import csv
import gzip
import json
import math
import os
import pandas as pd
import random
import requests
import shutil
import sys
import time
import re

from collections import OrderedDict
import urllib.parse
import urllib.request
from Bio import __version__ as biopython_version
from Bio import SeqIO
from Bio.Seq import Seq
from Bio.SeqRecord import SeqRecord

from ete3 import __version__ as ete3_version
from ete3 import NCBITaxa, is_taxadb_up_to_date

from SPARQLWrapper import __version__ as sparqlwrapper_version

from esmecata.utils import get_rest_uniprot_release, get_sparql_uniprot_release, is_valid_file, is_valid_dir, send_uniprot_sparql_query
from esmecata import __version__ as esmecata_version


url = 'http://rest.uniprot.org/beta/idmapping/run'

# Column names can be found at: https://www.uniprot.org/help/uniprotkb_column_names
# from and to are linked to mapping ID: https://www.uniprot.org/help/api%5Fidmapping

protein_queries = 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A0A4R5JUJ1,B0VJM5,A0A4R5JRK8,B0VHH9,A0A4R5JTS3,A0A4R5JU01,A0A4R5JSP0,B0VHR0,A0A4R5JQ56,B0VG72,A0A4R5JPJ5,A0A4R5JPU1,A0A4V6PI42,A0A4R5JSM4,A0A4R5JQL8,A0A4R5JMW9,B0VJ86,B0VIV1,B0VJM7,B0VGA4,B0VFD9,B0VJR6,A0A4R5JMU0,A0A4R5JPZ7,B0VJ35,A0A4R5JQP0,A0A4R5JS18,A0A4R5JPT8,A0A4R5JQG5,A0A4R5JN53,A0A4R5JSW2,B0VJ54,B0VEV8,B0VIX9,A0A4R5JU76,A0A4R5JPM8,A0A4R5JSN3,A0A4R5JQW3,B0VIF4,A0A4R5JSL5,A0A4V6PI48,A0A4R5JQ87,A0A4R5JNC5,B0VIB5,A0A4R5JQA5,A0A4R5JUE0,A0A4R5JMY7,A0A4R5JRA7,A0A4R5JN35,B0VJ81,A0A4R5JRC0,A0A4R5JNI8"

"""
simple_protein_queries = 'P21802,P12345'
params = {
    'from': 'UniProtKB_AC-ID',
    'to': 'UniProtKB',
    'ids': protein_queries
}
go_pattern = re.compile(r'\[GO:(?P<go>\d{7})\]')
data = urllib.parse.urlencode(params)
data = data.encode('utf-8')
req = urllib.request.Request(url, data)

data_js = json.load(urllib.request.urlopen(req))   
job_id = data_js['jobId']
print(job_id)

http_check_status = 'http://rest.uniprot.org/beta/idmapping/status/{0}'.format(job_id)

response = requests.head(http_check_status)
response.raise_for_status()
check_code = response.status_code
print(check_code)
while response.status_code != 303:
    time.sleep(1)
    if response.status_code == 303:
        break

