Metadata-Version: 2.1
Name: drawtetrado
Version: 1.3
Summary: Draw simplified, layer diagrams of quadruplexes.
Home-page: https://github.com/michal-zurkowski/drawtetrado
Author: Michal Zurkowski
Author-email: michal.zurkowski@cs.put.poznan.pl
License: UNKNOWN
Project-URL: Bug Tracker, https://github.com/michal-zurkowski/drawtetrado/issues
Platform: UNKNOWN
Classifier: Development Status :: 5 - Production/Stable
Classifier: Environment :: Console
Classifier: Intended Audience :: Science/Research
Classifier: License :: OSI Approved :: MIT License
Classifier: Operating System :: OS Independent
Classifier: Programming Language :: Python :: 3
Classifier: Topic :: Scientific/Engineering :: Bio-Informatics
Description-Content-Type: text/markdown
License-File: LICENSE

# Project description

DrawTetrado is a Python application to visualize quadruplexes and
G4-helices in DNA and RNA structures. It generates publication-quality
SVG files containing layer diagrams. They show the tetrads as a stack,
with each position having four nucleobases colored according to anti or
syn conformation. In addition, DrawTetrado visualizes the strands with
arrows for an accessible overview of their directionality and visual
determination of loop types.

DrawTetrado automatically optimizes the layout. The result is a visually
pleasing and readable image, even for the most complex cases like
V-loops and G4-helices (dimers).

# Installation

    pip install drawtetrado

# Dependencies

The project is written in Python 3.6+ and requires
[pycairo](https://github.com/pygobject/pycairo) and
[svgwrite](https://github.com/mozman/svgwrite). The internal
optimization routine is written in C++ and requires
[Cython](https://cython.org/) and a C++20-compliant compiler (e.g. GCC
8+).

DrawTetrado parses the output of
[ElTetrado](https://github.com/tzok/eltetrado) (Zok *et al.*, 2022;
Popenda *et al.*, 2020; Zok *et al.*, 2020). If you do not have that
installed, please install DSSR (Lu *et al.*, 2015) and run:

    pip install eltetrado

# Usage

    usage: drawtetrado [-h] [--config CONFIG] input output_template

    positional arguments:
      input            path to input JSON generated by ElTetrado
      output_template  path to output SVG file template

    optional arguments:
      -h, --help       show this help message and exit
      --config CONFIG  JSON config file containing all parameter changes and
                       individual nucleotide coloring overrides

    The output path is a template. Program will generate drawings for each
    individual quadruplex in each helice as well as each full helice.If we have
    file with 2 helices with 2 quadruplexes each, if output_template=/tmp/out.svg,
    the resulting files will be /tmp/out_0.svg, with full helice 0,
    /tmp/out_0_0.svg and /tmp/out_0_1.svg for each quadruplex in helice 0. Similar
    files will be created for helice 1 with /tmp/out_1.svg and /tmp/out_1_0.svg,
    /tmp/out_1_1.svg.

# Visual customization

DrawTetrado allows for wide veriaty of changes to the visual representation of
the resulting drawing.

All modifications to visual aspects of the drawing can be done using JSON
formatted config file. Example config.json is available in the respository with
all possible parameters and their default values.


``` json
{
  "_comment0": "Example config.json with all available parameters default values.",
  "_comment1": "All parameters explained in README",

  "scale": 1.0,

  "nucl-longer": 100.0,
  "nucl-shorter": 70.0,
  "nucl-spacing": 10.0,

  "angle": 50.0,
  "tetrad-spacing": 50.0,

  "line-stroke": 3.0,
  "point-size": 6.0,
  "point-stroke": 2.0,

  "se-label-spacing": 20.0,
  "se-label-font-size": 24.0,
  "font-family": "Arial, Helvetica",
  "label-font-size": 20.0,
  
  "tilted_labels": true,
  "label-chain": true,
  "label-nucl-name": true,
  "label-nucl-fullname": true,
  "label-number": true,

  "_comment2": "Colors in RGBA hex. If only RGB is provided, alpha of 1.0 is used",
  "_comment3": "for anything other than ONZ colors. Those default to 0.85.",
  "colors": {
    "connection": "#000000FF",
    "border": "#E23D28FF",
    "text": "#000000FF",
    "point": "#FFFFFFFF",
    "anti": "#FFFFFFFF",
    "syn": "#000000FF",
    "n/a": "#606060FF",
    "onz_default": "#646464D9",
    "o_plus": "#1F78B4D9",
    "o_minus": "#A6CEE3D9",
    "n_plus": "#33A02CD9",
    "n_minus": "#B2DF8AD9",
    "z_plus": "#FF7F00D9",
    "z_minus": "#FDBF6FD9"
  },

  "_comment3": "dictionary of nucleotide full name to desired color in RGBA hex.",
  "_comment4": "If only RGB is provided, alpha of 0.85 (aka. D9) is used.",
  "_comment_example": "'A.DG12': '#E23D28AA'",
  "nucl-color-override": {
  }
}
```


