP1,LRRFIP1,S100A10,IDS,KLF6,EZR,ATP2B1,TUBA1A,ADGRE5,MCL1,GPR183,CD27,IVNS1ABP,FOS,PPP1R15A,CCR7,YPEL5,AKAP13,MBNL1,S100A11,GLUD1,TAGAP,GNG2,SAMHD1,IQGAP1,YWHAQ,RALGDS,ETS1,JUND,PRMT2,CRIP2,CD27-AS1,TMEM43,ARHGAP9,ANXA2,UBB,CD7,CDC42,YWHAZ,C16orf54,ARL4C,ZFP36,SRGN,CA5B,FOSB,SLC25A3,TUBA1B,MAPRE2,ATP2B4,UFC1,CCDC167,TRIM22,ANKRD28,FAM107B,HNRNPDL,DYNLL1,CYTH1,DUSP1,DDX3X,RBM3,PTGES3,CCL5,EMP3,TMED10,DENND4A,ARHGDIB,PRKAR1A,FAM129A,ARID4B,RAB11A,RTN4,VCP,TMBIM6,CMTM7,NEU1,APOBEC3G,TRAM1,UBC,FAS,ITK,RARA,SF3B1,IK,JMJD1C,ITGA4,CASP8,HIPK1,ENSA,GOLGB1	Interleukin-2 signaling pathway; TNF-alpha Signaling via NF-kB; T cell receptor regulation of apoptosis; Pathogenic Escherichia coli infection; ERBB1 downstream pathway	TNF-alpha Signaling via NF-kB; Hypoxia; Apoptosis	cytokine-mediated signaling pathway (GO:0019221); extrinsic apoptotic signaling pathway (GO:0097191); negative regulation of cytokine production (GO:0001818)	Apoptosis Homo sapiens R-HSA-109581; Programmed Cell Death Homo sapiens R-HSA-5357801; Hemostasis Homo sapiens R-HSA-109582	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; ERBB1 downstream pathway	Pathogenic Escherichia coli infection WP2272; Spinal Cord Injury WP2431; Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation WP314	Pathogenic Escherichia coli infection; Salmonella infection; Apoptosis	cadherin binding (GO:0045296); ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389)	BRD4,STAT6,T,TAL1,RUNX1,TCF21,MYB,GATA3,NFE2,FOSL2,TBX21,CREBBP,KMT2A,BATF,CEBPA,SPI1,MAFB,SMAD1,NR3C1,TCF4	TC-797	TSC22D3,PBXIP1,CRIP2,FOSB,ARID4B	BRD4,STAT6,T,TAL1,RUNX1	GATA3,JUND,RARA,FOS	GATA3,JUND,RARA,FOS,JMJD1C,ETS1,TRIM22,FOXP1,KLF6	Mast,Th17
36	MeC_36	JUNB,EGR1,JUND,FOS,ZNF331,CEBPB,MAF	SPP1,RNASE1,CTSB,PLIN2,GPNMB,FCER1G,JUNB,C1QA,RGS1,HSPA1B,CD163,ITGB2,CCL2,LAPTM5,HLA-DRB5,S100A4,TGFBI,EGR1,APOE,JUND	SPP1,RNASE1,CTSB,PLIN2,GPNMB,FCER1G,JUNB,C1QA,RGS1,HSPA1B,CD163,ITGB2,CCL2,LAPTM5,HLA-DRB5,S100A4,TGFBI,EGR1,APOE,JUND,RPL4,CD14,ZFP36L1,TYROBP,HERPUD1,PLAUR,FOLR2,TUBA1A,FOS,NUPR1,TXNIP,TREM2,RPL13AP5,HSP90AA1,HSPA5,SELENOP,LSP1,CLEC5A,EEF2,FCGR2A,PGK1,LDHA,CD81,PABPC1,APLP2,ZNF331,GSN,A2M,ATP1B3,MYL6,TUBA1B,VIM,CD74,FCGR2B,C6orf62,PSAP,CTSD,TUBA1C,RPL19,SLC2A3,MSR1,H3F3B,RPLP1,LGALS1,C1QC,PPT1,HSP90B1,CXCL3,ALOX5AP,HK2,RPS14,MEF2C,FABP5,FN1,NPC2,RPL7A,CEBPB,TAGLN2,ATP6V1B2,RPS25,VCAN,C5AR1,NAMPT,EIF4A1,RPS26,UBB,DAB2,VSIG4,FBP1,NKG7,RPS16,CSTB,MAF,CHMP1B,SLC11A1,HLA-DPA1,ANXA5,METRNL,RPLP2,PLEK	Coronavirus disease; neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); Cap-dependent Translation Initiation Homo sapiens R-HSA-72737	Complement; Hypoxia; TNF-alpha Signaling via NF-kB	neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283)	Eukaryotic Translation Initiation Homo sapiens R-HSA-72613; Peptide chain elongation Homo sapiens R-HSA-156902; Translation Homo sapiens R-HSA-72766	Translation; T cell receptor regulation of apoptosis; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; TYROBP Causal Network WP3945; Microglia Pathogen Phagocytosis Pathway WP3937	Coronavirus disease; Phagosome; Tuberculosis	amyloid-beta binding (GO:0001540); RNA binding (GO:0003723); MHC class II protein complex binding (GO:0023026)	SMAD1,SPI1,BRD4,IRF1,STAT1,CEBPA,FAIRE,CEBPB,TCF4,MED12,CREBBP,RUNX1,JMJD1C,RXRG,TCF7L2,KMT2A,MAX,DRAP1,HDAC2,RUNX1T1	U937,Pleura		SMAD1,SPI1,BRD4,IRF1,STAT1	CEBPB,FOS,JUND	CEBPB,FOS,JUND,JUNB,EGR1,ZNF331	M2,Monocyte,M1
37	MeC_37	LITAF,YBX1	APOC1,APOE,LGALS3,GPNMB,CTSD,CSTB,FABP5,CD9,LIPA,FTL,ACP5,ASAH1,CAPG,LGALS1,DBI,ATP6V1F,CD68,LGMN,CD52,NUPR1	APOC1,APOE,LGALS3,GPNMB,CTSD,CSTB,FABP5,CD9,LIPA,FTL,ACP5,ASAH1,CAPG,LGALS1,DBI,ATP6V1F,CD68,LGMN,CD52,NUPR1,PSAP,CTSB,CTSL,PLA2G7,GM2A,BRI3,TREM2,CD63,FTH1,CPM,PLD3,GRN,CYP27A1,GCHFR,VIM,IFI30,PRDX1,TXN,BCAP31,ANXA2,FBP1,DNASE2,LITAF,LYZ,CTSS,MGST3,LSP1,NOP10,RGCC,OTOA,S100A6,IGSF6,HEXB,FXYD5,TALDO1,NPL,CTSA,VAT1,LAMP1,TSPO,CTSH,CD48,ITGAX,SH3BGRL3,LGALS9,SDCBP,A2M,CXCL16,H2AFY,CHIT1,MYDGF,ATP6V0B,ATOX1,NAP1L1,GSTO1,ATP6V0D1,CD59,AREG,RNF130,FABP3,LRPAP1,SDS,SMS,UCP2,RNH1,HSPE1,PSMA7,LPL,HM13,YBX1,CHCHD6,MALAT1,CTSZ,CALM3,S100A11,CHCHD10,RAN,AKR1B1,PEBP1,GLUL	Lysosome; Lysosome; neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283)	Complement; Cholesterol Homeostasis; Reactive Oxygen Species Pathway	neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283)	MHC class II antigen presentation Homo sapiens R-HSA-2132295; Trafficking and processing of endosomal TLR Homo sapiens R-HSA-1679131; Metabolism Homo sapiens R-HSA-1430728	Lysosome; MHC class II antigen presentation; Toll-like receptor endosomal trafficking and processing	PPAR signaling pathway WP3942; Metabolic pathway of LDL, HDL and TG, including diseases WP4522; TYROBP Causal Network WP3945	Lysosome; Cholesterol metabolism; Tuberculosis	ferric iron binding (GO:0008199); cysteine-type endopeptidase activity (GO:0004197); cysteine-type peptidase activity (GO:0008234)	CEBPB,SPI1,PPARG,STAT1,SMAD1,CEBPA,HIF1A,EPAS1,IRF1,TP53,RELA,MITF,CD74,FAIRE,TFAP2C,NFE2,BRD4,AR,TCF4,USF1	Macrophage	LITAF,RAN,CREG1,ARID5B,BASP1	CEBPB,SPI1,PPARG,STAT1,SMAD1		JUNB,YBX1	M2,Monocyte,M1
38	MeC_38	PROX1,SOX4,KLF6,MAF,SMAD1	CCL21,TFPI,FABP5,TFF3,MMRN1,FABP4,EFEMP1,NTS,LAPTM5,GYPC,S100A10,CD9,PROX1,IGFBP7,PDPN,ANXA2,GNG11,PPP1R2,CLU,ANGPT2	CCL21,TFPI,FABP5,TFF3,MMRN1,FABP4,EFEMP1,NTS,LAPTM5,GYPC,S100A10,CD9,PROX1,IGFBP7,PDPN,ANXA2,GNG11,PPP1R2,CLU,ANGPT2,PTPRE,TIMP3,HSPB1,AKAP12,CLDN5,ARL4A,PPFIBP1,VIM,HYAL2,APP,LYVE1,LIMS1,STMN1,NNMT,SNCG,CAV1,NUDT4,ADD3,TM4SF1,NRP2,ARL6IP1,TUBA1A,GMFG,RAB11A,CAVIN2,LAMA4,SLC38A1,TIMP1,CD59,MARCKSL1,SDCBP,HLA-E,ADIRF,GADD45B,SOX4,RGS16,KLF6,RBP1,RAB11FIP1,RAMP2,FCGRT,WARS,GRN,POLR2L,S100A16,HLA-A,IL32,MRC1,SEMA3A,PROCR,SPTBN1,UNC5B,ATP5E,TMEM123,MAF,EGFL7,ISG20,ADM,EDNRB,TSPAN5,NEAT1,CCND1,MARCKS,THBD,SMAD1,SERPINB9,SDPR,TUBB,ECSCR,IGFBP5,MDK,CD99,CTSD,TIE1,LAYN,MGST2,RELN,DKK3,RARRES3,TGFBR2	BDNF signaling pathway; TGF-beta regulation of extracellular matrix; Apoptosis; Hemostasis Homo sapiens R-HSA-109582; UV Response Dn	Apoptosis; UV Response Dn; Estrogen Response Late	vasculogenesis (GO:0001570); blood vessel morphogenesis (GO:0048514); protection from natural killer cell mediated cytotoxicity (GO:0042270)	Hemostasis Homo sapiens R-HSA-109582; Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005; Platelet degranulation Homo sapiens R-HSA-114608	BDNF signaling pathway; TGF-beta regulation of extracellular matrix; FSH regulation of apoptosis	Mammary gland development pathway - Puberty (Stage 2 of 4) WP2814; TGF-beta Signaling Pathway WP366	Complement and coagulation cascades	hyaluronic acid binding (GO:0005540); endopeptidase inhibitor activity (GO:0004866)	TAL1,NR3C1,GATA2,JUN,AR,GATA3,FLI1,ATF3,RELA,FOS,DNMT3A,HOXB13,PGR,ZNF254,FOXA1,FOXO1,TP63,PR,TCF12,MAML3	Cord blood	SOX4,KLF6,MAF,ELK3,NFIB	TAL1,NR3C1,GATA2,JUN,AR	PROX1,NR2F2,SMAD1	PROX1,NR2F2,SMAD1,NR2F1,TCF4	Endothelial,Epithelial,Th1
39	MeC_39	TSC22D1,MAX,HMGB1	PPBP,PF4,TAGLN2,NAP1L1,OST4,GPX1,GNG11,NRGN,TUBA4A,RGS10,TUBB1,CCL5,CLU,SDPR,RGS18,HIST1H2AC,GPX4,NCOA4,MYL12A,ACRBP	PPBP,PF4,TAGLN2,NAP1L1,OST4,GPX1,GNG11,NRGN,TUBA4A,RGS10,TUBB1,CCL5,CLU,SDPR,RGS18,HIST1H2AC,GPX4,NCOA4,MYL12A,ACRBP,CALM3,ITM2B,GP9,GSTO1,LIMS1,FERMT3,TPM4,RAP1B,SPARC,ARPC1B,TSC22D1,YWHAH,TIMP1,RUFY1,PRDX6,TLN1,CTSA,TREML1,MAX,PTCRA,SAT1,ODC1,ARF1,UQCRH,PKM,GRAP2,CMTM5,SH3BGRL3,CD9,SNX3,MYL9,LAMTOR1,PDLIM1,MAP3K7CL,DYNLL1,MMD,TMEM40,ITGA2B,MPP1,PGRMC1,NT5C3A,ILK,F13A1,SNAP23,RAB11A,HLA-E,OAZ1,CLEC1B,TALDO1,MARCH2,TPM1,HMGB1,ACTG1,NGFRAP1,ARHGDIB,PTPN18,CCND3,CD99,PPDPF,RSU1,FLNA,RNF11,C9orf16,KIF2A,DNAJB6,ETFA,CALM1,NDUFS5,PARVB,EMC3,TPM3,VCL,C2orf88,ARPC5,CLDN5,ACTN1,TGFB1,SNCA,GMPR,LMNA	Response to elevated platelet cytosolic calcium; platelet degranulation (GO:0002576); regulated exocytosis (GO:0045055); Platelet degranulation Homo sapiens R-HSA-114608; Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005	Androgen Response; Epithelial Mesenchymal Transition; Apical Junction	platelet degranulation (GO:0002576); regulated exocytosis (GO:0045055); homotypic cell-cell adhesion (GO:0034109)	Platelet degranulation Homo sapiens R-HSA-114608; Response to elevated platelet cytosolic Ca2+ Homo sapiens R-HSA-76005; Platelet activation, signaling and aggregation Homo sapiens R-HSA-76002	Response to elevated platelet cytosolic calcium; Platelet activation, signaling and aggregation; Hemostasis pathway	Focal Adhesion WP306; Striated Muscle Contraction Pathway WP383; Myometrial Relaxation and Contraction Pathways WP289	Focal adhesion; Shigellosis; Leukocyte transendothelial migration		TAL1,LMO2,RUNX1,TP53,LYL1,RELA,SMAD1,FLI1,SPI1,FOS,GATA2,GATA1,ERG,JUN,RAD21,BMI1,SOX9,NIPBL,MED1,MAFF	Megakaryocyte,Cord blood	NCOA4,TSC22D1,PDLIM1,HMGB1,TSC22D3	TAL1,RUNX1,TP53,RELA,SMAD1	LYL1,NFE2	LYL1,NFE2,MAX	cDC1,pDC,Monocyte,M1,cDC2,Th17,Mast,Endothelial
40	MeC_40	ID2,JUN,TOX,TSC22D3,ZNF683,PRDM1	GZMB,CXCL13,GNLY,ALOX5AP,RBPJ,HAVCR2,NKG7,CD8A,RGS2,SAMSN1,GZMH,PHLDA1,PRF1,RGS1,ID2,CCL5,CTSW,LAG3,CD63,KRT86	GZMB,CXCL13,GNLY,ALOX5AP,RBPJ,HAVCR2,NKG7,CD8A,RGS2,SAMSN1,GZMH,PHLDA1,PRF1,RGS1,ID2,CCL5,CTSW,LAG3,CD63,KRT86,ENTPD1,LINC01871,ACP5,CTSD,IFNG,MT2A,HLA-DRB1,HLA-DRA,TIGIT,GZMA,FKBP1A,CD8B,LSP1,PDCD1,CCND2,CD82,CLEC2B,ITGB1,ITGAE,JUN,SIRPG,CLEC2D,CD27,IVNS1ABP,GAPDH,KLRB1,NDFIP2,DUSP4,TNFRSF9,CD7,CD3D,PGK1,RAB27A,PRDX6,VCAM1,CXCR6,PAG1,LAYN,TPI1,APOBEC3G,MIR155HG,BST2,TOX,HLA-DQB1,IGFLR1,ITM2A,TSC22D3,CD3G,LDHB,NELL2,JAML,EID1,LYST,PPDPF,FTL,CBLB,MYO7A,SIT1,CCL3,CHN1,LINC02195,SLC3A2,TNFSF4,ZNF683,TOB1,PIK3IP1,FAM3C,GOLIM4,PTMS,CHST12,SRGAP3,UBE2F,HLA-DPA1,TNIP3,PRDM1,ANXA5,PTPN6,TNFRSF1B,TRAF5,HLA-DPB1	Interleukin-2 signaling pathway; regulation of immune response (GO:0050776); PD-1 signaling; PD-1 signaling Homo sapiens R-HSA-389948; Allograft Rejection	Allograft Rejection; Inflammatory Response; Complement	regulation of immune response (GO:0050776); cellular response to interferon-gamma (GO:0071346); regulation of T cell activation (GO:0050863)	PD-1 signaling Homo sapiens R-HSA-389948; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427; Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430	Interleukin-2 signaling pathway; PD-1 signaling; Interleukin-12-mediated signaling events	Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863	Allograft rejection; Graft-versus-host disease; Th1 and Th2 cell differentiation	MHC class II receptor activity (GO:0032395)	T,KMT2A,GATA3,STAT5B,TBX21,NFKB1,SPI1,RUNX1,RUNX1T1,DRAP1,RELA,RELB,NR3C1,BCL3,JUND,ZNF525,SMAD1,ESR1,FOSL2,TCF4	Th1	ID2,TOX,TSC22D3,ZNF683,CREM	T,GATA3,STAT5B,TBX21,NFKB1	NR3C1,CEBPB	NR3C1,CEBPB,STAT3,BHLHE40,PRDM1,JUN	CD8Tex,CD4Teff,Th1,NK,TMKI67