time.sleep(1)
print(check_code)
if check_code == 303:
    http_download = 'http://rest.uniprot.org/beta/idmapping/uniprotkb/results/stream/{0}'.format(job_id)
    response = requests.get(http_download)
    response.raise_for_status()
    data = response.json()
"""
"""
data = {'results': [{'from': 'P21802', 'to': {'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P21802', 'secondaryAccessions': ['B4DFC2', 'E7EVR6', 'E9PCR0', 'P18443', 'Q01742', 'Q12922', 'Q14300', 'Q14301', 'Q14302', 'Q14303', 'Q14304', 'Q14305', 'Q14672', 'Q14718', 'Q14719', 'Q1KHY5', 'Q86YI4', 'Q8IXC7', 'Q96KL9', 'Q96KM0', 'Q96KM1', 'Q96KM2', 'Q9NZU2', 'Q9NZU3', 'Q9UD01', 'Q9UD02', 'Q9UIH3', 'Q9UIH4', 'Q9UIH5', 'Q9UIH6', 'Q9UIH7', 'Q9UIH8', 'Q9UM87', 'Q9UMC6', 'Q9UNS7', 'Q9UQH7', 'Q9UQH8', 'Q9UQH9', 'Q9UQI0'], 'uniProtkbId': 'FGFR2_HUMAN', 'entryAudit': {'firstPublicDate': '1991-05-01', 'lastAnnotationUpdateDate': '2021-06-02', 'lastSequenceUpdateDate': '1991-05-01', 'entryVersion': 260, 'sequenceVersion': 1}, 'annotationScore': 829.4, 'organism': {'scientificName': 'Homo sapiens', 'commonName': 'Human', 'taxonId': 9606, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Primates', 'Haplorrhini', 'Catarrhini', 'Hominidae', 'Homo']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Fibroblast growth factor receptor 2'}, 'shortNames': [{'value': 'FGFR-2'}], 'ecNumbers': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18056630'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21454610'}], 'value': '2.7.10.1'}]}, 'alternativeNames': [{'fullName': {'value': 'K-sam'}, 'shortNames': [{'value': 'KGFR'}]}, {'fullName': {'value': 'Keratinocyte growth factor receptor'}}], 'cdAntigenNames': [{'value': 'CD332'}], 'flag': 'Precursor'}, 'genes': [{'geneName': {'value': 'FGFR2'}, 'synonyms': [{'value': 'BEK'}, {'value': 'KGFR'}, {'value': 'KSAM'}]}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12529371'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15190072'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15629145'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16384934'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16597617'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17311277'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17623664'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18374639'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19103595'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19387476'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21596750'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8663044'}], 'value': 'Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1'}], 'commentType': 'FUNCTION'}, {'commentType': 'CATALYTIC ACTIVITY', 'reaction': {'name': 'ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]', 'reactionCrossReferences': [{'database': 'Rhea', 'id': 'RHEA:10596'}, {'database': 'Rhea', 'id': 'RHEA-COMP:10136'}, {'database': 'Rhea', 'id': 'RHEA-COMP:10137'}, {'database': 'ChEBI', 'id': 'CHEBI:15378'}, {'database': 'ChEBI', 'id': 'CHEBI:30616'}, {'database': 'ChEBI', 'id': 'CHEBI:46858'}, {'database': 'ChEBI', 'id': 'CHEBI:82620'}, {'database': 'ChEBI', 'id': 'CHEBI:456216'}], 'ecNumber': '2.7.10.1', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU10028'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18056630'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21454610'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21454610'}], 'value': 'Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by ARQ 523 and ARQ 069; these compounds maintain the kinase in an inactive conformation and inhibit autophosphorylation'}], 'commentType': 'ACTIVITY REGULATION'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P21803'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10618369'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10830168'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11069186'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11390973'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12529371'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12591959'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15190072'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15629145'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16384934'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16597617'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17623664'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18056630'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19103595'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21454610'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8663044'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8961926'}], 'value': 'Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, FGF10, FGF17, FGF18 and FGF22 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Isoform 1 has high affinity for FGF1 and FGF2, but low affinity for FGF7. Isoform 3 has high affinity for FGF1 and FGF7, and has much higher affinity for FGF7 than isoform 1 (in vitro). Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19 and FGF21. Interacts with PLCG1, GRB2 and PAK4. Interacts with FLRT2 (By similarity)'}], 'commentType': 'SUBUNIT'}, {'commentType': 'INTERACTION', 'interactions': [{'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P05230', 'geneName': 'FGF1', 'intActId': 'EBI-698068'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P05230', 'geneName': 'FGF1', 'chainId': 'PRO_0000008908', 'intActId': 'EBI-6880860'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'O15520', 'geneName': 'FGF10', 'intActId': 'EBI-1035684'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P09038', 'geneName': 'FGF2', 'intActId': 'EBI-977447'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P09038-2', 'geneName': 'FGF2', 'intActId': 'EBI-11122080'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P62993', 'geneName': 'GRB2', 'intActId': 'EBI-401755'}, 'numberOfExperiments': 5, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802', 'intActId': 'EBI-1028658'}, 'interactantTwo': {'uniProtKBAccession': 'P03968', 'geneName': 'FGF1', 'intActId': 'EBI-6358090'}, 'numberOfExperiments': 2, 'organismDiffer': True}, {'interactantOne': {'uniProtKBAccession': 'P21802-1', 'intActId': 'EBI-15489960'}, 'interactantTwo': {'uniProtKBAccession': 'P05230-1', 'geneName': 'FGF1', 'intActId': 'EBI-15489950'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802-1', 'intActId': 'EBI-15489960'}, 'interactantTwo': {'uniProtKBAccession': 'P09038', 'geneName': 'FGF2', 'intActId': 'EBI-977447'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802-1', 'intActId': 'EBI-15489960'}, 'interactantTwo': {'uniProtKBAccession': 'P21802-1', 'geneName': 'FGFR2', 'intActId': 'EBI-15489960'}, 'numberOfExperiments': 3, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802-1', 'intActId': 'EBI-15489960'}, 'interactantTwo': {'uniProtKBAccession': 'P19174', 'geneName': 'PLCG1', 'intActId': 'EBI-79387'}, 'numberOfExperiments': 9, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802-3', 'intActId': 'EBI-6354683'}, 'interactantTwo': {'uniProtKBAccession': 'P21781', 'geneName': 'FGF7', 'intActId': 'EBI-3937699'}, 'numberOfExperiments': 2, 'organismDiffer': False}, {'interactantOne': {'uniProtKBAccession': 'P21802-3', 'intActId': 'EBI-6354683'}, 'interactantTwo': {'uniProtKBAccession': 'P03968', 'geneName': 'FGF1', 'intActId': 'EBI-6358090'}, 'numberOfExperiments': 2, 'organismDiffer': True}]}, {'commentType': 'SUBCELLULAR LOCATION', 'note': {'texts': [{'value': 'Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded'}]}, 'subcellularLocations': [{'location': {'value': 'Cell membrane', 'id': 'SL-0039'}, 'topology': {'value': 'Single-pass type I membrane protein', 'id': 'SL-9905'}}, {'location': {'value': 'Golgi apparatus', 'id': 'SL-0132'}}, {'location': {'value': 'Cytoplasmic vesicle', 'id': 'SL-0088'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 1', 'note': {'texts': [{'value': 'After ligand binding, the activated receptor is rapidly internalized and degraded'}]}, 'subcellularLocations': [{'location': {'value': 'Cell membrane', 'id': 'SL-0039'}, 'topology': {'value': 'Single-pass type I membrane protein', 'id': 'SL-9905'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 3', 'note': {'texts': [{'value': 'After ligand binding, the activated receptor is rapidly internalized and degraded'}]}, 'subcellularLocations': [{'location': {'value': 'Cell membrane', 'id': 'SL-0039'}, 'topology': {'value': 'Single-pass type I membrane protein', 'id': 'SL-9905'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 8', 'subcellularLocations': [{'location': {'value': 'Secreted', 'id': 'SL-0243'}}]}, {'commentType': 'SUBCELLULAR LOCATION', 'molecule': 'Isoform 13', 'subcellularLocations': [{'location': {'value': 'Secreted', 'id': 'SL-0243'}}]}, {'commentType': 'ALTERNATIVE PRODUCTS', 'events': ['Alternative splicing'], 'isoforms': [{'name': {'value': '1'}, 'synonyms': [{'value': 'BEK'}, {'value': 'FGFR2IIIc'}], 'isoformIds': ['P21802-1'], 'isoformSequenceStatus': 'Displayed'}, {'name': {'value': '2'}, 'synonyms': [{'value': 'Short'}], 'isoformIds': ['P21802-2'], 'sequenceIds': ['VSP_002978'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '3'}, 'synonyms': [{'value': 'BFR-1'}, {'value': 'FGFR2IIIb'}, {'value': 'KGFR'}], 'isoformIds': ['P21802-3'], 'sequenceIds': ['VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '4'}, 'synonyms': [{'value': 'K-sam'}], 'isoformIds': ['P21802-4'], 'sequenceIds': ['VSP_002964', 'VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972', 'VSP_002975', 'VSP_002976'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '5'}, 'synonyms': [{'value': 'K-sam-I'}, {'value': 'BEK'}, {'value': 'IgIIIc'}], 'isoformIds': ['P21802-5'], 'sequenceIds': ['VSP_002975'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '6'}, 'synonyms': [{'value': 'K-sam-IIC2'}], 'isoformIds': ['P21802-6'], 'sequenceIds': ['VSP_002975', 'VSP_002984'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '7'}, 'synonyms': [{'value': 'K-sam-IIC3'}], 'isoformIds': ['P21802-8'], 'sequenceIds': ['VSP_002975', 'VSP_002978'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '8'}, 'synonyms': [{'value': 'K-sam-IV'}, {'value': 'Soluble KGFR'}], 'isoformIds': ['P21802-14'], 'sequenceIds': ['VSP_002965', 'VSP_002966'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '9'}, 'synonyms': [{'value': 'K-sam-III'}], 'isoformIds': ['P21802-15'], 'sequenceIds': ['VSP_002968'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '10'}, 'synonyms': [{'value': 'TK14'}], 'isoformIds': ['P21802-16'], 'sequenceIds': ['VSP_002967', 'VSP_002975'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '11'}, 'isoformIds': ['P21802-17'], 'sequenceIds': ['VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972', 'VSP_002978'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '12'}, 'synonyms': [{'value': 'K-sam-IIC1'}, {'value': 'KGFR'}, {'value': 'IgIIIb'}], 'isoformIds': ['P21802-18'], 'sequenceIds': ['VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972', 'VSP_002975'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '13'}, 'synonyms': [{'value': 'Soluble KGFR'}], 'isoformIds': ['P21802-19'], 'sequenceIds': ['VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972', 'VSP_002973', 'VSP_002974'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '14'}, 'isoformIds': ['P21802-20'], 'sequenceIds': ['VSP_019608', 'VSP_019609'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '15'}, 'isoformIds': ['P21802-21'], 'sequenceIds': ['VSP_002964', 'VSP_041915'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '16'}, 'isoformIds': ['P21802-22'], 'sequenceIds': ['VSP_002964', 'VSP_002969', 'VSP_002970', 'VSP_002971', 'VSP_002972', 'VSP_002978'], 'isoformSequenceStatus': 'Described'}, {'name': {'value': '17'}, 'isoformIds': ['P21802-23'], 'sequenceIds': ['VSP_041914'], 'isoformSequenceStatus': 'Described'}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8961926'}], 'value': 'The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Alternative splicing events affecting the third Ig-like domain are crucial for ligand selectivity'}], 'commentType': 'DOMAIN'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15629145'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}], 'value': 'Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on several tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-769 is essential for interaction with PLCG1'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17311277'}], 'value': 'N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus'}], 'commentType': 'PTM'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15190072'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '21596750'}], 'value': 'Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome'}], 'commentType': 'PTM'}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Crouzon syndrome', 'diseaseAccession': 'DI-00383', 'acronym': 'CS', 'description': 'An autosomal dominant syndrome