Nucleotide labels are made from 3 parts:
```
  A.DG12
  A  - Chain of the nucleotide. If label-chain is set to false, this information (and .)
       is not included in the creation of the labels.
  DG - Full name of the nucleotide. Setting label-nucl-fullname to false will result
       in normal short names like A, C, T, G. label-nucl-name to false will remove
       nucleotide name part altogether.
  12 - Index of the nucleotide. Can be removed with label-number set to false.
```

Examples of how A.DG12 label would look like with different label options:
```
A.DG12 - Default - All label parameters as true.
A.G12  - "label-nucl-fullname": false
A.12   - "label-nucl-name": false
DG12   - "label-chain": false
A.DG   - "label-number": false
A      - "label-number": false, "label-nucleotide": false

```

![Visual changes](https://github.com/michal-zurkowski/drawtetrado/blob/main/2hy9_visuals.svg?raw=true)

# Examples

## Human telomere DNA quadruplex

![[2HY9: Human telomere DNA quadruplex structure in K+ solution hybrid-1
form](https://www.rcsb.org/structure/2hy9)](https://github.com/michal-zurkowski/drawtetrado/blob/main/2hy9.svg?raw=true)

<details>
<summary>
Click to see the input JSON
</summary>

``` json
{
  "metals":[
    
  ],
  "nucleotides":[
    {
      "index":1,
      "model":1,
      "chain":"A",
      "number":1,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA1",
      "shortName":"A",
      "chi":22.308,
      "glycosidicBond":"syn"
    },
    {
      "index":2,
      "model":1,
      "chain":"A",
      "number":2,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA2",
      "shortName":"A",
      "chi":-123.055,
      "glycosidicBond":"anti"
    },
    {
      "index":3,
      "model":1,
      "chain":"A",
      "number":3,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA3",
      "shortName":"A",
      "chi":-94.966,
      "glycosidicBond":"anti"
    },
    {
      "index":4,
      "model":1,
      "chain":"A",
      "number":4,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG4",
      "shortName":"G",
      "chi":79.284,
      "glycosidicBond":"syn"
    },
    {
      "index":5,
      "model":1,
      "chain":"A",
      "number":5,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG5",
      "shortName":"G",
      "chi":-126.017,
      "glycosidicBond":"anti"
    },
    {
      "index":6,
      "model":1,
      "chain":"A",
      "number":6,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG6",
      "shortName":"G",
      "chi":-127.267,
      "glycosidicBond":"anti"
    },
    {
      "index":7,
      "model":1,
      "chain":"A",
      "number":7,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT7",
      "shortName":"T",
      "chi":-63.108,
      "glycosidicBond":"syn"
    },
    {
      "index":8,
      "model":1,
      "chain":"A",
      "number":8,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT8",
      "shortName":"T",
      "chi":-138.795,
      "glycosidicBond":"anti"
    },
    {
      "index":9,
      "model":1,
      "chain":"A",
      "number":9,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA9",
      "shortName":"A",
      "chi":-148.84,
      "glycosidicBond":"anti"
    },
    {
      "index":10,
      "model":1,
      "chain":"A",
      "number":10,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG10",
      "shortName":"G",
      "chi":58.779,
      "glycosidicBond":"syn"
    },
    {
      "index":11,
      "model":1,
      "chain":"A",
      "number":11,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG11",
      "shortName":"G",
      "chi":-123.857,
      "glycosidicBond":"anti"
    },
    {
      "index":12,
      "model":1,
      "chain":"A",
      "number":12,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG12",
      "shortName":"G",
      "chi":-84.367,
      "glycosidicBond":"syn"
    },
    {
      "index":13,
      "model":1,
      "chain":"A",
      "number":13,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT13",
      "shortName":"T",
      "chi":-30.819,
      "glycosidicBond":"syn"
    },
    {
      "index":14,
      "model":1,
      "chain":"A",
      "number":14,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT14",
      "shortName":"T",
      "chi":-168.518,
      "glycosidicBond":"anti"
    },
    {
      "index":15,
      "model":1,
      "chain":"A",
      "number":15,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA15",
      "shortName":"A",
      "chi":-105.729,
      "glycosidicBond":"anti"
    },
    {
      "index":16,
      "model":1,
      "chain":"A",
      "number":16,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG16",
      "shortName":"G",
      "chi":74.323,
      "glycosidicBond":"syn"
    },
    {
      "index":17,
      "model":1,
      "chain":"A",
      "number":17,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG17",
      "shortName":"G",
      "chi":81.084,
      "glycosidicBond":"syn"
    },
    {
      "index":18,
      "model":1,
      "chain":"A",
      "number":18,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG18",
      "shortName":"G",
      "chi":-122.904,
      "glycosidicBond":"anti"
    },
    {
      "index":19,
      "model":1,
      "chain":"A",
      "number":19,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT19",
      "shortName":"T",
      "chi":-102.982,
      "glycosidicBond":"anti"
    },
    {
      "index":20,
      "model":1,
      "chain":"A",
      "number":20,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT20",
      "shortName":"T",
      "chi":-112.151,
      "glycosidicBond":"anti"
    },
    {
      "index":21,
      "model":1,
      "chain":"A",
      "number":21,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA21",
      "shortName":"A",
      "chi":-89.071,
      "glycosidicBond":"syn"
    },
    {
      "index":22,
      "model":1,
      "chain":"A",
      "number":22,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG22",
      "shortName":"G",
      "chi":83.443,
      "glycosidicBond":"syn"
    },
    {
      "index":23,
      "model":1,
      "chain":"A",
      "number":23,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG23",
      "shortName":"G",
      "chi":-115.412,
      "glycosidicBond":"anti"
    },