41	MeC_41	TSC22D1,CEBPB	TAGLN,ACTA2,ADIRF,MYL9,DSTN,NDUFA4,TPM2,MYH11,CRIP1,S100A4,TPM1,MYL6,GADD45B,MYLK,SPARCL1,FLNA,LPP,MT1X,ACTB,IGFBP5	TAGLN,ACTA2,ADIRF,MYL9,DSTN,NDUFA4,TPM2,MYH11,CRIP1,S100A4,TPM1,MYL6,GADD45B,MYLK,SPARCL1,FLNA,LPP,MT1X,ACTB,IGFBP5,SOD3,MT2A,S100A6,CRYAB,RHOB,CALD1,C11orf96,ACTG2,CSRP1,PLN,CD9,LMOD1,ACTN1,CDKN1A,MGST3,NUPR1,PDK4,RERGL,PLAC9,PHLDA2,GSTP1,SH3BGRL,GPX3,LBH,TSC22D1,PNRC1,TRMT112,CNN1,CLU,MFAP4,BTG2,CSRP2,SBDS,SORBS2,MT1M,PTP4A3,PDLIM7,CALM2,SKP1,PALLD,SELM,PPP1CB,IER2,LTBP1,CAV1,SOD2,ADAMTS1,HSPB1,SELENOM,MAP1B,NEAT1,SNCG,VIM,COX6A1,CEBPB,YBX3,BCAM,PDLIM3,TINAGL1,FABP4,TOMM7,IGFBP4,IGFBP7,COX5B,APLP2,MFGE8,CD151,ZFP36,NET1,UBC,NNMT,AEBP1,TIMP3,CAVIN3,PPP1R12B,FHL1,CRIP2,MT1E,NDUFA4L2,NEXN	Smooth muscle contraction; Muscle contraction; Smooth Muscle Contraction Homo sapiens R-HSA-445355; Myogenesis; Epithelial Mesenchymal Transition	Myogenesis; Epithelial Mesenchymal Transition; TNF-alpha Signaling via NF-kB	muscle contraction (GO:0006936); platelet aggregation (GO:0070527); regulation of vascular associated smooth muscle cell proliferation (GO:1904705)	Smooth Muscle Contraction Homo sapiens R-HSA-445355; RHO GTPases activate PAKs Homo sapiens R-HSA-5627123; RHO GTPases Activate ROCKs Homo sapiens R-HSA-5627117	Smooth muscle contraction; Muscle contraction; FSH regulation of apoptosis	Striated Muscle Contraction Pathway WP383; Focal Adhesion WP306; Apoptosis-related network due to altered Notch3 in ovarian cancer WP2864	Vascular smooth muscle contraction; Oxytocin signaling pathway; Focal adhesion	cytochrome-c oxidase activity (GO:0004129); active ion transmembrane transporter activity (GO:0022853); protein kinase binding (GO:0019901)	KLF10,TCF21,AR,RELA,NFIC,ESR1,PR,PPARG,TP53,CEBPB,GATA3,ASCL1,BRD4,ZNF667,NEUROG2,ZBTB16,NR3C1,SRF,KDM6B,CTCF	A549,Epithelium,Lung	CSRP1,TSC22D1,CSRP2,AEBP1,CRIP2	KLF10,TCF21,AR,RELA,NFIC	CEBPB,ZBTB16,FOS,ATF3	CEBPB,ZBTB16,FOS,ATF3,KLF4,EGR1,IRF1,CEBPD	Fibroblasts
42	MeC_42	THAP2,REL,NFKB1,MXD1,XBP1,NFE2L2,FOSB,ETS2	CXCL3,CXCL2,IL1B,CXCL8,G0S2,CCL20,IER3,NFKBIA,SOD2,BCL2A1,CCL3,EREG,PLAUR,CCL4,TNFAIP3,PNRC1,BTG1,PTGS2,OLR1,C15orf48	CXCL3,CXCL2,IL1B,CXCL8,G0S2,CCL20,IER3,NFKBIA,SOD2,BCL2A1,CCL3,EREG,PLAUR,CCL4,TNFAIP3,PNRC1,BTG1,PTGS2,OLR1,C15orf48,CFLAR,PLEK,PDE4B,ICAM1,NLRP3,PPP1R15A,DUSP2,CCRL2,CCL3L3,C5AR1,THAP2,CXCL1,REL,MIR155HG,ANXA5,TNF,SERPINB9,IL1RN,NFKB1,ATP1B3,TNFAIP8,CHMP1B,SAMSN1,MXD1,NFKBIZ,AREG,WTAP,CD83,IL1A,PLIN2,CD44,THBS1,ATP2B1,CCL3L1,NINJ1,TNFAIP2,MT2A,XBP1,VEGFA,NFE2L2,EHD1,CCL4L2,OSM,LIMS1,IL10,KDM6B,BASP1,LCP2,BIRC3,AQP9,INHBA,HLA-DPB1,PPIF,MIR3945HG,PHACTR1,FOSB,ACSL1,TNFAIP6,IL6,MS4A7,TWISTNB,ABL2,RBKS,MAP2K3,CTSL,PIM3,VIM,PHLDA1,ETS2,HLA-A,NAMPT,CXCL5,HNRNPC,TIMP1,ATP13A3,SOCS3,TUBB,HBEGF,KYNU,ZFP36	TNF-alpha Signaling via NF-kB; Interleukin-1 regulation of extracellular matrix; TNF-alpha effects on cytokine activity, cell motility, and apoptosis; Inflammatory Response; cytokine-mediated signaling pathway (GO:0019221)	TNF-alpha Signaling via NF-kB; Inflammatory Response; Interferon Gamma Response	cytokine-mediated signaling pathway (GO:0019221); inflammatory response (GO:0006954); cellular response to lipopolysaccharide (GO:0071222)	Chemokine receptors bind chemokines Homo sapiens R-HSA-380108; Peptide ligand-binding receptors Homo sapiens R-HSA-375276; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	Interleukin-1 regulation of extracellular matrix; TNF-alpha effects on cytokine activity, cell motility, and apoptosis; Interleukin-5 regulation of apoptosis	Photodynamic therapy-induced NF-kB survival signaling WP3617; miRNAs involvement in the immune response in sepsis WP4329; Lung fibrosis WP3624	Rheumatoid arthritis; TNF signaling pathway; NF-kappa B signaling pathway	cytokine activity (GO:0005125); chemokine receptor binding (GO:0042379); chemokine activity (GO:0008009)	IRF1,JMJD1C,CEBPB,SMAD1,CEBPA,KMT2A,RUNX1,SPI1,STAT1,RARA,FLI1,RELA,BRD4,LYL1,RUNX1T1,RXRG,CREBBP,MED12,NR4A1,RXRA	Monocyte,Blood	NFKBIA,BTG1,THAP2,MXD1,XBP1	IRF1,JMJD1C,SMAD1,CEBPA,RUNX1	CEBPB,NFKB1,NFE2L2,FOSL2	CEBPB,NFKB1,NFE2L2,FOSL2,CREM,REL,ETS2	Th1,M1,Monocyte,cDC2,cDC1,M2
43	MeC_43	ZNF683,FOS,JUNB,LITAF,NR4A2,KLF2,GTF3A,ZNF331,LEF1,REL	CD7,ZFP36L2,TRGC2,HCST,ZNF683,LTB,IFITM2,CTSW,IL32,TRDC,DUSP2,LYAR,FOS,KLRD1,ZFP36,IFITM3,EZR,JUNB,NUCB2,HSPB1	CD7,ZFP36L2,TRGC2,HCST,ZNF683,LTB,IFITM2,CTSW,IL32,TRDC,DUSP2,LYAR,FOS,KLRD1,ZFP36,IFITM3,EZR,JUNB,NUCB2,HSPB1,LITAF,PLAC8,FXYD5,PPP2R5C,CCL5,NR4A2,GADD45B,XCL1,KLF2,RAC2,UBB,ITGB2,RP11-291B21.2,TAGLN2,STK17A,IFITM1,GUK1,GTF3A,S100A10,PIK3R1,TPM3,CD27,CDC42,ZNF331,CXCR3,FAM173A,LEF1,PABPC1,CD63,GYPC,KLRC2,EIF5A,CD52,REL,TXNIP,NCR3,TCF7,XCL2,RGCC,ISG20,S100A4,TRMT112,MBP,DDIT4,PGK1,CYBA,MYL12A,MYL12B,TMEM123,TRG-AS1,VAMP8,C1orf162,CD99,ARHGAP15,ACTG1,HSPE1,YBX1,HMGN1,SPINT2,EVL,ELF1,SET,XBP1,PSME1,DUSP1,MYL6,HOPX,TRDV1,ANXA6,RHOH,IL2RG,ANXA11,LIMD2,MATK,NFE2L2,NCL,AREG,CLIC1,RBM39,SLC25A5	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; TNF-alpha Signaling via NF-kB; Leukocyte transendothelial migration; Leukocyte transendothelial migration	TNF-alpha Signaling via NF-kB; Interferon Alpha Response; Allograft Rejection	cellular response to cytokine stimulus (GO:0071345); cytokine-mediated signaling pathway (GO:0019221); cellular response to tumor necrosis factor (GO:0071356)	Immune System Homo sapiens R-HSA-168256; Axon guidance Homo sapiens R-HSA-422475; Smooth Muscle Contraction Homo sapiens R-HSA-445355	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; Leukocyte transendothelial migration	Chromosomal and microsatellite instability in colorectal cancer  WP4216; Endometrial cancer WP4155; DNA Damage Response (only ATM dependent) WP710	Leukocyte transendothelial migration; Colorectal cancer; Fluid shear stress and atherosclerosis		T,GATA3,MYB,NCOR2,IKZF1,MEF2A,TAL1,TCF7L1,KMT2A,RXRG,RUNX1,RARA,STAT3,STAT5B,FLI1,NCOR1,SMAD1,PML,NR0B2,NR3C1	Th1	ZNF683,LITAF,NR4A2,KLF2,GTF3A	T,GATA3,MYB,NCOR2,IKZF1	ELF1	ELF1,JUNB,FOS,CEBPB,REL,LEF1,YBX1,XBP1,TCF7,ID3,NFE2L2	CD8Tex,NK,CD8Tem,CD8Tcm,Th1,CD8Teff
44	MeC_44	JUNB	UBC,DUSP2,HSPA6,HLA-C,RPLP0,DDIT4,RPL21,RNASET2,IL32,RPL12,JUNB,C1QB,RPS13,ADM,UBB,BTG1,RPL23,RPL13AP5,RPL31,RPL23A	UBC,DUSP2,HSPA6,HLA-C,RPLP0,DDIT4,RPL21,RNASET2,IL32,RPL12,JUNB,C1QB,RPS13,ADM,UBB,BTG1,RPL23,RPL13AP5,RPL31,RPL23A,NEAT1,RPS3,RPS24,B2M,TUBA1A,FTH1,CKB,MALAT1,CLU,RGS2,C1QA,RPS4X,HILPDA,PLEK,S100A11,SRGN,RPS18,RPS5,RPL27A,MIF,CALM2,RPL18,ALOX5AP,RGCC,CD53,RPL30,PSAP,CST3,LYZ,RPL14,RPL26,RPL4,CCL2,C3,PPP1R15A,ARPC2,GNLY,TUBA1B,GSN,TMSB10,MT-ND4,TPI1,FAU,SDCBP,GPX1,IFITM1,CHI3L2,CD9,RPS27A,PLXDC2,BCL2A1,GPM6B,RPL7A,RPL32,RPS4Y1,ARPC3,TYROBP,SRP14,CLK1,RPLP1,RPS17,RPS12,RPS10,CXCL8,ANXA5,LGALS3,DUSP1,EEF1B2,ATP6V0E1,CAPG,APOC2,S100A9,GZMH,RPL9,RPS23,CAPZA1,DBNDD2,CYBA,RPS11,CXCL13	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Selenocysteine synthesis Homo sapiens R-HSA-2408557; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	Coagulation; TNF-alpha Signaling via NF-kB; Myc Targets V1	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); protein targeting to ER (GO:0045047)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Cytoplasmic ribosomal proteins; Translation; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; TYROBP Causal Network WP3945	Coronavirus disease; Ribosome; Kaposi sarcoma-associated herpesvirus infection	RNA binding (GO:0003723); rRNA binding (GO:0019843); large ribosomal subunit rRNA binding (GO:0070180)	EZH2,CPSF3L,NR3C2,RELA,KAT2B,NELFE,BMI1,TP53,BRD4,GTF2A2,ZBTB17,NR3C1,CDK9,PML,STAT3,GTF2B,SNAPC1,AFF4,CD74,MED1	Proerythroblast,Fetal Liver	BTG1	EZH2,NR3C2,RELA,KAT2B,BMI1		JUNB	MAIT
45	MeC_45	JUN,JUNB,ATF3,DDIT3,SOX4,CEBPB,MYC,HMGA1,SUB1,ATF4	CXCL8,CXCL2,CXCL3,CXCL1,NFKBIA,NFKBIZ,C11orf96,HSPA5,JUN,EIF4A3,CYCS,PHLDA1,IL1B,PMAIP1,GPR183,APOE,ALOX5AP,RPS27L,MMP9,AC103591.3	CXCL8,CXCL2,CXCL3,CXCL1,NFKBIA,NFKBIZ,C11orf96,HSPA5,JUN,EIF4A3,CYCS,PHLDA1,IL1B,PMAIP1,GPR183,APOE,ALOX5AP,RPS27L,MMP9,AC103591.3,CTSL,HMOX1,JUNB,IL24,IL1RN,TMSB4X,THBS1,RPS18,ATF3,HERPUD1,SQSTM1,PLIN2,DUSP1,ITM2B,DDIT3,HLA-DRB1,NDUFB4,ENO1,PPDPF,LYZ,COX7B,SOX4,HSPD1,ZFAND5,RPS6,UBC,TPM4,EEF1A1,SERPINB2,CA2,MMP10,CEBPB,FTH1,C1QA,BAX,EIF4G2,SPARCL1,HLA-DQB1,COL6A2,RBPJ,MT-ND4L,PRSS23,CD44,HIST2H2AA4,RPS12,MEG3,NME1,GNA15,P2RY12,SERPINF1,C6orf62,FABP5,GSN,MYC,TMEM14C,SERPINH1,PTGS2,LTB,IER2,C3AR1,GEM,MARCKSL1,HIST2H2BE,C15orf48,SERPINE1,HMGA1,TFPI,MT1X,SUB1,AL157895.1,ATF4,GLUL,DUSP6,ERRFI1,MIF,TPM1,SLC25A3,C1orf43,RNASE2,MTND4LP30	TNF-alpha Signaling via NF-kB; Interleukin-4 regulation of apoptosis; Senescence and autophagy; Senescence and Autophagy in Cancer WP615; Interleukin-1 regulation of extracellular matrix	TNF-alpha Signaling via NF-kB; Hypoxia; Apoptosis	cytokine-mediated signaling pathway (GO:0019221); response to endoplasmic reticulum stress (GO:0034976); PERK-mediated unfolded protein response (GO:0036499)	PERK regulates gene expression Homo sapiens R-HSA-381042; ATF4 activates genes Homo sapiens R-HSA-380994; Unfolded Protein Response (UPR) Homo sapiens R-HSA-381119	Interleukin-4 regulation of apoptosis; Senescence and autophagy; Interleukin-1 regulation of extracellular matrix	Senescence and Autophagy in Cancer WP615; Spinal Cord Injury WP2431; Nonalcoholic fatty liver disease WP4396	Legionellosis; TNF signaling pathway; Lipid and atherosclerosis	CXCR chemokine receptor binding (GO:0045236); serine-type endopeptidase inhibitor activity (GO:0004867); chemokine activity (GO:0008009)	BRD4,CREBBP,RELA,FOXO1,MED1,STAT3,IRF1,NR3C1,VDR,SPI1,CEBPB,STAT1,DAXX,JUN,RUNX1,TCF7,NR1H3,TEAD1,CEBPA,RXRA	LX2,Hepatic Stellate Cell	NFKBIA,DDIT3,ENO1	BRD4,CREBBP,RELA,FOXO1,MED1	JUN,CEBPB,ATF3,JUNB	JUN,CEBPB,ATF3,JUNB,MYC,SOX4	Monocyte,cDC2,M1,M2,Th1,Tfh,Mast
46	MeC_46	YBX1,CSDE1,JUN,FOXP1,NFE2	HBA2,HBB,HBA1,UBB,HBD,ALAS2,SLC25A39,SLC25A37,CA1,BSG,SNCA,GYPC,BNIP3L,AHSP,BLVRB,HBM,PRDX2,BCL2L1,STRADB,DCAF12	HBA2,HBB,HBA1,UBB,HBD,ALAS2,SLC25A39,SLC25A37,CA1,BSG,SNCA,GYPC,BNIP3L,AHSP,BLVRB,HBM,PRDX2,BCL2L1,STRADB,DCAF12,NCOA4,MPP1,SELENBP1,LGALS3,HLA-J,FECH,MKRN1,EIF4A2,CAT,BPGM,MAP2K3,FKBP8,FBXO7,HBG2,HNRNPK,YBX3,RGS10,YBX1,TRIM58,CSDE1,RPS10,ADIPOR1,CTSB,CD44,BAG1,NDUFS5,GMPR,GABARAPL2,JUN,TOP1,ATP5L,CCNDBP1,DMTN,ATP5L2,CA2,GUK1,UBE2B,PPP1R15A,EIF1AY,RBM3,FOXP1,ANP32B,NUDT4,NFE2,HEMGN,PITHD1,GNLY,GLUL,RNR2,NDUFA1,ATP6V0C,EIF3K,TESC,AP2S1,DYNLL1,PDZK1IP1,NACA2,GLRX5,RBM38,TALDO1,TENT5C,ARL4A,PSMF1,C11orf31,STK17A,STOM,PRDX6,CD97,CCL5,HLA-DMA,MT-ND5,TERF2IP,APOBEC3G,GSPT1,RPIA,YPEL5,SELK,CD3D,S100A10,MYL4	heme Metabolism; hydrogen peroxide catabolic process (GO:0042744); Alpha-hemoglobin stabilizing enzyme (AHSP) pathway; hydrogen peroxide metabolic process (GO:0042743); Oxygen/carbon dioxide exchange in erythrocytes	heme Metabolism	hydrogen peroxide catabolic process (GO:0042744); hydrogen peroxide metabolic process (GO:0042743); regulation of cell death (GO:0010941)	Erythrocytes take up oxygen and release carbon dioxide Homo sapiens R-HSA-1247673; O2/CO2 exchange in erythrocytes Homo sapiens R-HSA-1480926; Erythrocytes take up carbon dioxide and release oxygen Homo sapiens R-HSA-1237044	Alpha-hemoglobin stabilizing enzyme (AHSP) pathway; Oxygen/carbon dioxide exchange in erythrocytes; Malaria		Mitophagy; Nitrogen metabolism; Malaria	hemoglobin alpha binding (GO:0031721); heme binding (GO:0020037); ubiquitin protein ligase binding (GO:0031625)	TAL1,GATA1,SMAD1,EZH2,GATA2,SIX1,STAT2,LDB1,5HMC,ZNF274,CEBPA,FOXO3,KLF1,ZBTB7A,SIRT6,BMI1,NFE2,KMT2A,SMARCA4,MTA2	Proerythroblast,Fetal Liver	NCOA4,TRIM58	TAL1,GATA1,SMAD1,EZH2,GATA2	NFE2,JUN	NFE2,JUN,YBX1,FOXP1,CSDE1	Mast,CD8Tem,B
47	MeC_47	FOS,ID2,NR4A1,JUNB	GAPDH,TPI1,LDHA,ALDOA,AC006064.4,S100A10,PGK1,RPL21,ENO1,RPS27,OLR1,CXCR4,MIF,TMSB4X,FOS,ADM,DUSP1,RPL3,SFRP2,NKG7	GAPDH,TPI1,LDHA,ALDOA,AC006064.4,S100A10,PGK1,RPL21,ENO1,RPS27,OLR1,CXCR4,MIF,TMSB4X,FOS,ADM,DUSP1,RPL3,SFRP2,NKG7,PKM,RPS19,HLA-E,TPT1,IFI6,HILPDA,IFITM2,IFNGR1,ID2,CD74,RGS2,ANXA2,RPL13A,LYZ,RPS10,ZFP36,APOE,EIF4A3,HLA-C,IFITM3,TXNIP,P2RY12,HSPA1B,RPS3A,PLTP,SOD1,OAZ1,SLC2A3,AIF1,RPL21P28,LGALS3,DDIT4,DNAJB1,RPS14,ANXA1,A2M,NPC2,CFD,LUM,PGAM1,RPL34,APOC1,H3F3B,ZFP36L1,RPS25,MT-ATP6,IFI27,NFKBIA,CCL19,CCL2,TNFRSF18,IL1B,COTL1,CYR61,HSPB1,LDHB,HLA-A,ANGPTL4,NR4A1,RPS13,ISG15,RPL10A,RPS28,SERPINE1,FUCA1,RPL23A,MT-ND4,RPL7,MYL6,SDCBP,TUBA1A,S100A11,FOLR2,MGP,MT-ND2,MT-ND1,MALAT1,IL7R,XCL2,JUNB	Coronavirus disease; Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Hypoxia; TNF-alpha Signaling via NF-kB; Glycolysis	nuclear-transcribed mRNA catabolic process (GO:0000956); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Viral mRNA Translation Homo sapiens R-HSA-192823	Influenza viral RNA transcription and replication; Cytoplasmic ribosomal proteins; Influenza infection	Cytoplasmic Ribosomal Proteins WP477; Glycolysis and Gluconeogenesis WP534; Spinal Cord Injury WP2431	Coronavirus disease; Ribosome; Glycolysis / Gluconeogenesis	RNA binding (GO:0003723); mRNA binding (GO:0003729); cadherin binding (GO:0045296)	NR3C2,HIF1A,EZH2,STAT3,STAT1,CIITA,CREBBP,DRAP1,TP53,KLF1,SPI1,NFE2,REST,RUNX1,RXRG,BRD4,NELFA,MAFB,MYB,SMAD1	Kidney	ENO1,ID2,NFKBIA	NR3C2,HIF1A,EZH2,STAT3,STAT1	FOS	FOS,NR4A1	TMKI67,cDC1,Treg,Monocyte,Fibroblasts
