// ═══════════════════════════════════════════════════════════════
// Auto-generated by ExposoGraph v0.0.3
// ═══════════════════════════════════════════════════════════════

const GRAPH_DATA = {
  "nodes": [
    {
      "id": "BaP",
      "label": "Benzo[a]pyrene",
      "type": "Carcinogen",
      "detail": "Reference PAH carcinogen used for the canonical activation-to-adduct chain.",
      "group": "PAH",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Reference PAH carcinogen used for the canonical activation-to-adduct chain.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "50-32-8",
      "canonical_label": "Benzo[a]pyrene",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BaP",
          "evidence": "Reference PAH carcinogen used for the canonical activation-to-adduct chain.",
          "citation": "Curated carcinogen entry for Benzo[a]pyrene"
        }
      ]
    },
    {
      "id": "DMBA",
      "label": "DMBA",
      "type": "Carcinogen",
      "detail": "Reference PAH-like polycyclic carcinogen included to mirror the manuscript class example.",
      "group": "PAH",
      "source_db": "Curated showcase",
      "evidence": "Reference PAH-like polycyclic carcinogen included to mirror the manuscript class example.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "DMBA",
      "canonical_label": "DMBA",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "DMBA",
          "evidence": "Reference PAH-like polycyclic carcinogen included to mirror the manuscript class example.",
          "citation": "Curated carcinogen entry for DMBA"
        }
      ]
    },
    {
      "id": "PhIP",
      "label": "PhIP",
      "type": "Carcinogen",
      "detail": "Representative heterocyclic amine produced during high-temperature cooking.",
      "group": "HCA",
      "iarc": "Group 2B",
      "source_db": "Curated showcase",
      "evidence": "Representative heterocyclic amine produced during high-temperature cooking.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "105650-23-5",
      "canonical_label": "PhIP",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "PhIP",
          "evidence": "Representative heterocyclic amine produced during high-temperature cooking.",
          "citation": "Curated carcinogen entry for PhIP"
        }
      ]
    },
    {
      "id": "MeIQx",
      "label": "MeIQx",
      "type": "Carcinogen",
      "detail": "Representative heterocyclic amine activated through N-hydroxylation and esterification.",
      "group": "HCA",
      "iarc": "Group 2B",
      "source_db": "Curated showcase",
      "evidence": "Representative heterocyclic amine activated through N-hydroxylation and esterification.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "77500-04-0",
      "canonical_label": "MeIQx",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "MeIQx",
          "evidence": "Representative heterocyclic amine activated through N-hydroxylation and esterification.",
          "citation": "Curated carcinogen entry for MeIQx"
        }
      ]
    },
    {
      "id": "4ABP",
      "label": "4-Aminobiphenyl",
      "type": "Carcinogen",
      "detail": "Representative aromatic amine requiring N-hydroxylation and acetyl-transfer activation.",
      "group": "Aromatic_Amine",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Representative aromatic amine requiring N-hydroxylation and acetyl-transfer activation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "92-67-1",
      "canonical_label": "4-Aminobiphenyl",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "4ABP",
          "evidence": "Representative aromatic amine requiring N-hydroxylation and acetyl-transfer activation.",
          "citation": "Curated carcinogen entry for 4-Aminobiphenyl"
        }
      ]
    },
    {
      "id": "Benzidine",
      "label": "Benzidine",
      "type": "Carcinogen",
      "detail": "Representative aromatic amine included for class-level alignment.",
      "group": "Aromatic_Amine",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Representative aromatic amine included for class-level alignment.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "92-87-5",
      "canonical_label": "Benzidine",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Benzidine",
          "evidence": "Representative aromatic amine included for class-level alignment.",
          "citation": "Curated carcinogen entry for Benzidine"
        }
      ]
    },
    {
      "id": "NNK",
      "label": "NNK",
      "type": "Carcinogen",
      "detail": "Tobacco-specific nitrosamine represented as a pyridyloxobutylating carcinogen context.",
      "group": "Nitrosamine",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Tobacco-specific nitrosamine represented as a pyridyloxobutylating carcinogen context.",
      "origin": "imported",
      "match_status": "alias",
      "canonical_id": "64091-91-4",
      "canonical_label": "4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NNK",
          "evidence": "Tobacco-specific nitrosamine represented as a pyridyloxobutylating carcinogen context.",
          "citation": "Curated carcinogen entry for NNK"
        }
      ]
    },
    {
      "id": "NDMA",
      "label": "NDMA",
      "type": "Carcinogen",
      "detail": "Small-molecule nitrosamine represented via methylating chemistry.",
      "group": "Nitrosamine",
      "iarc": "Group 2A",
      "source_db": "Curated showcase",
      "evidence": "Small-molecule nitrosamine represented via methylating chemistry.",
      "origin": "imported",
      "match_status": "alias",
      "canonical_id": "62-75-9",
      "canonical_label": "N-Nitrosodimethylamine",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NDMA",
          "evidence": "Small-molecule nitrosamine represented via methylating chemistry.",
          "citation": "Curated carcinogen entry for NDMA"
        }
      ]
    },
    {
      "id": "AFB1",
      "label": "Aflatoxin B1",
      "type": "Carcinogen",
      "detail": "Mycotoxin represented through CYP-mediated epoxidation and guanine adduct formation.",
      "group": "Mycotoxin",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Mycotoxin represented through CYP-mediated epoxidation and guanine adduct formation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "1162-65-8",
      "canonical_label": "Aflatoxin B1",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "AFB1",
          "evidence": "Mycotoxin represented through CYP-mediated epoxidation and guanine adduct formation.",
          "citation": "Curated carcinogen entry for Aflatoxin B1"
        }
      ]
    },
    {
      "id": "E2",
      "label": "17beta-Estradiol",
      "type": "Carcinogen",
      "detail": "Endogenous estrogen represented in the hormone-metabolism reference layer.",
      "group": "Estrogen",
      "source_db": "Curated showcase",
      "evidence": "Endogenous estrogen represented in the hormone-metabolism reference layer.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "E2",
      "canonical_label": "17beta-Estradiol",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "E2",
          "evidence": "Endogenous estrogen represented in the hormone-metabolism reference layer.",
          "citation": "Curated carcinogen entry for 17beta-Estradiol"
        }
      ]
    },
    {
      "id": "Testosterone",
      "label": "Testosterone",
      "type": "Carcinogen",
      "detail": "Androgen precursor node used to anchor the steroid-hormone metabolism branch.",
      "group": "Androgen",
      "source_db": "Curated showcase",
      "evidence": "Androgen precursor node used to anchor the steroid-hormone metabolism branch.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Testosterone",
      "canonical_label": "Testosterone",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Testosterone",
          "evidence": "Androgen precursor node used to anchor the steroid-hormone metabolism branch.",
          "citation": "Curated carcinogen entry for Testosterone"
        }
      ]
    },
    {
      "id": "DHT",
      "label": "5a-DHT",
      "type": "Carcinogen",
      "detail": "Dihydrotestosterone node included to mirror the manuscript example.",
      "group": "Androgen",
      "source_db": "Curated showcase",
      "evidence": "Dihydrotestosterone node included to mirror the manuscript example.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "DHT",
      "canonical_label": "5a-DHT",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "DHT",
          "evidence": "Dihydrotestosterone node included to mirror the manuscript example.",
          "citation": "Curated carcinogen entry for 5a-DHT"
        }
      ]
    },
    {
      "id": "Benzene",
      "label": "Benzene",
      "type": "Carcinogen",
      "detail": "Volatile solvent carcinogen represented through CYP2E1 oxidation and ROS-linked damage.",
      "group": "Solvent",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Volatile solvent carcinogen represented through CYP2E1 oxidation and ROS-linked damage.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "71-43-2",
      "canonical_label": "Benzene",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Benzene",
          "evidence": "Volatile solvent carcinogen represented through CYP2E1 oxidation and ROS-linked damage.",
          "citation": "Curated carcinogen entry for Benzene"
        }
      ]
    },
    {
      "id": "VinylChloride",
      "label": "Vinyl Chloride",
      "type": "Carcinogen",
      "detail": "Solvent carcinogen represented through etheno-adduct chemistry.",
      "group": "Solvent",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Solvent carcinogen represented through etheno-adduct chemistry.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "75-01-4",
      "canonical_label": "Vinyl chloride",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "VinylChloride",
          "evidence": "Solvent carcinogen represented through etheno-adduct chemistry.",
          "citation": "Curated carcinogen entry for Vinyl Chloride"
        }
      ]
    },
    {
      "id": "EthyleneOxide",
      "label": "Ethylene Oxide",
      "type": "Carcinogen",
      "detail": "Alkylating carcinogen represented through hydroxyethyl adduct formation.",
      "group": "Alkylating",
      "iarc": "Group 1",
      "source_db": "Curated showcase",
      "evidence": "Alkylating carcinogen represented through hydroxyethyl adduct formation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "75-21-8",
      "canonical_label": "Ethylene oxide",
      "canonical_namespace": "iarc",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "EthyleneOxide",
          "evidence": "Alkylating carcinogen represented through hydroxyethyl adduct formation.",
          "citation": "Curated carcinogen entry for Ethylene Oxide"
        }
      ]
    },
    {
      "id": "CYP1A1",
      "label": "CYP1A1",
      "type": "Enzyme",
      "detail": "PAH diol-epoxide formation; AhR-inducible; extrahepatic expression",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "lung, placenta, lymphocytes",
      "activity_score": 1.3,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP1A1",
      "canonical_label": "CYP1A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1543",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP1A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1543"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP1A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "lung, placenta, lymphocytes",
          "citation": "GTEx Portal expression profile for CYP1A1",