    {
      "index":24,
      "model":1,
      "chain":"A",
      "number":24,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG24",
      "shortName":"G",
      "chi":-111.148,
      "glycosidicBond":"anti"
    },
    {
      "index":25,
      "model":1,
      "chain":"A",
      "number":25,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA25",
      "shortName":"A",
      "chi":-58.324,
      "glycosidicBond":"syn"
    },
    {
      "index":26,
      "model":1,
      "chain":"A",
      "number":26,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA26",
      "shortName":"A",
      "chi":-90.841,
      "glycosidicBond":"anti"
    }
  ],
  "basePairs":[
    {
      "nt1":"A.DA2",
      "nt2":"A.DT20",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DT20",
      "nt2":"A.DA2",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA3",
      "nt2":"A.DA21",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA21",
      "nt2":"A.DA3",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DT7",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DT7",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG10",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DG22",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG22",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG5",
      "nt2":"A.DG11",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG11",
      "nt2":"A.DG5",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG5",
      "nt2":"A.DG23",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG23",
      "nt2":"A.DG5",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG6",
      "nt2":"A.DG12",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG12",
      "nt2":"A.DG6",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG6",
      "nt2":"A.DG24",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG24",
      "nt2":"A.DG6",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DT7",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG10",
      "nt2":"A.DT7",
      "stericity":"cis",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG10",
      "nt2":"A.DG18",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG18",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG11",
      "nt2":"A.DG17",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG17",
      "nt2":"A.DG11",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG12",
      "nt2":"A.DG16",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG16",
      "nt2":"A.DG12",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DT14",
      "nt2":"A.DA25",
      "stericity":"trans",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA25",
      "nt2":"A.DT14",
      "stericity":"trans",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA15",
      "nt2":"A.DA25",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA25",
      "nt2":"A.DA15",
      "stericity":"trans",
      "edge5":"Watson-Crick",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG16",
      "nt2":"A.DG24",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG24",
      "nt2":"A.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG17",
      "nt2":"A.DG23",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG23",
      "nt2":"A.DG17",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG18",
      "nt2":"A.DG22",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG22",
      "nt2":"A.DG18",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    }
  ],
  "helices":[
    {
      "quadruplexes":[
        {
          "tetrads":[
            {
              "id":"A.DG6-A.DG12-A.DG16-A.DG24",
              "nt1":"A.DG6",
              "nt2":"A.DG12",
              "nt3":"A.DG16",
              "nt4":"A.DG24",
              "onz":"O+",
              "gbaClassification":"VIa",
              "planarityDeviation":0.1829350977806063,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"A.DG5-A.DG11-A.DG17-A.DG23",
              "nt1":"A.DG5",
              "nt2":"A.DG11",
              "nt3":"A.DG17",
              "nt4":"A.DG23",
              "onz":"O+",
              "gbaClassification":"Va",
              "planarityDeviation":0.10474313820007491,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"A.DG4-A.DG22-A.DG18-A.DG10",
              "nt1":"A.DG4",
              "nt2":"A.DG22",
              "nt3":"A.DG18",
              "nt4":"A.DG10",
              "onz":"O-",
              "gbaClassification":"Vb",
              "planarityDeviation":0.17372283960377813,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            }
          ],
          "onzm":"Oh*",
          "loopClassification":"9a",
          "gbaClassification":[
            "V",
            "VI"
          ],
          "tracts":[
            [
              "A.DG16",
              "A.DG17",
              "A.DG18"
            ],
            [
              "A.DG24",
              "A.DG23",
              "A.DG22"
            ],
            [
              "A.DG6",
              "A.DG5",
              "A.DG4"
            ],
            [
              "A.DG12",
              "A.DG11",
              "A.DG10"
            ]
          ],
          "loops":[
            {
              "type":"propeller-",
              "nucleotides":[
                "A.DT7",
                "A.DT8",
                "A.DA9"
              ]
            },
            {
              "type":"lateral-",
              "nucleotides":[
                "A.DT13",
                "A.DT14",
                "A.DA15"
              ]
            },
            {
              "type":"lateral+",
              "nucleotides":[
                "A.DT19",
                "A.DT20",
                "A.DA21"
              ]
            }
          ]
        }
      ],
      "tetradPairs":[
        {
          "tetrad1":"A.DG6-A.DG12-A.DG16-A.DG24",
          "tetrad2":"A.DG5-A.DG11-A.DG17-A.DG23",
          "direction":"hybrid",
          "rise":3.1149939255558747,
          "twist":27.111587838260725
        },
        {
          "tetrad1":"A.DG5-A.DG11-A.DG17-A.DG23",
          "tetrad2":"A.DG4-A.DG22-A.DG18-A.DG10",
          "direction":"hybrid",
          "rise":3.2109650905140654,
          "twist":20.409525129779524
        }
      ]
    }
  ]
}
```

