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        <div class="dc:title">Xu2003 - Phosphoinositide turnover</div>
        <div class="dc:description">
          <p>The model reproduces the percentage change of PIP_PM, PIP2_PM and IP3_Cyt as depicted in Figure 1 of the paper.  The model also contains the equations for the analysis of PH-GFP experiments, however the initial value of PH_GFP has been set to zero to more accurately reproduce Figure 1. The units of cytosolic species are given in molecules/um^3. In order to convert them to uM, divide the concentration by 602. For the analysis of PH_GFP experiments, one should plug in the values of PH_GFP, IP3_PHGFP and PIP2_PHGFP from Table AI in the appendix. The model was successfully tested on MathSBML.</p>
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        <div class="dc:provenance">
          <p>This model has been generated by VCell</p>
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        <div class="dc:bibliographicCitation">
          <p>This model is described in the article:</p>
          <div class="bibo:title">
            <a href="http://identifiers.org/pubmed/12771127" title="Access to this publication">Kinetic analysis of receptor-activated phosphoinositide turnover.</a>
          </div>
          <div class="bibo:authorList">Xu C, Watras J, Loew LM.</div>
          <div class="bibo:Journal">J. Cell Biol. 2003 May; 161(4): 779-791</div>
          <p>Abstract:</p>
          <div class="bibo:abstract">
            <p>We studied the bradykinin-induced changes in phosphoinositide composition of N1E-115 neuroblastoma cells using a combination of biochemistry, microscope imaging, and mathematical modeling. Phosphatidylinositol-4,5-bisphosphate (PIP2) decreased over the first 30 s, and then recovered over the following 2-3 min. However, the rate and amount of inositol-1,4,5-trisphosphate (InsP3) production were much greater than the rate or amount of PIP2 decline. A mathematical model of phosphoinositide turnover based on this data predicted that PIP2 synthesis is also stimulated by bradykinin, causing an early transient increase in its concentration. This was subsequently confirmed experimentally. Then, we used single-cell microscopy to further examine phosphoinositide turnover by following the translocation of the pleckstrin homology domain of PLCdelta1 fused to green fluorescent protein (PH-GFP). The observed time course could be simulated by incorporating binding of PIP2 and InsP3 to PH-GFP into the model that had been used to analyze the biochemistry. Furthermore, this analysis could help to resolve a controversy over whether the translocation of PH-GFP from membrane to cytosol is due to a decrease in PIP2 on the membrane or an increase in InsP3 in cytosol; by computationally clamping the concentrations of each of these compounds, the model shows how both contribute to the dynamics of probe translocation.</p>
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        <div class="dc:publisher">
          <p>This model is hosted on        <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a>
            and identified by:        <a href="http://identifiers.org/biomodels.db/BIOMD0000000075">BIOMD0000000075</a>
            .        </p>
          <p>To cite BioModels Database, please use:        <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models</a>
            .        </p>
        </div>
        <div class="dc:license">
          <p>To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to        <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0 Public Domain Dedication</a>
            for more information.        </p>
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              <rdf:Description rdf:about="#COPASI1">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005576"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </compartment>
      <compartment constant="true" id="PM" metaid="COPASI2" name="PM" size="0.5555555555556" spatialDimensions="2" units="volume">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI2">
    <bqbiol:is>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005886"/>
    </rdf:Bag>
    </bqbiol:is>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI2">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005886"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </compartment>
      <compartment constant="true" id="Cytosol" metaid="COPASI3" name="Cytosol" size="1" spatialDimensions="3" units="volume">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI3">
    <bqbiol:is>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005622"/>
    </rdf:Bag>
    </bqbiol:is>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI3">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005622"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </compartment>
      <compartment constant="true" id="NM" metaid="COPASI4" name="NM" size="0.111111111111111" spatialDimensions="2" units="volume">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI4">
    <bqbiol:is>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/go/GO:0031965"/>
    </rdf:Bag>