48	MeC_48	ID2,HOPX,ETS1,CREM,IRF1,RUNX3,REL,ZNF331,NR4A2	CCL5,IL32,GNLY,GZMA,CD7,CD52,NKG7,HCST,PTPRC,SH3BGRL3,RAC2,CORO1A,SRGN,TMSB4X,CD2,CD247,LCP1,EVL,CD3E,HLA-A	CCL5,IL32,GNLY,GZMA,CD7,CD52,NKG7,HCST,PTPRC,SH3BGRL3,RAC2,CORO1A,SRGN,TMSB4X,CD2,CD247,LCP1,EVL,CD3E,HLA-A,ID2,GZMB,XCL2,CD69,CCL4,CXCR4,ARHGDIB,CTSW,KLRB1,RARRES3,CD3D,LCK,S100A4,ACTB,IL2RG,XCL1,DUSP2,LSP1,HLA-C,CYTIP,IFITM2,STK17A,ITM2A,CST7,IL2RB,PRF1,TNFRSF18,GMFG,CD96,CD53,STK17B,TRAC,ZFP36L2,HOPX,ETS1,CKLF,BTG1,FCER1G,CLEC2B,APOBEC3G,ACAP1,KLRC1,TNFAIP3,CREM,SLA,KLRD1,ARPC2,DDIT4,SPOCK2,IRF1,PFN1,GYPC,CALM1,TXNIP,TRBC2,KRT86,HSPA8,ZFP36,RUNX3,GNG2,TYROBP,ACTG1,FYB,B2M,TUBA4A,DNAJB1,REL,RGS16,HLA-B,CD99,JAK1,IFI16,PTPN7,CRIP1,CCND2,MYL12A,ZNF331,LTB,NR4A2,METRNL	Interleukin-2 signaling pathway; Allograft Rejection; T cell receptor regulation of apoptosis; Immune System Homo sapiens R-HSA-168256; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933	Allograft Rejection; Interferon Gamma Response; Complement	regulation of immune response (GO:0050776); cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345)	Immune System Homo sapiens R-HSA-168256; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Homo sapiens R-HSA-198933; Adaptive Immune System Homo sapiens R-HSA-1280218	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Immunoregulatory interactions between a lymphoid and a non-lymphoid cell	IL-2 Signaling Pathway WP49; Allograft Rejection WP2328; miRNAs involvement in the immune response in sepsis WP4329	Natural killer cell mediated cytotoxicity; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection	chemokine receptor binding (GO:0042379); chemokine activity (GO:0008009); CCR chemokine receptor binding (GO:0048020)	GATA3,T,RUNX1,LMO2,STAT6,TCF7L1,MYB,SMAD1,KMT2A,TAL1,NR3C1,SPI1,LYL1,RUNX1T1,MED12,STAT5B,FLI1,TBX21,PML,RARA	Th1	ID2,HOPX,BTG1,CREM,IFI16	GATA3,T,RUNX1,STAT6,TCF7L1	ETS1,JUNB,RUNX3,BATF	ETS1,JUNB,RUNX3,BATF,IRF1,REL	NK,CD8Tex,CD8Tcm,CD8Teff,CD4Teff,CD8Tem
49	MeC_49	EGR1,ID2,TSC22D3,NR4A2	RNASE1,SELENOP,C1QB,C1QA,C1QC,CTSB,PSAP,PLTP,HLA-DRB1,CD14,F13A1,NPC2,MS4A6A,CCR7,FCER1G,FOLR2,CTSC,LGMN,TPT1,IFITM3	RNASE1,SELENOP,C1QB,C1QA,C1QC,CTSB,PSAP,PLTP,HLA-DRB1,CD14,F13A1,NPC2,MS4A6A,CCR7,FCER1G,FOLR2,CTSC,LGMN,TPT1,IFITM3,FCGRT,RPS18,CTSD,RPL21,TYROBP,CD163,RPL12,HLA-DRB5,MS4A4A,CST3,AIF1,UBC,CCL13,FCGR3A,TMEM176B,SLC40A1,TGFBI,EEF1A1,RPS15A,GRN,FCGR2A,HLA-DPA1,ITM2B,IFI27,CD68,VSIG4,GPR34,LYVE1,CXCL1,C6orf62,SDCBP,PLAU,CALM2,SSR4,GLUL,PLD3,IFI6,GAPDH,SGK1,RPL41,CD69,DNAJB1,CD63,EGR1,ID2,CFD,HLA-A,HSPA6,MT-ND3,LGALS3BP,MT-ATP6,RNASET2,CREG1,HSPA1B,FCGR2B,IL32,ACTB,EIF3E,RPS6,C6orf48,RPL7,S100A4,FTH1,RPL10A,STAB1,ACTG1,HLA-DQA1,ASAH1,CCL2,RPL36,PMP22,RNASE6,MRC1,MS4A7,RPS8,RPS9,CXCL12,TSC22D3,RPLP1,NR4A2	Coronavirus disease; neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446); Peptide chain elongation Homo sapiens R-HSA-156902	Interferon Gamma Response; TNF-alpha Signaling via NF-kB; Complement	neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446)	Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Translation Homo sapiens R-HSA-72766	Translation; Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217	Coronavirus disease; Staphylococcus aureus infection; Phagosome	IgG binding (GO:0019864); MHC class II receptor activity (GO:0032395); RNA binding (GO:0003723)	SPI1,STAT1,IRF1,SMAD1,RUNX1,KDM1A,ZNF48,CIITA,BRD4,GFI1B,JMJD1C,YBX1,ZNF391,TCF4,BCL3,CD74,KMT2A,INO80,CEBPA,LMO2	Macrophage,Blood	ID2,CREG1,TSC22D3,NR4A2	SPI1,STAT1,IRF1,SMAD1,RUNX1		EGR1	M2,M1,cDC2,Monocyte
50	MeC_50	FOS,JUN,IRF1,FOXP1,SP100	TCL1A,FCER2,CXCR4,IL4R,FOS,CD69,BTG1,IGHD,CD79B,PLPP5,APLP2,IGHM,HVCN1,MEF2C,LINC00926,HLA-DRB1,CD52,BIRC3,IGLC2,TMSB10	TCL1A,FCER2,CXCR4,IL4R,FOS,CD69,BTG1,IGHD,CD79B,PLPP5,APLP2,IGHM,HVCN1,MEF2C,LINC00926,HLA-DRB1,CD52,BIRC3,IGLC2,TMSB10,LAPTM5,TSPAN13,CD74,DBI,IGLC3,FCRL1,CD72,TSPO,SELL,TUBA1A,HLA-DRA,CD79A,HLA-DMB,CD37,VPREB3,HLA-DQB1,CLEC2D,SEC62,SNX2,NCF1,YBX3,STK17A,LTA4H,CD22,DUSP1,ANXA1,JUN,CLEC2B,RCSD1,ABRACL,HLA-DRB5,TMEM123,IRF1,SARAF,FAM129C,H1FX,STX7,FOXP1,TAGAP,CD55,ISG20,MYL6,ZFP36L1,AES,CD200,C1orf162,SERF2,FKBP1A,ARPC3,HLA-DOB,IL2RG,ITGB2,GLTSCR2,RHOH,RNASE6,ITM2B,HLA-DMA,SNX29,BTLA,HLA-DPB1,IFI16,EVL,IL32,ADK,CD83,LYST,PPIB,NCL,FXYD5,SESN1,ICAM2,RPS4Y1,HLA-DPA1,SP100,BLOC1S2,ATP6V1G1,MYADM,PIK3IP1,H3F3A,POMP	Immune System Homo sapiens R-HSA-168256; Immune system; Hematopoietic cell lineage; Leishmaniasis; Leishmaniasis	Allograft Rejection; TNF-alpha Signaling via NF-kB; Interferon Gamma Response	regulation of immune response (GO:0050776); antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886); antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	Immune System Homo sapiens R-HSA-168256; Adaptive Immune System Homo sapiens R-HSA-1280218; CD22 mediated BCR regulation Homo sapiens R-HSA-5690714	Immune system; Leishmaniasis; Asthma	Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217; Human Complement System WP2806	Hematopoietic cell lineage; Leishmaniasis; Inflammatory bowel disease	MHC class II protein complex binding (GO:0023026); MHC class II receptor activity (GO:0032395); CD4 receptor binding (GO:0042609)	FOXO1,CD74,BCL6,KMT2A,MEF2B,CREBBP,NCOR2,NCOR1,RELA,SPI1,ZMYM3,SPIB,PAX5,IKZF1,CDK9,SMAD1,FOXP1,EBF1,CEBPA,NR3C1	B Lymphocyte,Tonsil	BTG1,AES,IFI16,SP100,EAF2	FOXO1,BCL6,MEF2B,CREBBP,NCOR2	FOXP1,PAX5,IRF1,BACH2,CIITA	FOXP1,PAX5,IRF1,BACH2,CIITA,JUN,FOS	B,MAIT,pDC
51	MeC_51	ID2,IRF1,REL,SUB1,KLF6,NFKB1	TXN,BIRC3,ID2,MARCKSL1,CCR7,CRIP1,FSCN1,CD83,GPX4,RPS27L,CDKN1A,PNRC1,SEC61B,GSTP1,VIM,RGS1,LSP1,CCL22,ZFP36L1,SAMSN1	TXN,BIRC3,ID2,MARCKSL1,CCR7,CRIP1,FSCN1,CD83,GPX4,RPS27L,CDKN1A,PNRC1,SEC61B,GSTP1,VIM,RGS1,LSP1,CCL22,ZFP36L1,SAMSN1,H2AFZ,SYNGR2,ACTB,LAMP3,IRF1,ZFAS1,HLA-DPB1,PPA1,NUB1,CST7,GSN,BCL2A1,MARCKS,HINT1,BASP1,LGALS1,IL7R,CSF2RA,MTHFD2,ACTG1,TYROBP,TYMP,RASSF4,DUSP5,TNFAIP2,GADD45A,ATOX1,GPR183,ISCU,CD40,HLA-DRA,PFN1,TMEM176B,TMSB10,GPR157,REL,IDO1,LCP1,NAP1L1,TUBB,ALDH2,ANXA6,CFLAR,HLA-DQA1,MGLL,DBI,PPDPF,BTG1,IL32,CCL17,PLEK,TMEM176A,DUSP1,DAPP1,SUB1,CD74,KLF6,IER2,STK4,CIRBP,PSME1,ZFAND5,GNG5,GABARAPL2,CTSZ,TBC1D4,NFKB1,FNBP1,TRAF1,MYO1G,HLA-DQB1,HLA-DPA1,EBI3,SRGN,RAB9A,RAP1B,CXCR4,IL4I1,CD86,YPEL5	TNF-alpha Signaling via NF-kB; T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; cytokine-mediated signaling pathway (GO:0019221); Thymic stromal lymphopoietin (TSLP) pathway	TNF-alpha Signaling via NF-kB; Inflammatory Response; Interferon Gamma Response	cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345); cellular response to interferon-gamma (GO:0071346)	Immune System Homo sapiens R-HSA-168256; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215; Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; Thymic stromal lymphopoietin (TSLP) pathway	Ebola Virus Pathway on Host WP4217; Allograft Rejection WP2328; Photodynamic therapy-induced NF-kB survival signaling WP3617	Viral myocarditis; Intestinal immune network for IgA production; Allograft rejection	MHC class II receptor activity (GO:0032395)	RELA,SPI1,NFKB2,RELB,TBP,KMT2A,EBF1,ETV6,CD74,NFKB1,RBPJ,MED1,FOXP1,TAF1,TP73,BCL6,REL,IKZF1,ZNF597,T	GM12878,B Lymphocyte,Blood	ID2,BASP1,BTG1,SUB1,KLF6	RELA,SPI1,NFKB2,EBF1,ETV6	NFKB1,REL,RELB,IRF1	NFKB1,REL,RELB,IRF1,IRF4,ATF3,ATF4	M2,cDC2,cDC1
52	MeC_52		LYZ,AC020656.1,MMP12,IFI30,PSAP,FCN1,CD74,TMSB10,FBP1,CST3,GRN,IFNGR1,ALDOA,VIM,RACK1,CTSS,RPS27,S100A11,ANXA2,MT1G	LYZ,AC020656.1,MMP12,IFI30,PSAP,FCN1,CD74,TMSB10,FBP1,CST3,GRN,IFNGR1,ALDOA,VIM,RACK1,CTSS,RPS27,S100A11,ANXA2,MT1G,COTL1,SH3BGRL3,CXCL2,RPS11,RPS6,RPL8,RGS2,CALM2,DUSP2,RPS19,CXCR4,EIF4A3,RPLP2,HLA-B,SDCBP,NPC2,BTG1,FCER1G,CAPG,HSPA8,RPL11,ANXA1,TYROBP,PTMA,CD14,COX7C,MS4A6A,ITGB2,TSPO,SLC25A6,RPL23A,CTSH,COX4I1,LDHA,SLC25A5,IFITM3,MT1X,LGALS3,RPS8,RPL15,PPT1,ALDH2,PDK4,OAZ1,LGALS1,NCF2,HSPA1A,TPI1,CD68,C3AR1,PGK1,ASAH1,EEF1B2,AREG,CXCL8,S100A10,NACA,HMGN2,RHOA,RPL12,GSTP1,TKT,ATP5MC2,S100A6,HLA-A,ATP6V1B2,RPL27A,RPL29,LIPA,LTA4H,FN1,IFI6,AIF1,THBS1,IL32,RPL28,DDIT4,CD69,RPS23,SUMO2	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802	Complement; Hypoxia; mTORC1 Signaling	neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957	Influenza infection; Influenza viral RNA transcription and replication; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Macrophage markers WP4146; Spinal Cord Injury WP2431	Ribosome; Coronavirus disease; Antigen processing and presentation	RNA binding (GO:0003723); cadherin binding (GO:0045296); metal ion binding (GO:0046872)	SPI1,KLF10,SMAD1,STAT1,IRF1,BMI1,CEBPA,EZH2,KMT2A,CDK8,BRD4,TP53,CEBPB,JMJD1C,MYC,KLF5,AFF4,FLI1,RUNX1,MAX	Monocyte	BTG1	SPI1,KLF10,SMAD1,STAT1,IRF1			M1,Monocyte,M2,cDC2
53	MeC_53		CALR,MALAT1,HLA-A,TMBIM6,HLA-B,PPIB,HLA-C,HSP90B1,PSAP,PDIA3,HSPA5,PDIA6,SRGN,CYBA,ITGB2,CD63,B2M,NEAT1,EMP3,HLA-DRB1	CALR,MALAT1,HLA-A,TMBIM6,HLA-B,PPIB,HLA-C,HSP90B1,PSAP,PDIA3,HSPA5,PDIA6,SRGN,CYBA,ITGB2,CD63,B2M,NEAT1,EMP3,HLA-DRB1,CD44,PTPRC,HLA-E,ITM2B,CANX,MTDH,BST2,SSR4,SARAF,BSG,FXYD5,CD74,GRN,HLA-DRB5,ARL6IP5,CD53,P4HB,MT-ND5,LMAN2,ATP6V0B,CTSD,TMEM59,ATP1B3,LY6E,TMED10,TIMP1,ITGB1,MT-CO1,CD99,LAPTM5,RPN2,MYDGF,HLA-DQB1,REEP5,LYZ,ATP6V0E1,SSR2,MT2A,MT-CO2,HCST,HM13,DAD1,TAPBP,CTSC,DDOST,RPN1,CXCR4,MT-ND4,MT-CYB,KRTCAP2,SPCS2,FKBP2,ATP6AP2,IFI6,SPCS3,SYNGR2,SDF2L1,MT-ND2,SPP1,HSPA1A,CUTA,IL2RG,COX6A1,CD48,CD164,PDIA4,OSTC,MT-ND1,CTSS,TMED9,MT-ATP6,HNRNPH1,MT-CO3,CD52,CD3D,CTSA,CST3,TPP1,APLP2,PPT1	Antigen processing and presentation; Antigen processing and presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC Homo sapiens R-HSA-983170; Protein processing in endoplasmic reticulum; Protein processing in the endoplasmic reticulum	Allograft Rejection; mTORC1 Signaling; Interferon Gamma Response	neutrophil degranulation (GO:0043312); neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446)	Antigen Presentation: Folding, assembly and peptide loading of class I MHC Homo sapiens R-HSA-983170; Immune System Homo sapiens R-HSA-168256; Adaptive Immune System Homo sapiens R-HSA-1280218	Antigen processing and presentation; Protein processing in the endoplasmic reticulum; Immune system	Ebola Virus Pathway on Host WP4217; Allograft Rejection WP2328; Proteasome Degradation WP183	Antigen processing and presentation; Protein processing in endoplasmic reticulum; Phagosome	oligosaccharyl transferase activity (GO:0004576); dolichyl-diphosphooligosaccharide-protein glycotransferase activity (GO:0004579); MHC protein binding (GO:0042287)	TP53,FOXP1,SPI1,EZH2,TAF1,RELA,FOS,NFYB,SMAD5,RUNX1,MAF,BRD4,MYC,YY1,JUND,CBFB,GATA3,MEF2C,MED1,CREBBP	Foreskin	NR4A2,ARID4B	TP53,FOXP1,SPI1,EZH2,TAF1	FOS	FOS,JUN,KLF6,CTNNB1	CD8Tex,Endothelial,CD8Tcm