</details>

## V-loop

![[6TCG: 2’-F-riboguanosine and 2’-F-arabinoguanosine modified
G-quadruplex with V-loop and all-syn
G-tract](https://www.rcsb.org/structure/6tcg)](https://github.com/michal-zurkowski/drawtetrado/blob/main/6tcg.svg?raw=true)

<details>
<summary>
Click to see the input JSON
</summary>

``` json
{
  "metals":[
    
  ],
  "nucleotides":[
    {
      "index":1,
      "model":1,
      "chain":"A",
      "number":1,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG1",
      "shortName":"G",
      "chi":54.111,
      "glycosidicBond":"syn"
    },
    {
      "index":2,
      "model":1,
      "chain":"A",
      "number":2,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG2",
      "shortName":"G",
      "chi":83.093,
      "glycosidicBond":"syn"
    },
    {
      "index":3,
      "model":1,
      "chain":"A",
      "number":3,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG3",
      "shortName":"G",
      "chi":-120.17,
      "glycosidicBond":"anti"
    },
    {
      "index":4,
      "model":1,
      "chain":"A",
      "number":4,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA4",
      "shortName":"A",
      "chi":-111.874,
      "glycosidicBond":"anti"
    },
    {
      "index":5,
      "model":1,
      "chain":"A",
      "number":5,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DT5",
      "shortName":"T",
      "chi":-153.281,
      "glycosidicBond":"anti"
    },
    {
      "index":6,
      "model":1,
      "chain":"A",
      "number":6,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG6",
      "shortName":"G",
      "chi":-106.483,
      "glycosidicBond":"anti"
    },
    {
      "index":7,
      "model":1,
      "chain":"A",
      "number":7,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG7",
      "shortName":"G",
      "chi":-122.668,
      "glycosidicBond":"anti"
    },
    {
      "index":8,
      "model":1,
      "chain":"A",
      "number":8,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG8",
      "shortName":"G",
      "chi":-125.241,
      "glycosidicBond":"anti"
    },
    {
      "index":9,
      "model":1,
      "chain":"A",
      "number":9,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA9",
      "shortName":"A",
      "chi":-90.027,
      "glycosidicBond":"anti"
    },
    {
      "index":10,
      "model":1,
      "chain":"A",
      "number":10,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DC10",
      "shortName":"C",
      "chi":-144.141,
      "glycosidicBond":"anti"
    },
    {
      "index":11,
      "model":1,
      "chain":"A",
      "number":11,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA11",
      "shortName":"A",
      "chi":-139.299,
      "glycosidicBond":"anti"
    },
    {
      "index":12,
      "model":1,
      "chain":"A",
      "number":12,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DC12",
      "shortName":"C",
      "chi":-89.925,
      "glycosidicBond":"syn"
    },
    {
      "index":13,
      "model":1,
      "chain":"A",
      "number":13,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA13",
      "shortName":"A",
      "chi":-116.926,
      "glycosidicBond":"anti"
    },
    {
      "index":14,
      "model":1,
      "chain":"A",
      "number":14,
      "icode":" ",
      "molecule":"Other",
      "fullName":"A.GF2/14",
      "shortName":"g",
      "chi":75.041,
      "glycosidicBond":"syn"
    },
    {
      "index":15,
      "model":1,
      "chain":"A",
      "number":15,
      "icode":" ",
      "molecule":"Other",
      "fullName":"A.GFL15",
      "shortName":"g",
      "chi":-167.524,
      "glycosidicBond":"anti"
    },
    {
      "index":16,
      "model":1,
      "chain":"A",
      "number":16,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG16",
      "shortName":"G",
      "chi":-100.43,
      "glycosidicBond":"anti"
    },
    {
      "index":17,
      "model":1,
      "chain":"A",
      "number":17,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG17",
      "shortName":"G",
      "chi":-140.143,
      "glycosidicBond":"anti"
    },
    {
      "index":18,
      "model":1,
      "chain":"A",
      "number":18,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA18",
      "shortName":"A",
      "chi":-100.903,
      "glycosidicBond":"anti"
    },
    {
      "index":19,
      "model":1,
      "chain":"A",
      "number":19,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DC19",
      "shortName":"C",
      "chi":-131.147,
      "glycosidicBond":"anti"
    },
    {
      "index":20,
      "model":1,
      "chain":"A",
      "number":20,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG20",
      "shortName":"G",
      "chi":-169.165,
      "glycosidicBond":"anti"
    },
    {
      "index":21,
      "model":1,
      "chain":"A",
      "number":21,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG21",
      "shortName":"G",
      "chi":-105.18,
      "glycosidicBond":"anti"
    },
    {
      "index":22,
      "model":1,
      "chain":"A",
      "number":22,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG22",
      "shortName":"G",
      "chi":-106.1,
      "glycosidicBond":"anti"
    }
  ],
  "basePairs":[
    {
      "nt1":"A.DG1",
      "nt2":"A.DG7",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DG1",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG1",