characterized by craniosynostosis, hypertelorism, exophthalmos and external strabismus, parrot-beaked nose, short upper lip, hypoplastic maxilla, and a relative mandibular prognathism.', 'diseaseCrossReference': {'database': 'MIM', 'id': '123500'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10574673'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11380921'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7581378'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7655462'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7874170'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7987400'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8528214'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8946174'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8956050'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9152842'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9521581'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.10'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Jackson-Weiss syndrome', 'diseaseAccession': 'DI-00602', 'acronym': 'JWS', 'description': 'An autosomal dominant craniosynostosis syndrome characterized by craniofacial abnormalities and abnormality of the feet: broad great toes with medial deviation and tarsal-metatarsal coalescence.', 'diseaseCrossReference': {'database': 'MIM', 'id': '123150'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7874170'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8528214'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9385368'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Apert syndrome', 'diseaseAccession': 'DI-00131', 'acronym': 'APRS', 'description': 'A syndrome characterized by facio-cranio-synostosis, osseous and membranous syndactyly of the four extremities, and midface hypoplasia. The craniosynostosis is bicoronal and results in acrocephaly of brachysphenocephalic type. Syndactyly of the fingers and toes may be total (mitten hands and sock feet) or partial affecting the second, third, and fourth digits. Intellectual deficit is frequent and often severe, usually being associated with cerebral malformations.', 'diseaseCrossReference': {'database': 'MIM', 'id': '101200'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11390973'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15190072'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7668257'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719344'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9002682'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9452027'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Pfeiffer syndrome', 'diseaseAccession': 'DI-00924', 'acronym': 'PS', 'description': 'A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).', 'diseaseCrossReference': {'database': 'MIM', 'id': '101600'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10394936'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10945669'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719333'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719345'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9002682'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9150725'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9693549'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9719378'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Beare-Stevenson cutis gyrata syndrome', 'diseaseAccession': 'DI-01270', 'acronym': 'BSTVS', 'description': 'An autosomal dominant disease characterized by craniofacial anomalies, particularly craniosynostosis, and ear defects, cutis gyrata, acanthosis nigricans, anogenital anomalies, skin tags, and prominent umbilical stump. The skin furrows have a corrugated appearance and are widespread. Cutis gyrata variably affects the scalp, forehead, face, preauricular area, neck, trunk, hands, and feet.', 'diseaseCrossReference': {'database': 'MIM', 'id': '123790'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '12000365'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8696350'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Familial scaphocephaly syndrome', 'diseaseAccession': 'DI-00498', 'acronym': 'FSPC', 'description': 'An autosomal dominant craniosynostosis syndrome characterized by scaphocephaly, macrocephaly, hypertelorism, maxillary retrusion, and mild intellectual disability. Scaphocephaly is the most common of the craniosynostosis conditions and is characterized by a long, narrow head. It is due to premature fusion of the sagittal suture or from external deformation.', 'diseaseCrossReference': {'database': 'MIM', 'id': '609579'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16061565'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Lacrimo-auriculo-dento-digital syndrome', 'diseaseAccession': 'DI-00627', 'acronym': 'LADDS', 'description': 'An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.', 'diseaseCrossReference': {'database': 'MIM', 'id': '149730'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16501574'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '18056630'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Antley-Bixler syndrome, without genital anomalies or disordered steroidogenesis', 'diseaseAccession': 'DI-00125', 'acronym': 'ABS2', 'description': 'A rare syndrome characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Arachnodactyly and/or camptodactyly have also been reported.', 'diseaseCrossReference': {'database': 'MIM', 'id': '207410'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10633130'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Bent bone dysplasia syndrome', 'diseaseAccession': 'DI-03429', 'acronym': 'BBDS', 'description': 'A perinatal lethal skeletal dysplasia characterized by poor mineralization of the calvarium, craniosynostosis, dysmorphic facial features, prenatal teeth, hypoplastic pubis and clavicles, osteopenia, and bent long bones. Dysmorphic facial features included low-set ears, hypertelorism, midface hypoplasia, prematurely erupted fetal teeth, and micrognathia.', 'diseaseCrossReference': {'database': 'MIM', 'id': '614592'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '22387015'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'commentType': 'DISEASE', 'disease': {'diseaseId': 'Saethre-Chotzen syndrome', 'diseaseAccession': 'DI-01006', 'acronym': 'SCS', 'description': 'A craniosynostosis syndrome characterized by coronal synostosis, brachycephaly, low frontal hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.', 'diseaseCrossReference': {'database': 'MIM', 'id': '101400'}, 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9585583'}]}, 'note': {'texts': [{'value': 'The disease is caused by variants affecting the gene represented in this entry'}]}}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}], 'value': 'Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily'}], 'commentType': 'SIMILARITY'}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89296.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89297.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89298.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89299.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89300.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Miscellaneous discrepancy', 'sequence': 'BAA89301.1', 'note': 'Contaminating sequence. Somatic variant that appeared in a cancer cell line as a result of genome instability.', 'evidences': [{'evidenceCode': 'ECO:0000305', 'source': 'PubMed', 'id': '10626794'}]}, {'commentType': 'SEQUENCE CAUTION', 'sequenceCautionType': 'Erroneous initiation', 'sequence': 'BAG57383.1', 'note': 'Extended N-terminus.', 'evidences': [{'evidenceCode': 'ECO:0000305'}]}, {'commentType': 'WEB RESOURCE', 'resourceName': 'Atlas of Genetics and Cytogenetics in Oncology and Haematology', 'resourceUrl': 'http://atlasgeneticsoncology.org/Genes/FGFR2ID40570ch10q26.html', 'ftp': False}, {'commentType': 'WEB RESOURCE', 'resourceName': 'NIEHS-SNPs', 'resourceUrl': 'http://egp.gs.washington.edu/data/fgfr2/', 'ftp': False}], 'features': [{'type': 'Signal', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 21, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0000255'}]}, {'type': 'Chain', 'location': {'start': {'value': 22, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'Fibroblast growth factor receptor 2', 'featureId': 'PRO_0000016783'}, {'type': 'Topological domain', 'location': {'start': {'value': 22, 'modifier': 'EXACT'}, 'end': {'value': 377, 'modifier': 'EXACT'}}, 'description': 'Extracellular', 'evidences': [{'evidenceCode': 'ECO:0000255'}]}, {'type': 'Transmembrane', 'location': {'start': {'value': 378, 'modifier': 'EXACT'}, 'end': {'value': 398, 'modifier': 'EXACT'}}, 'description': 'Helical', 'evidences': [{'evidenceCode': 'ECO:0000255'}]}, {'type': 'Topological domain', 'location': {'start': {'value': 399, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'Cytoplasmic', 'evidences': [{'evidenceCode': 'ECO:0000255'}]}, {'type': 'Domain', 'location': {'start': {'value': 25, 'modifier': 'EXACT'}, 'end': {'value': 125, 'modifier': 'EXACT'}}, 'description': 'Ig-like C2-type 1'}, {'type': 'Domain', 'location': {'start': {'value': 154, 'modifier': 'EXACT'}, 'end': {'value': 247, 'modifier': 'EXACT'}}, 'description': 'Ig-like C2-type 2'}, {'type': 'Domain', 'location': {'start': {'value': 256, 'modifier': 'EXACT'}, 'end': {'value': 358, 'modifier': 'EXACT'}}, 'description': 'Ig-like C2-type 3'}, {'type': 'Domain', 'location': {'start': {'value': 481, 'modifier': 'EXACT'}, 'end': {'value': 770, 'modifier': 'EXACT'}}, 'description': 'Protein kinase', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}]}, {'type': 'Nucleotide binding', 'location': {'start': {'value': 487, 'modifier': 'EXACT'}, 'end': {'value': 495, 'modifier': 'EXACT'}}, 'description': 'ATP', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Nucleotide binding', 'location': {'start': {'value': 565, 'modifier': 'EXACT'}, 'end': {'value': 567, 'modifier': 'EXACT'}}, 'description': 'ATP', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Region', 'location': {'start': {'value': 131, 'modifier': 'EXACT'}, 'end': {'value': 151, 'modifier': 'EXACT'}}, 'description': 'Disordered', 'evidences': [{'evidenceCode': 'ECO:0000256', 'source': 'SAM', 'id': 'MobiDB-lite'}]}, {'type': 'Region', 'location': {'start': {'value': 161, 'modifier': 'EXACT'}, 'end': {'value': 178, 'modifier': 'EXACT'}}, 'description': 'Heparin-binding'}, {'type': 'Active site', 'location': {'start': {'value': 626, 'modifier': 'EXACT'}, 'end': {'value': 626, 'modifier': 'EXACT'}}, 'description': 'Proton acceptor', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}, {'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU10028'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Binding site', 'location': {'start': {'value': 517, 'modifier': 'EXACT'}, 'end': {'value': 517, 'modifier': 'EXACT'}}, 'description': 'ATP', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Binding site', 'location': {'start': {'value': 571, 'modifier': 'EXACT'}, 'end': {'value': 571, 'modifier': 'EXACT'}}, 'description': 'ATP', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00159'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 466, 'modifier': 'EXACT'}, 'end': {'value': 466, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 586, 'modifier': 'EXACT'}, 'end': {'value': 586, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 588, 'modifier': 'EXACT'}, 'end': {'value': 588, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 656, 'modifier': 'EXACT'}, 'end': {'value': 656, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 657, 'modifier': 'EXACT'}, 'end': {'value': 657, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17803937'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19410646'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 769, 'modifier': 'EXACT'}, 'end': {'value': 769, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; by autocatalysis', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15629145'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '19060208'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 780, 'modifier': 'EXACT'}, 'end': {'value': 780, 'modifier': 'EXACT'}}, 'description': 'Phosphoserine', 'evidences': [{'evidenceCode': 'ECO:0007744', 'source': 'PubMed', 'id': '24275569'}]}, {'type': 'Glycosylation', 'location': {'start': {'value': 83, 'modifier': 'EXACT'}, 'end': {'value': 83, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 123, 'modifier': 'EXACT'}, 'end': {'value': 123, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 228, 'modifier': 'EXACT'}, 'end': {'value': 228, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 241, 'modifier': 'EXACT'}, 'end': {'value': 241, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 265, 'modifier': 'EXACT'}, 'end': {'value': 265, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 297, 'modifier': 'EXACT'}, 'end': {'value': 297, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 318, 'modifier': 'EXACT'}, 'end': {'value': 318, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Glycosylation', 'location': {'start': {'value': 331, 'modifier': 'EXACT'}, 'end': {'value': 331, 'modifier': 'EXACT'}}, 'description': 'N-linked (GlcNAc...) asparagine', 'evidences': [{'evidenceCode': 'ECO:0000255'}], 'featureId': ''}, {'type': 'Disulfide bond', 'location': {'start': {'value': 62, 'modifier': 'EXACT'}, 'end': {'value': 107, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00114'}]}, {'type': 'Disulfide bond', 'location': {'start': {'value': 179, 'modifier': 'EXACT'}, 'end': {'value': 231, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00114'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16384934'}]}, {'type': 'Disulfide bond', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': '', 'evidences': [{'evidenceCode': 'ECO:0000255', 'source': 'PROSITE-ProRule', 'id': 'PRU00114'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16384934'}]}, {'type': 'Alternative sequence', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 152, 'modifier': 'EXACT'}}, 'description': 'in isoform 14', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '15489334'}], 'featureId': 'VSP_019608', 'alternativeSequence': {'originalSequence': 'EPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR', 'alternativeSequences': ['G']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 37, 'modifier': 'EXACT'}, 'end': {'value': 125, 'modifier': 'EXACT'}}, 'description': 'in isoform 4, isoform 15 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}], 'featureId': 'VSP_002964', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'in isoform 17', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'Reference', 'id': 'Ref.14'}], 'featureId': 'VSP_041914', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 250, 'modifier': 'EXACT'}, 'end': {'value': 254, 'modifier': 'EXACT'}}, 'description': 'in isoform 8', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1313574'}], 'featureId': 'VSP_002965', 'alternativeSequence': {'originalSequence': 'ERSPH', 'alternativeSequences': ['GSQGL']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 255, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 8', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1313574'}], 'featureId': 'VSP_002966', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 313, 'modifier': 'EXACT'}, 'end': {'value': 313, 'modifier': 'EXACT'}}, 'description': 'in isoform 10', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2172978'}], 'featureId': 'VSP_002967', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['KVTK']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 314, 'modifier': 'EXACT'}, 'end': {'value': 429, 'modifier': 'EXACT'}}, 'description': 'in isoform 9', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1313574'}], 'featureId': 'VSP_002968', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 314, 'modifier': 'EXACT'}, 'end': {'value': 330, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '10626794'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1647213'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002969', 'alternativeSequence': {'originalSequence': 'AAGVNTTDKEIEVLYIR', 'alternativeSequences': ['HSGINSSNAEVLALF']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 334, 'modifier': 'EXACT'}, 'end': {'value': 335, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '10626794'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1647213'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002970', 'alternativeSequence': {'originalSequence': 'FE', 'alternativeSequences': ['EA']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 341, 'modifier': 'EXACT'}, 'end': {'value': 353, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '10626794'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1647213'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002971', 'alternativeSequence': {'originalSequence': 'TCLAGNSIGISFH', 'alternativeSequences': ['ICKVSNYIGQANQ']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 361, 'modifier': 'EXACT'}, 'end': {'value': 361, 'modifier': 'EXACT'}}, 'description': 'in isoform 3, isoform 4, isoform 11, isoform 12, isoform 13 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '10626794'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1400433'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1647213'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002972', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['PKQQ']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 362, 'modifier': 'EXACT'}, 'end': {'value': 365, 'modifier': 'EXACT'}}, 'description': 'in isoform 13', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002973', 'alternativeSequence': {'originalSequence': 'APGR', 'alternativeSequences': ['GRRC']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 366, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 13', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1309608'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '7866434'}], 'featureId': 'VSP_002974', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 428, 'modifier': 'EXACT'}, 'end': {'value': 429, 'modifier': 'EXACT'}}, 'description': 'in isoform 4, isoform 5, isoform 6, isoform 7, isoform 10 and isoform 12', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1313574'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2172978'}, {'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}], 'featureId': 'VSP_002975', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 429, 'modifier': 'EXACT'}, 'end': {'value': 430, 'modifier': 'EXACT'}}, 'description': 'in isoform 14', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '15489334'}], 'featureId': 'VSP_019609', 'alternativeSequence': {}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 761, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 4', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '2377625'}], 'featureId': 'VSP_002976', 'alternativeSequence': {'originalSequence': 'LTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT', 'alternativeSequences': ['PPNPSLMSIFRK']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 768, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 2, isoform 7, isoform 11 and isoform 16', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '1647213'}], 'featureId': 'VSP_002978', 'alternativeSequence': {'originalSequence': 'EYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT', 'alternativeSequences': ['I']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 769, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 15', 'evidences': [{'evidenceCode': 'ECO:0000303', 'source': 'PubMed', 'id': '14702039'}], 'featureId': 'VSP_041915', 'alternativeSequence': {'originalSequence': 'YLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT', 'alternativeSequences': ['EKKVSGAVDCHKPPCNPSHLPCVLAVDQ']}}, {'type': 'Alternative sequence', 'location': {'start': {'value': 778, 'modifier': 'EXACT'}, 'end': {'value': 821, 'modifier': 'EXACT'}}, 'description': 'in isoform 6', 'evidences': [{'evidenceCode': 'ECO:0000305'}], 'featureId': 'VSP_002984', 'alternativeSequence': {'originalSequence': 'QYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT', 'alternativeSequences': ['PYSPCYPDPR']}}, {'type': 'Natural variant', 'location': {'start': {'value': 6, 'modifier': 'EXACT'}, 'end': {'value': 6, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs3750819', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.15'}], 'featureId': 'VAR_017258', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 57, 'modifier': 'EXACT'}, 'end': {'value': 57, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs56226109', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17344846'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '26429889'}], 'featureId': 'VAR_042204', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 105, 'modifier': 'EXACT'}, 'end': {'value': 105, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs1434545235', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8946174'}], 'featureId': 'VAR_004112', 'alternativeSequence': {'originalSequence': 'Y', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 172, 'modifier': 'EXACT'}, 'end': {'value': 172, 'modifier': 'EXACT'}}, 'description': 'in PS; requires 2 nucleotide substitutions', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}], 'featureId': 'VAR_017259', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 186, 'modifier': 'EXACT'}, 'end': {'value': 186, 'modifier': 'EXACT'}}, 'description': 'in dbSNP:rs755793', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17344846'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.15'}], 'featureId': 'VAR_017260', 'alternativeSequence': {'originalSequence': 'M', 'alternativeSequences': ['T']}}, {'type': 'Natural variant', 'location': {'start': {'value': 203, 'modifier': 'EXACT'}, 'end': {'value': 203, 'modifier': 'EXACT'}}, 'description': 'in breast cancer samples; infiltrating ductal carcinoma; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16959974'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17344846'}], 'featureId': 'VAR_036380', 'alternativeSequence': {'originalSequence': 'R', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 252, 'modifier': 'EXACT'}, 'end': {'value': 253, 'modifier': 'EXACT'}}, 'description': 'in PS; dbSNP:rs281865420', 'featureId': 'VAR_004116', 'alternativeSequence': {'originalSequence': 'SP', 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dbSNP:rs79184941', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '15190072'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7668257'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719344'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9452027'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9719378'}], 'featureId': 'VAR_004115', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 253, 'modifier': 'EXACT'}, 'end': {'value': 253, 'modifier': 'EXACT'}}, 'description': 'in APRS; common mutation; dbSNP:rs77543610', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7668257'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719344'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9452027'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}], 'featureId': 'VAR_004117', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 263, 'modifier': 'EXACT'}, 'end': {'value': 263, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs779326224', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}], 'featureId': 'VAR_017261', 'alternativeSequence': {'originalSequence': 'P', 'alternativeSequences': ['L']}}, {'type': 'Natural variant', 'location': {'start': {'value': 267, 'modifier': 'EXACT'}, 'end': {'value': 267, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs121918505', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}], 'featureId': 'VAR_004118', 'alternativeSequence': {'originalSequence': 'S', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 268, 'modifier': 'EXACT'}, 'end': {'value': 268, 'modifier': 'EXACT'}}, 'description': 'in CS', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}], 'featureId': 'VAR_004119', 'alternativeSequence': {'originalSequence': 'T', 'alternativeSequences': ['TG']}}, {'type': 'Natural variant', 'location': {'start': {'value': 269, 'modifier': 'EXACT'}, 'end': {'value': 270, 'modifier': 'EXACT'}}, 'description': 'in SCS', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9585583'}], 'featureId': 'VAR_075856', 'alternativeSequence': {}}, {'type': 'Natural variant', 'location': {'start': {'value': 272, 'modifier': 'EXACT'}, 'end': {'value': 272, 'modifier': 'EXACT'}}, 'description': 'in an ovarian serous carcinoma sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17344846'}], 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{'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in CS, JWS and PS; forms disulfide-linked dimers with constitutive kinase activity, is retained in an intracellular compartment and not detected at the cell surface; dbSNP:rs776587763', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '16844695'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}], 'featureId': 'VAR_004121', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['F']}}, {'type': 'Natural variant', 'location': {'start': {'value': 278, 'modifier': 'EXACT'}, 'end': {'value': 278, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs776587763', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}], 'featureId': 'VAR_017263', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['Y']}}, {'type': 'Natural variant', 'location': {'start': {'value': 281, 'modifier': 'EXACT'}, 'end': {'value': 281, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs1057519038', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11380921'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}], 'featureId': 'VAR_017264', 'alternativeSequence': {'originalSequence': 