54	MeC_54	ID2,JUNB,CREM	RPS18,RPS27,RPL13AP5,RPL31,RPL18A,RPL37A,RPL29,RPL4,IFITM3,CST3,ACTG1,FTH1,MIF,RPS12,IFNGR1,HLA-DRB1,SRGN,TUBA1B,RPL3,RPS9	RPS18,RPS27,RPL13AP5,RPL31,RPL18A,RPL37A,RPL29,RPL4,IFITM3,CST3,ACTG1,FTH1,MIF,RPS12,IFNGR1,HLA-DRB1,SRGN,TUBA1B,RPL3,RPS9,ZFP36,MYL6,CTSB,ID2,RPSA,NPY,RPS19,DNAJB1,RPL36,JUNB,LAPTM5,CALM2,RPLP2,RPS26,HERPUD1,BCL2A1,TUBA1A,CD14,HLA-DPA1,RPL18,H3F3B,C1QA,GPX1,LIPA,IFITM2,CD63,AREG,HLA-DQA1,RPS17,TYROBP,NPC2,C6orf62,CTGF,FN1,HLA-DRB5,MTRNR2L8,TOB1,SOD2,CTSD,GPR183,TXNIP,TREM2,ALOX5AP,DUSP2,OLR1,ASAH1,ITM2B,HIST1H4C,EEF1D,RPL7A,LYZ,MTRNR2L1,IL32,RPS5,UBB,IL7R,IER2,S100A10,GSN,TPT1,APOC1,CD2,TUBA4A,FABP5,RPL36A,SARAF,S100A6,SGK1,MTRNR2L10,GAPDH,ACTB,ACTA2,VIM,CD3D,RPL34,SLC25A3,PDK4,CYBA,LAMTOR1,CREM	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Viral mRNA Translation Homo sapiens R-HSA-192823; Eukaryotic Translation Termination Homo sapiens R-HSA-72764; Selenocysteine synthesis Homo sapiens R-HSA-2408557	TNF-alpha Signaling via NF-kB; Apoptosis; Coagulation	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); protein targeting to ER (GO:0045047)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Viral mRNA Translation Homo sapiens R-HSA-192823	Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication; Translation	Cytoplasmic Ribosomal Proteins WP477; Ebola Virus Pathway on Host WP4217; Pathogenic Escherichia coli infection WP2272	Ribosome; Coronavirus disease; Phagosome	RNA binding (GO:0003723); MHC class II receptor activity (GO:0032395)	EZH2,BMI1,TP53,EZH1,KAT2B,GTF2B,EBF1,PAF1,ZNF22,DRAP1,NELFE,MYC,RELA,BRD4,TAL1,SMAD5,SNRNP70,MED1,CPSF3L,REL	Proerythroblast,Fetal Liver	ID2	EZH2,BMI1,TP53,EZH1,KAT2B		JUNB	CD8Tn,CD4Tn,Th17,B
55	MeC_55	IRF8,ID2,BATF3,KLF6,FOS,SPI1	RGCC,CST3,SNX3,IRF8,ID2,C1orf54,CPVL,CLEC9A,LYZ,S100A10,CPNE3,C1orf162,DNASE1L3,GSTP1,CCND1,TAGLN2,PTPRE,WDFY4,PSAP,IDO1	RGCC,CST3,SNX3,IRF8,ID2,C1orf54,CPVL,CLEC9A,LYZ,S100A10,CPNE3,C1orf162,DNASE1L3,GSTP1,CCND1,TAGLN2,PTPRE,WDFY4,PSAP,IDO1,TAP1,RAB32,NAAA,CADM1,LGALS2,UCP2,BASP1,RGS10,BATF3,PPT1,MPEG1,LSP1,CD59,HLA-DPB1,CD48,CLEC2B,GYPC,HLA-DPA1,SHTN1,SAT1,LIMD2,LMNA,FGL2,SAMHD1,ANPEP,CSTB,ACTB,CLNK,ISG15,ICAM3,EVI2B,LGMN,CYB5R3,PLEK,SELPLG,VIM,TMSB4X,SLAMF8,HSPA5,SRGN,FNBP1,C20orf27,DDIT4,KLF6,DUSP4,CALR,CDK2AP2,SERPINB9,CKLF,SERPINF1,COX7C,FOS,TUBA1A,THBD,SPI1,PPA1,HLA-DRB5,ITGB2,CLEC7A,CD74,SERPINB1,TRMT112,NEAT1,CXCL16,CYCS,HLA-DRB1,H2AFY,KLRB1,RNASET2,HLA-DQB1,SLAMF7,ACTG1,MYL6,TGFBI,EVL,EVI2A,TACSTD2,P2RY6,ATG3,FUCA1	Viral myocarditis; Antigen processing and presentation; Phagosome; Viral myocarditis; Antigen processing and presentation	TNF-alpha Signaling via NF-kB; Interferon Gamma Response; Epithelial Mesenchymal Transition	neutrophil activation involved in immune response (GO:0002283); neutrophil mediated immunity (GO:0002446); neutrophil degranulation (GO:0043312)	Generation of second messenger molecules Homo sapiens R-HSA-202433; Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427	Viral myocarditis; Antigen processing and presentation; Phagosome	Ebola Virus Pathway on Host WP4217; Development of pulmonary dendritic cells and macrophage subsets WP3892; Allograft Rejection WP2328	Viral myocarditis; Antigen processing and presentation; Phagosome	MHC class II receptor activity (GO:0032395)	SPI1,STAT1,KMT2A,SMAD1,CEBPB,DROSHA,EBNA3,CD74,TCF4,TRIM28,JMJD6,BRD4,TFAP2A,JARID2,ESR1,NFE2,IRF1,CTCF,SMC3,FOXO1	Monocyte	IRF8,ID2,BASP1,BATF3,KLF6	STAT1,SMAD1,CEBPB,TCF4,TRIM28	SPI1,ETV6	SPI1,ETV6,SATB1,FOS	cDC1,M2,cDC2,pDC,M1,Monocyte
56	MeC_56	CREM,NR3C1,ARID5B,ELF1,TSC22D3,STAT4,LITAF,ZNF331,HMGB2,FOXP1	CREM,CXCR4,SYTL3,LEPROTL1,SRGN,FYN,PIK3R1,EML4,DDIT4,SH2D2A,TNFAIP3,SPOCK2,CD7,CNOT6L,NR3C1,SARAF,FTH1,PDE4B,YWHAB,SAMSN1	CREM,CXCR4,SYTL3,LEPROTL1,SRGN,FYN,PIK3R1,EML4,DDIT4,SH2D2A,TNFAIP3,SPOCK2,CD7,CNOT6L,NR3C1,SARAF,FTH1,PDE4B,YWHAB,SAMSN1,LDHA,YPEL5,DNAJB1,DUSP4,WIPF1,CD5,SRSF7,ZFP36L2,ARID5B,RGS1,PFKFB3,DUSP2,CST7,ELF1,LGALS1,SYAP1,TSC22D3,FAM177A1,TNFRSF1B,STAT4,ZFP36,GPR171,SMCHD1,PABPC1,PTPRC,PPP1CB,ITM2A,ISG20,LITAF,ARHGDIB,NDUFS5,PDE3B,DYNLT1,RNF125,ZNF331,CD8A,AKNA,PPP2R5C,HMGB2,EVI2A,STK17B,UBB,KMT2E,PBXIP1,UBE2B,FXYD5,STK4,UBC,CEMIP2,SELK,G3BP2,IQGAP2,USP36,CD55,PAIP2,TPM4,AOAH,CYBA,TENT5C,HSPE1,FAM129A,SRSF2,GUK1,OAZ1,CDC42SE2,BTG1,TECR,PARP8,DNAJB6,SDCBP,TSEN54,PTPN22,ALOX5AP,FOXP1,AKAP13,IRF1,MT-ATP6,HERPUD1,PRKAR1A,IL7R	Interleukin-2 signaling pathway; TNF-alpha Signaling via NF-kB; Hypoxia; T cell receptor regulation of apoptosis; Negative regulation of MAPK pathway Homo sapiens R-HSA-5675221	TNF-alpha Signaling via NF-kB; Hypoxia; Interferon Gamma Response	regulation of mRNA stability (GO:0043488); regulation of mRNA catabolic process (GO:0061013); response to lipopolysaccharide (GO:0032496)	Negative regulation of MAPK pathway Homo sapiens R-HSA-5675221; IRS-mediated signalling Homo sapiens R-HSA-112399; Insulin receptor signalling cascade Homo sapiens R-HSA-74751	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Immune system	Nuclear Receptors Meta-Pathway WP2882; Viral Acute Myocarditis WP4298; Interferon type I signaling pathways WP585			STAT6,CD74,GATA3,MYB,NR3C1,STAT5B,RELA,CEBPA,SPI1,KMT2A,IKZF1,TAL1,MAF,SMAD1,EBNA3C,MED1,AFF1,TCF12,EBF1,BRD4	T Lymphocyte,Cord blood	CREM,YWHAB,ARID5B,TSC22D3,STAT4	STAT6,GATA3,MYB,STAT5B,RELA	NR3C1,FOXP1,CEBPB,IRF1,RUNX3	NR3C1,FOXP1,CEBPB,IRF1,RUNX3,ETS1,ELF1,REL,NFE2L2,ZNF331	CD8Tex,Th1,CD8Tem,CD8Tcm,Tfh
57	MeC_57	JUN,FOS,ID2,KLF6,EGR1,FOSB,MAFB,ATF4,ATF3,ID3	JUN,IER2,FOS,ID2,GADD45B,KLF6,CITED2,DUSP1,EGR1,FOSB,NFKBIA,PPP1R15A,NEAT1,RHOB,SAT1,BRD2,CD69,BTG2,HEXIM1,SRSF3	JUN,IER2,FOS,ID2,GADD45B,KLF6,CITED2,DUSP1,EGR1,FOSB,NFKBIA,PPP1R15A,NEAT1,RHOB,SAT1,BRD2,CD69,BTG2,HEXIM1,SRSF3,TXNIP,EIF4A2,RSRP1,UBB,MT-CYB,HSPA8,FUS,RPL3,SRSF7,TRBC2,TUBA1A,C12orf57,SLC38A2,HIST1H1C,RAN,MAFB,TLE4,RPL28,UBC,GIMAP7,ATF4,IGKC,SQSTM1,H3F3B,MYLIP,NFKBIZ,ATF3,CCNL1,MYL6,EIF4A3,HLA-DRA,RPL11,AC007952.4,COMMD6,INTS6,GSTP1,Z93241.1,H1FX,ANXA6,IFRD1,TNF,TPI1,HSP90AB1,TRA2B,NKG7,DDX3X,DNAJA1,IFITM2,TMEM107,WDR74,SERTAD1,MT1X,AC245014.3,CCL2,ID3,JUND,HAMP,GNLY,CD37,H2AFX,CSKMT,KLF2,MORF4L1,IFNG,RPL22L1,FAM53C,TUBB4B,RPL7,SNHG7,PPP1CA,PMAIP1,ARPC5,RACK1,PNRC1,RALY,IER5,AMD1,CYCS,IER3,TMSB10	TNF-alpha Signaling via NF-kB; Apoptosis; BDNF signaling pathway; T cell receptor regulation of apoptosis; AP-1 transcription factor network	TNF-alpha Signaling via NF-kB; Apoptosis; p53 Pathway	positive regulation of programmed cell death (GO:0043068); positive regulation of apoptotic process (GO:0043065); regulation of cell cycle (GO:0051726)	NF-kB is activated and signals survival Homo sapiens R-HSA-209560; p75NTR signals via NF-kB Homo sapiens R-HSA-193639; Cellular responses to stress Homo sapiens R-HSA-2262752	BDNF signaling pathway; T cell receptor regulation of apoptosis; AP-1 transcription factor network	Hypertrophy Model WP516; Spinal Cord Injury WP2431; Nuclear Receptors Meta-Pathway WP2882	IL-17 signaling pathway; Fluid shear stress and atherosclerosis; Apoptosis	ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389); RNA binding (GO:0003723)	RELA,NR3C2,NELFE,GTF2B,KAT2B,GTF2A2,DNMT3B,CDK7,ELL2,MAFB,MED1,CPSF3L,BRD4,ZMYND11,PAF1,REL,SNAPC1,CD74,SNRNP70,MAF	Endothelial Cell,Umbilical Vein	ID2,CITED2,FOSB,NFKBIA,RAN	RELA,NR3C2,KAT2B,GTF2A2,DNMT3B	MAFB,JUN,JUND,FOS	MAFB,JUN,JUND,FOS,EGR1,ATF3,ATF4,KLF4,KLF6,ID3	Mast,Endothelial,MAIT,Fibroblasts
58	MeC_58	KLF2,CEBPB,MAFB,YBX1,KLF10	ZFP36L1,LGALS2,PSME2,NPC2,HLA-DPB1,HLA-DRA,HLA-DRB1,PLAC8,HLA-DMA,CCL3,VAMP8,HLA-DPA1,CD63,NEAT1,CPVL,TXNIP,FTH1,NFKBIA,APOBEC3A,IFITM3	ZFP36L1,LGALS2,PSME2,NPC2,HLA-DPB1,HLA-DRA,HLA-DRB1,PLAC8,HLA-DMA,CCL3,VAMP8,HLA-DPA1,CD63,NEAT1,CPVL,TXNIP,FTH1,NFKBIA,APOBEC3A,IFITM3,FCN1,UCP2,CD4,DOK2,AIF1,PRELID1,CRIP1,HLA-DQA1,HCST,GPX4,CFD,TIMP1,RHOA,DUSP6,EMP3,FTL,IL1B,HSPA8,POLR2L,CALM2,HLA-DQB1,SERPINA1,CD74,YBX3,MS4A6A,LGALS3,ZFP36,MARCKS,RGS10,IL32,UBB,G0S2,HLA-DMB,TAGLN2,CLEC7A,KLF2,CD52,ITM2B,FGL2,HSP90AA1,CEBPB,MT2A,SAT1,NAAA,TNFAIP2,CD7,GSTO1,CLIC1,PID1,CD3D,GIMAP4,MAFB,RGCC,TNFRSF1B,TRAC,RPS4Y1,FKBP1A,NAMPT,NOSIP,NPM1,VAMP5,CUTA,CD300E,TMEM176B,PSME1,CD99,PTMA,SH3BGRL3,YBX1,ISG20,RPL36AL,EIF3E,CXCL8,THBS1,SEPT9,APRT,CCNI,KLF10,TMEM123,AP2S1	Antigen processing and presentation; Antigen processing and presentation; Interferon Gamma Response; Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427	Interferon Gamma Response; Allograft Rejection; TNF-alpha Signaling via NF-kB	cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345); antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427; Downstream TCR signaling Homo sapiens R-HSA-202424	Antigen processing and presentation; PD-1 signaling; Generation of second messenger molecules	Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217; Lung fibrosis WP3624	Antigen processing and presentation; Th17 cell differentiation; Hematopoietic cell lineage	MHC class II protein complex binding (GO:0023026); MHC class II receptor activity (GO:0032395)	CIITA,SPI1,STAT1,CREBBP,KMT2A,IRF1,RELA,TBP,RUNX1,IKZF1,MAPK1,IRF3,FOS,PML,EBF1,JMJD1C,SP1,NFYA,TCF4,SMAD1	Raji,B Lymphocyte,Blood	NFKBIA,KLF2,MAFB,NPM1,YBX1	CIITA,SPI1,CREBBP,IRF1,RELA	STAT1,IKZF1,CEBPB	STAT1,IKZF1,CEBPB,KLF10,JUND,XBP1,ZEB2	M1,cDC2,M2,Monocyte,pDC
59	MeC_59	CREM,FOS,LITAF,FOSB,KLF2,MYC	IGLC2,IGLC3,IGHGP,IGHG1,EMP3,CD37,CD79A,TXNIP,TMBIM6,SH3BGRL3,HLA-DPA1,SSR2,RGS2,CREM,IGLC7,EZR,ERP29,HLA-DRB1,FOS,TAGLN2	IGLC2,IGLC3,IGHGP,IGHG1,EMP3,CD37,CD79A,TXNIP,TMBIM6,SH3BGRL3,HLA-DPA1,SSR2,RGS2,CREM,IGLC7,EZR,ERP29,HLA-DRB1,FOS,TAGLN2,MT2A,MT-ATP6,LAMTOR5,FKBP1A,MT-ND1,DDX21,PPDPF,CRIP1,CD74,SNU13,MT-CYB,RGS1,EEF2,TOMM7,HMGN2,HLA-DQA1,S100A11,IGHD,HNRNPA1,MS4A1,PPP1CB,ARF6,LITAF,HSPA8,FOSB,SSR4,TRAPPC1,SUMO2,MYL6,GPR183,MZB1,HLA-DRA,HLA-DPB1,CCDC12,TIMP1,HSPE1,SDCBP,HERPUD1,WTAP,RHOC,IFITM2,PLP2,NEDD8,RBMX,PFDN5,COL1A1,KLF2,SLC25A3,COTL1,MAP3K8,CD83,CIRBP,MT1X,LTB,MT-ND4L,SLPI,ANKRD12,MYC,RPL36A,CAPZA1,GZMB,MT-CO3,P2RX5,RAN,S100A4,RPS21,EIF4G2,MORF4L1,HLA-B,RPL11,PIM2,ATP5D,ANAPC5,H3F3B,EIF6,HLA-DQB1,ITM2A,SNX9,DDX5,LMNA	Graft-versus-host disease; Type I diabetes mellitus; Allograft rejection; Allograft rejection; Graft-versus-host disease	TNF-alpha Signaling via NF-kB; Interferon Gamma Response; Myc Targets V1	interferon-gamma-mediated signaling pathway (GO:0060333); cytokine-mediated signaling pathway (GO:0019221); antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	Translocation of ZAP-70 to Immunological synapse Homo sapiens R-HSA-202430; Phosphorylation of CD3 and TCR zeta chains Homo sapiens R-HSA-202427; PD-1 signaling Homo sapiens R-HSA-389948	Allograft rejection; Graft-versus-host disease; BDNF signaling pathway	Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217	Graft-versus-host disease; Type I diabetes mellitus; Allograft rejection	MHC class II receptor activity (GO:0032395); MHC class II protein complex binding (GO:0023026); cadherin binding (GO:0045296)	CIITA,FOXO1,PAX5,KMT2A,MYC,SPI1,TBP,BRD4,CD74,KAT2B,MED1,BHLHE40,GATA3,CREBBP,RELA,CTCF,JUND,RUNX1,ZNF143,ZNF30	Raji,B Lymphocyte,Blood	HMGN2,LITAF,FOSB,PFDN5,KLF2	CIITA,FOXO1,PAX5,SPI1,BRD4	MYC	MYC,FOS,CREM	Plasma
60	MeC_60	JUN	RGS1,JUN,S100A4,GNLY,RPL17,RPS18,ACTB,RPL7,HSPA1A,BTG1,MALAT1,IL1B,RPS3,RPS3A,CD55,RPS14,CD69,MT-CYB,G0S2,RBM39	RGS1,JUN,S100A4,GNLY,RPL17,RPS18,ACTB,RPL7,HSPA1A,BTG1,MALAT1,IL1B,RPS3,RPS3A,CD55,RPS14,CD69,MT-CYB,G0S2,RBM39,MT-ND2,IFITM3,RPL9,S100A9,NKG7,UBB,RPL26,CLEC2B,LYZ,DUSP4,MIF,FTH1,RPLP0,ITM2B,SOD2,CD63,RPS13,EEF1G,CCL2,S100A6,SRP14,RPL21,IFRD1,HSPA8,CXCL2,CIB1,TSPO,DYNLL1,TMEM59,GMFG,HAMP,RPL15,ACKR1,ZC3HAV1,RP11-138A9.2,MT-ATP6,DNAJA1,RPL8,RPS6,CCNL1,ATP5L,CYTIP,CYBA,AHSA1,HMGN3,COX7B,TIMP1,S100A8,EIF1AX,ATP1B3,IGFBP7,CXCL8,FKBP4,RPLP2,EIF3G,TUBA1B,SUMO2,LDHA,MT-ND5,CTSW,MGP,IFITM2,ARGLU1,FAM133B,GADD45B,FUS,PPP1CB,ANXA2,PDIA3,TPI1,RPL13,AIF1,MT-CO2,GPR65,CLDN5,GUK1,RNASET2,NBEAL1,CCL3,LGALS3	Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279; GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706; Translation Homo sapiens R-HSA-72766	Apoptosis; TNF-alpha Signaling via NF-kB; Inflammatory Response	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); protein targeting to ER (GO:0045047)	Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279	Translation; Cytoplasmic ribosomal proteins; Influenza infection	Cytoplasmic Ribosomal Proteins WP477; Lung fibrosis WP3624; Spinal Cord Injury WP2431	Coronavirus disease; Ribosome; Lipid and atherosclerosis	RNA binding (GO:0003723); C3HC4-type RING finger domain binding (GO:0055131); mRNA 5'-UTR binding (GO:0048027)	KAT2B,RELA,HSF1,SNAPC1,WDR5,TP53,RUNX1,CEBPA,ERG,SPI1,KMT2A,MED1,STAT3,BRD4,RXRG,ZBED1,EZH2,IRF1,NELFE,EBF1	HeLa-S3,Epithelium,Cervix	BTG1	KAT2B,RELA,HSF1,TP53,RUNX1	JUN	JUN	CD4Teff,CD8Tex