          "url": "https://gtexportal.org/home/gene/CYP1A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA27092",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP1A1",
          "url": "https://www.clinpgx.org/gene/PA27092"
        }
      ]
    },
    {
      "id": "CYP1B1",
      "label": "CYP1B1",
      "type": "Enzyme",
      "detail": "PAH and estrogen activation; 4-OH-estradiol formation",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "breast, prostate, uterus, lung",
      "activity_score": 1.3,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP1B1",
      "canonical_label": "CYP1B1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1545",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP1B1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1545"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP1B1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "breast, prostate, uterus, lung",
          "citation": "GTEx Portal expression profile for CYP1B1",
          "url": "https://gtexportal.org/home/gene/CYP1B1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA27094",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP1B1",
          "url": "https://www.clinpgx.org/gene/PA27094"
        }
      ]
    },
    {
      "id": "CYP1A2",
      "label": "CYP1A2",
      "type": "Enzyme",
      "detail": "HCA and aromatic amine activation; AhR-inducible; hepatic",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver",
      "activity_score": 1.5,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP1A2",
      "canonical_label": "CYP1A2",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1544",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP1A2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1544"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP1A2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver",
          "citation": "GTEx Portal expression profile for CYP1A2",
          "url": "https://gtexportal.org/home/gene/CYP1A2"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA27093",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP1A2",
          "url": "https://www.clinpgx.org/gene/PA27093"
        }
      ]
    },
    {
      "id": "CYP2A6",
      "label": "CYP2A6",
      "type": "Enzyme",
      "detail": "NNK and nitrosamine activation; nicotine metabolism",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, nasal mucosa",
      "activity_score": 2.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP2A6",
      "canonical_label": "CYP2A6",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1548",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP2A6 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1548"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP2A6",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, nasal mucosa",
          "citation": "GTEx Portal expression profile for CYP2A6",
          "url": "https://gtexportal.org/home/gene/CYP2A6"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA121",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP2A6",
          "url": "https://www.clinpgx.org/gene/PA121"
        }
      ]
    },
    {
      "id": "CYP2A13",
      "label": "CYP2A13",
      "type": "Enzyme",
      "detail": "Primary lung NNK-metabolizing CYP; tobacco-smoke carcinogen activation",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "lung, nasal mucosa",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP2A13",
      "canonical_label": "CYP2A13",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1553",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP2A13 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1553"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP2A13",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "lung, nasal mucosa",
          "citation": "GTEx Portal expression profile for CYP2A13",
          "url": "https://gtexportal.org/home/gene/CYP2A13"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA27101",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP2A13",
          "url": "https://www.clinpgx.org/gene/PA27101"
        }
      ]
    },
    {
      "id": "CYP2E1",
      "label": "CYP2E1",
      "type": "Enzyme",
      "detail": "Small-molecule carcinogen activation; ethanol, benzene, NDMA",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, lung",
      "activity_score": 1.3,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP2E1",
      "canonical_label": "CYP2E1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1571",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP2E1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1571"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP2E1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, lung",
          "citation": "GTEx Portal expression profile for CYP2E1",
          "url": "https://gtexportal.org/home/gene/CYP2E1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA129",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP2E1",
          "url": "https://www.clinpgx.org/gene/PA129"
        }
      ]
    },
    {
      "id": "CYP3A4",
      "label": "CYP3A4",
      "type": "Enzyme",
      "detail": "Aflatoxin B1 8,9-epoxidation; broad substrate range",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, intestine",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP3A4",
      "canonical_label": "CYP3A4",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1576",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP3A4 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1576"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP3A4",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, intestine",
          "citation": "GTEx Portal expression profile for CYP3A4",
          "url": "https://gtexportal.org/home/gene/CYP3A4"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA130",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP3A4",
          "url": "https://www.clinpgx.org/gene/PA130"
        }
      ]
    },
    {
      "id": "EPHX1",
      "label": "EPHX1",
      "type": "Enzyme",
      "detail": "Microsomal epoxide hydrolysis; both activation and detoxification roles",
      "phase": "II",
      "role": "Mixed",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, lung",
      "activity_score": 1.25,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "EPHX1",
      "canonical_label": "EPHX1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "2052",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for EPHX1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/2052"
        },
        {
          "source_db": "GTEx",
          "record_id": "EPHX1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, lung",
          "citation": "GTEx Portal expression profile for EPHX1",
          "url": "https://gtexportal.org/home/gene/EPHX1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA27829",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for EPHX1",
          "url": "https://www.clinpgx.org/gene/PA27829"
        }
      ]
    },
    {
      "id": "CYP17A1",
      "label": "CYP17A1",
      "type": "Enzyme",
      "detail": "Steroid 17alpha-hydroxylase/17,20-lyase; androgen precursor synthesis in hormone-linked carcinogen context",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "adrenal, gonad, prostate",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP17A1",
      "canonical_label": "CYP17A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1586",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP17A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1586"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP17A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "adrenal, gonad, prostate",
          "citation": "GTEx Portal expression profile for CYP17A1",
          "url": "https://gtexportal.org/home/gene/CYP17A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "CYP17A1",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP17A1",
          "url": "https://www.clinpgx.org/gene/CYP17A1"
        }
      ]
    },
    {
      "id": "SRD5A2",
      "label": "SRD5A2",
      "type": "Enzyme",
      "detail": "5alpha-reductase type 2; major DHT-forming enzyme in prostate and urogenital tissues",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "prostate, seminal vesicle, genital skin, liver",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "SRD5A2",
      "canonical_label": "SRD5A2",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "6716",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for SRD5A2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/6716"
        },
        {
          "source_db": "GTEx",
          "record_id": "SRD5A2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "prostate, seminal vesicle, genital skin, liver",
          "citation": "GTEx Portal expression profile for SRD5A2",
          "url": "https://gtexportal.org/home/gene/SRD5A2"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "SRD5A2",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for SRD5A2",
          "url": "https://www.clinpgx.org/gene/SRD5A2"
        }
      ]
    },
    {
      "id": "SRD5A1",
      "label": "SRD5A1",
      "type": "Enzyme",
      "detail": "5alpha-reductase type 1; converts testosterone to DHT in peripheral hormone-metabolism tissues",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "skin, liver, prostate, breast",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "SRD5A1",
      "canonical_label": "SRD5A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "6715",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for SRD5A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/6715"
        },
        {
          "source_db": "GTEx",
          "record_id": "SRD5A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "skin, liver, prostate, breast",
          "citation": "GTEx Portal expression profile for SRD5A1",
          "url": "https://gtexportal.org/home/gene/SRD5A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "SRD5A1",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for SRD5A1",
          "url": "https://www.clinpgx.org/gene/SRD5A1"
        }
      ]
    },
    {
      "id": "CYP19A1",
      "label": "CYP19A1",
      "type": "Enzyme",
      "detail": "Aromatase; converts androgen precursors to estrogens in breast and other hormone-responsive tissues",
      "phase": "I",
      "role": "Activation",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "adipose, ovary, breast, placenta, brain",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "CYP19A1",
      "canonical_label": "CYP19A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1588",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for CYP19A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1588"
        },
        {
          "source_db": "GTEx",
          "record_id": "CYP19A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "adipose, ovary, breast, placenta, brain",
          "citation": "GTEx Portal expression profile for CYP19A1",
          "url": "https://gtexportal.org/home/gene/CYP19A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "CYP19A1",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for CYP19A1",
          "url": "https://www.clinpgx.org/gene/CYP19A1"
        }
      ]
    },
    {
      "id": "CYP3A5",
      "label": "CYP3A5",
      "type": "Enzyme",
      "detail": "6\u03b2-hydroxylation of testosterone; AR nuclear translocation in prostate",
      "phase": "I",
      "role": "Mixed",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "AKR1C3",