'Y', 'alternativeSequences': ['C']}}, {'type': 'Natural variant', 'location': {'start': {'value': 283, 'modifier': 'EXACT'}, 'end': {'value': 283, 'modifier': 'EXACT'}}, 'description': 'in a lung squamous cell carcinoma sample; somatic mutation', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '17344846'}], 'featureId': 'VAR_042206', 'alternativeSequence': {'originalSequence': 'D', 'alternativeSequences': ['N']}}, {'type': 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[{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8528214'}], 'featureId': 'VAR_017266', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 290, 'modifier': 'EXACT'}, 'end': {'value': 290, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs121918501', 'featureId': 'VAR_004125', 'alternativeSequence': {'originalSequence': 'W', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 292, 'modifier': 'EXACT'}, 'end': {'value': 292, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs121918500', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9152842'}], 'featureId': 'VAR_004126', 'alternativeSequence': {'originalSequence': 'K', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 301, 'modifier': 'EXACT'}, 'end': {'value': 301, 'modifier': 'EXACT'}}, 'description': 'in CS; 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{'value': 331, 'modifier': 'EXACT'}}, 'description': 'in CS', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8956050'}], 'featureId': 'VAR_004131', 'alternativeSequence': {'originalSequence': 'N', 'alternativeSequences': ['I']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in CS', 'featureId': 'VAR_004132', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['ANA']}}, {'type': 'Natural variant', 'location': {'start': {'value': 337, 'modifier': 'EXACT'}, 'end': {'value': 337, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs387906676', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}], 'featureId': 'VAR_017268', 'alternativeSequence': {'originalSequence': 'A', 'alternativeSequences': ['P']}}, {'type': 'Natural variant', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs1057519044', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8946174'}], 'featureId': 'VAR_004133', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['E']}}, {'type': 'Natural variant', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs1057519043', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7581378'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}], 'featureId': 'VAR_015011', 'alternativeSequence': {'originalSequence': 'G', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 340, 'modifier': 'EXACT'}, 'end': {'value': 340, 'modifier': 'EXACT'}}, 'description': 'in PS; dbSNP:rs1554928884', 'evidences': [{'evidenceCode': 'ECO:0000269', 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{'originalSequence': 'C', 'alternativeSequences': ['G']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in CS, JWS, PS and ABS2; dbSNP:rs121918488', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10633130'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11380921'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719345'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7987400'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8528214'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9677057'}], 'featureId': 'VAR_004137', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['R']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in CS, JWS, PS and ABS2; dbSNP:rs121918488', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '10633130'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7581378'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7987400'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8644708'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9385368'}, {'evidenceCode': 'ECO:0000269', 'source': 'Reference', 'id': 'Ref.10'}], 'featureId': 'VAR_004138', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['S']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in CS; dbSNP:rs121918496', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '8528214'}], 'featureId': 'VAR_017271', 'alternativeSequence': {'originalSequence': 'C', 'alternativeSequences': ['W']}}, {'type': 'Natural variant', 'location': {'start': {'value': 342, 'modifier': 'EXACT'}, 'end': {'value': 342, 'modifier': 'EXACT'}}, 'description': 'in CS and PS; dbSNP:rs121918487', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11173845'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11380921'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '11781872'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7581378'}, {'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '7719345'}, {'evidenceCode': 'ECO:0000269', 'source': 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'Ig-like_dom'}]}, {'database': 'InterPro', 'id': 'IPR036179', 'properties': [{'key': 'EntryName', 'value': 'Ig-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR013783', 'properties': [{'key': 'EntryName', 'value': 'Ig-like_fold'}]}, {'database': 'InterPro', 'id': 'IPR013098', 'properties': [{'key': 'EntryName', 'value': 'Ig_I-set'}]}, {'database': 'InterPro', 'id': 'IPR003599', 'properties': [{'key': 'EntryName', 'value': 'Ig_sub'}]}, {'database': 'InterPro', 'id': 'IPR003598', 'properties': [{'key': 'EntryName', 'value': 'Ig_sub2'}]}, {'database': 'InterPro', 'id': 'IPR011009', 'properties': [{'key': 'EntryName', 'value': 'Kinase-like_dom_sf'}]}, {'database': 'InterPro', 'id': 'IPR000719', 'properties': [{'key': 'EntryName', 'value': 'Prot_kinase_dom'}]}, {'database': 'InterPro', 'id': 'IPR017441', 'properties': [{'key': 'EntryName', 'value': 'Protein_kinase_ATP_BS'}]}, {'database': 'InterPro', 'id': 'IPR001245', 'properties': [{'key': 'EntryName', 'value': 'Ser-Thr/Tyr_kinase_cat_dom'}]}, {'database': 'InterPro', 'id': 'IPR008266', 'properties': [{'key': 'EntryName', 'value': 'Tyr_kinase_AS'}]}, {'database': 'InterPro', 'id': 'IPR020635', 'properties': [{'key': 'EntryName', 'value': 'Tyr_kinase_cat_dom'}]}, {'database': 'Pfam', 'id': 'PF18123', 'properties': [{'key': 'EntryName', 'value': 'FGFR3_TM'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF07679', 'properties': [{'key': 'EntryName', 'value': 'I-set'}, {'key': 'MatchStatus', 'value': '2'}]}, {'database': 'Pfam', 'id': 'PF07714', 'properties': [{'key': 'EntryName', 'value': 'PK_Tyr_Ser-Thr'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PIRSF', 'id': 'PIRSF000628', 'properties': [{'key': 'EntryName', 'value': 'FGFR'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PRINTS', 'id': 'PR00109', 'properties': [{'key': 'EntryName', 'value': 'TYRKINASE'}]}, {'database': 'SMART', 'id': 'SM00409', 'properties': [{'key': 'EntryName', 'value': 'IG'}, {'key': 'MatchStatus', 'value': '3'}]}, {'database': 'SMART', 'id': 'SM00408', 'properties': [{'key': 'EntryName', 'value': 'IGc2'}, {'key': 'MatchStatus', 'value': '3'}]}, {'database': 'SMART', 'id': 'SM00219', 'properties': [{'key': 'EntryName', 'value': 'TyrKc'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'SUPFAM', 'id': 'SSF48726', 'properties': [{'key': 'EntryName', 'value': 'SSF48726'}, {'key': 'MatchStatus', 'value': '3'}]}, {'database': 'SUPFAM', 'id': 'SSF56112', 'properties': [{'key': 'EntryName', 'value': 'SSF56112'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS50835', 'properties': [{'key': 'EntryName', 'value': 'IG_LIKE'}, {'key': 'MatchStatus', 'value': '3'}]}, {'database': 'PROSITE', 'id': 'PS00107', 'properties': [{'key': 'EntryName', 'value': 'PROTEIN_KINASE_ATP'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS50011', 'properties': [{'key': 'EntryName', 'value': 'PROTEIN_KINASE_DOM'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS00109', 'properties': [{'key': 'EntryName', 'value': 'PROTEIN_KINASE_TYR'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT', 'length': 821, 'molWeight': 92025, 'crc64': '6CD5001C960ED82F', 'md5': '8278583234A3EDA2A192D8BB50E1FAB8'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'CATALYTIC ACTIVITY': 1, 'ACTIVITY REGULATION': 1, 'SUBUNIT': 1, 'INTERACTION': 13, 'SUBCELLULAR LOCATION': 5, 'ALTERNATIVE PRODUCTS': 17, 'DOMAIN': 1, 'PTM': 3, 'DISEASE': 10, 'SIMILARITY': 1, 'SEQUENCE CAUTION': 7, 'WEB RESOURCE': 2}, 'countByFeatureType': {'Signal': 1, 'Chain': 1, 'Topological domain': 2, 'Transmembrane': 1, 'Domain': 4, 'Nucleotide binding': 2, 'Region': 2, 'Active site': 1, 'Binding site': 2, 'Modified residue': 7, 'Glycosylation': 8, 'Disulfide bond': 3, 'Alternative sequence': 19, 'Natural variant': 74, 'Mutagenesis': 5, 'Sequence conflict': 3, 'Beta strand': 34, 'Turn': 7, 'Helix': 19}, 'uniParcId': 'UPI000012A72A'}}}, {'from': 'P12345', 'to': {'entryType': 'UniProtKB reviewed (Swiss-Prot)', 'primaryAccession': 'P12345', 'secondaryAccessions': ['G1SKL2'], 'uniProtkbId': 'AATM_RABIT', 'entryAudit': {'firstPublicDate': '1989-10-01', 'lastAnnotationUpdateDate': '2021-06-02', 'lastSequenceUpdateDate': '2013-09-18', 'entryVersion': 131, 'sequenceVersion': 2}, 'annotationScore': 93.1, 'organism': {'scientificName': 'Oryctolagus cuniculus', 'commonName': 'Rabbit', 'taxonId': 9986, 'lineage': ['Eukaryota', 'Metazoa', 'Chordata', 'Craniata', 'Vertebrata', 'Euteleostomi', 'Mammalia', 'Eutheria', 'Euarchontoglires', 'Glires', 'Lagomorpha', 'Leporidae', 'Oryctolagus']}, 'proteinExistence': '1: Evidence at protein level', 'proteinDescription': {'recommendedName': {'fullName': {'value': 'Aspartate aminotransferase, mitochondrial'}, 'shortNames': [{'value': 'mAspAT'}], 'ecNumbers': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00507'}], 'value': '2.6.1.1'}, {'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00507'}], 'value': '2.6.1.7'}]}, 'alternativeNames': [{'fullName': {'value': 'Fatty acid-binding protein'}, 'shortNames': [{'value': 'FABP-1'}]}, {'fullName': {'value': 'Glutamate oxaloacetate transaminase 2'}}, {'fullName': {'value': 'Kynurenine aminotransferase 4'}}, {'fullName': {'value': 'Kynurenine aminotransferase IV'}}, {'fullName': {'value': 'Kynurenine--oxoglutarate transaminase 4'}}, {'fullName': {'value': 'Kynurenine--oxoglutarate transaminase IV'}}, {'fullName': {'value': 'Plasma membrane-associated fatty acid-binding protein'}, 'shortNames': [{'value': 'FABPpm'}]}, {'fullName': {'value': 'Transaminase A'}}], 'flag': 'Precursor'}, 'genes': [{'geneName': {'value': 'GOT2'}}], 'comments': [{'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}], 'value': 'Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids'}], 'commentType': 'FUNCTION'}, {'commentType': 'CATALYTIC ACTIVITY', 'reaction': {'name': '2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate', 'reactionCrossReferences': [{'database': 'Rhea', 'id': 'RHEA:21824'}, {'database': 'ChEBI', 'id': 'CHEBI:16452'}, {'database': 'ChEBI', 'id': 'CHEBI:16810'}, {'database': 'ChEBI', 'id': 'CHEBI:29985'}, {'database': 'ChEBI', 'id': 'CHEBI:29991'}], 'ecNumber': '2.6.1.1', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00507'}]}}, {'commentType': 'CATALYTIC ACTIVITY', 'reaction': {'name': '2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-glutamate', 'reactionCrossReferences': [{'database': 'Rhea', 'id': 'RHEA:65560'}, {'database': 'ChEBI', 'id': 'CHEBI:15377'}, {'database': 'ChEBI', 'id': 'CHEBI:16810'}, {'database': 'ChEBI', 'id': 'CHEBI:29985'}, {'database': 'ChEBI', 'id': 'CHEBI:57959'}, {'database': 'ChEBI', 'id': 'CHEBI:58454'}], 'ecNumber': '2.6.1.7', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00507'}]}}, {'commentType': 'COFACTOR', 'cofactors': [{'name': "pyridoxal 5'-phosphate", 'evidences': [{'evidenceCode': 'ECO:0000250'}], 'cofactorCrossReference': {'database': 'ChEBI', 'id': 'CHEBI:597326'}}]}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000250'}], 'value': 'Homodimer'}], 'commentType': 'SUBUNIT'}, {'commentType': 'SUBCELLULAR LOCATION', 'subcellularLocations': [{'location': {'evidences': [{'evidenceCode': 'ECO:0000250'}], 'value': 'Mitochondrion matrix', 'id': 'SL-0170'}}, {'location': {'evidences': [{'evidenceCode': 'ECO:0000250'}], 'value': 'Cell membrane', 'id': 'SL-0039'}}]}, {'texts': [{'value': 'In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes'}], 'commentType': 'MISCELLANEOUS'}, {'texts': [{'evidences': [{'evidenceCode': 'ECO:0000305'}], 'value': 'Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family'}], 'commentType': 'SIMILARITY'}], 'features': [{'type': 'Transit peptide', 'location': {'start': {'value': 1, 'modifier': 'EXACT'}, 'end': {'value': 29, 'modifier': 'EXACT'}}, 'description': 'Mitochondrion', 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '4030726'}]}, {'type': 'Chain', 'location': {'start': {'value': 30, 'modifier': 'EXACT'}, 'end': {'value': 430, 'modifier': 'EXACT'}}, 'description': 'Aspartate aminotransferase, mitochondrial', 'featureId': 'PRO_0000123886'}, {'type': 'Binding site', 'location': {'start': {'value': 65, 'modifier': 'EXACT'}, 'end': {'value': 65, 'modifier': 'EXACT'}}, 'description': 