<?xml version='1.0' encoding='utf-8'?>
<!--  FILE :  albrecht_model_2002.xml

CREATED :  21st March 2002

LAST MODIFIED : 9th April 2003

AUTHOR :  Catherine Lloyd
          Bioengineering Institute
          The University of Auckland
          
MODEL STATUS :  This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.

DESCRIPTION :  This file contains a CellML description of Albrecht et al's
2002 model of differential regulation of ER Ca2+ uptake and release rates.

CHANGES:  
  18/07/2002 - CML - Added more metadata.
  09/04/2003 - AAC - Added publication date information.  
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="albrecht_colegrove_friel_2002_version01" name="albrecht_colegrove_friel_2002_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.

</para>
<para>
ValidateCellML found unit inconsistencies in this model
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
Calcium is an important signalling ion, and changes in Ca<superscript>2+</superscript> concentration ([Ca<superscript>2+</superscript>]) regulate diverse processes in many cellular compartments.  In excitable cells, depolarisation-induced Ca<superscript>2+</superscript> entry increases [Ca<superscript>2+</superscript>]<subscript>i</subscript>, leading to secondary changes in [Ca<superscript>2+</superscript>] within organelles such as mitochondria and ER that regulate specific Ca<superscript>2+</superscript>-sensitive targets within these organelles.  Although mitochondria accumulate Ca<superscript>2+</superscript> in response to depolarisation-evoked [Ca<superscript>2+</superscript>]<subscript>i</subscript> elevations (see <ulink url="${HTML_EXMPL_COLEGROVE_MODEL}">The Colegrove <emphasis>et al</emphasis> Model Of Mitochondrial Ca<superscript>2+</superscript> Uptake And Release, 2000</ulink>), the ER is also an important component in Ca<superscript>2+</superscript> signalling in virtually all non-muscle cells, and it has been described as either a Ca<superscript>2+</superscript> source or sink.  Different modes of net ER Ca<superscript>2+</superscript> transport are expected to have very different effects on cytoplasmic and intraluminal Ca<superscript>2+</superscript> signals and on the processes they regulate (see <ulink url="${HTML_EXMPL_ALBRECHT_MODEL1}">The Albrecht <emphasis>et al</emphasis> Model Of Multiple Modes of Ca<superscript>2+</superscript>-induced Ca<superscript>2+</superscript> Release in Sympathetic Neurons, 2001</ulink>).   
</para>

<para>
In a follow up study to their 2001 paper, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel have examined how differential regulation of ER Ca<superscript>2+</superscript> uptake and release rates accounts for multiple modes of Ca<superscript>2+</superscript>-induced Ca<superscript>2+</superscript> release.  Three different macroscopic Ca<superscript>2+</superscript> fluxes were modelled: J<subscript>SERCA</subscript>, the rate of Ca<superscript>2+</superscript> uptake via SR Ca-ATPases; J<subscript>ICa</subscript>, the total cytoplasmic Ca<superscript>2+</superscript> flux when SR Ca-ATPases are inhibited; and J<subscript>pm</subscript>, the rate of Ca<superscript>2+</superscript> extrusion across the plasma membrane.  One additional flux J<subscript>release</subscript> was calculated from the difference between J<subscript>ICa</subscript> and J<subscript>pm</subscript> (see <xref linkend="fig_cell_diagram"/> below).  This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
<ulink url="http://www.jgp.org/cgi/content/abstract/119/3/211">Differential Regulation of ER Ca<superscript>2+</superscript> Uptake and Release Rates Accounts for Multiple Modes of Ca<superscript>2+</superscript>-induced Ca<superscript>2+</superscript> Release</ulink>, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel, 2002, <ulink url="http://www.jgp.org/">
            <emphasis>The Journal Of General Physiology</emphasis>
          </ulink>, 119, 211-233.  (<ulink url="http://www.jgp.org/cgi/content/full/119/3/211">Full text</ulink> and <ulink url="http://www.jgp.org/cgi/reprint/119/3/211.pdf">PDF</ulink> versions of the article are available for Journal Members on the JGP website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11865019&amp;dopt=Abstract">PubMed ID: 11865019</ulink>  
</para>