      "nt2":"A.DG16",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG16",
      "nt2":"A.DG1",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG2",
      "nt2":"A.DG6",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG6",
      "nt2":"A.DG2",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG2",
      "nt2":"A.GFL15",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.GFL15",
      "nt2":"A.DG2",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG3",
      "nt2":"A.DG6",
      "stericity":"cis",
      "edge5":"Sugar",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG6",
      "nt2":"A.DG3",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG3",
      "nt2":"A.DG20",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG20",
      "nt2":"A.DG3",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG6",
      "nt2":"A.DG20",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG20",
      "nt2":"A.DG6",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DG21",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG21",
      "nt2":"A.DG7",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG8",
      "nt2":"A.GF2/14",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.GF2/14",
      "nt2":"A.DG8",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG8",
      "nt2":"A.DG22",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG22",
      "nt2":"A.DG8",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DC12",
      "nt2":"A.DA13",
      "stericity":"cis",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA13",
      "nt2":"A.DC12",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.GF2/14",
      "nt2":"A.DG17",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG17",
      "nt2":"A.GF2/14",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.GFL15",
      "nt2":"A.DG20",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG20",
      "nt2":"A.GFL15",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG16",
      "nt2":"A.DA18",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA18",
      "nt2":"A.DG16",
      "stericity":"trans",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG16",
      "nt2":"A.DG21",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG21",
      "nt2":"A.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG17",
      "nt2":"A.DG22",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG22",
      "nt2":"A.DG17",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    }
  ],
  "helices":[
    {
      "quadruplexes":[
        {
          "tetrads":[
            {
              "id":"A.DG2-A.GFL15-A.DG20-A.DG6",
              "nt1":"A.DG2",
              "nt2":"A.GFL15",
              "nt3":"A.DG20",
              "nt4":"A.DG6",
              "onz":"N-",
              "gbaClassification":"VIIb",
              "planarityDeviation":0.2180730955436729,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"A.DG1-A.DG16-A.DG21-A.DG7",
              "nt1":"A.DG1",
              "nt2":"A.DG16",
              "nt3":"A.DG21",
              "nt4":"A.DG7",
              "onz":"N-",
              "gbaClassification":"VIIb",
              "planarityDeviation":0.23623267132215198,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"A.DG8-A.GF2/14-A.DG17-A.DG22",
              "nt1":"A.DG8",
              "nt2":"A.GF2/14",
              "nt3":"A.DG17",
              "nt4":"A.DG22",
              "onz":"O+",
              "gbaClassification":"IIIa",
              "planarityDeviation":0.12292426530184954,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            }
          ],
          "onzm":"Mh*",
          "loopClassification":"7b",
          "gbaClassification":[
            "III",
            "VII"
          ],
          "tracts":[
            [
              "A.DG20",
              "A.DG21",
              "A.DG22"
            ],
            [
              "A.DG6",
              "A.DG7",
              "A.DG8"
            ],
            [
              "A.DG2",
              "A.DG1",
              "A.GF2/14"
            ],
            [
              "A.GFL15",
              "A.DG16",
              "A.DG17"
            ]
          ],
          "loops":[
            {
              "type":"lateral+",
              "nucleotides":[
                "A.DG3",
                "A.DA4",
                "A.DT5"
              ]
            },
            {
              "type":"lateral-",
              "nucleotides":[
                "A.DA9",
                "A.DC10",
                "A.DA11",
                "A.DC12",
                "A.DA13"
              ]
            },
            {
              "type":"propeller-",
              "nucleotides":[
                "A.DA18",
                "A.DC19"
              ]
            }
          ]
        }
      ],
      "tetradPairs":[
        {
          "tetrad1":"A.DG2-A.GFL15-A.DG20-A.DG6",
          "tetrad2":"A.DG1-A.DG16-A.DG21-A.DG7",
          "direction":"hybrid",
          "rise":3.4053905200064882,
          "twist":32.09137702765124
        },
        {
          "tetrad1":"A.DG1-A.DG16-A.DG21-A.DG7",
          "tetrad2":"A.DG8-A.GF2/14-A.DG17-A.DG22",
          "direction":"parallel",
          "rise":3.4862467282164604,
          "twist":29.215089333872314
        }
      ]
    }
  ]
}
```