'Substrate; via amide nitrogen', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Binding site', 'location': {'start': {'value': 162, 'modifier': 'EXACT'}, 'end': {'value': 162, 'modifier': 'EXACT'}}, 'description': 'Substrate', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Binding site', 'location': {'start': {'value': 215, 'modifier': 'EXACT'}, 'end': {'value': 215, 'modifier': 'EXACT'}}, 'description': 'Substrate', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Binding site', 'location': {'start': {'value': 407, 'modifier': 'EXACT'}, 'end': {'value': 407, 'modifier': 'EXACT'}}, 'description': 'Substrate', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 48, 'modifier': 'EXACT'}, 'end': {'value': 48, 'modifier': 'EXACT'}}, 'description': 'Phosphothreonine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 59, 'modifier': 'EXACT'}, 'end': {'value': 59, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 73, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 73, 'modifier': 'EXACT'}, 'end': {'value': 73, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 82, 'modifier': 'EXACT'}, 'end': {'value': 82, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 90, 'modifier': 'EXACT'}, 'end': {'value': 90, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 90, 'modifier': 'EXACT'}, 'end': {'value': 90, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 96, 'modifier': 'EXACT'}, 'end': {'value': 96, 'modifier': 'EXACT'}}, 'description': "3'-nitrotyrosine; alternate", 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 96, 'modifier': 'EXACT'}, 'end': {'value': 96, 'modifier': 'EXACT'}}, 'description': 'Phosphotyrosine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 122, 'modifier': 'EXACT'}, 'end': {'value': 122, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 122, 'modifier': 'EXACT'}, 'end': {'value': 122, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; 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alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 185, 'modifier': 'EXACT'}, 'end': {'value': 185, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 227, 'modifier': 'EXACT'}, 'end': {'value': 227, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 234, 'modifier': 'EXACT'}, 'end': {'value': 234, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 279, 'modifier': 'EXACT'}, 'end': {'value': 279, 'modifier': 'EXACT'}}, 'description': 'N6-(pyridoxal phosphate)lysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 279, 'modifier': 'EXACT'}, 'end': {'value': 279, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 296, 'modifier': 'EXACT'}, 'end': {'value': 296, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 296, 'modifier': 'EXACT'}, 'end': {'value': 296, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 302, 'modifier': 'EXACT'}, 'end': {'value': 302, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 309, 'modifier': 'EXACT'}, 'end': {'value': 309, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 309, 'modifier': 'EXACT'}, 'end': {'value': 309, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P12344'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 313, 'modifier': 'EXACT'}, 'end': {'value': 313, 'modifier': 'EXACT'}}, 'description': 'Asymmetric dimethylarginine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 338, 'modifier': 'EXACT'}, 'end': {'value': 338, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 345, 'modifier': 'EXACT'}, 'end': {'value': 345, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 363, 'modifier': 'EXACT'}, 'end': {'value': 363, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 363, 'modifier': 'EXACT'}, 'end': {'value': 363, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 364, 'modifier': 'EXACT'}, 'end': {'value': 364, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 387, 'modifier': 'EXACT'}, 'end': {'value': 387, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 396, 'modifier': 'EXACT'}, 'end': {'value': 396, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 396, 'modifier': 'EXACT'}, 'end': {'value': 396, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 404, 'modifier': 'EXACT'}, 'end': {'value': 404, 'modifier': 'EXACT'}}, 'description': 'N6-acetyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P00505'}]}, {'type': 'Modified residue', 'location': {'start': {'value': 404, 'modifier': 'EXACT'}, 'end': {'value': 404, 'modifier': 'EXACT'}}, 'description': 'N6-succinyllysine; alternate', 'evidences': [{'evidenceCode': 'ECO:0000250', 'source': 'UniProtKB', 'id': 'P05202'}]}], 'keywords': [{'id': 'KW-0007', 'category': 'PTM', 'name': 'Acetylation'}, {'id': 'KW-0032', 'category': 'Molecular function', 'name': 'Aminotransferase'}, {'id': 'KW-1003', 'category': 'Cellular component', 'name': 'Cell membrane'}, {'id': 'KW-0903', 'category': 'Technical term', 'name': 'Direct protein sequencing'}, {'id': 'KW-0445', 'category': 'Biological process', 'name': 'Lipid transport'}, {'id': 'KW-0472', 'category': 'Cellular component', 'name': 'Membrane'}, {'id': 'KW-0488', 'category': 'PTM', 'name': 'Methylation'}, {'id': 'KW-0496', 'category': 'Cellular component', 'name': 'Mitochondrion'}, {'id': 'KW-0944', 'category': 'PTM', 'name': 'Nitration'}, {'id': 'KW-0597', 'category': 'PTM', 'name': 'Phosphoprotein'}, {'id': 'KW-0663', 'category': 'Ligand', 'name': 'Pyridoxal phosphate'}, {'id': 'KW-1185', 'category': 'Technical term', 'name': 'Reference proteome'}, {'id': 'KW-0808', 'category': 'Molecular function', 'name': 'Transferase'}, {'id': 'KW-0809', 'category': 'Domain', 'name': 'Transit peptide'}, {'id': 'KW-0813', 'category': 'Biological process', 'name': 'Transport'}], 'references': [{'citation': {'id': 'CI-7QM34G8ELGT3G', 'citationType': 'submission', 'authoringGroup': ['The Genome Sequencing Platform'], 'authors': ['Di Palma F.', 'Heiman D.', 'Young S.', 'Gnerre S.', 'Johnson J.', 'Lander E.S.', 'Lindblad-Toh K.'], 'title': 'Genome Sequence of Oryctolagus cuniculus (European rabbit).', 'publicationDate': 'AUG-2009', 'submissionDatabase': 'EMBL/GenBank/DDBJ databases'}, 'referencePositions': ['NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]'], 'referenceComments': [{'value': 'Thorbecke', 'type': 'STRAIN'}]}, {'citation': {'id': '4030726', 'citationType': 'journal article', 'authors': ['Kuramitsu S.', 'Inoue K.', 'Kondo K.', 'Aki K.', 'Kagamiyama H.'], 'citationCrossReferences': [{'database': 'PubMed', 'id': '4030726'}, {'database': 'DOI', 'id': '10.1093/oxfordjournals.jbchem.a135186'}], 'title': 'Aspartate aminotransferase isozymes from rabbit liver. Purification and properties.', 'publicationDate': '1985', 'journal': 'J. Biochem.', 'firstPage': '1337', 'lastPage': '1345', 'volume': '97'}, 'referencePositions': ['PROTEIN SEQUENCE OF 30-59'], 'referenceComments': [{'value': 'Liver', 'type': 'TISSUE'}]}], 'uniProtKBCrossReferences': [{'database': 'EMBL', 'id': 'AAGW02052878', 'properties': [{'key': 'ProteinId', 'value': '-'}, {'key': 'Status', 'value': 'NOT_ANNOTATED_CDS'}, {'key': 'MoleculeType', 'value': 'Genomic_DNA'}]}, {'database': 'PIR', 'id': 'B27103', 'properties': [{'key': 'EntryName', 'value': 'B27103'}]}, {'database': 'RefSeq', 'id': 'XP_002711597.1', 'properties': [{'key': 'NucleotideSequenceId', 'value': 'XM_002711551.3'}]}, {'database': 'SMR', 'id': 'P12345', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'STRING', 'id': '9986.ENSOCUP00000003357', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'GeneID', 'id': '100348732', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'KEGG', 'id': 'ocu:100348732', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'CTD', 'id': '2806', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'eggNOG', 'id': 'KOG1411', 'properties': [{'key': 'ToxonomicScope', 'value': 'Eukaryota'}]}, {'database': 'HOGENOM', 'id': 'CLU_032440_1_2_1', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'OMA', 'id': 'VGACTIV', 'properties': [{'key': 'Fingerprint', 'value': '-'}]}, {'database': 'OrthoDB', 'id': '1104596at2759', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'TreeFam', 'id': 'TF300641', 'properties': [{'key': 'Description', 'value': '-'}]}, {'database': 'Proteomes', 'id': 'UP000001811', 'properties': [{'key': 'Component', 'value': 'Unplaced'}]}, {'database': 'Bgee', 'id': 'ENSOCUG00000003871', 'properties': [{'key': 'ExpressionPatterns', 'value': 'Expressed in heart and 17 other tissues'}]}, {'database': 'GO', 'id': 'GO:0005759', 'properties': [{'key': 'GoTerm', 'value': 'C:mitochondrial matrix'}, {'key': 'GoEvidenceType', 'value': 'IEA:UniProtKB-SubCell'}]}, {'database': 'GO', 'id': 'GO:0005739', 'properties': [{'key': 'GoTerm', 'value': 'C:mitochondrion'}, {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]}, {'database': 'GO', 'id': 'GO:0005886', 'properties': [{'key': 'GoTerm', 'value': 'C:plasma membrane'}, {'key': 'GoEvidenceType', 'value': 'IEA:UniProtKB-SubCell'}]}, {'database': 'GO', 'id': 'GO:0016212', 'properties': [{'key': 'GoTerm', 'value': 'F:kynurenine-oxoglutarate transaminase activity'}, {'key': 'GoEvidenceType', 'value': 'IEA:UniProtKB-EC'}]}, {'database': 'GO', 'id': 'GO:0004069', 'properties': [{'key': 'GoTerm', 'value': 'F:L-aspartate:2-oxoglutarate aminotransferase activity'}, {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]}, {'database': 'GO', 'id': 'GO:0030170', 'properties': [{'key': 'GoTerm', 'value': 'F:pyridoxal phosphate binding'}, {'key': 'GoEvidenceType', 'value': 'IEA:InterPro'}]}, {'database': 'GO', 'id': 'GO:0006103', 'properties': [{'key': 'GoTerm', 'value': 'P:2-oxoglutarate metabolic process'}, {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]}, {'database': 'GO', 'id': 'GO:0006531', 'properties': [{'key': 'GoTerm', 'value': 'P:aspartate metabolic process'}, {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]}, {'database': 'GO', 'id': 'GO:0009058', 'properties': [{'key': 'GoTerm', 'value': 'P:biosynthetic process'}, {'key': 'GoEvidenceType', 'value': 'IEA:InterPro'}]}, {'database': 'GO', 'id': 'GO:0006536', 'properties': [{'key': 'GoTerm', 'value': 'P:glutamate metabolic process'}, {'key': 'GoEvidenceType', 'value': 'ISS:UniProtKB'}]}, {'database': 'GO', 'id': 'GO:0006869', 'properties': [{'key': 'GoTerm', 'value': 'P:lipid transport'}, {'key': 'GoEvidenceType', 'value': 'IEA:UniProtKB-KW'}]}, {'database': 'GO', 'id': 'GO:0006457', 'properties': [{'key': 'GoTerm', 'value': 'P:protein folding'}, {'key': 'GoEvidenceType', 'value': 'TAS:HGNC'}], 'evidences': [{'evidenceCode': 'ECO:0000269', 'source': 'PubMed', 'id': '9683573'}]}, {'database': 'Gene3D', 'id': '3.40.640.10', 'properties': [{'key': 'EntryName', 'value': '-'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Gene3D', 'id': '3.90.1150.10', 'properties': [{'key': 'EntryName', 'value': '-'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'InterPro', 'id': 'IPR004839', 'properties': [{'key': 'EntryName', 'value': 'Aminotransferase_I/II'}]}, {'database': 'InterPro', 'id': 'IPR000796', 'properties': [{'key': 'EntryName', 'value': 'Asp_trans'}]}, {'database': 'InterPro', 'id': 'IPR004838', 'properties': [{'key': 'EntryName', 'value': 'NHTrfase_class1_PyrdxlP-BS'}]}, {'database': 'InterPro', 'id': 'IPR015424', 'properties': [{'key': 'EntryName', 'value': 'PyrdxlP-dep_Trfase'}]}, {'database': 'InterPro', 'id': 'IPR015422', 'properties': [{'key': 'EntryName', 'value': 'PyrdxlP-dep_Trfase_dom1'}]}, {'database': 'InterPro', 'id': 'IPR015421', 'properties': [{'key': 'EntryName', 'value': 'PyrdxlP-dep_Trfase_major'}]}, {'database': 'PANTHER', 'id': 'PTHR11879', 'properties': [{'key': 'EntryName', 'value': 'PTHR11879'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'Pfam', 'id': 'PF00155', 'properties': [{'key': 'EntryName', 'value': 'Aminotran_1_2'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PRINTS', 'id': 'PR00799', 'properties': [{'key': 'EntryName', 'value': 'TRANSAMINASE'}]}, {'database': 'SUPFAM', 'id': 'SSF53383', 'properties': [{'key': 'EntryName', 'value': 'SSF53383'}, {'key': 'MatchStatus', 'value': '1'}]}, {'database': 'PROSITE', 'id': 'PS00105', 'properties': [{'key': 'EntryName', 'value': 'AA_TRANSFER_CLASS_1'}, {'key': 'MatchStatus', 'value': '1'}]}], 'sequence': {'value': 'MALLHSARVLSGVASAFHPGLAAAASARASSWWAHVEMGPPDPILGVTEAYKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKGLDKEYLPIGGLAEFCRASAELALGENSEVVKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDAGMQLQSYRYYDPKTCGFDFTGALEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTVICKDADEAKRVESQLKILIRPMYSNPPIHGARIASTILTSPDLRKQWLQEVKGMADRIIGMRTQLVSNLKKEGSTHSWQHITDQIGMFCFTGLKPEQVERLTKEFSIYMTKDGRISVAGVTSGNVGYLAHAIHQVTK', 'length': 430, 'molWeight': 47409, 'crc64': '12F54284974D27A5', 'md5': 'CF84DAC1BDDD05632A89E4C1F186D0D3'}, 'extraAttributes': {'countByCommentType': {'FUNCTION': 1, 'CATALYTIC ACTIVITY': 2, 'COFACTOR': 1, 'SUBUNIT': 1, 'SUBCELLULAR LOCATION': 1, 'MISCELLANEOUS': 1, 'SIMILARITY': 1}, 'countByFeatureType': {'Transit peptide': 1, 'Chain': 1, 'Binding site': 4, 'Modified residue': 37}, 'uniParcId': 'UPI0001C61C61'}}}]}
"""