61	MeC_61	FOS,JUNB,JUN,KLF6,TSC22D3,FOSB,KLF2,NR4A2,LITAF,XBP1	FOS,DUSP1,JUNB,JUN,KLF6,TSC22D3,CD69,PPP1R15A,ZFP36,CXCR4,UBC,TUBA1A,FOSB,H3F3B,TAGAP,UCP2,BTG2,ZFP36L2,CITED2,RGS2	FOS,DUSP1,JUNB,JUN,KLF6,TSC22D3,CD69,PPP1R15A,ZFP36,CXCR4,UBC,TUBA1A,FOSB,H3F3B,TAGAP,UCP2,BTG2,ZFP36L2,CITED2,RGS2,NFKBIA,DNAJB1,PNRC1,EIF1,TNFAIP3,RPS26,KLF2,TUBA1B,UBB,NR4A2,GZMB,SRSF3,IER2,YPEL5,RHOA,FKBP5,CCND3,PMAIP1,PPIA,DUSP2,LITAF,IGHM,COX7A2,TUBA4A,IDH2,RBM3,SRSF7,HMGN2,RPS4Y1,MORF4L1,RGS1,EIF4A1,EIF3F,SRSF5,IL6ST,GZMH,HSPA8,TCL1A,YWHAQ,RPL36AL,PPP1CA,SLC2A3,HNRNPK,CYCS,ACTG1,CD27,IFNG,GZMA,GBP5,KRT10,HNRNPDL,HNRNPA0,XBP1,CCNL1,NEAT1,COX7C,ADTRP,GTF3A,KIAA1551,STAT1,GADD45B,APOBEC3G,ZNF331,SUB1,ARPC2,EEF1B2,ITGB2,HIST1H4C,ENO1,CALM2,DBI,PRF1,CNN2,COMMD6,EIF4A2,SOCS3,RPL39,JUND,IDS,CTLA4	TNF-alpha Signaling via NF-kB; Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Hypoxia; BDNF signaling pathway	TNF-alpha Signaling via NF-kB; Hypoxia; UV Response Up	cellular response to cytokine stimulus (GO:0071345); apoptotic process (GO:0006915); cytokine-mediated signaling pathway (GO:0019221)	Gene Expression Homo sapiens R-HSA-74160; Signaling by TGF-beta Receptor Complex Homo sapiens R-HSA-170834; Interferon Signaling Homo sapiens R-HSA-913531	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; BDNF signaling pathway	Pathogenic Escherichia coli infection WP2272; Oncostatin M Signaling Pathway WP2374; Nuclear Receptors Meta-Pathway WP2882	Apoptosis; Osteoclast differentiation; Parkinson disease	RNA binding (GO:0003723); ubiquitin-like protein ligase binding (GO:0044389); ubiquitin protein ligase binding (GO:0031625)	CD74,CREBBP,KAT2B,NR3C2,RELA,BRD4,FOXO1,MED1,MAF,ZMYND11,TCF7L1,MYB,SPI1,SMAD1,T,NCOR1,HDAC6,NFE2,CPSF3L,CEBPA	B Lymphocyte	TSC22D3,FOSB,CITED2,NFKBIA,KLF2	CREBBP,KAT2B,NR3C2,RELA,BRD4	JUN,JUND,FOS,STAT1,STAT3	JUN,JUND,FOS,STAT1,STAT3,JUNB,XBP1,KLF6	MAIT,Endothelial,Mast,M2
62	MeC_62	JUNB,CREM,FOSB,ZNF655	JUNB,ZFP36,HSPA1B,IER2,DNAJB1,RPS15A,RPL8,EEF1A1,EEF1G,BTG1,GADD45B,CREM,PTMA,RPL27,CORO1A,RPS6,TUBA1B,IFI27,RACK1,HLA-DRB1	JUNB,ZFP36,HSPA1B,IER2,DNAJB1,RPS15A,RPL8,EEF1A1,EEF1G,BTG1,GADD45B,CREM,PTMA,RPL27,CORO1A,RPS6,TUBA1B,IFI27,RACK1,HLA-DRB1,RGS2,RPS11,RPL23A,CD74,HSPA1A,RPS3,RPS10,FOSB,GPR183,RPL13A,ENO1,ANXA2,CD52,ZFP36L2,RPL36AL,MYL12A,TPT1,NACA,RPL34,ALDOA,RPSA,TNFAIP3,SUMO2,PTPRC,CXCL13,EEF1B2,CHMP1B,VIM,TSPYL2,HNRNPH1,HLA-DRA,ISG15,RBKS,RBMX,TRBC2,FKBP1A,TRAT1,PABPC1,SPARC,SYTL3,MYL12B,SOD1,RPLP2,CCL3,COTL1,MT-ND3,RPL29,SOCS3,IGFBP7,IFITM1,RPL28,MT-ND4,HLA-A,ZNF655,ITM2B,MYDGF,SPP1,C15orf48,HMGN2,TPI1,COX4I1,CRIP1,RPL12,H2AFZ,TMBIM6,TAGAP,MRPL1,SERF2,MRPL23,CSTB,DEF6,ARF5,LDHA,DCXR,CKS1B,ATP5IF1,PSMA1,HILPDA,SCAND1,ITM2C	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Translation; Translation Homo sapiens R-HSA-72766; Peptide chain elongation Homo sapiens R-HSA-156902; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956	Myc Targets V1; TNF-alpha Signaling via NF-kB; Hypoxia	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); cotranslational protein targeting to membrane (GO:0006613)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Translation Homo sapiens R-HSA-72766; Peptide chain elongation Homo sapiens R-HSA-156902	Translation; Influenza viral RNA transcription and replication; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Glycolysis and Gluconeogenesis WP534	Ribosome; Coronavirus disease; Antigen processing and presentation	RNA binding (GO:0003723); cadherin binding (GO:0045296); MHC class II protein complex binding (GO:0023026)	KAT2B,EZH2,KLF10,REL,BRD4,TP53,RELA,SMAD5,GTF2F1,MED1,MAFB,GTF2B,CPSF3L,NELFE,MAF,EZH1,ELL2,CREBBP,RFX5,SNAPC1	GM12878,B Lymphocyte,Blood	BTG1,FOSB,ENO1,ZNF655,HMGN2	KAT2B,EZH2,KLF10,REL,BRD4	CREM	CREM,JUNB	MAIT,Mast
63	MeC_63	JUN,JUNB	HLA-DRA,HLA-DRB1,HLA-DPA1,HLA-DQA1,IFI30,HLA-DRB5,TUBA1B,HLA-DQB1,RPL4,S100A4,DUSP2,NKG7,SRGN,TPT1,PPP1R15A,MALAT1,RPL31,RPS18,RPS3,SAT1	HLA-DRA,HLA-DRB1,HLA-DPA1,HLA-DQA1,IFI30,HLA-DRB5,TUBA1B,HLA-DQB1,RPL4,S100A4,DUSP2,NKG7,SRGN,TPT1,PPP1R15A,MALAT1,RPL31,RPS18,RPS3,SAT1,RPS19,CXCL10,RPS15,RPLP1,APOE,GSN,TRBC2,JUN,A2M,RPL10,BTG1,HLA-A,TMSB10,EIF1,IER2,RPL36,FCGBP,GNLY,WARS,MYL6,C3AR1,IFITM1,CCL2,RPS15A,ITM2B,MYL12A,MTRNR2L8,SARAF,CD9,ACTB,CXCL3,MT-ND3,UBB,JUNB,RPL13AP5,MTRNR2L1,SLC25A3,RPS3A,CALM1,HLA-DMA,P2RY12,AREG,HSPA1B,MT-ND4,PABPC1,UBA52,RPL38,CST7,ANXA2,LIPA,HLA-DMB,KLRK1,RPL32,HNRNPA2B1,TXNIP,IFI27,S100A10,MGP,CTSC,SPARC,FAU,RPS10,MT-ND2,FCER1A,RPL35A,MYL12B,CD3D,IL7R,EEF1A1,IGHV1-46,IGHV4-34,COMP,ANXA5,RPS7,RPS28,TPI1,HLA-DQB2,CCR7,RPS14,DNAJB1	Peptide chain elongation Homo sapiens R-HSA-156902; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	TNF-alpha Signaling via NF-kB; Interferon Gamma Response; Allograft Rejection	cotranslational protein targeting to membrane (GO:0006613); nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); cytoplasmic translation (GO:0002181)	Peptide chain elongation Homo sapiens R-HSA-156902; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842	Translation; Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217	Coronavirus disease; Ribosome; Asthma	MHC class II receptor activity (GO:0032395); RNA binding (GO:0003723); MHC class II protein complex binding (GO:0023026)	CIITA,KAT2B,DRAP1,EZH2,BRD4,EZH1,RELA,MED1,CDK9,SMAD5,FOXP1,BMI1,CD74,KLF10,REST,REL,FAIRE,RFX5,NFYB,TCF12	Raji,B Lymphocyte,Blood	BTG1	CIITA,KAT2B,EZH2,BRD4,EZH1		JUNB,JUN	M1,cDC2,M2,pDC,Monocyte,B,cDC1
64	MeC_64	EGR1,FOSB,JUN,ID2,DDIT3,NR4A2,ATF4,NR4A1	IER2,EGR1,EIF4A3,FOSB,SERTAD1,TUBB4B,SAT1,JUN,CITED2,DNAJA1,BRD2,GADD45B,ID2,H2AFZ,DDIT4,TNF,SRSF2,DDX3X,DDIT3,BTG2	IER2,EGR1,EIF4A3,FOSB,SERTAD1,TUBB4B,SAT1,JUN,CITED2,DNAJA1,BRD2,GADD45B,ID2,H2AFZ,DDIT4,TNF,SRSF2,DDX3X,DDIT3,BTG2,DDX5,RSRP1,TPI1,NR4A2,ATF4,FUS,TOB1,SRSF5,CCNL1,H3F3B,UBB,SAP18,DYNLL1,EIF4A2,PPP1R15A,CHMP1B,C6orf62,WSB1,ARL6IP1,NXF1,NEU1,UBE2S,ZFAS1,TUBA1A,TXNIP,PPP1R10,CALM1,MAT2A,TUBA1B,SNHG12,EIF1,ARF4,GTF2B,CKS2,CYCS,SNHG8,IFRD1,MARCKSL1,SRSF7,H2AFX,HERPUD1,SLC38A2,SRSF3,FAM53C,ODC1,AREG,UBC,SNHG1,SFPQ,PCF11,PNRC1,CDKN1A,ZC3HAV1,CD53,TRAF3IP3,EIF5,GAS5,NR4A1,HNRNPH1,CD27,TMSB10,POLR2A,TUBA1C,NASP,SNHG5,SLC25A3,RHOB,POLR2L,PNP,ITM2B,PMAIP1,GPX1,HIST2H2AA4,GSTK1,SLC1A5,MYLIP,MCL1,HEXIM1,GLA,TUBA4A	TNF-alpha Signaling via NF-kB; BDNF signaling pathway; Apoptosis; Apoptosis; mRNA Splicing - Major Pathway Homo sapiens R-HSA-72163	TNF-alpha Signaling via NF-kB; Apoptosis; mTORC1 Signaling	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377); mRNA splicing, via spliceosome (GO:0000398); mRNA processing (GO:0006397)	mRNA Splicing - Major Pathway Homo sapiens R-HSA-72163; mRNA Splicing Homo sapiens R-HSA-72172; Processing of Capped Intron-Containing Pre-mRNA Homo sapiens R-HSA-72203	BDNF signaling pathway; T cell receptor regulation of apoptosis; Capped intron-containing pre-mRNA processing	mRNA Processing WP411; Pathogenic Escherichia coli infection WP2272; DNA Damage Response WP707	Apoptosis; Amyotrophic lateral sclerosis; Parkinson disease	RNA binding (GO:0003723); ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389)	KAT2B,NR3C2,NELFE,DNMT3B,CPSF3L,MAFB,PHF8,SNAPC1,GTF2B,SNRNP70,ELL2,RELA,BRD4,PAF1,HDAC6,GTF2F1,MAF,MED1,TET2,REL	GM12878,B Lymphocyte,Blood	FOSB,SERTAD1,CITED2,ID2,SRSF2	KAT2B,NR3C2,DNMT3B,MAFB,RELA	EGR1	EGR1,FOS,JUN,NR4A1,ATF4,DDX5	Mast
65	MeC_65	ID2,REL,BATF,ZBTB32,CREM,VDR,STAT3,ID3,GATA3	TNFRSF4,TNFRSF18,TNFRSF9,ID2,SERPINB9,CLEC2D,SH2D2A,LGALS1,SYNGR2,ICOS,DDIT4,NFKBIA,BIRC3,PKM,REL,TNFRSF1B,IL2RA,TRAF1,CFLAR,NINJ1	TNFRSF4,TNFRSF18,TNFRSF9,ID2,SERPINB9,CLEC2D,SH2D2A,LGALS1,SYNGR2,ICOS,DDIT4,NFKBIA,BIRC3,PKM,REL,TNFRSF1B,IL2RA,TRAF1,CFLAR,NINJ1,DUSP2,RHOG,IL21R,IL1R2,EMP3,CCND2,ZFP36,CCR8,CD82,TYMP,PIM3,PTP4A3,MIR155HG,BATF,MAP2K3,APOBEC3G,ZBTB32,SDC4,CST7,HSP90AB1,GADD45B,CXCR6,HSPA5,CREM,TFRC,TUBB,LCP1,DOK2,BCL2L1,FYN,TNFAIP3,HSPB1,PPA1,ANP32E,RHOH,KCNN4,PSMA2,ZFP36L1,RAN,GADD45A,NDFIP1,VDR,LDHA,ANXA6,GRSF1,C7orf25,PTPN6,STAT3,ID3,CXCR3,SMS,LTA,NFKBID,NCL,CCL22,PSMA6,SLC3A2,LY75,SLC7A5,IL21R-AS1,ARF6,PDIA6,EBI3,MAT2A,MYO1G,NAMPT,SOD1,LINC01588,SYTL3,SPECC1L,GATA3,HLA-DQA1,GCNT1,TC2N,ZNFX1,RBM3,ADORA2A,RHOF,LAIR2,PARK7	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; TNF-alpha Signaling via NF-kB; IL-2/STAT5 Signaling; cytokine-mediated signaling pathway (GO:0019221)	TNF-alpha Signaling via NF-kB; IL-2/STAT5 Signaling; Inflammatory Response	cytokine-mediated signaling pathway (GO:0019221); cellular response to tumor necrosis factor (GO:0071356); tumor necrosis factor-mediated signaling pathway (GO:0033209)	Immune System Homo sapiens R-HSA-168256; TNFR2 non-canonical NF-kB pathway Homo sapiens R-HSA-5668541; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; TNF-alpha signaling pathway	TNF alpha Signaling Pathway WP231; Apoptosis WP254; VEGFA-VEGFR2 Signaling Pathway WP3888	NF-kappa B signaling pathway; Cytokine-cytokine receptor interaction; TNF signaling pathway	kinase binding (GO:0019900); cytokine receptor activity (GO:0004896); C-C chemokine binding (GO:0019957)	CD74,RELA,LYL1,NFKB2,NFKB1,CDK9,T,EBF1,RELB,RBPJ,PML,MYB,STAT3,GATA3,ZNF597,TCF7L1,STAT5,STAT5B,JUND,RARA	B Lymphocyte	ID2,NFKBIA,ZBTB32,CREM,RAN	RELA,LYL1,NFKB1,T,EBF1	STAT3,GATA3,NFKB2,REL,IKZF1,BATF	STAT3,GATA3,NFKB2,REL,IKZF1,BATF,RUNX3,STAT5A,IRF4,VDR,NR4A1,FOXP3,ID3,POU2F2,PRDM1,YBX1,CSDE1	Treg,cDC1,Mast,Th1,cDC2,CD8Tex
66	MeC_66	JUN	CCL2,EIF4A3,DBI,TUBA1B,MT2A,CYR61,RPL21P28,RPL19,RPS14,CD14,FCER1G,FCN3,IL6,EMP1,JUN,CSF3,RPL18A,PLAUR,PLEK,GPR183	CCL2,EIF4A3,DBI,TUBA1B,MT2A,CYR61,RPL21P28,RPL19,RPS14,CD14,FCER1G,FCN3,IL6,EMP1,JUN,CSF3,RPL18A,PLAUR,PLEK,GPR183,RPS6,PFN1,HNRNPA1,RPL8,CKB,RPL10A,H2AFZ,RPL3,ERRFI1,A2M,C6orf62,GPX1,BIRC3,TUBB4B,ISG20,ZFP36,RPL41,COCH,PTGDS,HMOX1,PLPP3,TGFBI,COL1A1,CTSL,PABPC1,RPL12,SLC25A5,RPS7,IL1RL1,SERPINE1,GADD45B,BRI3,DNAJB1,CD53,DAB2,MARCKS,ICAM1,GSTO1,NEAT1,RPS4Y1,RPS27,RGS2,LINC00152,HSPB1,NINJ1,BTG1,SPARCL1,SEPT11,RPL34,PTGES,FAM3C,LGALS3,NPM1,NPY,CYP1B1,RPS5,RPL13AP5,HLA-C,CALM2,LYZ,H1FX,MPC2,SSR3,TIMP1,RPL15,CXCR4,PSME2,S100A4,CST3,CNN3,RPL27A,CD44,PHLDA2,MAP2K3,H3F3B,MAT2A,CHIC2,RPS10,TM4SF1,MT1M	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Peptide chain elongation Homo sapiens R-HSA-156902; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827	TNF-alpha Signaling via NF-kB; Apoptosis; Hypoxia	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956	Influenza viral RNA transcription and replication; Translation; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Lung fibrosis WP3624; Senescence and Autophagy in Cancer WP615	Coronavirus disease; Ribosome; Fluid shear stress and atherosclerosis	RNA binding (GO:0003723)	ZNF22,STAT5A,PPARG,TP53,STAT3,MAFB,RXRG,PML,FOXA2,RARA,EZH2,GTF2B,FLI1,RELA,MYC,NELFE,CPSF3L,IRF1,KAT2B,TCF21	HEK293,Epithelium,Embryonic Kidney	BTG1,NPM1	ZNF22,STAT5A,PPARG,TP53,STAT3	JUN	JUN	TMKI67,M1,cDC2,M2,Fibroblasts