</details>

## G4-helix (dimer)

![[1MYQ: An intramolecular quadruplex of (GGA)(4) triplet repeat DNA
with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric
interaction](https://www.rcsb.org/structure/1myq)](https://github.com/michal-zurkowski/drawtetrado/blob/main/1myq.svg?raw=true)

<details>
<summary>
Click to see the input JSON
</summary>

``` json
{
  "metals":[
    
  ],
  "nucleotides":[
    {
      "index":1,
      "model":1,
      "chain":"A",
      "number":1,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG1",
      "shortName":"G",
      "chi":-109.42,
      "glycosidicBond":"anti"
    },
    {
      "index":2,
      "model":1,
      "chain":"A",
      "number":2,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG2",
      "shortName":"G",
      "chi":-128.871,
      "glycosidicBond":"anti"
    },
    {
      "index":3,
      "model":1,
      "chain":"A",
      "number":3,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA3",
      "shortName":"A",
      "chi":-56.59,
      "glycosidicBond":"syn"
    },
    {
      "index":4,
      "model":1,
      "chain":"A",
      "number":4,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG4",
      "shortName":"G",
      "chi":-171.001,
      "glycosidicBond":"anti"
    },
    {
      "index":5,
      "model":1,
      "chain":"A",
      "number":5,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG5",
      "shortName":"G",
      "chi":-127.906,
      "glycosidicBond":"anti"
    },
    {
      "index":6,
      "model":1,
      "chain":"A",
      "number":6,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA6",
      "shortName":"A",
      "chi":-87.061,
      "glycosidicBond":"syn"
    },
    {
      "index":7,
      "model":1,
      "chain":"A",
      "number":7,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG7",
      "shortName":"G",
      "chi":-159.577,
      "glycosidicBond":"anti"
    },
    {
      "index":8,
      "model":1,
      "chain":"A",
      "number":8,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG8",
      "shortName":"G",
      "chi":-135.751,
      "glycosidicBond":"anti"
    },
    {
      "index":9,
      "model":1,
      "chain":"A",
      "number":9,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA9",
      "shortName":"A",
      "chi":-50.982,
      "glycosidicBond":"syn"
    },
    {
      "index":10,
      "model":1,
      "chain":"A",
      "number":10,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG10",
      "shortName":"G",
      "chi":-135.29,
      "glycosidicBond":"anti"
    },
    {
      "index":11,
      "model":1,
      "chain":"A",
      "number":11,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DG11",
      "shortName":"G",
      "chi":-113.575,
      "glycosidicBond":"anti"
    },
    {
      "index":12,
      "model":1,
      "chain":"A",
      "number":12,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"A.DA12",
      "shortName":"A",
      "chi":-110.595,
      "glycosidicBond":"anti"
    },
    {
      "index":13,
      "model":1,
      "chain":"B",
      "number":13,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG13",
      "shortName":"G",
      "chi":-112.685,
      "glycosidicBond":"anti"
    },
    {
      "index":14,
      "model":1,
      "chain":"B",
      "number":14,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG14",
      "shortName":"G",
      "chi":-136.989,
      "glycosidicBond":"anti"
    },
    {
      "index":15,
      "model":1,
      "chain":"B",
      "number":15,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DA15",
      "shortName":"A",
      "chi":-57.076,
      "glycosidicBond":"syn"
    },
    {
      "index":16,
      "model":1,
      "chain":"B",
      "number":16,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG16",
      "shortName":"G",
      "chi":-169.156,
      "glycosidicBond":"anti"
    },
    {
      "index":17,
      "model":1,
      "chain":"B",
      "number":17,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG17",
      "shortName":"G",
      "chi":-124.27,
      "glycosidicBond":"anti"
    },
    {
      "index":18,
      "model":1,
      "chain":"B",
      "number":18,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DA18",
      "shortName":"A",
      "chi":-84.463,
      "glycosidicBond":"syn"
    },
    {
      "index":19,
      "model":1,
      "chain":"B",
      "number":19,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG19",
      "shortName":"G",
      "chi":-164.508,
      "glycosidicBond":"anti"
    },
    {
      "index":20,
      "model":1,
      "chain":"B",
      "number":20,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG20",
      "shortName":"G",
      "chi":-141.652,
      "glycosidicBond":"anti"
    },
    {
      "index":21,
      "model":1,
      "chain":"B",
      "number":21,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DA21",
      "shortName":"A",
      "chi":-59.955,
      "glycosidicBond":"syn"
    },
    {
      "index":22,
      "model":1,
      "chain":"B",
      "number":22,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG22",
      "shortName":"G",
      "chi":-128.818,
      "glycosidicBond":"anti"
    },
    {
      "index":23,
      "model":1,
      "chain":"B",
      "number":23,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DG23",
      "shortName":"G",
      "chi":-108.407,
      "glycosidicBond":"anti"
    },
    {
      "index":24,
      "model":1,
      "chain":"B",
      "number":24,
      "icode":" ",
      "molecule":"DNA",
      "fullName":"B.DA24",
      "shortName":"A",
      "chi":-115.199,
      "glycosidicBond":"anti"
    }
  ],
  "basePairs":[
    {
      "nt1":"A.DG1",
      "nt2":"A.DA3",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA3",
      "nt2":"A.DG1",
      "stericity":"trans",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG1",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DG1",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG1",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG10",
      "nt2":"A.DG1",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG2",
      "nt2":"A.DG5",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG5",
      "nt2":"A.DG2",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG2",
      "nt2":"A.DG11",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG11",
      "nt2":"A.DG2",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG2",
      "nt2":"A.DA12",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA12",
      "nt2":"A.DG2",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA3",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DA3",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DA6",
      "stericity":"cis",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA6",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG4",
      "nt2":"A.DG7",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG4",
      "nt2":"B.DG22",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG22",
      "nt2":"A.DG4",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG5",
      "nt2":"A.DG8",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG8",
      "nt2":"A.DG5",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DA6",
      "nt2":"A.DG7",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DA6",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DA9",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA9",
      "nt2":"A.DG7",