<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell schematic for the model</title>
    </objectinfo>
    <imagedata fileref="albrecht_2002.png"/>
  </imageobject>
</mediaobject>
<caption>Schematic of the model indicating Ca<superscript>2+</superscript> compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca<superscript>2+</superscript> ion movement between the compartments.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
  
  
  <!--
    Below, we define some additional units for association with variables and
    constants within the model. The identifiers are fairly self-explanatory.
  -->
  
  <units name="per_second">
    <unit units="second" exponent="-1"/>
  </units>
  
  <units name="millivolt">
    <unit units="volt" prefix="milli"/>
  </units>
  
  <units name="millimolar">
    <unit units="mole" prefix="micro"/>
    <unit units="litre" exponent="-1"/>
  </units>
  
  <units name="micromolar">
    <unit units="mole" prefix="micro"/>
    <unit units="litre" exponent="-1"/>
  </units>
  
  <units name="nanomolar">
    <unit units="mole" prefix="nano"/>
    <unit units="litre" exponent="-1"/>
  </units>
  
  <units name="nanomolar_per_second">
    <unit units="nanomolar"/>
    <unit units="second" exponent="-1"/>
  </units>
  
  <units name="micromolar_per_second">
    <unit units="micromolar"/>
    <unit units="second" exponent="-1"/>
  </units>
  
  <units name="micro_litre">
    <unit units="litre" prefix="micro"/>
  </units>
  
  <units name="coulomb_per_millimole">
    <unit units="coulomb"/>
    <unit units="mole" prefix="milli" exponent="-1"/>
  </units>
  
  <units2 name="picoA">
    <unit units="ampere" prefix="pico"/>
  </units2>
  
  <!--
    The "environment" component is used to declare variables that are used by
    all or most of the other components, in this case just "time".
  -->
  <component name="environment">
    <variable units="second" public_interface="out" name="time"/>
  </component>
  
  <component name="cytoplasmic_calcium">
    <variable units="nanomolar" public_interface="out" name="Ca_i"/>
    
    <variable units="nanomolar_per_second" name="J_i"/>
    
    <variable units="nanomolar_per_second" public_interface="in" name="J_ER"/>
    <variable units="nanomolar_per_second" public_interface="in" name="J_pm"/>
    <variable units="second" public_interface="in" name="time"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="Ca_i_diff_eq">
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci> time </ci>
          </bvar>
          <ci> Ca_i </ci>
        </apply>
        <apply>
          <minus/>
          <ci> J_i </ci>
        </apply>
      </apply>
      
      <apply id="J_i_calculation">
        <eq/>
        <ci> J_i </ci>
        <apply>
          <plus/>
          <ci> J_pm </ci>
          <ci> J_ER </ci>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="intraluminal_calcium">
    <variable units="nanomolar" public_interface="out" name="Ca_ER"/>
    
    <variable units="micro_litre" name="v_ER"/>
    <variable units="dimensionless" name="k_ER"/>
    <variable units="nanomolar" name="Ca_ER_init"/>
   
    <variable units="nanomolar" public_interface="in" name="Ca_i"/>
    <variable units="micro_litre" public_interface="in" name="v_i"/>
    <variable units="dimensionless" public_interface="in" name="k_i"/>
    <variable units="nanomolar_per_second" public_interface="in" name="J_ER"/>
    <variable units="per_second" public_interface="in" name="P_ER"/>
    <variable units="nanomolar_per_second" public_interface="in" name="J_SERCA"/>
    <variable units="second" public_interface="in" name="time"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="Ca_ER_diff_eq">
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci> time </ci>
          </bvar>
          <ci> Ca_ER </ci>
        </apply>
        <apply>
          <times/>
          <ci> J_ER </ci>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> v_i </ci>
              <ci> k_i </ci>
            </apply>
            <apply>
              <times/>
              <ci> v_ER </ci>
              <ci> k_ER </ci>
            </apply>
          </apply>
        </apply>
      </apply>
      