    </bqbiol:is>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI4">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/go/GO:0031965"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </compartment>
      <compartment constant="true" id="Nucleus" metaid="COPASI5" name="Nucleus" size="0.111111111111111" spatialDimensions="3" units="volume">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI5">
    <bqbiol:is>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005634"/>
    </rdf:Bag>
    </bqbiol:is>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI5">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/go/GO:0005634"/>
                  </rdf:Bag>
                </CopasiMT:is>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </compartment>
    </listOfCompartments>
    <listOfSpecies>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PIP2_PHGFP_PM" initialConcentration="0" metaid="COPASI6" name="PIP2_PHGFP_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PIP2_PHGFP"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI6">
              <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18348"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    
    <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI6">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18348"/>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="Cytosol" constant="false" hasOnlySubstanceUnits="false" id="PH_GFP_Cyt" initialConcentration="0" metaid="COPASI7" name="PH_GFP_Cyt" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PH_GFP"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI7">
              <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    
    <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI7">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PI_PM" initialConcentration="142857" metaid="COPASI8" name="PI_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PI"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI8">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:28874"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI8">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:28874"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="true" compartment="PM" constant="true" hasOnlySubstanceUnits="false" id="stim_PM" initialConcentration="1" metaid="COPASI9" name="stim_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="stim"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI9">
    <bqbiol:hasProperty>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/opb/OPB_01072"/>
    </rdf:Bag>
    </bqbiol:hasProperty>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI9">
                <bqbiol:hasProperty>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/opb/OPB_01072"/>
                  </rdf:Bag>
                </bqbiol:hasProperty>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="Cytosol" constant="false" hasOnlySubstanceUnits="false" id="IP3_PHGFP_Cyt" initialConcentration="0" metaid="COPASI10" name="IP3_PHGFP_Cyt" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="IP3_PHGFP"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI10">
              <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    
    <bqbiol:hasPart>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
    </rdf:Bag>
    </bqbiol:hasPart>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI10">
                <CopasiMT:hasPart>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR001849"/>
                    <rdf:li rdf:resource="http://identifiers.org/interpro/IPR011584"/>
                  </rdf:Bag>
                </CopasiMT:hasPart>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PIP2_PM" initialConcentration="4000" metaid="COPASI11" name="PIP2_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PIP2"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI11">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18348"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI11">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18348"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PIP_PM" initialConcentration="2857" metaid="COPASI12" name="PIP_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PIP"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI12">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:26034"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI12">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:26034"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="DAG_PM" initialConcentration="2000" metaid="COPASI13" name="DAG_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="DAG"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI13">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18035"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI13">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:18035"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="true" compartment="Cytosol" constant="true" hasOnlySubstanceUnits="false" id="hv_Cytosol" initialConcentration="0" metaid="COPASI14" name="hv_Cytosol" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="hv"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI14">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:30212"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI14">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:30212"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="true" compartment="Cytosol" constant="true" hasOnlySubstanceUnits="false" id="IP3X_Cytosol" initialConcentration="0" metaid="COPASI15" name="IP3X_Cytosol" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="IP3X"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI15">