      "label": "AKR1C3",
      "type": "Enzyme",
      "detail": "17-ketosteroid reductase and quinone reductase; local androgen/estrogen activation with redox-metabolism overlap",
      "phase": "I",
      "role": "Mixed",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "prostate, breast, liver, endometrium",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "AKR1C3",
      "canonical_label": "AKR1C3",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "8644",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for AKR1C3 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/8644"
        },
        {
          "source_db": "GTEx",
          "record_id": "AKR1C3",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "prostate, breast, liver, endometrium",
          "citation": "GTEx Portal expression profile for AKR1C3",
          "url": "https://gtexportal.org/home/gene/AKR1C3"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "AKR1C3",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for AKR1C3",
          "url": "https://www.clinpgx.org/gene/AKR1C3"
        }
      ]
    },
    {
      "id": "GSTM1",
      "label": "GSTM1",
      "type": "Enzyme",
      "detail": "GSH conjugation of PAH diol-epoxides and AFB1-epoxide; null polymorphism common",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, lung",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "GSTM1",
      "canonical_label": "GSTM1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "2944",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for GSTM1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/2944"
        },
        {
          "source_db": "GTEx",
          "record_id": "GSTM1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, lung",
          "citation": "GTEx Portal expression profile for GSTM1",
          "url": "https://gtexportal.org/home/gene/GSTM1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA182",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for GSTM1",
          "url": "https://www.clinpgx.org/gene/PA182"
        }
      ]
    },
    {
      "id": "GSTT1",
      "label": "GSTT1",
      "type": "Enzyme",
      "detail": "GSH conjugation of small electrophiles; null polymorphism common",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, kidney, blood cells",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "GSTT1",
      "canonical_label": "GSTT1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "2952",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for GSTT1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/2952"
        },
        {
          "source_db": "GTEx",
          "record_id": "GSTT1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, kidney, blood cells",
          "citation": "GTEx Portal expression profile for GSTT1",
          "url": "https://gtexportal.org/home/gene/GSTT1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA183",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for GSTT1",
          "url": "https://www.clinpgx.org/gene/PA183"
        }
      ]
    },
    {
      "id": "GSTP1",
      "label": "GSTP1",
      "type": "Enzyme",
      "detail": "GSH conjugation of BPDE and other PAH diol-epoxides",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "lung, brain, placenta",
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "GSTP1",
      "canonical_label": "GSTP1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "2950",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for GSTP1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/2950"
        },
        {
          "source_db": "GTEx",
          "record_id": "GSTP1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "lung, brain, placenta",
          "citation": "GTEx Portal expression profile for GSTP1",
          "url": "https://gtexportal.org/home/gene/GSTP1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA29028",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for GSTP1",
          "url": "https://www.clinpgx.org/gene/PA29028"
        }
      ]
    },
    {
      "id": "NAT2",
      "label": "NAT2",
      "type": "Enzyme",
      "detail": "N-acetylation of aromatic amines; rapid vs slow acetylator phenotypes",
      "phase": "II",
      "role": "Mixed",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, intestine",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NAT2",
      "canonical_label": "NAT2",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "10",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for NAT2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/10"
        },
        {
          "source_db": "GTEx",
          "record_id": "NAT2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, intestine",
          "citation": "GTEx Portal expression profile for NAT2",
          "url": "https://gtexportal.org/home/gene/NAT2"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA18",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for NAT2",
          "url": "https://www.clinpgx.org/gene/PA18"
        }
      ]
    },
    {
      "id": "NAT1",
      "label": "NAT1",
      "type": "Enzyme",
      "detail": "O-acetylation and N-acetylation of aromatic/heterocyclic amines in peripheral tissues",
      "phase": "II",
      "role": "Mixed",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "bladder, colon, breast, lung",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NAT1",
      "canonical_label": "NAT1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "6530",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for NAT1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/6530"
        },
        {
          "source_db": "GTEx",
          "record_id": "NAT1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "bladder, colon, breast, lung",
          "citation": "GTEx Portal expression profile for NAT1",
          "url": "https://gtexportal.org/home/gene/NAT1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA17",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for NAT1",
          "url": "https://www.clinpgx.org/gene/PA17"
        }
      ]
    },
    {
      "id": "SULT1A1",
      "label": "SULT1A1",
      "type": "Enzyme",
      "detail": "Sulfation of phenolic compounds, HCA intermediates, PAH metabolites",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, GI tract, platelets, brain",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "SULT1A1",
      "canonical_label": "SULT1A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "6817",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for SULT1A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/6817"
        },
        {
          "source_db": "GTEx",
          "record_id": "SULT1A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, GI tract, platelets, brain",
          "citation": "GTEx Portal expression profile for SULT1A1",
          "url": "https://gtexportal.org/home/gene/SULT1A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA343",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for SULT1A1",
          "url": "https://www.clinpgx.org/gene/PA343"
        }
      ]
    },
    {
      "id": "UGT1A1",
      "label": "UGT1A1",
      "type": "Enzyme",
      "detail": "Glucuronidation of PAH metabolites and bilirubin",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, intestine",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "UGT1A1",
      "canonical_label": "UGT1A1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "54658",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for UGT1A1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/54658"
        },
        {
          "source_db": "GTEx",
          "record_id": "UGT1A1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, intestine",
          "citation": "GTEx Portal expression profile for UGT1A1",
          "url": "https://gtexportal.org/home/gene/UGT1A1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA420",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for UGT1A1",
          "url": "https://www.clinpgx.org/gene/PA420"
        }
      ]
    },
    {
      "id": "UGT2B7",
      "label": "UGT2B7",
      "type": "Enzyme",
      "detail": "Glucuronidation of steroid hormones, carcinogen metabolites",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, kidney, GI tract, mammary",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "UGT2B7",
      "canonical_label": "UGT2B7",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "7364",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for UGT2B7 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/7364"
        },
        {
          "source_db": "GTEx",
          "record_id": "UGT2B7",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, kidney, GI tract, mammary",
          "citation": "GTEx Portal expression profile for UGT2B7",
          "url": "https://gtexportal.org/home/gene/UGT2B7"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA361",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for UGT2B7",
          "url": "https://www.clinpgx.org/gene/PA361"
        }
      ]
    },
    {
      "id": "NQO1",
      "label": "NQO1",
      "type": "Enzyme",
      "detail": "Two-electron quinone reduction; prevents ROS from redox cycling",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, lung, colon",
      "activity_score": 1.0,
      "tier": 1,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NQO1",
      "canonical_label": "NQO1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1728",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for NQO1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1728"
        },
        {
          "source_db": "GTEx",
          "record_id": "NQO1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, lung, colon",
          "citation": "GTEx Portal expression profile for NQO1",
          "url": "https://gtexportal.org/home/gene/NQO1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA31744",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for NQO1",
          "url": "https://www.clinpgx.org/gene/PA31744"
        }
      ]
    },
    {
      "id": "COMT",
      "label": "COMT",
      "type": "Enzyme",
      "detail": "O-methylation of catechol estrogens and other catechols; limits redox-cycling estrogen metabolites",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, breast, brain, endometrium",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "COMT",
      "canonical_label": "COMT",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1312",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for COMT (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1312"
        },
        {
          "source_db": "GTEx",
          "record_id": "COMT",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, breast, brain, endometrium",
          "citation": "GTEx Portal expression profile for COMT",
          "url": "https://gtexportal.org/home/gene/COMT"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA119",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for COMT",
          "url": "https://www.clinpgx.org/gene/PA119"
        }
      ]
    },
    {
      "id": "UGT2B17",
      "label": "UGT2B17",
      "type": "Enzyme",
      "detail": "Glucuronidation of testosterone, DHT, and related androgen metabolites",
      "phase": "II",
      "role": "Detoxification",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, prostate, intestine",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "UGT2B17",