      <apply id="Ca_ER_init_calculation">
        <eq/>
        <ci> Ca_ER_init </ci>
        <apply>
          <plus/>
          <ci> Ca_i </ci>
          <apply>
            <divide/>
            <apply>
              <times/>
              <ci> J_SERCA </ci>
              <ci> Ca_i </ci>
            </apply>
            <apply>
              <times/>
              <ci> P_ER </ci>
              <apply>
                <divide/>
                <ci> Ca_i </ci>
                <ci> v_i </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="total_cytoplasmic_Ca_flux">
    <variable units="nanomolar_per_second" public_interface="out" name="J_ICa"/>
    <variable units="micro_litre" public_interface="out" name="v_i"/>
    <variable units="dimensionless" public_interface="out" name="k_i"/>
   
    <variable units="coulomb_per_millimole" name="F" initial_value="96.5"/>
    <variable units="picoA" name="I_Ca"/>
   
    <variable units="second" public_interface="in" name="time"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_ICa_calculation">
        <eq/>
        <ci> J_ICa </ci>
        <apply>
          <divide/>
          <ci> I_Ca </ci>
          <apply>
            <times/>
            <cn cellml:units="dimensionless"> 2.0 </cn>
            <ci> F </ci>
            <ci> v_i </ci>
            <ci> k_i </ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <component name="Ca_extrusion_across_the_plasma_membrane">
    <variable units="nanomolar_per_second" public_interface="out" name="J_pm"/>
  
    <variable units="nanomolar_per_second" name="J_extru"/>
    <variable units="per_second" name="k_leak_pm" initial_value="0.00000015"/>
    <variable units="nanomolar_per_second" name="Vmax_extru" initial_value="25.0"/>
    <variable units="nanomolar" name="EC50_extru" initial_value="386.0"/>
    <variable units="dimensionless" name="n_extru" initial_value="2.4"/>
    <variable units="millimolar" name="Ca_o" initial_value="2.0"/>
    
    <variable units="nanomolar_per_second" public_interface="in" name="J_ICa"/>
    <variable units="dimensionless" public_interface="in" name="k_i"/> 
    <variable units="nanomolar" public_interface="in" name="Ca_i"/>
    <variable units="second" public_interface="in" name="time"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_pm_calculation">
        <eq/>
        <ci> J_pm </ci>
        <apply>
          <plus/>
          <ci> J_extru </ci>
          <ci> J_ICa </ci>
        </apply>
      </apply>
      
      <apply id="J_extru_calculation">
        <eq/>
        <ci> J_extru </ci>
        <apply>
          <times/>
          <apply>
            <power/>
            <ci> k_i </ci>
            <cn cellml:units="dimensionless"> -1.0 </cn>
          </apply>
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> k_leak_pm </ci>
              <apply>
                <minus/>
                <ci> Ca_i </ci>
                <ci> Ca_o </ci>
              </apply>
            </apply>
            <apply>
              <divide/>
              <ci> Vmax_extru </ci>
              <apply>
                <plus/>
                <cn cellml:units="dimensionless"> 1.0 </cn>
                <apply>
                  <power/>
                  <apply>
                    <divide/>
                    <ci> EC50_extru </ci>
                    <ci> Ca_i </ci>
                  </apply>
                  <ci> n_extru </ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
      
  <component name="Ca_uptake_by_SR_Ca_ATPase">        
    <variable units="nanomolar_per_second" public_interface="out" name="J_SERCA"/>
    
    <variable units="nanomolar_per_second" name="Vmax_SERCA" initial_value="2146.0"/>
    <variable units="micromolar" name="EC50_SERCA" initial_value="30.3"/>
    <variable units="dimensionless" name="n_SERCA" initial_value="2.5"/>
   
    <variable units="dimensionless" public_interface="in" name="k_i"/>
    <variable units="nanomolar" public_interface="in" name="Ca_i"/>
    <variable units="second" public_interface="in" name="time"/>
    