      "stericity":"trans",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"A.DG7",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG10",
      "nt2":"A.DG7",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG8",
      "nt2":"A.DG11",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG11",
      "nt2":"A.DG8",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG8",
      "nt2":"A.DA12",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DA12",
      "nt2":"A.DG8",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"A.DG10",
      "nt2":"B.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG16",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"A.DG10",
      "nt2":"B.DG22",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG22",
      "nt2":"A.DG10",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG13",
      "nt2":"B.DA15",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DA15",
      "nt2":"B.DG13",
      "stericity":"trans",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"B.DG13",
      "nt2":"B.DG16",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG16",
      "nt2":"B.DG13",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG13",
      "nt2":"B.DG22",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG22",
      "nt2":"B.DG13",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG14",
      "nt2":"B.DG17",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG17",
      "nt2":"B.DG14",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG14",
      "nt2":"B.DG23",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG23",
      "nt2":"B.DG14",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG14",
      "nt2":"B.DA24",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DA24",
      "nt2":"B.DG14",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DA15",
      "nt2":"B.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG16",
      "nt2":"B.DA15",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG16",
      "nt2":"B.DA18",
      "stericity":"cis",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DA18",
      "nt2":"B.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"B.DG16",
      "nt2":"B.DG19",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG19",
      "nt2":"B.DG16",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG17",
      "nt2":"B.DG20",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG20",
      "nt2":"B.DG17",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DA18",
      "nt2":"B.DG19",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG19",
      "nt2":"B.DA18",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG19",
      "nt2":"B.DA21",
      "stericity":"trans",
      "edge5":"Sugar",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DA21",
      "nt2":"B.DG19",
      "stericity":"trans",
      "edge5":"Hoogsteen",
      "edge3":"Sugar"
    },
    {
      "nt1":"B.DG19",
      "nt2":"B.DG22",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG22",
      "nt2":"B.DG19",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    },
    {
      "nt1":"B.DG20",
      "nt2":"B.DG23",
      "stericity":"cis",
      "edge5":"Watson-Crick",
      "edge3":"Hoogsteen"
    },
    {
      "nt1":"B.DG23",
      "nt2":"B.DG20",
      "stericity":"cis",
      "edge5":"Hoogsteen",
      "edge3":"Watson-Crick"
    }
  ],
  "helices":[
    {
      "quadruplexes":[
        {
          "tetrads":[
            {
              "id":"B.DG14-B.DG17-B.DG20-B.DG23",
              "nt1":"B.DG14",
              "nt2":"B.DG17",
              "nt3":"B.DG20",
              "nt4":"B.DG23",
              "onz":"O+",
              "gbaClassification":"VIIIa",
              "planarityDeviation":0.16023147318800904,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"B.DG13-B.DG16-B.DG19-B.DG22",
              "nt1":"B.DG13",
              "nt2":"B.DG16",
              "nt3":"B.DG19",
              "nt4":"B.DG22",
              "onz":"O+",
              "gbaClassification":"VIIIa",
              "planarityDeviation":0.45582726991701444,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            }
          ],
          "onzm":"Op+",
          "loopClassification":"1a",
          "gbaClassification":[
            "VIII"
          ],
          "tracts":[
            [
              "B.DG23",
              "B.DG22"
            ],
            [
              "B.DG14",
              "B.DG13"
            ],
            [
              "B.DG17",
              "B.DG16"
            ],
            [
              "B.DG20",
              "B.DG19"
            ]
          ],
          "loops":[
            {
              "type":"propeller-",
              "nucleotides":[
                "B.DA15"
              ]
            },
            {
              "type":"propeller-",
              "nucleotides":[
                "B.DA18"
              ]
            },
            {
              "type":"propeller-",
              "nucleotides":[
                "B.DA21"
              ]
            }
          ]
        },
        {
          "tetrads":[
            {
              "id":"A.DG1-A.DG4-A.DG7-A.DG10",
              "nt1":"A.DG1",
              "nt2":"A.DG4",
              "nt3":"A.DG7",
              "nt4":"A.DG10",
              "onz":"O+",
              "gbaClassification":"VIIIa",
              "planarityDeviation":0.5675509888987945,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            },
            {
              "id":"A.DG2-A.DG5-A.DG8-A.DA12",
              "nt1":"A.DG2",
              "nt2":"A.DG5",
              "nt3":"A.DG8",
              "nt4":"A.DA12",
              "onz":"O+",
              "gbaClassification":"VIIIa",
              "planarityDeviation":0.7820234571290057,
              "ionsChannel":[
                
              ],
              "ionsOutside":[
                
              ]
            }
          ],
          "onzm":"Op+",
          "loopClassification":"1a",
          "gbaClassification":[
            "VIII"
          ],
          "tracts":[
            [
              "A.DG7",
              "A.DG8"
            ],
            [
              "A.DG10",
              "A.DA12"
            ],
            [
              "A.DG1",
              "A.DG2"
            ],
            [
              "A.DG4",
              "A.DG5"
            ]
          ],
          "loops":[
            {
              "type":"propeller-",
              "nucleotides":[
                "A.DA3"
              ]
            },
            {
              "type":"propeller-",
              "nucleotides":[
                "A.DA6"
              ]
            },
            {
              "type":"propeller-",
              "nucleotides":[
                "A.DA9"
              ]
            }
          ]
        }
      ],
      "tetradPairs":[
        {
          "tetrad1":"B.DG14-B.DG17-B.DG20-B.DG23",
          "tetrad2":"B.DG13-B.DG16-B.DG19-B.DG22",
          "direction":"parallel",
          "rise":3.4598098620083153,
          "twist":26.65295578601502
        },
        {
          "tetrad1":"B.DG13-B.DG16-B.DG19-B.DG22",
          "tetrad2":"A.DG1-A.DG4-A.DG7-A.DG10",
          "direction":"parallel",
          "rise":3.1498276292124316,
          "twist":7.769329062763674
        },
        {
          "tetrad1":"A.DG1-A.DG4-A.DG7-A.DG10",
          "tetrad2":"A.DG2-A.DG5-A.DG8-A.DA12",
          "direction":"parallel",
          "rise":4.363977409213413,
          "twist":53.69239641441069
        }
      ]
    }
  ]
}
```