      "canonical_label": "UGT2B17",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "7367",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for UGT2B17 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/7367"
        },
        {
          "source_db": "GTEx",
          "record_id": "UGT2B17",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, prostate, intestine",
          "citation": "GTEx Portal expression profile for UGT2B17",
          "url": "https://gtexportal.org/home/gene/UGT2B17"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "UGT2B17",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for UGT2B17",
          "url": "https://www.clinpgx.org/gene/UGT2B17"
        }
      ]
    },
    {
      "id": "UGT2B15",
      "label": "UGT2B15",
      "type": "Enzyme",
      "detail": "Glucuronidation of DHT/androsterone; compensates for UGT2B17 deletion",
      "phase": "II",
      "role": "Detoxification",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "HSD3B2",
      "label": "HSD3B2",
      "type": "Enzyme",
      "detail": "3\u03b2-Hydroxysteroid dehydrogenase type 2; DHEA\u2192androstenedione conversion",
      "phase": "I",
      "role": "Activation",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "AKR1C2",
      "label": "AKR1C2",
      "type": "Enzyme",
      "detail": "3\u03b1-Hydroxysteroid dehydrogenase; DHT\u21923\u03b1-androstanediol inactivation",
      "phase": "II",
      "role": "Detoxification",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "ABCB1",
      "label": "ABCB1",
      "type": "Enzyme",
      "detail": "P-gp; ATP-driven efflux of hydrophobic xenobiotics and carcinogens",
      "phase": "III",
      "role": "Transport",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, intestine, kidney, BBB, placenta",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "ABCB1",
      "canonical_label": "ABCB1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "5243",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for ABCB1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/5243"
        },
        {
          "source_db": "GTEx",
          "record_id": "ABCB1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, intestine, kidney, BBB, placenta",
          "citation": "GTEx Portal expression profile for ABCB1",
          "url": "https://gtexportal.org/home/gene/ABCB1"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA267",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for ABCB1",
          "url": "https://www.clinpgx.org/gene/PA267"
        }
      ]
    },
    {
      "id": "ABCC2",
      "label": "ABCC2",
      "type": "Enzyme",
      "detail": "MRP2; export of GSH/glucuronide/sulfate conjugates of carcinogen metabolites",
      "phase": "III",
      "role": "Transport",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, kidney, intestine",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "ABCC2",
      "canonical_label": "ABCC2",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "1244",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for ABCC2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/1244"
        },
        {
          "source_db": "GTEx",
          "record_id": "ABCC2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, kidney, intestine",
          "citation": "GTEx Portal expression profile for ABCC2",
          "url": "https://gtexportal.org/home/gene/ABCC2"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA116",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for ABCC2",
          "url": "https://www.clinpgx.org/gene/PA116"
        }
      ]
    },
    {
      "id": "ABCG2",
      "label": "ABCG2",
      "type": "Enzyme",
      "detail": "BCRP; efflux of PAHs, PhIP, porphyrins",
      "phase": "III",
      "role": "Transport",
      "source_db": "NCBI Gene; GTEx; ClinPGx",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "intestine, liver, placenta, mammary, BBB",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "ABCG2",
      "canonical_label": "ABCG2",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "9429",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for ABCG2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/9429"
        },
        {
          "source_db": "GTEx",
          "record_id": "ABCG2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "intestine, liver, placenta, mammary, BBB",
          "citation": "GTEx Portal expression profile for ABCG2",
          "url": "https://gtexportal.org/home/gene/ABCG2"
        },
        {
          "source_db": "ClinPGx",
          "record_id": "PA390",
          "evidence": "Pharmacogenomics and xenobiotic-response gene resource.",
          "citation": "ClinPGx gene resource for ABCG2",
          "url": "https://www.clinpgx.org/gene/PA390"
        }
      ]
    },
    {
      "id": "XRCC1",
      "label": "XRCC1",
      "type": "Enzyme",
      "detail": "BER scaffold protein; coordinates repair of oxidative/alkylation DNA damage",
      "group": "DNA Repair (BER)",
      "role": "Repair",
      "source_db": "NCBI Gene; GTEx; CTD",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "ubiquitous",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "XRCC1",
      "canonical_label": "XRCC1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "7515",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for XRCC1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/7515"
        },
        {
          "source_db": "GTEx",
          "record_id": "XRCC1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "ubiquitous",
          "citation": "GTEx Portal expression profile for XRCC1",
          "url": "https://gtexportal.org/home/gene/XRCC1"
        },
        {
          "source_db": "CTD",
          "record_id": "XRCC1",
          "evidence": "Toxicogenomic context supporting the DNA Repair (BER) assignment.",
          "citation": "Comparative Toxicogenomics Database record for XRCC1",
          "url": "https://ctdbase.org/detail.go?type=gene&acc=XRCC1"
        }
      ]
    },
    {
      "id": "XPC",
      "label": "XPC",
      "type": "Enzyme",
      "detail": "GG-NER damage sensor; recognizes bulky DNA adducts from PAHs",
      "group": "DNA Repair (NER)",
      "role": "Repair",
      "source_db": "NCBI Gene; GTEx; CTD",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "ubiquitous",
      "activity_score": 1.0,
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "XPC",
      "canonical_label": "XPC",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "7508",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for XPC (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/7508"
        },
        {
          "source_db": "GTEx",
          "record_id": "XPC",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "ubiquitous",
          "citation": "GTEx Portal expression profile for XPC",
          "url": "https://gtexportal.org/home/gene/XPC"
        },
        {
          "source_db": "CTD",
          "record_id": "XPC",
          "evidence": "Toxicogenomic context supporting the DNA Repair (NER) assignment.",
          "citation": "Comparative Toxicogenomics Database record for XPC",
          "url": "https://ctdbase.org/detail.go?type=gene&acc=XPC"
        }
      ]
    },
    {
      "id": "ERCC2",
      "label": "ERCC2/XPD",
      "type": "Enzyme",
      "detail": "NER helicase; unwinds DNA at damage sites for bulky adduct excision",
      "group": "DNA Repair (NER)",
      "role": "Repair",
      "source_db": "NCBI Gene; GTEx; CTD",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "ubiquitous",
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "ERCC2",
      "canonical_label": "ERCC2/XPD",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "2068",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for ERCC2 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/2068"
        },
        {
          "source_db": "GTEx",
          "record_id": "ERCC2",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "ubiquitous",
          "citation": "GTEx Portal expression profile for ERCC2",
          "url": "https://gtexportal.org/home/gene/ERCC2"
        },
        {
          "source_db": "CTD",
          "record_id": "ERCC2",
          "evidence": "Toxicogenomic context supporting the DNA Repair (NER) assignment.",
          "citation": "Comparative Toxicogenomics Database record for ERCC2",
          "url": "https://ctdbase.org/detail.go?type=gene&acc=ERCC2"
        }
      ]
    },
    {
      "id": "OGG1",
      "label": "OGG1",
      "type": "Enzyme",
      "detail": "8-oxoguanine DNA glycosylase; excises oxidative DNA damage (8-oxodG)",
      "group": "DNA Repair (BER)",
      "role": "Repair",
      "source_db": "NCBI Gene; GTEx; CTD",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "ubiquitous (nuclear + mitochondrial)",
      "activity_score": 1.0,
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "OGG1",
      "canonical_label": "OGG1",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "4968",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for OGG1 (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/4968"
        },
        {
          "source_db": "GTEx",
          "record_id": "OGG1",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "ubiquitous (nuclear + mitochondrial)",
          "citation": "GTEx Portal expression profile for OGG1",
          "url": "https://gtexportal.org/home/gene/OGG1"
        },
        {
          "source_db": "CTD",
          "record_id": "OGG1",
          "evidence": "Toxicogenomic context supporting the DNA Repair (BER) assignment.",
          "citation": "Comparative Toxicogenomics Database record for OGG1",
          "url": "https://ctdbase.org/detail.go?type=gene&acc=OGG1"
        }
      ]
    },
    {
      "id": "MGMT",
      "label": "MGMT",
      "type": "Enzyme",
      "detail": "Direct reversal of O6-alkylguanine; single-use suicidal repair enzyme",
      "group": "DNA Repair (Direct Reversal)",
      "role": "Repair",
      "source_db": "NCBI Gene; GTEx; CTD",
      "evidence": "Canonical human gene identifier and nomenclature.",
      "tissue": "liver, colon, lung, brain",
      "activity_score": 1.0,
      "tier": 2,
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "MGMT",
      "canonical_label": "MGMT",
      "canonical_namespace": "reference_panel",
      "provenance": [
        {
          "source_db": "NCBI Gene",
          "record_id": "4255",
          "evidence": "Canonical human gene identifier and nomenclature.",
          "citation": "NCBI Gene record for MGMT (Homo sapiens)",
          "url": "https://www.ncbi.nlm.nih.gov/gene/4255"
        },
        {
          "source_db": "GTEx",
          "record_id": "MGMT",
          "evidence": "Human tissue-expression context used to seed the panel tissue field.",
          "tissue": "liver, colon, lung, brain",
          "citation": "GTEx Portal expression profile for MGMT",
          "url": "https://gtexportal.org/home/gene/MGMT"
        },
        {
          "source_db": "CTD",
          "record_id": "MGMT",
          "evidence": "Toxicogenomic context supporting the DNA Repair (Direct Reversal) assignment.",
          "citation": "Comparative Toxicogenomics Database record for MGMT",
          "url": "https://ctdbase.org/detail.go?type=gene&acc=MGMT"
        }
      ]
    },
    {
      "id": "BPDE",
      "label": "BPDE",
      "type": "Metabolite",
      "detail": "Ultimate diol-epoxide carcinogen formed from BaP.",
      "reactivity": "High",
      "source_db": "Curated showcase",
      "evidence": "Ultimate diol-epoxide carcinogen formed from BaP.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "BPDE",