67	MeC_67	TSC22D3,NR4A1,ARID5B,YBX1,LITAF,KLF6,ELF1,CREM,SUB1,ARID4B	HSPA1A,HSPA1B,DDIT4,SAT1,DNAJB1,SON,GNLY,HSP90AA1,H2AFZ,MORF4L1,MT2A,FTH1,TSC22D3,HNRNPA2B1,GIMAP7,WSB1,HSPH1,PCBP1,NR4A1,PDCD4	HSPA1A,HSPA1B,DDIT4,SAT1,DNAJB1,SON,GNLY,HSP90AA1,H2AFZ,MORF4L1,MT2A,FTH1,TSC22D3,HNRNPA2B1,GIMAP7,WSB1,HSPH1,PCBP1,NR4A1,PDCD4,HNRNPK,ZFAS1,AREG,H3F3A,ARID5B,CD74,NDUFS5,NEAT1,CLEC2D,BTG1,HLA-DRB1,YBX1,VIM,ATP6V0E1,LITAF,COX8A,CXCR4,CXCL13,DDX5,MGP,SLC25A6,KLF6,COX6A1,ARHGDIB,COMMD6,PPIB,SELT,C19orf53,SLC25A3,H2AFV,DDX17,ELF1,IFI16,UQCRB,ATP5L,BIRC3,BRK1,SH3BGRL3,CCL4,CD48,TPI1,LTB,RBM25,ZFP36L1,RTN4,GABARAPL1,CREM,TAF1D,CDK2AP2,APOC1,JTB,SERP1,LIMD2,BAG3,SUB1,RBM39,CHCHD2,ARID4B,HNRNPLL,ANXA2,CALM2,SEC11A,SRP14,ATP5G3,CORO1A,MT1E,NDUFB11,NR4A2,ANXA5,PCBP2,MAT2B,LAPTM4A,CD99,IGFBP7,SNRPG,RGCC,ATPIF1,POMP,HMGB1,SUMO2	RNA binding (GO:0003723); T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; Electron transport chain; Hypoxia	Hypoxia; TNF-alpha Signaling via NF-kB; Oxidative Phosphorylation	response to unfolded protein (GO:0006986); mRNA metabolic process (GO:0016071); regulation of cellular response to heat (GO:1900034)	HSF1 activation Homo sapiens R-HSA-3371511; Attenuation phase Homo sapiens R-HSA-3371568; HSF1-dependent transactivation Homo sapiens R-HSA-3371571	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; Electron transport chain	Ferroptosis WP4313; mRNA Processing WP411; Electron Transport Chain (OXPHOS system in mitochondria) WP111	Spliceosome; Prion disease; Antigen processing and presentation	RNA binding (GO:0003723); ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389)	KAT2B,HSF1,BRD4,MEF2B,RELA,STAT5B,MAFB,MYB,CREBBP,CD74,PAF1,IRF1,ELL2,GTF2B,TP53,NR3C2,CPSF3L,TAF1,SPI1,CEBPB	GM12878,B Lymphocyte,Blood	MORF4L1,TSC22D3,ARID5B,BTG1,YBX1	KAT2B,HSF1,BRD4,MEF2B,RELA	CEBPB,NR4A1,ELF1	CEBPB,NR4A1,ELF1,CREM,DDX5,TAF7,KLF6	Treg,cDC1
68	MeC_68	NR4A1,NR4A2,REL,EGR2,ID2,ARID5B,EGR1,NR4A3,KLF6,IRF4	NFKBIA,CD69,SDCBP,ZFP36L1,NR4A1,DUSP2,NR4A2,NFKBID,EVI2A,REL,GBP2,IFNG,TAGAP,ICOS,IER2,BIRC3,CD48,TNF,RGCC,EGR2	NFKBIA,CD69,SDCBP,ZFP36L1,NR4A1,DUSP2,NR4A2,NFKBID,EVI2A,REL,GBP2,IFNG,TAGAP,ICOS,IER2,BIRC3,CD48,TNF,RGCC,EGR2,SLA,BTG2,SERPINB9,PTGER4,SRGN,ID2,ARID5B,RILPL2,NFKBIZ,GADD45B,KDM6B,TRAF1,PIM3,EGR1,RHOH,NR4A3,NAMPT,CRTAM,MIR155HG,PTPN7,RNF19A,PRNP,TNFRSF9,FASLG,MAP3K8,RASSF5,KLF6,HCST,TNFAIP3,HNRNPA2B1,TIGIT,SOD1,IRF4,XCL2,TNFSF14,CD53,CREM,GHITM,LBH,SRSF5,EVI2B,XCL1,SYNE2,GZMB,DENND2D,EZR,CD83,FOXP1,TNFRSF1B,ITM2B,NDFIP1,BCL2A1,DEK,TUBA4A,ISG20,STAT3,VSIR,CKLF,EIF4G2,CYTOR,MAP2K3,CD52,ARL6IP1,PPP1R2,CD2,PHLDA1,PTPN22,MYC,ARF6,DDX3X,KMT2E,UBE2D3,PDCD1,CFLAR,LINC00861,CTLA4,PGAM1,PPP1R15A,GBP5,ANXA5	TNF-alpha Signaling via NF-kB; T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; IL-2/STAT5 Signaling; Apoptosis WP254	TNF-alpha Signaling via NF-kB; IL-2/STAT5 Signaling; Apoptosis	cytokine-mediated signaling pathway (GO:0019221); negative regulation of cytokine production (GO:0001818); positive regulation of cytokine production (GO:0001819)	Immune System Homo sapiens R-HSA-168256; Death Receptor Signalling Homo sapiens R-HSA-73887; Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215	T cell receptor regulation of apoptosis; Interleukin-2 signaling pathway; TNF-alpha signaling pathway	Apoptosis WP254; TNF alpha Signaling Pathway WP231; T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection WP3863	NF-kappa B signaling pathway; Apoptosis; TNF signaling pathway	glucocorticoid receptor binding (GO:0035259); DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228); cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027)	CD74,CDK9,T,BRD4,GATA3,STAT5B,MAF,RELA,NCOR2,KMT2A,BCL6,IRF1,NCOR1,FOXO1,HDAC6,TAL1,TBX21,MEF2B,CREBBP,NFKB2	B Lymphocyte	NFKBIA,NR4A2,ID2,ARID5B,NR4A3	T,BRD4,GATA3,STAT5B,MAF	FOXP1,RUNX3,STAT3,REL,NR4A1,BATF,IRF4,JUNB,BHLHE40	FOXP1,RUNX3,STAT3,REL,NR4A1,BATF,IRF4,JUNB,BHLHE40,MYC,EGR1,EGR2,ATF3,NFE2L2,FOSL2	Mast,MAIT,M2
69	MeC_69	TSC22D3,ID2,ZNF331,CEBPD,HMGB1	CXCR4,IL32,HERPUD1,TSC22D3,ZFP36L2,GAPDH,RPLP0,RPL35,RPL19,ACTB,AREG,RPL37A,PTMA,MT-ND3,RPL5,CXCL13,RPS9,HSPA1A,SGK1,CD63	CXCR4,IL32,HERPUD1,TSC22D3,ZFP36L2,GAPDH,RPLP0,RPL35,RPL19,ACTB,AREG,RPL37A,PTMA,MT-ND3,RPL5,CXCL13,RPS9,HSPA1A,SGK1,CD63,ITM2B,CCL2,SAT1,GZMK,HSPA5,RPL7A,RPL18A,GPR183,YPEL5,RPS3A,RPL13,TUBA4A,IFITM2,DDIT4,GPX1,RPL26,MIF,RPL3,RPL11,MT-ND1,IFITM3,CYBA,TYROBP,HLA-DRA,TPI1,RNASET2,RPL38,IFI27,GZMA,TPT1,RPS19,ID2,KLRB1,GSTP1,IFI30,TPSAB1,ZNF331,SEPP1,RPS24,NEAT1,HAMP,FTL,CEBPD,TIMP1,AC020656.1,S100A9,AIF1,CPA3,RPS21,C5AR1,ENO1,CTSW,PGK1,RPL23,TNFRSF18,HLA-DRB5,EIF4A1,RPS11,CLU,RPS23,HSP90B1,TMSB10,LGALS1,ISG15,S100A11,MALAT1,MT-RNR1,CCL22,MGP,S100A6,CFD,HMGB1,SPP1,RPL8,LDHA,AC006064.4,HLA-E,CCL5,IL1B,GNLY	Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Selenocysteine synthesis Homo sapiens R-HSA-2408557; Eukaryotic Translation Termination Homo sapiens R-HSA-72764; L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827	Allograft Rejection; mTORC1 Signaling; TNF-alpha Signaling via NF-kB	cytoplasmic translation (GO:0002181); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613)	Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Selenocysteine synthesis Homo sapiens R-HSA-2408557	Cytoplasmic ribosomal proteins; Influenza infection; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Cori Cycle WP1946; Glycolysis and Gluconeogenesis WP534	Coronavirus disease; Ribosome; Antigen processing and presentation	RNA binding (GO:0003723); rRNA binding (GO:0019843); cytokine activity (GO:0005125)	MYC,KAT2B,TP53,MAFB,EZH2,RUNX1,KLF10,RELA,GTF2B,KMT2A,EZH1,NR3C1,STAT6,MAF,SNAPC1,SPI1,CREBBP,MYB,REL,CEBPB	U87,Glioblastoma cell	TSC22D3,ID2,ENO1	MYC,KAT2B,TP53,MAFB,EZH2		CEBPD,ZNF331	CD8Tex,Th1,CD8Tcm,CD8Tem
70	MeC_70	KLF6,RORA,ARID5B,HMGB2,JUN,IKZF3,MAF,ZBTB38	S100A4,KLF6,KLRB1,FYN,GPR183,S100A11,SYNE2,AHNAK,DUSP1,IL10RA,PPP2R5C,ANXA1,CLIC1,TIGIT,ALOX5AP,IFI16,PYHIN1,ITGB1,CLDND1,SLA	S100A4,KLF6,KLRB1,FYN,GPR183,S100A11,SYNE2,AHNAK,DUSP1,IL10RA,PPP2R5C,ANXA1,CLIC1,TIGIT,ALOX5AP,IFI16,PYHIN1,ITGB1,CLDND1,SLA,CD99,COTL1,GAPDH,SH3BGRL3,BIRC3,CD2,CD82,SRGN,IL32,CCR6,ANKRD12,GLIPR1,CD84,CCL5,RNF19A,MYO1F,KIAA1551,PLP2,S100A10,GSTK1,RORA,ARID5B,CD74,CD69,FXYD5,OPTN,HMGB2,JUN,SAT1,ANXA2,STOM,INPP4B,IL2RB,RNASET2,MIAT,GZMK,SH2D1A,TTC39C,YWHAB,IKZF3,RCSD1,ZFP36L2,NCL,RGS1,IDS,CST7,CTSA,LCP1,NFKBIA,MAF,PBXIP1,TXN,EML4,NABP1,PTPRC,SLAMF1,LYAR,TRADD,RPL22L1,CRIP1,EZR,MBP,LTB,IL7R,FCRL3,KLRC4-KLRK1,ARPC1B,LIMS1,KLRK1,CYBA,PPP1R15A,SPCS2,CKLF,PTPRCAP,ZBTB38,ARHGAP15,MACF1,ICAM3,FAS,CXCR5	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; TNF-alpha Signaling via NF-kB; Inflammatory Response; Pathogenic Escherichia coli infection	TNF-alpha Signaling via NF-kB; Inflammatory Response; Interferon Gamma Response	cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345); regulation of DNA binding (GO:0051101)	Immune System Homo sapiens R-HSA-168256; Adaptive Immune System Homo sapiens R-HSA-1280218; Regulated Necrosis Homo sapiens R-HSA-5218859	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; BDNF signaling pathway	TNF alpha Signaling Pathway WP231; VEGFA-VEGFR2 Signaling Pathway WP3888; Pathogenic Escherichia coli infection WP2272	Pathogenic Escherichia coli infection; Salmonella infection; TNF signaling pathway	actin binding (GO:0003779); cadherin binding (GO:0045296); chemokine binding (GO:0019956)	CD74,T,MYB,GATA3,KMT2A,JUNB,FOXP3,NR3C1,LYL1,FOXO1,STAT5B,BACH2,SPI1,STAT6,RUNX1T1,CREBBP,TAL1,EBNA3,SMAD1,JUND	B Lymphocyte	KLF6,IFI16,PYHIN1,RORA,ARID5B	T,MYB,FOXP3,NR3C1,LYL1	GATA3,JUNB,IRF1,JUN,FOS,MAF	GATA3,JUNB,IRF1,JUN,FOS,MAF,SP140	MAIT
71	MeC_71	ID2,JUNB,KLF6	MT-CO2,TPT1,MT-ND1,MT-ND3,EEF1A1,MT-ND2,MT-RNR1,RPL19,MT-ND5,PABPC1,RPL41,HLA-B,RPL17,HLA-C,CCL5,HLA-A,RPS16,DUSP2,TNFAIP3,RPS27	MT-CO2,TPT1,MT-ND1,MT-ND3,EEF1A1,MT-ND2,MT-RNR1,RPL19,MT-ND5,PABPC1,RPL41,HLA-B,RPL17,HLA-C,CCL5,HLA-A,RPS16,DUSP2,TNFAIP3,RPS27,RPL4,PTMA,RPS23,HSPA1A,RPS29,RPS15A,RPL30,MT-ATP6,RPL27A,SRGN,IFITM1,ID2,SPP1,IFITM2,DNAJB1,RPL5,RPL18A,RPL37A,VIM,EIF1,RPSA,RPL39,NFKBIA,VSIG4,IGHA2,JUNB,COX4I1,RPL23A,DUSP1,PSME1,CD69,NEAT1,RPL7A,RPS4X,PPIA,NACA,RPS17,S100A11,HLA-E,EMP3,CD74,S100A10,GABARAP,IL32,TMSB10,TRBC2,RPL26,HLA-DRB1,G0S2,MTRNR2L1,S100A9,RPL35A,GZMK,PLAUR,MTRNR2L12,IFI6,MT-CYB,UBC,RPS6,GZMA,RPS3A,FN1,CD8A,LGALS1,IGKV2-28,TXN,C1QA,MT-ATP8,SLC25A6,ALOX5AP,KLF6,RPL10,IGHM,GADD45B,AIF1,CSTB,RPL12,GRN,HLA-DRB5,CD81	Peptide chain elongation Homo sapiens R-HSA-156902; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Selenocysteine synthesis Homo sapiens R-HSA-2408557	TNF-alpha Signaling via NF-kB; Interferon Gamma Response; Epithelial Mesenchymal Transition	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cytoplasmic translation (GO:0002181); cotranslational protein targeting to membrane (GO:0006613)	Peptide chain elongation Homo sapiens R-HSA-156902; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842	Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication; Influenza infection	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Proteasome Degradation WP183	Ribosome; Coronavirus disease; Antigen processing and presentation	RNA binding (GO:0003723); mRNA 5'-UTR binding (GO:0048027); MHC protein binding (GO:0042287)	EZH2,TP53,EZH1,MED1,RELA,SNAPC1,GTF2B,KAT2B,MAF,SMAD5,FOXP1,MYC,BRD4,NELFE,CBFB,DRAP1,NIPBL,KAT5,CDK9,AFF4	Proerythroblast,Fetal Liver	ID2,NFKBIA	EZH2,TP53,EZH1,MED1,RELA			MAIT
72	MeC_72	JUN,TSC22D3	SAT1,BTG1,ZFP36L2,RPS4X,EEF1A1,RPLP2,JUN,RPS15,S100A4,CD74,GZMA,TUBA1B,CSTB,CD52,RPS27,HSPA1A,PFN1,MT-ND3,RPS3,LGALS3	SAT1,BTG1,ZFP36L2,RPS4X,EEF1A1,RPLP2,JUN,RPS15,S100A4,CD74,GZMA,TUBA1B,CSTB,CD52,RPS27,HSPA1A,PFN1,MT-ND3,RPS3,LGALS3,RPL3,TMSB10,MT-CYB,RPL31,RPLP1,RPLP0,RPS18,ACTG1,HSPA1B,MT2A,PRDX1,TXN,FABP5,PLTP,SEC61B,HLA-C,EIF5A,STMN1,CALM2,GLTSCR2,PARK7,P4HB,HNRNPK,CD3D,HMGN2,SPP1,MALAT1,GSN,PPIA,TOB1,LMNA,HNRNPA2B1,ACTA2,RPS16,SF3B5,SNU13,CCL5,DAD1,SFRP2,AQP1,RPL4,RPS20,NKG7,IGFBP7,SEC61G,SF1,RPL23A,RPS29,CCL3,CD7,TSC22D3,CRIP1,RPS19,INSIG1,DNAJB9,SDF2L1,TUBB,IGHG4,CYTIP,CCL4,XRCC6,PLIN2,SERBP1,SPARC,CALR,RPS27A,CLDN5,ARL4A,BCAS2,APOC1,RPL35,PDIA6,PTGES3,FABP4,ARF1,C9orf16,SLC38A2,EID1,HNRNPF,NDUFA4	Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane (GO:0006614); Viral mRNA Translation Homo sapiens R-HSA-192823	Allograft Rejection; Myc Targets V1; Androgen Response	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); protein targeting to ER (GO:0045047); cotranslational protein targeting to membrane (GO:0006613)	Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339	Translation; Influenza infection; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Lung fibrosis WP3624; Senescence and Autophagy in Cancer WP615	Ribosome; Coronavirus disease; Protein processing in endoplasmic reticulum	RNA binding (GO:0003723); CCR1 chemokine receptor binding (GO:0031726); CCR5 chemokine receptor binding (GO:0031730)	KAT2B,EZH2,NR3C2,TP53,KLF10,EZH1,GTF2B,GTF2A2,SNAPC1,GTF2E2,BRD4,MED1,CDK7,BCL3,ELL2,CPSF3L,SCML2,MAFB,BMI1,FOXP1	Proerythroblast,Fetal Liver	BTG1,HMGN2,TSC22D3	KAT2B,EZH2,NR3C2,TP53,KLF10		JUN	Th1