</details>

# Bibliography

<div id="refs" class="references csl-bib-body">

1.  ONQUADRO: a database of experimentally determined quadruplex
    structures. T. Zok, N. Kraszewska, J. Miskiewicz, P. Pielacinska, M.
    Zurkowski, M. Szachniuk. *Nucleic Acids Research*. 2022.
    50(D1):D253–D258.
    doi:[10.1093/nar/gkab1118](https://doi.org/10.1093/nar/gkab1118)

2.  Topology-based classification of tetrads and quadruplex
    structures. M. Popenda, J. Miskiewicz, J. Sarzynska, T. Zok, M.
    Szachniuk. *Bioinformatics*. 2020. 36(4):1129–1134.
    doi:[10.1093/bioinformatics/btz738](https://doi.org/10.1093/bioinformatics/btz738)

3.  ElTetrado: a tool for identification and classification of tetrads
    and quadruplexes. T. Zok, M. Popenda, M. Szachniuk. *BMC
    Bioinformatics*. 2020. 21(1):40.
    doi:[10.1186/s12859-020-3385-1](https://doi.org/10.1186/s12859-020-3385-1)

4.  DSSR: an integrated software tool for dissecting the spatial
    structure of RNA. X.-J. Lu, H.J. Bussemaker, W.K. Olson. *Nucleic
    Acids Research*. 2015. 43(21):e142.
    doi:[f73r8c](https://doi.org/f73r8c)

</div>