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_SERCA_calculation">
        <eq/>
        <ci> J_SERCA </ci>
        <apply>
          <divide/>
          <ci> Vmax_SERCA </ci>
          <apply>
            <times/>
            <ci> k_i </ci>
            <apply>
              <plus/>
              <cn cellml:units="dimensionless"> 1.0 </cn>
              <apply>
                <power/>
                <apply>
                  <divide/>
                  <ci> EC50_SERCA </ci>
                  <ci> Ca_i </ci>
                </apply>
                <ci> n_SERCA </ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component> 
  
  <component name="ER_Ca_release">     
    <variable units="nanomolar_per_second" public_interface="out" name="J_ER"/>       
    <variable units="per_second" public_interface="out" name="P_ER"/>
    
    <variable units="per_second" name="P_basal" initial_value="0.009"/>
    <variable units="per_second" name="Pmax_RyR" initial_value="0.05"/>
    <variable units="nanomolar" name="EC50_RyR" initial_value="2641.0"/>
    <variable units="dimensionless" name="n_RyR" initial_value="0.96"/>
    <variable units="nanomolar_per_second" name="J_release"/>
    
    <variable units="nanomolar_per_second" public_interface="in" name="J_SERCA"/>
    <variable units="micro_litre" public_interface="in" name="v_i"/>
    <variable units="dimensionless" public_interface="in" name="k_i"/>        
    <variable units="nanomolar" public_interface="in" name="Ca_i"/>
    <variable units="nanomolar" public_interface="in" name="Ca_ER"/>         
    <variable units="second" public_interface="in" name="time"/>        
            
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply id="J_release_calculation">
        <eq/>
        <ci> J_release </ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <ci> P_ER </ci>
            <apply>
              <minus/>
              <ci> Ca_i </ci>
              <ci> Ca_ER </ci> 
            </apply>
          </apply>
          <apply>
            <times/>
            <ci> v_i </ci>
            <ci> k_i </ci>
          </apply>
        </apply>
      </apply>
      
      <apply id="J_ER_calculation">
        <eq/>
        <ci> J_ER </ci>
        <apply>
          <plus/>
          <ci> J_SERCA </ci>
          <ci> J_release </ci>
        </apply>
      </apply>
      
      <apply id="P_ER_v_i_calculation">
        <eq/>
        <ci> P_ER </ci>
          <apply>
          <times/>
          <ci> v_i </ci>
          <apply>
            <plus/>
            <ci> P_basal </ci>
            <apply>
              <divide/>
              <ci> Pmax_RyR </ci>
              <apply>
                <plus/>
                <cn cellml:units="dimensionless"> 1.0 </cn>
                <apply>
                  <power/>
                  <apply>
                    <divide/>
                    <ci> EC50_RyR </ci>
                    <ci> Ca_i </ci>
                  </apply>
                  <ci> n_RyR </ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  
  <connection>
    <map_components component_2="environment" component_1="cytoplasmic_calcium"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="environment" component_1="intraluminal_calcium"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="environment" component_1="total_cytoplasmic_Ca_flux"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="environment" component_1="Ca_extrusion_across_the_plasma_membrane"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="environment" component_1="Ca_uptake_by_SR_Ca_ATPase"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="environment" component_1="ER_Ca_release"/>
    <map_variables variable_2="time" variable_1="time"/>
  </connection>
  
  <connection>
    <map_components component_2="Ca_extrusion_across_the_plasma_membrane" component_1="cytoplasmic_calcium"/>
    <map_variables variable_2="Ca_i" variable_1="Ca_i"/>
    <map_variables variable_2="J_pm" variable_1="J_pm"/>
  </connection>
  
  <connection>
    <map_components component_2="Ca_uptake_by_SR_Ca_ATPase" component_1="cytoplasmic_calcium"/>
    <map_variables variable_2="Ca_i" variable_1="Ca_i"/>
  </connection>
  
  <connection>
    <map_components component_2="ER_Ca_release" component_1="cytoplasmic_calcium"/>
    <map_variables variable_2="Ca_i" variable_1="Ca_i"/>
    <map_variables variable_2="J_ER" variable_1="J_ER"/>
  </connection>
  
  <connection>
    <map_components component_2="intraluminal_calcium" component_1="cytoplasmic_calcium"/>
    <map_variables variable_2="Ca_i" variable_1="Ca_i"/>
  </connection>
  