73	MeC_73	TSC22D3,JUNB	RPL27A,MT-ATP8,RPS9,RPL3,RPS18,RPL27,CXCR4,HLA-A,CALM2,EIF4A2,RPS6,RPL38,RPL37A,MT-ATP6,ANXA2,SRSF7,RPS29,SRSF2,EIF3E,ZFAS1	RPL27A,MT-ATP8,RPS9,RPL3,RPS18,RPL27,CXCR4,HLA-A,CALM2,EIF4A2,RPS6,RPL38,RPL37A,MT-ATP6,ANXA2,SRSF7,RPS29,SRSF2,EIF3E,ZFAS1,RPL35,SRSF5,RPL21,RPS27,RPS20,RPL10A,RBM3,TSC22D3,RPS11,HNRNPC,TMSB4X,MT-ND1,SSR4,RPL4,STK4,CALR,CD44,TUBA1B,MTRNR2L12,HLA-B,HNRNPA0,RPL23A,JUNB,RPL13A,EIF3G,RPL9,EIF3D,ATP5B,EIF3L,LGALS1,GLTSCR2,CRIP1,RPS25,TPT1,HCST,SF3B1,DUSP1,CAPZA1,LAPTM5,LTB,ZFP36,C6orf48,CD6,RPS16,LPXN,HSP90AA1,CORO1A,CYCS,SRSF3,RBM39,UXT,PRRC2C,RPL13,RPL23,HSPA1B,TOMM20,TRMT112,TUBA4A,BSG,CLEC2D,EDF1,PIM2,CCNL1,UQCRH,PTPN22,ICAM3,N4BP2L2,BUB3,SNHG8,CHD2,HLA-C,TOMM7,UBA52,CD63,AHNAK,CFL1,ARGLU1,CD7,FKBP8,RPL17	L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279; Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689; Eukaryotic Translation Initiation Homo sapiens R-HSA-72613	Myc Targets V1; Allograft Rejection	cytoplasmic translation (GO:0002181); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613)	L13a-mediated translational silencing of Ceruloplasmin expression Homo sapiens R-HSA-156827; GTP hydrolysis and joining of the 60S ribosomal subunit Homo sapiens R-HSA-72706; 3' -UTR-mediated translational regulation Homo sapiens R-HSA-157279	Cytoplasmic ribosomal proteins; Translation; Influenza infection	Cytoplasmic Ribosomal Proteins WP477; mRNA Processing WP411; Translation Factors WP107	Ribosome; Coronavirus disease; Antigen processing and presentation	RNA binding (GO:0003723); translation initiation factor activity (GO:0003743); ubiquitin protein ligase binding (GO:0031625)	KAT2B,BRD4,FOXM1,MYC,MED1,GTF2B,ZNF22,SNRNP70,SNAPC1,BCL3,MAFB,EZH2,TP53,BMI1,AFF4,NELFE,FOXP1,DNMT3B,PAF1,CPSF3L	HeLa-S3,Epithelium,Cervix	SRSF2,TSC22D3,EDF1,ID2,MORF4L1	KAT2B,BRD4,FOXM1,MYC,MED1	TAF7	TAF7,CHD2,JUNB,XBP1,CSDE1	CD8Tn,CD4Tn
74	MeC_74	HMGB2,ID2,SUB1,CEBPD	S100A8,S100A9,S100A12,HMGB2,VCAN,SELL,CTSD,PKM,RETN,ALOX5AP,METTL9,SLC2A3,GAPDH,LTA4H,FCN1,SERPINB1,PGAM1,VIM,TSPO,PLAC8	S100A8,S100A9,S100A12,HMGB2,VCAN,SELL,CTSD,PKM,RETN,ALOX5AP,METTL9,SLC2A3,GAPDH,LTA4H,FCN1,SERPINB1,PGAM1,VIM,TSPO,PLAC8,TALDO1,CCND3,LGALS1,CSTA,MNDA,PLBD1,CAPG,PGD,NCF1,ITGAM,CTSS,ID2,APLP2,GRN,CES1,NDUFB9,GCA,MYH9,RBP7,QPCT,CD36,SUB1,MSN,MEGF9,RNASE2,MCL1,MSRB1,MGST1,STXBP2,COX6C,GLIPR1,IGHM,CYP1B1,ENO1,PSMA7,ARF1,UQCRH,RHOG,WSB1,PPDPF,CEBPD,BLVRB,ANXA6,CD14,CKAP4,NUP214,PADI4,RNF213,CSTB,MCEMP1,LYZ,ARHGDIB,YPEL5,TKT,MGST3,MS4A6A,EMB,PLEC,ZFAND5,CAP1,STK17B,ADD3,KCTD12,PPIA,NDUFA11,RPS21,TPM3,CYBB,SQSTM1,BLOC1S1,LBR,CDC42,S100A6,RP11-1143G9.4,ATP5I,RPL37A,CSF3R,COX7B,TMPO,ARPC5	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312); Complement; Metabolic reprogramming in colon cancer WP4290	Complement; Adipogenesis; mTORC1 Signaling	neutrophil mediated immunity (GO:0002446); neutrophil activation involved in immune response (GO:0002283); neutrophil degranulation (GO:0043312)	Metabolism Homo sapiens R-HSA-1430728; Metabolism of carbohydrates Homo sapiens R-HSA-71387; Cross-presentation of particulate exogenous antigens (phagosomes) Homo sapiens R-HSA-1236973	TGF-beta regulation of extracellular matrix; Leptin influence on immune response; T cell receptor regulation of apoptosis	Metabolic reprogramming in colon cancer WP4290; Pentose Phosphate Metabolism WP134; Glycolysis and Gluconeogenesis WP534	Diabetic cardiomyopathy; Phagosome; Non-alcoholic fatty liver disease	RAGE receptor binding (GO:0050786); icosatetraenoic acid binding (GO:0050543); arachidonic acid binding (GO:0050544)	LYL1,SMAD1,FLI1,CEBPA,JMJD1C,KMT2A,CEBPB,RUNX1,SPI1,RXRG,MED12,NFE2,STAT1,BRD4,USP7,RUNX1T1,IRF1,TP53,NCOR1,ERG	HL-60,Promyeloblast,Blood	HMGB2,MNDA,ID2,SUB1,ENO1	LYL1,SMAD1,FLI1,CEBPA,JMJD1C	NFE2,IRF1,SMARCB1	NFE2,IRF1,SMARCB1,CUX1,CEBPD,ZEB2,JUN	Monocyte
75	MeC_75	HOPX,ID2,TSC22D3,HMGB1,XBP1,RUNX3,GATA3,FOS,BHLHE40,IRF1	GNLY,IFITM2,SELL,CMC1,COTL1,CD7,GZMK,CD44,FXYD5,CTSW,KLRC1,DUSP2,TAGLN2,NFKBIA,HOPX,CD52,TYROBP,XCL1,IFITM3,SRGN	GNLY,IFITM2,SELL,CMC1,COTL1,CD7,GZMK,CD44,FXYD5,CTSW,KLRC1,DUSP2,TAGLN2,NFKBIA,HOPX,CD52,TYROBP,XCL1,IFITM3,SRGN,XCL2,CD63,SSR4,CD2,IFITM1,ICAM3,KLRD1,CRIP1,TRDC,LY6E,IL2RB,FCER1G,HINT1,STK17A,SEC61G,NKG7,ITGB1,ID2,JAK1,TMEM123,CALM2,CD74,SPTSSB,FKBP1A,TSC22D3,MIF,CAPG,KLRF1,GAPDH,S100A10,TSPO,EIF3G,CDKN2D,WDR83OS,CXCR3,TNFRSF18,HMGB1,ARF6,EIF4G2,GMFG,BST2,IL10RA,MATK,XBP1,SRSF2,MAP3K8,H3F3AP4,COX5A,C1orf162,HCST,TPT1,RUNX3,EMP3,RPL22L1,LINC01871,BTG1,SNRPD2,DYNLL1,SRP14,GATA3,RPS24,AHNAK,FOS,ADGRE5,BHLHE40,RAP1B,GPR183,ARF1,ANXA1,ISG20,POLR2L,CLIC1,LDHA,EDF1,CDC42SE1,IRF1,C9orf16,DOK2,MYADM,TUBB	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; cytokine-mediated signaling pathway (GO:0019221); Immune system; Immune System Homo sapiens R-HSA-168256	Interferon Gamma Response; IL-2/STAT5 Signaling; Interferon Alpha Response	cytokine-mediated signaling pathway (GO:0019221); regulation of immune response (GO:0050776); response to interferon-gamma (GO:0034341)	Immune System Homo sapiens R-HSA-168256; Hemostasis Homo sapiens R-HSA-109582; Interferon alpha/beta signaling Homo sapiens R-HSA-909733	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; Immune system	IL-4 Signaling Pathway WP395; Prolactin Signaling Pathway WP2037; TYROBP Causal Network WP3945	Th1 and Th2 cell differentiation; Salmonella infection; Pathogenic Escherichia coli infection	cadherin binding (GO:0045296); cytokine receptor activity (GO:0004896)	MAPK1,T,GATA3,STAT3,STAT5B,MYB,KMT2A,TAL1,ERG,CD74,SPI1,RUNX1,TBX21,RUNX1T1,EZH2,CHRM2,LMO2,SMAD1,GABPA,JMJD1C	HeLa,Epithelium,Cervix	NFKBIA,HOPX,ID2,TSC22D3,HMGB1	T,STAT3,STAT5B,MYB,TAL1	GATA3,BHLHE40,RUNX3	GATA3,BHLHE40,RUNX3,IRF1,FOS,HIF1A	NK,CD8Tcm,CD8Tex
76	MeC_76	ID2,IRF8,EGR2	RGS2,CXCL1,LAPTM5,P2RY12,ID2,CXCR4,BCL2A1,PDK4,RPL4,EIF4A3,ITM2B,GADD45B,CD14,CXCL2,CALM2,TYROBP,RPL8,IFNGR1,HLA-E,HNRNPA1	RGS2,CXCL1,LAPTM5,P2RY12,ID2,CXCR4,BCL2A1,PDK4,RPL4,EIF4A3,ITM2B,GADD45B,CD14,CXCL2,CALM2,TYROBP,RPL8,IFNGR1,HLA-E,HNRNPA1,MT2A,HSPA6,RPS14,DUSP2,BTG2,RPL6,SGK1,MTRNR2L8,RPSA,NAA20,PLIN2,EEF1A1,RNASE1,MTND4LP30,EEF1G,RPS3A,CD69,KLRK1,ANXA1,PTGS2,UGDH-AS1,NACA,CHMP1B,C6orf62,MAT2A,RPS24,YWHAH,CD53,ATP1B3,HLA-DQB2,RPL39,RPL10A,HAVCR2,PSMB9,RPL21P28,SPARC,RPL21,PTGDS,PSME2,EFEMP1,ARPC2,SPP1,HLA-C,RPL23,RPL13A,SELENOK,ATP6V1B2,GSN,CNBP,PSME1,SERPINB9,TMIGD3,EIF3E,PSMA4,UBE2L6,ARL4C,CD9,ACTB,RPL7,SLC25A6,CORO1A,COX7C,IRF8,LYZ,RPS11,EGR2,PLAU,SNX10,ARPC3,RPS28,CSF1R,XCL2,GAPDH,GDI2,UBE2D3,SRSF7,CKLF,SELENOF,CD47,RPLP2	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689; Viral mRNA Translation Homo sapiens R-HSA-192823; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957	TNF-alpha Signaling via NF-kB; Interferon Gamma Response; Interferon Alpha Response	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Formation of a pool of free 40S subunits Homo sapiens R-HSA-72689	Translation; Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Proteasome Degradation WP183; Spinal Cord Injury WP2431	Ribosome; Coronavirus disease; Legionellosis	RNA binding (GO:0003723); chemokine activity (GO:0008009); chemokine receptor binding (GO:0042379)	IRF1,SPI1,KMT2A,SMAD1,CEBPA,RXRG,RUNX1,CEBPB,FLI1,LYL1,STAT1,JMJD1C,RARA,BRD4,RELA,FOS,JUN,NELFE,HES2,STAT3	Monocyte,Blood	ID2,IRF8	IRF1,SPI1,SMAD1,CEBPA,RUNX1		EGR2	M1,Mast,Th1,cDC2,Monocyte,M2
77	MeC_77	TSC22D3,LITAF,JUN,FOSB,SUB1,ID3,ARID5B,JUND,EGR1,FOS	JCHAIN,IGHA1,VIM,CD48,IER2,PABPC4,TIMP1,IGHA2,IGKC,SRGN,EZR,CIRBP,LMNA,DUSP1,TSC22D3,SRSF7,LITAF,AHNAK,CD69,JUN	JCHAIN,IGHA1,VIM,CD48,IER2,PABPC4,TIMP1,IGHA2,IGKC,SRGN,EZR,CIRBP,LMNA,DUSP1,TSC22D3,SRSF7,LITAF,AHNAK,CD69,JUN,HSP90B1,MT2A,SRSF5,SPINK2,HMGN2,FOSB,RNASET2,HSP90AB1,RPL36AL,CALR,TNFRSF17,SEC61B,TBCA,ZFP36,SUB1,LGALS1,TMSB10,GLTSCR2,TNFRSF18,HNRNPA1,CD53,IL2RG,DDX18,S100A10,PDIA3,ITM2B,EIF3F,TMCO1,ID3,TAGLN2,PPIB,CLK1,FXYD5,EVI2B,SNRPD2,GMFG,ANXA2,SNRPE,ATP5L,CCL3,SEC62,TNFRSF13B,HNRNPA3,S100A6,EEF1A1,H3F3B,HINT1,TXNDC5,YPEL5,BTF3,PCBP2,ANP32B,UBE2J1,SPCS2,VAMP8,EIF3D,GNG7,ARID5B,HCLS1,SEC11A,SMAP2,ANKRD37,DBI,JUND,EGR1,PTPN6,MEF2C,PTGES3,CCL5,SHFM1,SF3B5,SELENOS,PTMA,OS9,FOS,CLECL1,C11ORF31,HNRNPM,CXCL13,IGKV3-11	T cell receptor regulation of apoptosis; RNA binding (GO:0003723); AP-1 transcription factor network; BDNF signaling pathway; Interleukin-2 signaling pathway	TNF-alpha Signaling via NF-kB; Myc Targets V1; Allograft Rejection	cytokine-mediated signaling pathway (GO:0019221); endoplasmic reticulum to cytosol transport (GO:1903513); cellular response to cytokine stimulus (GO:0071345)	mRNA Splicing - Major Pathway Homo sapiens R-HSA-72163; mRNA Splicing Homo sapiens R-HSA-72172; Processing of Capped Intron-Containing Pre-mRNA Homo sapiens R-HSA-72203	T cell receptor regulation of apoptosis; AP-1 transcription factor network; BDNF signaling pathway	mRNA Processing WP411; IL-3 Signaling Pathway WP286	Protein processing in endoplasmic reticulum; Spliceosome; Protein export	RNA binding (GO:0003723); mRNA binding (GO:0003729); RNA polymerase binding (GO:0070063)	NFKB2,RELA,MED1,MEF2A,TP53,ZMYND11,T,NCOR1,SPI1,STAT1,ETV6,RARA,GATA3,ZMYM3,NFKB1,HDAC6,KAT2B,JUND,CREB1,TCF7L1	L1236,Hodgkin Lymphoma Cell	TSC22D3,LITAF,HMGN2,FOSB,SUB1	NFKB2,RELA,MED1,MEF2A,TP53	JUND,JUN,FOS	JUND,JUN,FOS,EGR1,NR4A1	Plasma
78	MeC_78	RORA,KLF6,JUN,GATA3,FOS,XBP1,FOXP1	S100A4,ANXA1,LTB,ITGB1,IL7R,S100A11,KLRB1,CRIP1,IL32,RNASET2,LDHA,VIM,TRADD,LGALS1,AQP3,TNFAIP3,RORA,TIMP1,PSME2,PLP2	S100A4,ANXA1,LTB,ITGB1,IL7R,S100A11,KLRB1,CRIP1,IL32,RNASET2,LDHA,VIM,TRADD,LGALS1,AQP3,TNFAIP3,RORA,TIMP1,PSME2,PLP2,CD40LG,KLF6,FXYD5,S100A10,TRAT1,JUN,SH3BGRL3,GPR183,ALOX5AP,CD69,EMP3,CD99,MIF,ANXA2,AHNAK,IFITM2,GLIPR1,TTC39C,TNFRSF4,GIMAP7,GATA3,MYL6,PPIB,FOS,IFITM1,TXN,DDIT4,GSTK1,COTL1,CD2,DSTN,FTH1,ZFP36L2,PRDX1,NFKBIA,BIRC3,SAMSN1,XBP1,FKBP11,PIM1,TRAC,GAPDH,RAN,ZFP36L1,TSPO,FOXP1,PPP1R15A,PTGER2,PDIA6,FLNA,CCR6,RGS1,PPP2R5C,USP10,PBXIP1,C1QBP,CD6,SEC61G,GLIPR2,TXNIP,ARL6IP5,ANKRD12,MAL,TPM4,DUSP1,LPAR6,TC2N,NME2,CTSH,HSPA5,PRDX2,CALM1,CYBA,HSP90AA1,TNFSF13B,UBC,IGHM,CKLF,AC058791.1,TLN1	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; cytokine-mediated signaling pathway (GO:0019221); BDNF signaling pathway; Hypoxia	Hypoxia; Epithelial Mesenchymal Transition; TNF-alpha Signaling via NF-kB	cytokine-mediated signaling pathway (GO:0019221); cellular response to cytokine stimulus (GO:0071345); regulation of apoptotic process (GO:0042981)	Immune System Homo sapiens R-HSA-168256; Smooth Muscle Contraction Homo sapiens R-HSA-445355; TNFR2 non-canonical NF-kB pathway Homo sapiens R-HSA-5668541	Interleukin-2 signaling pathway; T cell receptor regulation of apoptosis; BDNF signaling pathway	TNF alpha Signaling Pathway WP231; Prolactin Signaling Pathway WP2037; Photodynamic therapy-induced unfolded protein response WP3613	Salmonella infection; NF-kappa B signaling pathway; Lipid and atherosclerosis	cadherin binding (GO:0045296); phosphatase activator activity (GO:0019211); protein phosphatase activator activity (GO:0072542)	T,GATA3,TAL1,MYB,KMT2A,STAT5B,BRD4,SMAD1,CDK9,RUNX1,MAF,STAT6,FOS,TBX21,RELA,TRIM28,SPI1,CEBPA,NR4A1,JUN	Th1	RORA,NFKBIA,RAN,PBXIP1,ARID5B	T,TAL1,MYB,STAT5B,BRD4	GATA3,FOS,JUN,MAF	GATA3,FOS,JUN,MAF,ELF1,CEBPB,KLF6,FOXP1,XBP1	Th17
79	MeC_79	TSC22D3,KLF6,FOS,CREM,ATF3	TSC22D3,TNFAIP3,HSPA8,RPL12,SGK1,KLF6,RPL19,EIF1,RPS6,CD83,RPS27,ANXA1,RPL8,FOS,CD7,RPL29,RPS25,MYL6,DNAJA1,VIM	TSC22D3,TNFAIP3,HSPA8,RPL12,SGK1,KLF6,RPL19,EIF1,RPS6,CD83,RPS27,ANXA1,RPL8,FOS,CD7,RPL29,RPS25,MYL6,DNAJA1,VIM,TMSB10,OAZ1,SRGN,S100A6,RPL11,SARAF,C1QA,ACTG1,HSPA1A,GPR183,PLAUR,PTMA,APOE,TXNIP,TAGLN2,S100A10,MT-ND4,S100A11,H2AFZ,H3F3B,RPS16,MT-CO1,CRIP1,TOB1,TYROBP,HSPA5,HNRNPH1,IL7R,HLA-C,TIGIT,TUBA1B,SDCBP,RPS3,LAPTM5,PABPC1,RPL34,RPS12,CALM1,BIRC3,RPS14,TUBA1A,ITM2B,RPS13,IFI30,TRBC2,RPS26,RPL30,TPI1,RAN,CALM2,TNF,SOD1,FCGR3A,EZR,EIF4A3,CD74,GZMB,RPL21,RPS15A,CD27,NPM1,APOC1,CD44,SLA,RNASE1,FXYD5,LGMN,PFDN5,CREM,MTND4LP30,YWHAZ,RPS11,ATF3,CXCL1,LMNA,CLK1,CD14,HSP90AB1,DDX3X,SQSTM1	Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	TNF-alpha Signaling via NF-kB; Apoptosis; Complement	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613)	Nonsense-Mediated Decay (NMD) Homo sapiens R-HSA-927802; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Homo sapiens R-HSA-975957; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956	Influenza viral RNA transcription and replication; Influenza infection; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Apoptosis-related network due to altered Notch3 in ovarian cancer WP2864; Pathogenic Escherichia coli infection WP2272	Coronavirus disease; Ribosome; Antigen processing and presentation	RNA binding (GO:0003723); cadherin binding (GO:0045296); ubiquitin protein ligase binding (GO:0031625)	EZH2,KAT2B,SNAPC1,TP53,KLF10,MAFB,JUN,GTF2B,WDR5,MAF,MYB,BCL3,SPI1,SMAD1,HDAC6,BRD4,CREBBP,REL,ELL2,ZNF22	Proerythroblast,Fetal Liver	TSC22D3,RAN,NPM1,PFDN5	EZH2,KAT2B,TP53,KLF10,MAFB	FOS	FOS,ATF3,CREM,KLF6	Th1,Tfh