"""
results = {}
for result in data['results']:
    protein_id = result['from']
    protein_data = result['to']
    reviewed = protein_data['entryType']
    if 'reviewed' in reviewed:
        review = True
    else:
        review = False
    protein_description = protein_data['proteinDescription']
    if 'recommendedName' in protein_description:
        if 'ecNumbers' in protein_description['recommendedName']:
            protein_ecs = list(set([ecnumber['value'] for ecnumber in protein_description['recommendedName']['ecNumbers']]))
        else:
            protein_ecs = []
        protein_fullname = protein_description['recommendedName']['fullName']['value']
    else:
        protein_ecs = []
        protein_fullname = ''

    gene_names = [gene['geneName']['value'] for gene in protein_data['genes'] if 'geneName' in gene]
    if len(gene_names) > 0:
        gene_name = gene_names[0]
    else:
        gene_name = ''
    protein_xrefs = protein_data['uniProtKBCrossReferences']

    rhea_ids = []
    if 'comments' in protein_data:
        protein_comments = protein_data['comments']
        protein_reactions = [comment['reaction'] for comment in protein_comments if comment['commentType'] == 'CATALYTIC ACTIVITY']
        for reaction in protein_reactions:
            if 'reactionCrossReferences' in reaction:
                rhea_ids.extend([dbxref['id'] for dbxref in reaction['reactionCrossReferences'] if dbxref['database'] == 'Rhea' and 'RHEA:' in dbxref['id']])
        rhea_ids = list(set(rhea_ids))
    gos = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'GO']))
    interpros = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'InterPro']))
    results[protein_id] = [protein_fullname, review, gos, protein_ecs, interpros, rhea_ids, gene_name]
"""