  <connection>
    <map_components component_2="ER_Ca_release" component_1="intraluminal_calcium"/>
    <map_variables variable_2="Ca_ER" variable_1="Ca_ER"/>
    <map_variables variable_2="J_ER" variable_1="J_ER"/>
    <map_variables variable_2="P_ER" variable_1="P_ER"/>
  </connection>
  
  <connection>
    <map_components component_2="Ca_uptake_by_SR_Ca_ATPase" component_1="intraluminal_calcium"/>
    <map_variables variable_2="J_SERCA" variable_1="J_SERCA"/>
  </connection>
  
  <connection>
    <map_components component_2="ER_Ca_release" component_1="Ca_uptake_by_SR_Ca_ATPase"/>
    <map_variables variable_2="J_SERCA" variable_1="J_SERCA"/>
  </connection>
  
  <connection>
    <map_components component_2="Ca_extrusion_across_the_plasma_membrane" component_1="total_cytoplasmic_Ca_flux"/>
    <map_variables variable_2="J_ICa" variable_1="J_ICa"/>
    <map_variables variable_2="k_i" variable_1="k_i"/>
  </connection>
  
  <connection>
    <map_components component_2="intraluminal_calcium" component_1="total_cytoplasmic_Ca_flux"/>
    <map_variables variable_2="v_i" variable_1="v_i"/>
    <map_variables variable_2="k_i" variable_1="k_i"/>
  </connection> 
  
  <connection>
    <map_components component_2="ER_Ca_release" component_1="total_cytoplasmic_Ca_flux"/>
    <map_variables variable_2="v_i" variable_1="v_i"/>
    <map_variables variable_2="k_i" variable_1="k_i"/>
  </connection>
  
  <connection>
    <map_components component_2="Ca_uptake_by_SR_Ca_ATPase" component_1="total_cytoplasmic_Ca_flux"/>
    <map_variables variable_2="k_i" variable_1="k_i"/>
  </connection>