80	MeC_80	HMGB1,ZNF683,HMGB2	FTH1,HLA-E,CCL5,APOE,RPL5,PFN1,IFITM2,RPL3,RPS4X,RPS3,HMGN2,RPLP1,HSPA8,HNRNPA1,RPS29,IFI27,HLA-B,UBB,CORO1A,HLA-C	FTH1,HLA-E,CCL5,APOE,RPL5,PFN1,IFITM2,RPL3,RPS4X,RPS3,HMGN2,RPLP1,HSPA8,HNRNPA1,RPS29,IFI27,HLA-B,UBB,CORO1A,HLA-C,TUBA1B,RGS1,RPL30,RPSA,MGP,AQP1,CD69,RPS27,RPL4,SELENOP,MALAT1,SFRP2,ACKR1,C1QC,CYR61,ACTG1,IL7R,IL32,NKG7,PABPC1,GSN,RPL37A,YWHAB,GADD45B,COL1A1,CFL1,CTSW,RPLP2,RPS15A,HYAL2,RPL10A,C6orf62,TGFBI,DEPP1,KLRK1,RPL37,IGFBP7,LTF,HIST1H4C,RPS28,RPL29,MTRNR2L8,RPL41,RPL23,TUBB,RPL35,GIMAP7,SPARC,BTG2,HLA-A,RNASE1,RHOG,UGDH-AS1,MZB1,RPL18A,MAT2A,TRBC2,CFD,EEF1G,HMGB1,HLA-DRB5,PTGDS,SRP14,NPM1,HDAC1,PPIA,SLC25A5,FKBP1A,TM4SF1,HLA-DQA2,PLTP,ADM,ZNF683,HMGB2,NAP1L4,PPT1,PSMB9,HNRNPF,PMEL,RPS12	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; SRP-dependent cotranslational protein targeting to membrane (GO:0006614); Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Interferon Gamma Response; Inflammatory Response; Apoptosis	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); protein targeting to ER (GO:0045047)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Homo sapiens R-HSA-975956; Viral mRNA Translation Homo sapiens R-HSA-192823	Translation; Influenza viral RNA transcription and replication; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Ebola Virus Pathway on Host WP4217	Ribosome; Coronavirus disease; Phagosome	RNA binding (GO:0003723); supercoiled DNA binding (GO:0097100); ubiquitin ligase inhibitor activity (GO:1990948)	EZH2,EZH1,TP53,FOXP1,RELA,YY1,BMI1,KLF10,STAT5B,KAT2B,SP1,CBFB,DRAP1,BRD4,MYC,CHD1,MAF,DNMT3B,IRF1,MED1	Proerythroblast,Fetal Liver	HMGN2,YWHAB,HMGB1,NPM1	EZH2,EZH1,TP53,FOXP1,RELA		HDAC1	CD4Teff
81	MeC_81	ATF4,CSDE1	MT2A,CPE,VEGFA,ENO1,ZFAS1,TIMP1,TGFBI,NDRG1,PGK1,FN1,MT1E,RPS27L,BNIP3,SERPINE1,ENO2,LDHA,TIMP3,GAPDH,PLOD2,CCNI	MT2A,CPE,VEGFA,ENO1,ZFAS1,TIMP1,TGFBI,NDRG1,PGK1,FN1,MT1E,RPS27L,BNIP3,SERPINE1,ENO2,LDHA,TIMP3,GAPDH,PLOD2,CCNI,ACTG1,ANGPTL4,CCDC85B,P4HA1,IGFBP5,BNIP3L,ALDOA,LGALS3,CIRBP,ATF4,IGFBP3,ADM,PLP2,CLEC2B,VIM,LOX,CA9,CA12,TMEM45A,MME,LOXL2,ERO1A,MIF,RND3,C1R,CANX,PLIN2,FTH1,CD44,EMP3,SEC62,RPL14,SLC2A1,CSDE1,EIF1,MORF4L1,NPM1,PTGES3,CAST,THBS2,SLC16A3,LRRFIP1,PSAP,SYF2,DARS,SMS,PLAUR,TAF1D,CTSL,SELENOM,SERPINE2,IGFBP6,ERRFI1,IL32,FAM162A,SLC3A2,NAP1L1,HILPDA,HSP90B1,PKM,GAS5,SPON2,DDIT4,P4HA2,WSB1,DNAJB9,EGLN3,EIF4B,SH3BP5,ITGB1,STC1,DUSP1,NDUFA4L2,SCG5,RPS26,PHPT1,PTTG1IP,LMAN1,FTL,SEC63	Hypoxia; Glycolysis; HIF-1 transcriptional activity in hypoxia; Epithelial Mesenchymal Transition; mTORC1 Signaling	Hypoxia; Glycolysis; Epithelial Mesenchymal Transition	glycolytic process (GO:0006096); pyruvate metabolic process (GO:0006090); carbohydrate catabolic process (GO:0016052)	Extracellular matrix organization Homo sapiens R-HSA-1474244; Glycolysis Homo sapiens R-HSA-70171; Gluconeogenesis Homo sapiens R-HSA-70263	HIF-1 transcriptional activity in hypoxia; BDNF signaling pathway; TGF-beta regulation of extracellular matrix	Photodynamic therapy-induced HIF-1 survival signaling WP3614; Pathways in clear cell renal cell carcinoma WP4018; Glycolysis and Gluconeogenesis WP534	HIF-1 signaling pathway; Glycolysis / Gluconeogenesis; Proteoglycans in cancer	cadherin binding (GO:0045296); RNA binding (GO:0003723); insulin-like growth factor II binding (GO:0031995)	TP53,HIF1A,CREBBP,BRD4,SMAD3,CEBPB,KLF11,FOSL2,GTF2B,TCF21,ATF3,MYOD1,MED1,CPSF3L,MAX,BCL3,TFAP2A,CTCF,NKX2-1,IKZF2	Foreskin	ENO1,BNIP3,CSDE1,MORF4L1,NPM1	TP53,HIF1A,CREBBP,BRD4,SMAD3	MXI1	MXI1,GTF2F1,ATF4	Fibroblasts
82	MeC_82	CEBPD,KLF6,TSC22D3,KLF2,CEBPB,CREM	DUSP1,RPS4X,RPS27,GNLY,SGK1,ZFP36L2,RPL9,CEBPD,PTPRCAP,ISG15,SSR4,RPL4,RPS12,RPL17,RHOB,IFI27,NKG7,KLF6,CST3,ARHGDIB	DUSP1,RPS4X,RPS27,GNLY,SGK1,ZFP36L2,RPL9,CEBPD,PTPRCAP,ISG15,SSR4,RPL4,RPS12,RPL17,RHOB,IFI27,NKG7,KLF6,CST3,ARHGDIB,CTSB,FN1,H2AFZ,ALDH1A1,CCNI,HNRNPH1,RPS27A,IFI6,UBE2D3,FXYD5,MTRNR2L2,NAP1L1,HINT1,LAPTM5,DBI,IL32,COTL1,NNMT,PNRC1,RPL21,POSTN,MIF,TSC22D3,HERPUD1,DAZAP2,S100A10,HNRNPA1P10,ATP6V0E1,CFL1,SSR2,ACTR3,UCP2,CTSD,STK4,VSIG4,SRSF3,LAMTOR1,BTG1,OST4,CXCL13,CXCL8,PPIA,NDUFB2,SON,GMFG,SRSF7,ACTA2,KLF2,CEBPB,RPL31,HSPB1,ARRDC3,RPS28,MYL6,BIRC3,ANXA1,TPT1,RPS29,NEDD8,RAC1,HNRNPA2B1,COX6A1,PIM2,PGAM1,CD163,MT-CO2,RPSA,RPS3,CLU,PMAIP1,TYMP,CLDN5,CREM,PGK1,HNRNPA0,FYB,ARPC1B,MT-ATP6,CCL4L2,RPL13AP5	SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339; cotranslational protein targeting to membrane (GO:0006613); Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Selenoamino acid metabolism Homo sapiens R-HSA-2408522	TNF-alpha Signaling via NF-kB; Myc Targets V1; Epithelial Mesenchymal Transition	cotranslational protein targeting to membrane (GO:0006613); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cytoplasmic translation (GO:0002181)	SRP-dependent cotranslational protein targeting to membrane Homo sapiens R-HSA-1799339; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	T cell receptor regulation of apoptosis; Translation; Cytoplasmic ribosomal proteins	Cytoplasmic Ribosomal Proteins WP477; Exercise-induced Circadian Regulation WP410; Transcriptional cascade regulating adipogenesis WP4211	Ribosome; Coronavirus disease; Salmonella infection	RNA binding (GO:0003723)	TP53,GTF2B,NFATC1,IRF1,SPI1,CPSF3L,NKX2-1,ELF3,FOXA2,BCL3,MYC,PAF1,PHF8,YY1,HEY1,NR3C1,FOXA1,CREB1,RNF2,POLR2H	Foreskin	KLF6,TSC22D3,BTG1,KLF2	TP53,NFATC1,IRF1,SPI1,NKX2-1	CEBPB	CEBPB,CEBPD	MAIT,CD4Teff
83	MeC_83	JUN,YBX1	TIMP1,DDIT4,MT2A,NNMT,SERPINE1,IL1B,DUSP1,CCL20,TUBA1B,RPS29,IGFBP3,ARHGDIB,ITM2B,RPS24,CORO1A,ENO1,RPS8,HSPA1B,PTPRCAP,APOE	TIMP1,DDIT4,MT2A,NNMT,SERPINE1,IL1B,DUSP1,CCL20,TUBA1B,RPS29,IGFBP3,ARHGDIB,ITM2B,RPS24,CORO1A,ENO1,RPS8,HSPA1B,PTPRCAP,APOE,HSPA8,IFITM3,THBS1,IFI27,LDHA,SRGN,RPS4X,RPL12,HLA-E,GZMA,TNC,OAZ1,GZMK,MALAT1,RPL23,RPS27A,LDHB,MT1X,RPL6,APOC1,TMSB10,SH3BGRL3,MMP9,JUN,CTSB,MGST1,IFI30,MTRNR2L10,NME1,FCN1,YBX1,C1QB,MT-ATP6,GPM6B,HLA-DPB1,TMBIM6,RPS3,ANGPTL4,UGDH-AS1,PSAP,RPL23A,RPL30,C1QA,BTF3,RPS3A,FBP1,AREG,RACK1,RPS28,CHI3L2,CCL5,RPL9,CXCL14,CYP1B1,APOBEC3A,ARPC2,CCL22,AQP1,CD53,MT1G,TNFRSF11B,PGK1,EEF1B2,PLAUR,RGS1,RPS11,TCP1,UBC,RPL4,CALM1,DUSP2,IL1RN,RPL28,RPS13,KLRK1,CXCL1,NPY,PTPRC,LTB,CXCL13	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902; Selenocysteine synthesis Homo sapiens R-HSA-2408557; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	Allograft Rejection; Complement; Hypoxia	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); cytoplasmic translation (GO:0002181)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Viral mRNA Translation Homo sapiens R-HSA-192823; Peptide chain elongation Homo sapiens R-HSA-156902	Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication; Translation	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Senescence and Autophagy in Cancer WP615	Coronavirus disease; Ribosome; Rheumatoid arthritis	RNA binding (GO:0003723); cytokine activity (GO:0005125); chemokine activity (GO:0008009)	EZH2,TP53,SNAPC1,TERF2,DNMT3B,RELA,KLF10,EZH1,ZNF528,CPSF3L,RUNX1,NFE2,MYB,NR3C1,BCL3,HIF1A,CEBPB,KAT2B,TCF12,STAT3	Proerythroblast,Fetal Liver	ENO1,YBX1	EZH2,TP53,TERF2,DNMT3B,RELA	JUN	JUN	Fibroblasts,Endothelial
84	MeC_84	TSC22D3,HMGB2,ATF3,DDIT3	FTL,EEF1A1,SPARC,PTMA,EIF1,RPLP1,ACTB,RPL8,IGFBP7,TSC22D3,RPL41,HLA-A,RPLP2,CORO1A,RPL9,RPS13,GPR183,TUBA1B,RPS12,CXCR4	FTL,EEF1A1,SPARC,PTMA,EIF1,RPLP1,ACTB,RPL8,IGFBP7,TSC22D3,RPL41,HLA-A,RPLP2,CORO1A,RPL9,RPS13,GPR183,TUBA1B,RPS12,CXCR4,ACKR1,CD74,AQP1,SPARCL1,NEAT1,H2AFZ,LDHA,COL9A1,TUBA1A,RPL3,DUSP2,ARHGDIB,EZR,DLK1,GSN,RPS4X,IFITM2,UBC,RPL21P28,S100B,GZMA,PLVAP,COL1A1,FMO1,HNRNPH1,TMSB10,FBLN5,HMGB2,RPL11,CD69,VIM,CCL5,TUBB,SAMSN1,ENO1,CRIP2,GAS5,CXCL13,TRMT112,TNFAIP3,CRIP1,LDHB,RPL18,RPS10,RPS8,ENO2,LTB,NME1-NME2,ATF3,KRT18,GZMB,EFEMP1,MS4A1,CLIC1,C6orf62,ATP5PO,RPS27A,MT-CYB,EMP3,HYAL2,SIVA1,SUMO2,SOD1,ISG20,LMNA,MYL12A,SKP1,AREG,MAP1LC3B,CD83,HSPA8,HILPDA,ARF1,RPL39,CCL19,DDIT3,DDX5,GNLY,FKBP1A,TPSAB1	Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Eukaryotic Translation Termination Homo sapiens R-HSA-72764; Viral mRNA Translation Homo sapiens R-HSA-192823; Selenocysteine synthesis Homo sapiens R-HSA-2408557	Apoptosis; Allograft Rejection; TNF-alpha Signaling via NF-kB	cotranslational protein targeting to membrane (GO:0006613); SRP-dependent cotranslational protein targeting to membrane (GO:0006614); protein targeting to ER (GO:0045047)	Peptide chain elongation Homo sapiens R-HSA-156902; Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	Cytoplasmic ribosomal proteins; Disease; Translation	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328; Pathogenic Escherichia coli infection WP2272	Ribosome; Coronavirus disease; Apoptosis	RNA binding (GO:0003723); ubiquitin protein ligase binding (GO:0031625); ubiquitin-like protein ligase binding (GO:0044389)	EZH2,KAT2B,EZH1,KLF10,TP53,RELA,NR3C2,SNRNP70,ZNF22,BRD4,SNAPC1,BMI1,CD74,GTF2B,MED1,REL,BATF,GTF2A2,MYC,BCL3	Proerythroblast,Fetal Liver	TSC22D3,HMGB2,ENO1,CRIP2	EZH2,KAT2B,EZH1,KLF10,TP53			Fibroblasts,Endothelial
85	MeC_85	JUN,JUNB,KLF6	ACTB,RPS19,TPT1,MALAT1,EEF1A1,H3F3B,CXCR4,IFITM3,RNASE1,RPL12,RPL13A,NEAT1,RPS27,MT-CYB,RPS2,CD74,HLA-C,MT-ND4,APOC1,IFITM2	ACTB,RPS19,TPT1,MALAT1,EEF1A1,H3F3B,CXCR4,IFITM3,RNASE1,RPL12,RPL13A,NEAT1,RPS27,MT-CYB,RPS2,CD74,HLA-C,MT-ND4,APOC1,IFITM2,HSPA5,BTG1,B2M,EIF1,RPS14,CSTB,RPL31,FAU,FTL,HAMP,NUPR1,HSPA8,IFI27,HLA-E,PLIN2,MTRNR2L1,RPL37A,CLDN5,RPL32,CD69,C1QB,LUM,CXCL3,IFITM1,TMSB10,MGP,IGFBP7,RPL10,DUSP2,DDIT4,TPSAB1,RPS11,RPS25,CCL5,AC020656.1,JUN,CXCL2,RPS18,SSR4,DNAJB1,SRGN,CLU,ZFP36L2,MT-ND1,C1QA,RPL35A,NTS,RPS15A,FTH1,HSP90B1,UGDH-AS1,MTND4LP30,RPS12,TRBC2,FABP4,GZMB,RPL36,CD63,EFEMP1,RGS1,RPL23A,RPS20,SLC2A3,RPS23,ZFP36L1,RGCC,RPL26,DCN,RNASET2,JUNB,UBB,EEF1G,RPL34,RPL41,CCL3L3,HYAL2,ANXA1,KLF6,PPIB,GSN	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Viral mRNA Translation Homo sapiens R-HSA-192823; Selenocysteine synthesis Homo sapiens R-HSA-2408557; Eukaryotic Translation Termination Homo sapiens R-HSA-72764	TNF-alpha Signaling via NF-kB; Interferon Alpha Response; Hypoxia	SRP-dependent cotranslational protein targeting to membrane (GO:0006614); cotranslational protein targeting to membrane (GO:0006613); cytoplasmic translation (GO:0002181)	Eukaryotic Translation Elongation Homo sapiens R-HSA-156842; Peptide chain elongation Homo sapiens R-HSA-156902; Viral mRNA Translation Homo sapiens R-HSA-192823	Translation; Cytoplasmic ribosomal proteins; Influenza viral RNA transcription and replication	Cytoplasmic Ribosomal Proteins WP477; Allograft Rejection WP2328	Coronavirus disease; Ribosome; Antigen processing and presentation	RNA binding (GO:0003723)	KAT2B,TP53,CDK9,EZH1,ZBED1,BMI1,MED1,GTF2F1,EZH2,SMAD5,ELL2,RELA,NELFE,NR3C2,GTF2B,SNAPC1,CD74,SCML2,ZBTB18,NFE2L2	GM12878,B Lymphocyte,Blood	BTG1	KAT2B,TP53,EZH1,ZBED1,BMI1		JUN,JUNB,EGR1,KLF6	CD8Tn,CD4Tn