      "canonical_label": "BPDE",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BPDE",
          "evidence": "Ultimate diol-epoxide carcinogen formed from BaP.",
          "citation": "Curated metabolite entry for BPDE"
        }
      ]
    },
    {
      "id": "BaP_diol",
      "label": "BaP-7,8-diol",
      "type": "Metabolite",
      "detail": "Hydrolysis product of the BaP epoxide intermediate.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Hydrolysis product of the BaP epoxide intermediate.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "BaP_diol",
      "canonical_label": "BaP-7,8-diol",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BaP_diol",
          "evidence": "Hydrolysis product of the BaP epoxide intermediate.",
          "citation": "Curated metabolite entry for BaP-7,8-diol"
        }
      ]
    },
    {
      "id": "BaP_epoxide",
      "label": "BaP-7,8-epoxide",
      "type": "Metabolite",
      "detail": "Initial PAH epoxide intermediate formed during BaP activation.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Initial PAH epoxide intermediate formed during BaP activation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "BaP_epoxide",
      "canonical_label": "BaP-7,8-epoxide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BaP_epoxide",
          "evidence": "Initial PAH epoxide intermediate formed during BaP activation.",
          "citation": "Curated metabolite entry for BaP-7,8-epoxide"
        }
      ]
    },
    {
      "id": "NOH_PhIP",
      "label": "N-hydroxy-PhIP",
      "type": "Metabolite",
      "detail": "Phase I activated PhIP intermediate prior to sulfate ester formation.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Phase I activated PhIP intermediate prior to sulfate ester formation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NOH_PhIP",
      "canonical_label": "N-hydroxy-PhIP",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NOH_PhIP",
          "evidence": "Phase I activated PhIP intermediate prior to sulfate ester formation.",
          "citation": "Curated metabolite entry for N-hydroxy-PhIP"
        }
      ]
    },
    {
      "id": "NOH_4ABP",
      "label": "N-hydroxy-4-ABP",
      "type": "Metabolite",
      "detail": "N-hydroxylated 4-aminobiphenyl activation intermediate.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "N-hydroxylated 4-aminobiphenyl activation intermediate.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NOH_4ABP",
      "canonical_label": "N-hydroxy-4-ABP",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NOH_4ABP",
          "evidence": "N-hydroxylated 4-aminobiphenyl activation intermediate.",
          "citation": "Curated metabolite entry for N-hydroxy-4-ABP"
        }
      ]
    },
    {
      "id": "NOH_Benzidine",
      "label": "N-hydroxy-benzidine",
      "type": "Metabolite",
      "detail": "Benzidine activation intermediate represented for class completeness.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Benzidine activation intermediate represented for class completeness.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NOH_Benzidine",
      "canonical_label": "N-hydroxy-benzidine",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NOH_Benzidine",
          "evidence": "Benzidine activation intermediate represented for class completeness.",
          "citation": "Curated metabolite entry for N-hydroxy-benzidine"
        }
      ]
    },
    {
      "id": "NNK_hydroxyl",
      "label": "NNK alpha-hydroxylated intermediate",
      "type": "Metabolite",
      "detail": "Primary NNK activation intermediate for the nitrosamine branch.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Primary NNK activation intermediate for the nitrosamine branch.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NNK_hydroxyl",
      "canonical_label": "NNK alpha-hydroxylated intermediate",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NNK_hydroxyl",
          "evidence": "Primary NNK activation intermediate for the nitrosamine branch.",
          "citation": "Curated metabolite entry for NNK alpha-hydroxylated intermediate"
        }
      ]
    },
    {
      "id": "AFB1_epoxide",
      "label": "AFB1-8,9-epoxide",
      "type": "Metabolite",
      "detail": "Canonical aflatoxin epoxide intermediate.",
      "reactivity": "High",
      "source_db": "Curated showcase",
      "evidence": "Canonical aflatoxin epoxide intermediate.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "AFB1_epoxide",
      "canonical_label": "AFB1-8,9-epoxide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "AFB1_epoxide",
          "evidence": "Canonical aflatoxin epoxide intermediate.",
          "citation": "Curated metabolite entry for AFB1-8,9-epoxide"
        }
      ]
    },
    {
      "id": "HydroxyE2",
      "label": "4-Hydroxyestradiol",
      "type": "Metabolite",
      "detail": "Catechol estrogen intermediate formed during CYP1B1-mediated estrogen activation.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Catechol estrogen intermediate formed during CYP1B1-mediated estrogen activation.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "HydroxyE2",
      "canonical_label": "4-Hydroxyestradiol",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "HydroxyE2",
          "evidence": "Catechol estrogen intermediate formed during CYP1B1-mediated estrogen activation.",
          "citation": "Curated metabolite entry for 4-Hydroxyestradiol"
        }
      ]
    },
    {
      "id": "2OHE2",
      "label": "2-OH-Estradiol",
      "type": "Metabolite",
      "detail": "Catechol estrogen; less genotoxic pathway",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "E2_quinone",
      "label": "Estradiol-3,4-quinone",
      "type": "Metabolite",
      "detail": "Reactive estrogen quinone that yields depurinating DNA adducts.",
      "reactivity": "High",
      "source_db": "Curated showcase",
      "evidence": "Reactive estrogen quinone that yields depurinating DNA adducts.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "E2_quinone",
      "canonical_label": "Estradiol-3,4-quinone",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "E2_quinone",
          "evidence": "Reactive estrogen quinone that yields depurinating DNA adducts.",
          "citation": "Curated metabolite entry for Estradiol-3,4-quinone"
        }
      ]
    },
    {
      "id": "Benzene_oxide",
      "label": "Benzene oxide",
      "type": "Metabolite",
      "detail": "Early benzene oxidation product linked to downstream quinone chemistry.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Early benzene oxidation product linked to downstream quinone chemistry.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Benzene_oxide",
      "canonical_label": "Benzene oxide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Benzene_oxide",
          "evidence": "Early benzene oxidation product linked to downstream quinone chemistry.",
          "citation": "Curated metabolite entry for Benzene oxide"
        }
      ]
    },
    {
      "id": "HQ",
      "label": "Hydroquinone",
      "type": "Metabolite",
      "detail": "Benzene metabolite; oxidized to benzoquinone",
      "reactivity": "High",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "Benzoquinone",
      "label": "Benzoquinone",
      "type": "Metabolite",
      "detail": "Representative ROS-linked benzene metabolite.",
      "reactivity": "High",
      "source_db": "Curated showcase",
      "evidence": "Representative ROS-linked benzene metabolite.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Benzoquinone",
      "canonical_label": "Benzoquinone",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Benzoquinone",
          "evidence": "Representative ROS-linked benzene metabolite.",
          "citation": "Curated metabolite entry for Benzoquinone"
        }
      ]
    },
    {
      "id": "Chloroethylene_oxide",
      "label": "Chloroethylene oxide",
      "type": "Metabolite",
      "detail": "Reactive vinyl chloride intermediate that yields etheno adducts.",
      "reactivity": "High",
      "source_db": "Curated showcase",
      "evidence": "Reactive vinyl chloride intermediate that yields etheno adducts.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Chloroethylene_oxide",
      "canonical_label": "Chloroethylene oxide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Chloroethylene_oxide",
          "evidence": "Reactive vinyl chloride intermediate that yields etheno adducts.",
          "citation": "Curated metabolite entry for Chloroethylene oxide"
        }
      ]
    },
    {
      "id": "PhIP_NAc",
      "label": "PhIP-N-acetyl",
      "type": "Metabolite",
      "detail": "N-acetylated PhIP; detoxified conjugate",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "BPDE_GSH",
      "label": "BPDE-GSH conjugate",
      "type": "Metabolite",
      "detail": "Glutathione-conjugated detoxification product of BPDE.",
      "reactivity": "Low",
      "source_db": "Curated showcase",
      "evidence": "Glutathione-conjugated detoxification product of BPDE.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "BPDE_GSH",
      "canonical_label": "BPDE-GSH conjugate",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BPDE_GSH",
          "evidence": "Glutathione-conjugated detoxification product of BPDE.",
          "citation": "Curated metabolite entry for BPDE-GSH conjugate"
        }
      ]
    },
    {
      "id": "AFB1_GSH",
      "label": "AFB1-GSH",
      "type": "Metabolite",
      "detail": "Glutathione conjugate of AFB1 epoxide; detoxified",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "PhIP_gluc",
      "label": "PhIP-glucuronide",
      "type": "Metabolite",
      "detail": "Glucuronide conjugate; renal excretion",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "E2_methyl",
      "label": "Methoxy-E2",
      "type": "Metabolite",
      "detail": "Methylated catechol estrogen; non-genotoxic",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "NDMA_hydroxyl",
      "label": "NDMA alpha-hydroxylated intermediate",
      "type": "Metabolite",
      "detail": "Primary NDMA activation intermediate.",
      "reactivity": "Intermediate",
      "source_db": "Curated showcase",
      "evidence": "Primary NDMA activation intermediate.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "NDMA_hydroxyl",
      "canonical_label": "NDMA alpha-hydroxylated intermediate",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "NDMA_hydroxyl",
          "evidence": "Primary NDMA activation intermediate.",
          "citation": "Curated metabolite entry for NDMA alpha-hydroxylated intermediate"
        }
      ]
    },
    {
      "id": "DHEA",
      "label": "DHEA",
      "type": "Metabolite",
      "detail": "Dehydroepiandrosterone; adrenal androgen precursor",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "Androstenedione",
      "label": "Androstenedione",
      "type": "Metabolite",
      "detail": "\u03944-Androstenedione; immediate testosterone precursor",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "HydroxyTestosterone",
      "label": "6\u03b2-OH-Testosterone",
      "type": "Metabolite",
      "detail": "CYP3A4/5-catalyzed hydroxylated testosterone; inactive metabolite",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "Testosterone_gluc",
      "label": "Testosterone-17-glucuronide",
      "type": "Metabolite",
      "detail": "Representative androgen detoxification product.",
      "reactivity": "Low",