<rdf:RDF>
  <rdf:Bag rdf:about="rdf:#8d6d8ff2-88c9-4e05-851b-737fcc458f9d">
    <rdf:li>neuron</rdf:li>
    <rdf:li>electrophysiology</rdf:li>
    <rdf:li>calcium dynamics</rdf:li>
    <rdf:li>er</rdf:li>
  </rdf:Bag>
  <rdf:Seq rdf:about="rdf:#10a6f2e1-447d-4bf2-ae2b-f4417adc8871">
    <rdf:li rdf:resource="rdf:#e3ea6eca-928f-451b-9cd1-ca013e677550"/>
    <rdf:li rdf:resource="rdf:#2c9fddfb-d78f-424c-a603-c5be16f70ce8"/>
    <rdf:li rdf:resource="rdf:#90813684-7a7b-468e-a041-3ff09dbba116"/>
  </rdf:Seq>
  <rdf:Description rdf:about="rdf:#ac2a32d9-fbca-4912-aee9-ad8260bbcd91">
    <vCard:Given>Catherine</vCard:Given>
    <vCard:Family>Lloyd</vCard:Family>
    <vCard:Other>May</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="">
    <dc:publisher>The University of Auckland, Bioengineering Institute</dc:publisher>
    <cmeta:comment rdf:resource="rdf:#b9e90e28-b72c-45e4-9849-9331052e90ae"/>
    <dcterms:created rdf:resource="rdf:#42e0b75e-f35f-46b5-baf5-73f3456cb750"/>
    <dc:creator rdf:resource="rdf:#c067077b-f7ad-4aba-808e-9dc70835e0d4"/>
    <cmeta:modification rdf:resource="rdf:#6e35936f-2c34-4b29-9d02-a49e7f850df3"/>
    <cmeta:modification rdf:resource="rdf:#24b0e4e2-b175-4156-8d6e-f70c3806c172"/>
    <cmeta:modification rdf:resource="rdf:#4d873d62-ff2e-436d-ba16-9c4d05218d24"/>
  </rdf:Description>
  <rdf:Description rdf:about="#albrecht_colegrove_friel_2002_version01">
    <dc:title>
        Differential regulation of ER Ca2+ uptake and release.
      </dc:title>
    <cmeta:bio_entity>sympathetic neuron</cmeta:bio_entity>
    <cmeta:comment rdf:resource="rdf:#8c76b646-2c23-42de-a543-f65e73c9c8db"/>
    <bqs:reference rdf:resource="rdf:#16c21c1f-b111-4f11-a1ce-97429d7f213b"/>
    <bqs:reference rdf:resource="rdf:#3685de9e-447a-404b-b4a7-fcfc718d872d"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#8905d384-47da-4f96-bcf1-715e354d64fd">
    <vCard:Given>Stephen</vCard:Given>
    <vCard:Family>Colegrove</vCard:Family>
    <vCard:Other>L</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#90813684-7a7b-468e-a041-3ff09dbba116">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N rdf:resource="rdf:#d5e9e357-b7fb-460f-9c9a-6b96524d37d9"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#0e7be0e6-81f5-48a6-aadb-60e516a4e655">
    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
    <rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#a72eecbd-8b6e-4c2d-8769-359866ae4502">
    <dcterms:W3CDTF>2002-07-18</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#0590c7c2-1c63-4565-8bcb-f111bb4b34a0">
    <vCard:FN/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#02c48610-5c40-4907-8955-b8768b779384">
    <dc:title>Journal of General Physiology</dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#c041b9d1-61ed-4e2f-a325-5f2f06ad94a4">
    <vCard:Given>Catherine</vCard:Given>
    <vCard:Family>Lloyd</vCard:Family>
    <vCard:Other>May</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#d5e9e357-b7fb-460f-9c9a-6b96524d37d9">
    <vCard:Given>David</vCard:Given>
    <vCard:Family>Friel</vCard:Family>
    <vCard:Other>D</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#3685de9e-447a-404b-b4a7-fcfc718d872d">
    <dc:subject rdf:resource="rdf:#272080ca-109d-4a01-8c26-a2f10c8fc20a"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#8c76b646-2c23-42de-a543-f65e73c9c8db">
    <dc:creator rdf:resource="rdf:#cf692c47-3391-4ee6-a672-a5c586e88a5c"/>
    <rdf:value>This is the CellML description of Albrecht et al's 2002 model of &#13;
          differential regulation of ER Ca2+ uptake and rates.</rdf:value>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#cf692c47-3391-4ee6-a672-a5c586e88a5c">
    <vCard:FN>Catherine Lloyd</vCard:FN>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#6e35936f-2c34-4b29-9d02-a49e7f850df3">
    <dcterms:modified rdf:resource="rdf:#2971f739-eac9-4821-baf4-a3cce68fd58b"/>
    <rdf:value>updated curation status</rdf:value>
    <cmeta:modifier rdf:resource="rdf:#985752d7-2dbb-4922-8a55-17afa8ed38a6"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#69a82cd0-0866-4717-a6d7-97af7a176c00">
    <vCard:Orgname>The University of Auckland</vCard:Orgname>