def test_prot(protein_queries):
    output_dict = {}

    url = 'http://rest.uniprot.org/beta/idmapping/run'

    # Column names can be found at: https://www.uniprot.org/help/uniprotkb_column_names
    # from and to are linked to mapping ID: https://www.uniprot.org/help/api%5Fidmapping

    params = {
        'from': 'UniProtKB_AC-ID',
        'to': 'UniProtKB',
        'ids': protein_queries
    }

    data = urllib.parse.urlencode(params)
    data = data.encode('utf-8')
    req = urllib.request.Request(url, data)

    data_js = json.load(urllib.request.urlopen(req))
    job_id = data_js['jobId']
    print(job_id)
    http_check_status = 'http://rest.uniprot.org/beta/idmapping/status/{0}'.format(job_id)

    response = requests.get(http_check_status)
    response.raise_for_status()
    check_code = response.status_code
    # Issue check_code is actually at 200 instead of 303...
    print(response.status_code)
    while response.status_code != 303:
        time.sleep(1)
        if response.status_code == 303:
            break
    """
    simple_protein_queries = 'P21802,P12345'
    params = {
        'from': 'UniProtKB_AC-ID',
        'to': 'UniProtKB',
        'ids': protein_queries
    }
    go_pattern = re.compile(r'\[GO:(?P<go>\d{7})\]')
    data = urllib.parse.urlencode(params)
    data = data.encode('utf-8')
    req = urllib.request.Request(url, data)

    data_js = json.load(urllib.request.urlopen(req))   
    job_id = data_js['jobId']
    print(job_id)
    """
    http_check_status = 'http://rest.uniprot.org/beta/idmapping/status/{0}'.format(job_id)

    response = requests.head(http_check_status)
    response.raise_for_status()
    check_code = response.status_code
    print(check_code)
    while response.status_code != 303:
        time.sleep(1)
        if response.status_code == 303:
            break

    if check_code == 303:
        http_download = 'http://rest.uniprot.org/beta/idmapping/uniprotkb/results/stream/{0}'.format(job_id)
        response = requests.get(http_download)
        response.raise_for_status()
        data = response.json()

        results = {}
        for result in data['results']:
            protein_id = result['from']
            protein_data = result['to']
            reviewed = protein_data['entryType']
            if 'reviewed' in reviewed:
                review = True
            else:
                review = False
            protein_description = protein_data['proteinDescription']
            if 'recommendedName' in protein_description:
                if 'ecNumbers' in protein_description['recommendedName']:
                    protein_ecs = list(set([ecnumber['value'] for ecnumber in protein_description['recommendedName']['ecNumbers']]))
                else:
                    protein_ecs = []
                protein_fullname = protein_description['recommendedName']['fullName']['value']
            else:
                protein_ecs = []
                protein_fullname = ''

            gene_names = [gene['geneName']['value'] for gene in protein_data['genes'] if 'geneName' in gene]
            if len(gene_names) > 0:
                gene_name = gene_names[0]
            else:
                gene_name = ''
            protein_xrefs = protein_data['uniProtKBCrossReferences']

            rhea_ids = []
            if 'comments' in protein_data:
                protein_comments = protein_data['comments']
                protein_reactions = [comment['reaction'] for comment in protein_comments if comment['commentType'] == 'CATALYTIC ACTIVITY']
                for reaction in protein_reactions:
                    if 'reactionCrossReferences' in reaction:
                        rhea_ids.extend([dbxref['id'] for dbxref in reaction['reactionCrossReferences'] if dbxref['database'] == 'Rhea' and 'RHEA:' in dbxref['id']])
                rhea_ids = list(set(rhea_ids))
            gos = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'GO']))
            interpros = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'InterPro']))
            results[protein_id] = [protein_fullname, review, gos, protein_ecs, interpros, rhea_ids, gene_name]
            output_dict.update(results)
    print(output_dict)
#test_prot(protein_queries)

def rest_query_uniprot_to_retrieve_function(protein_queries, beta):
    output_dict = {}

    # Column names can be found at: https://www.uniprot.org/help/uniprotkb_column_names
    # from and to are linked to mapping ID: https://www.uniprot.org/help/api%5Fidmapping
    if not beta:
        url = 'https://www.uniprot.org/uploadlists/'

        params = {
            'from': 'ACC+ID',
            'to': 'ACC',
            'format': 'tab',
            'query': protein_queries,
            'columns': 'id,protein names,reviewed,go,ec,interpro(db_abbrev),rhea-id,genes(PREFERRED)'
        }

        go_pattern = re.compile(r'\[GO:(?P<go>\d{7})\]')
        data = urllib.parse.urlencode(params)
        data = data.encode('utf-8')
        req = urllib.request.Request(url, data, headers=URLLIB_HEADERS)
 
        with urllib.request.urlopen(req) as f:
            response_text = f.read().decode('utf-8')
            if response_text != '':
                csvreader = csv.reader(response_text.splitlines(), delimiter='\t')
                # Avoid header
                next(csvreader)
            else:
                csvreader = []

        results = {}
        for line in csvreader:
            protein_name = line[1]
            if line[2] == 'reviewed':
                review = True
            else:
                review = False
            go_result = go_pattern.findall(line[3])
            gos = ['GO:'+ go_term for go_term in go_result]
            ec_numbers = [ec for ec in line[4].split('; ') if ec != '']
            interpros =  [interpro for interpro in line[5].split('; ') if interpro != '']
            rhea_ids = [rhea_id for rhea_id in line[6].split('; ') if rhea_id != '']
            gene_name = line[7]
            results[line[0]] = [protein_name, review, gos, ec_numbers, interpros, rhea_ids, gene_name]
            output_dict.update(results)
    else:
        url = 'http://rest.uniprot.org/beta/idmapping/run'

        # Column names can be found at: https://www.uniprot.org/help/uniprotkb_column_names
        # from and to are linked to mapping ID: https://www.uniprot.org/help/api%5Fidmapping

        params = {
            'from': 'UniProtKB_AC-ID',
            'to': 'UniProtKB',
            'ids': protein_queries
        }
        data = urllib.parse.urlencode(params)
        data = data.encode('utf-8')
        req = urllib.request.Request(url, data)

        data_js = json.load(urllib.request.urlopen(req))   
        job_id = data_js['jobId']

        http_check_status = 'http://rest.uniprot.org/beta/idmapping/status/{0}'.format(job_id)

        response = requests.head(http_check_status)
        response.raise_for_status()
        check_code = response.status_code
        print(check_code)
        # Not working because the code is 200 instead of 303...
        while response.status_code != 303:
            time.sleep(5)
            response = requests.head(http_check_status)
            print('delay', response.status_code)
            if response.status_code == 303:
                break

        if check_code == 303:
            http_download = 'http://rest.uniprot.org/beta/idmapping/uniprotkb/results/stream/{0}'.format(job_id)
            response = requests.get(http_download)
            response.raise_for_status()
            data = response.json()

            results = {}
            for result in data['results']:
                protein_id = result['from']
                protein_data = result['to']
                reviewed = protein_data['entryType']
                if 'reviewed' in reviewed:
                    review = True
                else:
                    review = False
                protein_description = protein_data['proteinDescription']
                if 'recommendedName' in protein_description:
                    if 'ecNumbers' in protein_description['recommendedName']:
                        protein_ecs = list(set([ecnumber['value'] for ecnumber in protein_description['recommendedName']['ecNumbers']]))
                    else:
                        protein_ecs = []
                    protein_fullname = protein_description['recommendedName']['fullName']['value']
                else:
                    protein_ecs = []
                    protein_fullname = ''

                gene_names = [gene['geneName']['value'] for gene in protein_data['genes'] if 'geneName' in gene]
                if len(gene_names) > 0:
                    gene_name = gene_names[0]
                else:
                    gene_name = ''
                protein_xrefs = protein_data['uniProtKBCrossReferences']

                rhea_ids = []
                if 'comments' in protein_data:
                    protein_comments = protein_data['comments']
                    protein_reactions = [comment['reaction'] for comment in protein_comments if comment['commentType'] == 'CATALYTIC ACTIVITY']
                    for reaction in protein_reactions:
                        if 'reactionCrossReferences' in reaction:
                            rhea_ids.extend([dbxref['id'] for dbxref in reaction['reactionCrossReferences'] if dbxref['database'] == 'Rhea' and 'RHEA:' in dbxref['id']])
                    rhea_ids = list(set(rhea_ids))
                gos = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'GO']))
                interpros = list(set([xref['id'] for xref in protein_xrefs if xref['database'] == 'InterPro']))
                results[protein_id] = [protein_fullname, review, gos, protein_ecs, interpros, rhea_ids, gene_name]
                output_dict.update(results)

    return output_dict

output_dict = rest_query_uniprot_to_retrieve_function(protein_queries, True)