      "source_db": "Curated showcase",
      "evidence": "Representative androgen detoxification product.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Testosterone_gluc",
      "canonical_label": "Testosterone-17-glucuronide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Testosterone_gluc",
          "evidence": "Representative androgen detoxification product.",
          "citation": "Curated metabolite entry for Testosterone-17-glucuronide"
        }
      ]
    },
    {
      "id": "DHT_gluc",
      "label": "DHT-17-glucuronide",
      "type": "Metabolite",
      "detail": "Representative DHT conjugate used for androgen detoxification.",
      "reactivity": "Low",
      "source_db": "Curated showcase",
      "evidence": "Representative DHT conjugate used for androgen detoxification.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "DHT_gluc",
      "canonical_label": "DHT-17-glucuronide",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "DHT_gluc",
          "evidence": "Representative DHT conjugate used for androgen detoxification.",
          "citation": "Curated metabolite entry for DHT-17-glucuronide"
        }
      ]
    },
    {
      "id": "3aAdiol",
      "label": "3\u03b1-Androstanediol",
      "type": "Metabolite",
      "detail": "AKR1C2-catalyzed DHT metabolite; weak ER\u03b2 agonist",
      "reactivity": "Low",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "E2_from_T",
      "label": "E2 (from T)",
      "type": "Metabolite",
      "detail": "Estradiol produced by aromatization of testosterone; genotoxic bridge",
      "reactivity": "High",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "BPDE_dG",
      "label": "BPDE-N2-dG",
      "type": "DNA_Adduct",
      "detail": "Canonical bulky PAH DNA adduct.",
      "source_db": "Curated showcase",
      "evidence": "Canonical bulky PAH DNA adduct.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "BPDE_dG",
      "canonical_label": "BPDE-N2-dG",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "BPDE_dG",
          "evidence": "Canonical bulky PAH DNA adduct.",
          "citation": "Curated DNA adduct entry for BPDE-N2-dG"
        }
      ]
    },
    {
      "id": "PhIP_dG",
      "label": "PhIP-C8-dG",
      "type": "DNA_Adduct",
      "detail": "Representative HCA DNA adduct formed from activated PhIP.",
      "source_db": "Curated showcase",
      "evidence": "Representative HCA DNA adduct formed from activated PhIP.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "PhIP_dG",
      "canonical_label": "PhIP-C8-dG",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "PhIP_dG",
          "evidence": "Representative HCA DNA adduct formed from activated PhIP.",
          "citation": "Curated DNA adduct entry for PhIP-C8-dG"
        }
      ]
    },
    {
      "id": "ABP_dG",
      "label": "dG-C8-4-ABP",
      "type": "DNA_Adduct",
      "detail": "Representative aromatic-amine guanine adduct.",
      "source_db": "Curated showcase",
      "evidence": "Representative aromatic-amine guanine adduct.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "ABP_dG",
      "canonical_label": "dG-C8-4-ABP",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "ABP_dG",
          "evidence": "Representative aromatic-amine guanine adduct.",
          "citation": "Curated DNA adduct entry for dG-C8-4-ABP"
        }
      ]
    },
    {
      "id": "O6_methyl_dG",
      "label": "O6-methyl-dG",
      "type": "DNA_Adduct",
      "detail": "Representative NDMA-derived methyl DNA adduct.",
      "source_db": "Curated showcase",
      "evidence": "Representative NDMA-derived methyl DNA adduct.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "O6_methyl_dG",
      "canonical_label": "O6-methyl-dG",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "O6_methyl_dG",
          "evidence": "Representative NDMA-derived methyl DNA adduct.",
          "citation": "Curated DNA adduct entry for O6-methyl-dG"
        }
      ]
    },
    {
      "id": "POB_dG",
      "label": "O6-POB-dG",
      "type": "DNA_Adduct",
      "detail": "Representative NNK-derived pyridyloxobutyl DNA adduct.",
      "source_db": "Curated showcase",
      "evidence": "Representative NNK-derived pyridyloxobutyl DNA adduct.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "POB_dG",
      "canonical_label": "O6-POB-dG",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "POB_dG",
          "evidence": "Representative NNK-derived pyridyloxobutyl DNA adduct.",
          "citation": "Curated DNA adduct entry for O6-POB-dG"
        }
      ]
    },
    {
      "id": "AFB1_Gua",
      "label": "AFB1-N7-Gua",
      "type": "DNA_Adduct",
      "detail": "Canonical aflatoxin-derived guanine adduct.",
      "source_db": "Curated showcase",
      "evidence": "Canonical aflatoxin-derived guanine adduct.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "AFB1_Gua",
      "canonical_label": "AFB1-N7-Gua",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "AFB1_Gua",
          "evidence": "Canonical aflatoxin-derived guanine adduct.",
          "citation": "Curated DNA adduct entry for AFB1-N7-Gua"
        }
      ]
    },
    {
      "id": "etheno_dA",
      "label": "\u03b5dA (etheno-dA)",
      "type": "DNA_Adduct",
      "detail": "1,N6-etheno-deoxyadenosine; vinyl chloride marker",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "etheno_dC",
      "label": "\u03b5dC (etheno-dC)",
      "type": "DNA_Adduct",
      "detail": "3,N4-etheno-deoxycytidine; vinyl chloride marker",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "E2_depurin",
      "label": "E2-depurinating",
      "type": "DNA_Adduct",
      "detail": "4-OHE2 depurinating adducts; apurinic sites \u2192 mutations",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "Oxo_dG",
      "label": "8-oxo-dG",
      "type": "DNA_Adduct",
      "detail": "Representative oxidative DNA lesion linked to ROS pathway activity.",
      "source_db": "Curated showcase",
      "evidence": "Representative oxidative DNA lesion linked to ROS pathway activity.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "Oxo_dG",
      "canonical_label": "8-oxo-dG",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "Oxo_dG",
          "evidence": "Representative oxidative DNA lesion linked to ROS pathway activity.",
          "citation": "Curated DNA adduct entry for 8-oxo-dG"
        }
      ]
    },
    {
      "id": "BQ_dG",
      "label": "BQ-DNA",
      "type": "DNA_Adduct",
      "detail": "Benzoquinone-DNA adducts; hematotoxic lesions",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "hsa00980",
      "label": "Xenobiotic metabolism by cytochrome P450",
      "type": "Pathway",
      "detail": "Core xenobiotic biotransformation pathway for phase I carcinogen metabolism.",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "hsa00980",
      "canonical_label": "Xenobiotic metabolism by cytochrome P450",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00980",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Xenobiotic metabolism by cytochrome P450",
          "url": "https://www.kegg.jp/entry/hsa00980"
        }
      ]
    },
    {
      "id": "hsa05208",
      "label": "Chemical carcinogenesis - reactive oxygen species",
      "type": "Pathway",
      "detail": "ROS-linked carcinogenesis and oxidative damage context.",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "hsa05208",
      "canonical_label": "Chemical carcinogenesis - reactive oxygen species",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa05208",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Chemical carcinogenesis - reactive oxygen species",
          "url": "https://www.kegg.jp/entry/hsa05208"
        }
      ]
    },
    {
      "id": "hsa05204",
      "label": "Chemical carcinogenesis - DNA adducts",
      "type": "Pathway",
      "detail": "Reactive-metabolite to DNA-adduct formation and repair context.",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "hsa05204",
      "canonical_label": "Chemical carcinogenesis - DNA adducts",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa05204",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Chemical carcinogenesis - DNA adducts",
          "url": "https://www.kegg.jp/entry/hsa05204"
        }
      ]
    },
    {
      "id": "KEGG982",
      "label": "Drug Metabolism\nCYP450 (KEGG:00982)",
      "type": "Pathway",
      "detail": "Drug metabolism \u2014 cytochrome P450",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "KEGG980G",
      "label": "Glutathione\nMetabolism (KEGG:00480)",
      "type": "Pathway",
      "detail": "Glutathione metabolism pathway",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "id": "hsa00140",
      "label": "Steroid hormone biosynthesis",
      "type": "Pathway",
      "detail": "Hormone-metabolism context relevant to estrogenic carcinogen processing.",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_id": "hsa00140",
      "canonical_label": "Steroid hormone biosynthesis",
      "canonical_namespace": "curated_showcase",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    }
  ],
  "edges": [
    {
      "source": "BaP",
      "target": "Oxo_dG",
      "type": "FORMS_ADDUCT",
      "label": "ROS generation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "FORMS_ADDUCT",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "BaP",
      "target": "hsa05204",
      "type": "PATHWAY",
      "label": "Pathway membership: Chemical carcinogenesis - DNA adducts",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa05204",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Chemical carcinogenesis - DNA adducts",
          "url": "https://www.kegg.jp/entry/hsa05204"
        }
      ]
    },
    {
      "source": "BaP",
      "target": "hsa00980",
      "type": "PATHWAY",
      "label": "Pathway membership: Xenobiotic metabolism by cytochrome P450",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00980",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Xenobiotic metabolism by cytochrome P450",
          "url": "https://www.kegg.jp/entry/hsa00980"
        }
      ]
    },
    {
      "source": "PhIP",
      "target": "hsa00980",
      "type": "PATHWAY",
      "label": "Pathway membership: Xenobiotic metabolism by cytochrome P450",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00980",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Xenobiotic metabolism by cytochrome P450",
          "url": "https://www.kegg.jp/entry/hsa00980"
        }
      ]
    },
    {
      "source": "NNK",
      "target": "hsa05204",
      "type": "PATHWAY",
      "label": "DNA adduct pathway",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "AFB1",
      "target": "hsa05204",
      "type": "PATHWAY",
      "label": "DNA adduct pathway",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "Testosterone",
      "target": "Oxo_dG",
      "type": "FORMS_ADDUCT",
      "label": "ROS via AR signaling",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "FORMS_ADDUCT",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "Testosterone",
      "target": "hsa00140",
      "type": "PATHWAY",
      "label": "Pathway membership: Steroid hormone biosynthesis",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    },
    {
      "source": "Testosterone",
      "target": "hsa05208",
      "type": "PATHWAY",
      "label": "ROS carcinogenesis",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "DHT",
      "target": "hsa00140",
      "type": "PATHWAY",
      "label": "Pathway membership: Steroid hormone biosynthesis",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    },