    <vCard:Orgunit>The Bioengineering Institute</vCard:Orgunit>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#7b701f7c-dac1-460b-828f-c3c3a3e834e2">
    <vCard:N rdf:resource="rdf:#c041b9d1-61ed-4e2f-a325-5f2f06ad94a4"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#985752d7-2dbb-4922-8a55-17afa8ed38a6">
    <vCard:N rdf:resource="rdf:#2c045f90-0bd3-45cb-9212-616e81cd06c7"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#2c9fddfb-d78f-424c-a603-c5be16f70ce8">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N rdf:resource="rdf:#8905d384-47da-4f96-bcf1-715e354d64fd"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#4d873d62-ff2e-436d-ba16-9c4d05218d24">
    <dcterms:modified rdf:resource="rdf:#a72eecbd-8b6e-4c2d-8769-359866ae4502"/>
    <rdf:value>
          Added more metadata.
        </rdf:value>
    <cmeta:modifier rdf:resource="rdf:#7b701f7c-dac1-460b-828f-c3c3a3e834e2"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#e3ea6eca-928f-451b-9cd1-ca013e677550">
    <rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
    <vCard:N rdf:resource="rdf:#1c5d231a-412e-45e5-a848-29fbe05790df"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#3a97e47c-7a5d-4da1-892e-587514e8c357">
    <dcterms:W3CDTF>2002-03</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#d7845bf3-bfea-4206-86f6-6ddc9992c52e">
    <vCard:N rdf:resource="rdf:#cfaa4748-ab60-4a61-b6e6-c81ed81710d3"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#24b0e4e2-b175-4156-8d6e-f70c3806c172">
    <dcterms:modified rdf:resource="rdf:#95293d60-7bb5-44d6-964d-890032037c27"/>
    <rdf:value>
          Added publication date information.
        </rdf:value>
    <cmeta:modifier rdf:resource="rdf:#d7845bf3-bfea-4206-86f6-6ddc9992c52e"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#95293d60-7bb5-44d6-964d-890032037c27">
    <dcterms:W3CDTF>2003-04-09</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#cfaa4748-ab60-4a61-b6e6-c81ed81710d3">
    <vCard:Given>Autumn</vCard:Given>
    <vCard:Family>Cuellar</vCard:Family>
    <vCard:Other>A</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#42e0b75e-f35f-46b5-baf5-73f3456cb750">
    <dcterms:W3CDTF>2002-03-21T00:00:00+00:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#272080ca-109d-4a01-8c26-a2f10c8fc20a">
    <bqs:subject_type>keyword</bqs:subject_type>
    <rdf:value rdf:resource="rdf:#8d6d8ff2-88c9-4e05-851b-737fcc458f9d"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#3612e477-8065-48d4-871f-305bfb0c83d6">
    <dc:creator rdf:resource="rdf:#10a6f2e1-447d-4bf2-ae2b-f4417adc8871"/>
    <dc:title>Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts             for Multiple Modes of Ca2+-induced Ca2+ Release</dc:title>
    <bqs:volume>119</bqs:volume>
    <bqs:first_page>211</bqs:first_page>
    <bqs:Journal rdf:resource="rdf:#02c48610-5c40-4907-8955-b8768b779384"/>
    <dcterms:issued rdf:resource="rdf:#3a97e47c-7a5d-4da1-892e-587514e8c357"/>
    <bqs:last_page>233</bqs:last_page>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#16c21c1f-b111-4f11-a1ce-97429d7f213b">
    <bqs:Pubmed_id>11865019</bqs:Pubmed_id>
    <bqs:JournalArticle rdf:resource="rdf:#3612e477-8065-48d4-871f-305bfb0c83d6"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#c067077b-f7ad-4aba-808e-9dc70835e0d4">
    <vCard:ORG rdf:resource="rdf:#69a82cd0-0866-4717-a6d7-97af7a176c00"/>
    <vCard:EMAIL rdf:resource="rdf:#0e7be0e6-81f5-48a6-aadb-60e516a4e655"/>
    <vCard:N rdf:resource="rdf:#ac2a32d9-fbca-4912-aee9-ad8260bbcd91"/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#2971f739-eac9-4821-baf4-a3cce68fd58b">
    <dcterms:W3CDTF>2009-04-30T16:04:07+12:00</dcterms:W3CDTF>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#b9e90e28-b72c-45e4-9849-9331052e90ae">
    <dc:creator rdf:resource="rdf:#0590c7c2-1c63-4565-8bcb-f111bb4b34a0"/>
    <rdf:value/>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#1c5d231a-412e-45e5-a848-29fbe05790df">
    <vCard:Given>Meredith</vCard:Given>
    <vCard:Family>Albrecht</vCard:Family>
    <vCard:Other>A</vCard:Other>
  </rdf:Description>
  <rdf:Description rdf:about="rdf:#2c045f90-0bd3-45cb-9212-616e81cd06c7">
    <vCard:Given>James</vCard:Given>
    <vCard:Family>Lawson</vCard:Family>
    <vCard:Other>Richard</vCard:Other>
  </rdf:Description>
</rdf:RDF>
</model>