    {
      "source": "Benzene",
      "target": "hsa05208",
      "type": "PATHWAY",
      "label": "Pathway membership: Chemical carcinogenesis - reactive oxygen species",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa05208",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Chemical carcinogenesis - reactive oxygen species",
          "url": "https://www.kegg.jp/entry/hsa05208"
        }
      ]
    },
    {
      "source": "Benzene",
      "target": "hsa00980",
      "type": "PATHWAY",
      "label": "Pathway membership: Xenobiotic metabolism by cytochrome P450",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00980",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Xenobiotic metabolism by cytochrome P450",
          "url": "https://www.kegg.jp/entry/hsa00980"
        }
      ]
    },
    {
      "source": "CYP1A1",
      "target": "BaP_epoxide",
      "type": "ACTIVATES",
      "label": "BaP epoxidation",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "BaP epoxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A1->BaP_epoxide",
          "evidence": "BaP epoxidation",
          "citation": "BaP epoxidation"
        }
      ]
    },
    {
      "source": "CYP1A1",
      "target": "BPDE",
      "type": "ACTIVATES",
      "label": "Second epoxidation to BPDE",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "Second epoxidation to BPDE",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A1->BPDE",
          "evidence": "Second epoxidation to BPDE",
          "citation": "Second epoxidation to BPDE"
        }
      ]
    },
    {
      "source": "CYP1A1",
      "target": "2OHE2",
      "type": "ACTIVATES",
      "label": "2-hydroxylation",
      "carcinogen": "E2",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "CYP1A1",
      "target": "hsa00980",
      "type": "PATHWAY",
      "label": "Pathway membership: Xenobiotic metabolism by cytochrome P450",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00980",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Xenobiotic metabolism by cytochrome P450",
          "url": "https://www.kegg.jp/entry/hsa00980"
        }
      ]
    },
    {
      "source": "CYP1B1",
      "target": "BaP_epoxide",
      "type": "ACTIVATES",
      "label": "Extrahepatic BaP epoxidation",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "Extrahepatic BaP epoxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1B1->BaP_epoxide",
          "evidence": "Extrahepatic BaP epoxidation",
          "citation": "Extrahepatic BaP epoxidation"
        }
      ]
    },
    {
      "source": "CYP1B1",
      "target": "BPDE",
      "type": "ACTIVATES",
      "label": "Second epoxidation to BPDE",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "Second epoxidation to BPDE",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1B1->BPDE",
          "evidence": "Second epoxidation to BPDE",
          "citation": "Second epoxidation to BPDE"
        }
      ]
    },
    {
      "source": "CYP1B1",
      "target": "HydroxyE2",
      "type": "ACTIVATES",
      "label": "Catechol estrogen formation",
      "carcinogen": "E2",
      "source_db": "Curated showcase",
      "evidence": "Catechol estrogen formation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1B1->HydroxyE2",
          "evidence": "Catechol estrogen formation",
          "citation": "Catechol estrogen formation"
        }
      ]
    },
    {
      "source": "CYP1A2",
      "target": "NOH_PhIP",
      "type": "ACTIVATES",
      "label": "N-hydroxylation",
      "carcinogen": "PhIP",
      "source_db": "Curated showcase",
      "evidence": "N-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A2->NOH_PhIP",
          "evidence": "N-hydroxylation",
          "citation": "N-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP1A2",
      "target": "NOH_4ABP",
      "type": "ACTIVATES",
      "label": "N-hydroxylation",
      "carcinogen": "4ABP",
      "source_db": "Curated showcase",
      "evidence": "N-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A2->NOH_4ABP",
          "evidence": "N-hydroxylation",
          "citation": "N-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP1A2",
      "target": "NOH_Benzidine",
      "type": "ACTIVATES",
      "label": "Benzidine N-hydroxylation",
      "carcinogen": "Benzidine",
      "source_db": "Curated showcase",
      "evidence": "Benzidine N-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A2->NOH_Benzidine",
          "evidence": "Benzidine N-hydroxylation",
          "citation": "Benzidine N-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP1A2",
      "target": "AFB1_epoxide",
      "type": "ACTIVATES",
      "label": "Secondary epoxidation",
      "carcinogen": "AFB1",
      "source_db": "Curated showcase",
      "evidence": "Secondary epoxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP1A2->AFB1_epoxide",
          "evidence": "Secondary epoxidation",
          "citation": "Secondary epoxidation"
        }
      ]
    },
    {
      "source": "CYP1A2",
      "target": "KEGG982",
      "type": "PATHWAY",
      "label": "member",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "CYP2A6",
      "target": "NNK_hydroxyl",
      "type": "ACTIVATES",
      "label": "Alpha-hydroxylation",
      "carcinogen": "NNK",
      "source_db": "Curated showcase",
      "evidence": "Alpha-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP2A6->NNK_hydroxyl",
          "evidence": "Alpha-hydroxylation",
          "citation": "Alpha-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP2A13",
      "target": "NNK_hydroxyl",
      "type": "ACTIVATES",
      "label": "Pulmonary alpha-hydroxylation",
      "carcinogen": "NNK",
      "source_db": "Curated showcase",
      "evidence": "Pulmonary alpha-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP2A13->NNK_hydroxyl",
          "evidence": "Pulmonary alpha-hydroxylation",
          "citation": "Pulmonary alpha-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP2E1",
      "target": "NDMA_hydroxyl",
      "type": "ACTIVATES",
      "label": "Alpha-hydroxylation",
      "carcinogen": "NDMA",
      "source_db": "Curated showcase",
      "evidence": "Alpha-hydroxylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP2E1->NDMA_hydroxyl",
          "evidence": "Alpha-hydroxylation",
          "citation": "Alpha-hydroxylation"
        }
      ]
    },
    {
      "source": "CYP2E1",
      "target": "Benzene_oxide",
      "type": "ACTIVATES",
      "label": "Benzene oxidation",
      "carcinogen": "Benzene",
      "source_db": "Curated showcase",
      "evidence": "Benzene oxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP2E1->Benzene_oxide",
          "evidence": "Benzene oxidation",
          "citation": "Benzene oxidation"
        }
      ]
    },
    {
      "source": "CYP2E1",
      "target": "Chloroethylene_oxide",
      "type": "ACTIVATES",
      "label": "Vinyl chloride oxidation",
      "carcinogen": "VinylChloride",
      "source_db": "Curated showcase",
      "evidence": "Vinyl chloride oxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP2E1->Chloroethylene_oxide",
          "evidence": "Vinyl chloride oxidation",
          "citation": "Vinyl chloride oxidation"
        }
      ]
    },
    {
      "source": "CYP2E1",
      "target": "hsa00980",
      "type": "PATHWAY",
      "label": "member",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "CYP3A4",
      "target": "AFB1_epoxide",
      "type": "ACTIVATES",
      "label": "Aflatoxin epoxidation",
      "carcinogen": "AFB1",
      "source_db": "Curated showcase",
      "evidence": "Aflatoxin epoxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "CYP3A4->AFB1_epoxide",
          "evidence": "Aflatoxin epoxidation",
          "citation": "Aflatoxin epoxidation"
        }
      ]
    },
    {
      "source": "CYP3A4",
      "target": "HydroxyTestosterone",
      "type": "DETOXIFIES",
      "label": "6\u03b2-hydroxylation",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "CYP3A4",
      "target": "KEGG982",
      "type": "PATHWAY",
      "label": "member",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "EPHX1",
      "target": "BaP_diol",
      "type": "ACTIVATES",
      "label": "hydrolysis",
      "carcinogen": "BaP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "EPHX1",
      "target": "AFB1_epoxide",
      "type": "DETOXIFIES",
      "label": "hydrolysis",
      "carcinogen": "AFB1",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "CYP17A1",
      "target": "DHEA",
      "type": "ACTIVATES",
      "label": "17,20-lyase",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "CYP17A1",
      "target": "hsa00140",
      "type": "PATHWAY",
      "label": "Pathway membership: Steroid hormone biosynthesis",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    },
    {
      "source": "SRD5A2",
      "target": "DHT",
      "type": "ACTIVATES",
      "label": "5\u03b1-reduction (prostate)",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "SRD5A2",
      "target": "hsa00140",
      "type": "PATHWAY",
      "label": "Pathway membership: Steroid hormone biosynthesis",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    },
    {
      "source": "SRD5A1",
      "target": "DHT",
      "type": "ACTIVATES",
      "label": "5\u03b1-reduction (peripheral)",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "CYP19A1",
      "target": "E2_from_T",
      "type": "ACTIVATES",
      "label": "aromatization",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "CYP19A1",
      "target": "hsa00140",
      "type": "PATHWAY",
      "label": "Pathway membership: Steroid hormone biosynthesis",
      "source_db": "KEGG",
      "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "PATHWAY",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "KEGG",
          "record_id": "hsa00140",
          "evidence": "Curated KEGG reference pathway tracked by ExposoGraph.",
          "citation": "KEGG pathway record for Steroid hormone biosynthesis",
          "url": "https://www.kegg.jp/entry/hsa00140"
        }
      ]
    },
    {
      "source": "CYP3A5",
      "target": "HydroxyTestosterone",
      "type": "DETOXIFIES",
      "label": "6\u03b2-hydroxylation",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "AKR1C3",
      "target": "Testosterone",
      "type": "ACTIVATES",
      "label": "17\u03b2-reduction",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "GSTM1",
      "target": "BPDE_GSH",
      "type": "DETOXIFIES",
      "label": "Glutathione conjugation",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "Glutathione conjugation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "GSTM1->BPDE_GSH",
          "evidence": "Glutathione conjugation",
          "citation": "Glutathione conjugation"
        }
      ]
    },
    {
      "source": "GSTM1",
      "target": "NOH_4ABP",
      "type": "DETOXIFIES",
      "label": "GSH conjugation",
      "carcinogen": "4ABP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "GSTM1",
      "target": "AFB1_GSH",
      "type": "DETOXIFIES",
      "label": "GSH conjugation",
      "carcinogen": "AFB1",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "GSTM1",
      "target": "KEGG980G",
      "type": "PATHWAY",
      "label": "glutathione pathway",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "GSTT1",
      "target": "AFB1_GSH",
      "type": "DETOXIFIES",
      "label": "GSH conjugation",
      "carcinogen": "AFB1",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "GSTT1",
      "target": "Benzene_oxide",
      "type": "DETOXIFIES",
      "label": "GSH conjugation",
      "carcinogen": "Benzene",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "GSTT1",
      "target": "Chloroethylene_oxide",
      "type": "DETOXIFIES",
      "label": "GSH conjugation",
      "carcinogen": "VinylChloride",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "GSTT1",
      "target": "KEGG980G",
      "type": "PATHWAY",
      "label": "glutathione pathway",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "GSTP1",
      "target": "BPDE_GSH",
      "type": "DETOXIFIES",
      "label": "Glutathione conjugation",
      "carcinogen": "BaP",
      "source_db": "Curated showcase",
      "evidence": "Glutathione conjugation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": [
        {
          "source_db": "Curated showcase",
          "record_id": "GSTP1->BPDE_GSH",
          "evidence": "Glutathione conjugation",
          "citation": "Glutathione conjugation"
        }
      ]
    },
    {
      "source": "NAT2",
      "target": "NOH_PhIP",
      "type": "ACTIVATES",
      "label": "O-acetylation",
      "carcinogen": "PhIP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NAT2",
      "target": "PhIP_NAc",
      "type": "DETOXIFIES",
      "label": "N-acetylation",
      "carcinogen": "PhIP",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "NAT2",
      "target": "4ABP",
      "type": "DETOXIFIES",
      "label": "N-acetylation (deactivation)",
      "carcinogen": "4ABP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NAT1",
      "target": "NOH_4ABP",
      "type": "ACTIVATES",
      "label": "O-acetylation (bladder)",
      "carcinogen": "4ABP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "SULT1A1",
      "target": "NOH_PhIP",
      "type": "ACTIVATES",
      "label": "O-sulfonation",
      "carcinogen": "PhIP",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "SULT1A1",
      "target": "HydroxyE2",
      "type": "DETOXIFIES",
      "label": "sulfation",
      "carcinogen": "E2",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "UGT1A1",
      "target": "PhIP_gluc",
      "type": "DETOXIFIES",
      "label": "glucuronidation",
      "carcinogen": "PhIP",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "UGT1A1",
      "target": "HydroxyE2",
      "type": "DETOXIFIES",
      "label": "glucuronidation",
      "carcinogen": "E2",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "UGT2B7",
      "target": "NNK_hydroxyl",
      "type": "DETOXIFIES",
      "label": "glucuronidation",
      "carcinogen": "NNK",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NQO1",
      "target": "E2_quinone",
      "type": "DETOXIFIES",
      "label": "quinone reduction",
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    },
    {
      "source": "NQO1",
      "target": "Benzoquinone",
      "type": "DETOXIFIES",
      "label": "quinone reduction",
      "carcinogen": "Benzene",
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      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "COMT",
      "target": "E2_methyl",
      "type": "DETOXIFIES",
      "label": "O-methylation",
      "carcinogen": "E2",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "UGT2B17",
      "target": "Testosterone_gluc",
      "type": "DETOXIFIES",
      "label": "glucuronidation",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "DETOXIFIES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "UGT2B17",
      "target": "DHT_gluc",
      "type": "DETOXIFIES",
      "label": "Glucuronidation",
      "carcinogen": "DHT",
      "source_db": "Curated showcase",
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      "origin": "imported",
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        {
          "source_db": "Curated showcase",
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          "evidence": "Glucuronidation",
          "citation": "Glucuronidation"
        }
      ]
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    {
      "source": "UGT2B15",
      "target": "DHT_gluc",
      "type": "DETOXIFIES",
      "label": "glucuronidation",
      "carcinogen": "DHT",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "HSD3B2",
      "target": "Androstenedione",
      "type": "ACTIVATES",
      "label": "3\u03b2-oxidation",
      "carcinogen": "Testosterone",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "AKR1C2",
      "target": "3aAdiol",
      "type": "DETOXIFIES",
      "label": "3\u03b1-reduction",
      "carcinogen": "DHT",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
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    {
      "source": "ABCB1",
      "target": "BPDE_GSH",
      "type": "TRANSPORTS",
      "label": "efflux",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "TRANSPORTS",
      "canonical_namespace": "schema",
      "provenance": []
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    {
      "source": "ABCB1",
      "target": "NNK_hydroxyl",
      "type": "TRANSPORTS",
      "label": "efflux",
      "origin": "imported",
      "match_status": "canonical",
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    {
      "source": "ABCB1",
      "target": "DHT_gluc",
      "type": "TRANSPORTS",
      "label": "efflux",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "TRANSPORTS",
      "canonical_namespace": "schema",
      "provenance": []
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    {
      "source": "ABCC2",
      "target": "BPDE_GSH",
      "type": "TRANSPORTS",
      "label": "biliary efflux",
      "origin": "imported",
      "match_status": "canonical",
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      "provenance": []
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    {
      "source": "ABCC2",
      "target": "AFB1_GSH",
      "type": "TRANSPORTS",
      "label": "biliary efflux",
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      "match_status": "unmatched",
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    {
      "source": "ABCG2",
      "target": "PhIP_gluc",
      "type": "TRANSPORTS",
      "label": "efflux",
      "origin": "imported",
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      "provenance": []
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    {
      "source": "ABCG2",
      "target": "Testosterone_gluc",
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      "label": "efflux",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "TRANSPORTS",
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      "provenance": []
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    {
      "source": "XRCC1",
      "target": "PhIP_dG",
      "type": "REPAIRS",
      "label": "BER",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
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    {
      "source": "XRCC1",
      "target": "ABP_dG",
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      "match_status": "canonical",
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    {
      "source": "XRCC1",
      "target": "BQ_dG",
      "type": "REPAIRS",
      "label": "BER",
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      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "XRCC1",
      "target": "etheno_dA",
      "type": "REPAIRS",
      "label": "BER",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "XPC",
      "target": "BPDE_dG",
      "type": "REPAIRS",
      "label": "NER recognition",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "XPC",
      "target": "AFB1_Gua",
      "type": "REPAIRS",
      "label": "NER",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "ERCC2",
      "target": "BPDE_dG",
      "type": "REPAIRS",
      "label": "NER helicase",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "OGG1",
      "target": "Oxo_dG",
      "type": "REPAIRS",
      "label": "8-oxoG excision",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "MGMT",
      "target": "O6_methyl_dG",
      "type": "REPAIRS",
      "label": "methyl transfer",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "REPAIRS",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "BPDE",
      "target": "BPDE_dG",
      "type": "FORMS_ADDUCT",
      "label": "N2-dG adduct",
      "origin": "imported",
      "match_status": "canonical",
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      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NOH_PhIP",
      "target": "PhIP_dG",
      "type": "FORMS_ADDUCT",
      "label": "C8-dG adduct",
      "origin": "imported",
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      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NOH_4ABP",
      "target": "ABP_dG",
      "type": "FORMS_ADDUCT",
      "label": "C8-dG adduct",
      "origin": "imported",
      "match_status": "canonical",
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      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NNK_hydroxyl",
      "target": "O6_methyl_dG",
      "type": "FORMS_ADDUCT",
      "label": "methylation",
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      "match_status": "canonical",
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      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "NNK_hydroxyl",
      "target": "POB_dG",
      "type": "FORMS_ADDUCT",
      "label": "POB adduction",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "FORMS_ADDUCT",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "AFB1_epoxide",
      "target": "AFB1_Gua",
      "type": "FORMS_ADDUCT",
      "label": "N7-dG adduct",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "FORMS_ADDUCT",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "HydroxyE2",
      "target": "E2_quinone",
      "type": "ACTIVATES",
      "label": "auto-oxidation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "ACTIVATES",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "E2_quinone",
      "target": "E2_depurin",
      "type": "FORMS_ADDUCT",
      "label": "depurinating adduct",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "Benzene_oxide",
      "target": "HQ",
      "type": "ACTIVATES",
      "label": "rearrangement/hydroxylation",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "HQ",
      "target": "Benzoquinone",
      "type": "ACTIVATES",
      "label": "auto-oxidation",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "Benzoquinone",
      "target": "BQ_dG",
      "type": "FORMS_ADDUCT",
      "label": "quinone adducts",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "Chloroethylene_oxide",
      "target": "etheno_dA",
      "type": "FORMS_ADDUCT",
      "label": "\u03b5dA formation",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "Chloroethylene_oxide",
      "target": "etheno_dC",
      "type": "FORMS_ADDUCT",
      "label": "\u03b5dC formation",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "NDMA_hydroxyl",
      "target": "O6_methyl_dG",
      "type": "FORMS_ADDUCT",
      "label": "methylation",
      "origin": "imported",
      "match_status": "canonical",
      "canonical_predicate": "FORMS_ADDUCT",
      "canonical_namespace": "schema",
      "provenance": []
    },
    {
      "source": "E2_from_T",
      "target": "HydroxyE2",
      "type": "ACTIVATES",
      "label": "CYP1B1 \u2192 catechol",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    },
    {
      "source": "E2_from_T",
      "target": "E2_depurin",
      "type": "FORMS_ADDUCT",
      "label": "via quinone pathway",
      "origin": "imported",
      "match_status": "unmatched",
      "provenance": []
    }
  ]
};