              <bqbiol:is>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/pato/PATO:0002355"/>
    </rdf:Bag>
    </bqbiol:is>
    
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI15">
                <CopasiMT:is>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/pato/PATO:0002355"/>
                  </rdf:Bag>
                </CopasiMT:is>
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PLC_PM" initialConcentration="100" metaid="COPASI16" name="PLC_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PLC"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI16">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q8K4S1"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI16">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q8K4S1"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="PM" constant="false" hasOnlySubstanceUnits="false" id="PLC_act_PM" initialConcentration="0" metaid="COPASI17" name="PLC_act_PM" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="PLC_act"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI17">
              <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q8K4S1"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    
    <bqbiol:hasProperty>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.4.11"/>
    </rdf:Bag>
    </bqbiol:hasProperty>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI17">
                <bqbiol:hasProperty>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/ec-code/3.1.4.11"/>
                  </rdf:Bag>
                </bqbiol:hasProperty>
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/uniprot/Q8K4S1"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
      <species boundaryCondition="false" compartment="Cytosol" constant="false" hasOnlySubstanceUnits="false" id="IP3_Cyt" initialConcentration="96.32" metaid="COPASI18" name="IP3_Cyt" substanceUnits="substance">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <Compound Name="IP3"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI18">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI18">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16595"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
            </species>
    </listOfSpecies>
    <listOfParameters>
      <parameter constant="true" id="KMOLE" metaid="COPASI19" name="KMOLE" units="unit_0" value="0.00166112956810631"/>
      <parameter constant="true" id="PIP_basal_PIPSyn" metaid="COPASI20" name="PIP_basal_PIPSyn" units="unit_1" value="2857"/>
      <parameter constant="true" id="kBasalSynPIP_PIPSyn" metaid="COPASI21" name="kBasalSynPIP_PIPSyn" units="unit_2" value="0.0055"/>
      <parameter constant="true" id="kStimSynPIP_PIPSyn" metaid="COPASI22" name="kStimSynPIP_PIPSyn" units="unit_2" value="0.019"/>
      <parameter constant="true" id="tauPIPsyn_PIPSyn" metaid="COPASI23" name="tauPIPsyn_PIPSyn" units="unit_3" value="0.05"/>
      <parameter constant="true" id="PIPsyndecay_PIPSyn" metaid="COPASI24" name="PIPsyndecay_PIPSyn" units="unit_3" value="1"/>
      <parameter constant="false" id="Ratebasal_PIPsyn_PIPSyn" metaid="COPASI25" name="Ratebasal_PIPsyn_PIPSyn" units="unit_2" value="0"/>
      <parameter constant="false" id="Ratestim_PIPsyn_PIPSyn" metaid="COPASI26" name="Ratestim_PIPsyn_PIPSyn" units="unit_2" value="0"/>
      <parameter constant="true" id="tau0_PLCact" metaid="COPASI27" name="tau0_PLCact" units="unit_3" value="0.05"/>
      <parameter constant="true" id="stimdecay_PLCact" metaid="COPASI28" name="stimdecay_PLCact" units="unit_3" value="1"/>
      <parameter constant="false" id="signal_PLCact" metaid="COPASI29" name="signal_PLCact" units="unit_4" value="0"/>
      <parameter constant="true" id="kf_PIP2PH_PIP2_PH" metaid="COPASI30" name="kf_PIP2PH_PIP2_PH" units="unit_5" value="0.12"/>
      <parameter constant="true" id="KdPIP2PH_PIP2_PH" metaid="COPASI31" name="KdPIP2PH_PIP2_PH" units="unit_6" value="2"/>
      <parameter constant="false" id="kr_PIP2PH_PIP2_PH" metaid="COPASI32" name="kr_PIP2PH_PIP2_PH" units="unit_2" value="0.24"/>
      <parameter constant="true" id="kStimSynPIP2_PIP2Syn" metaid="COPASI33" name="kStimSynPIP2_PIP2Syn" units="unit_2" value="0.92"/>
      <parameter constant="true" id="tauPIP2syn_PIP2Syn" metaid="COPASI34" name="tauPIP2syn_PIP2Syn" units="unit_3" value="0.05"/>
      <parameter constant="true" id="PIP2syndecay_PIP2Syn" metaid="COPASI35" name="PIP2syndecay_PIP2Syn" units="unit_3" value="1"/>
      <parameter constant="true" id="PIP2_basal_PIP2Syn" metaid="COPASI36" name="PIP2_basal_PIP2Syn" units="unit_1" value="4000"/>
      <parameter constant="true" id="kBasalSynPIP2_PIP2Syn" metaid="COPASI37" name="kBasalSynPIP2_PIP2Syn" units="unit_2" value="0.048"/>
      <parameter constant="false" id="Rate_PIP2Synbasal_PIP2Syn" metaid="COPASI38" name="Rate_PIP2Synbasal_PIP2Syn" units="unit_2" value="0"/>
      <parameter constant="false" id="Rate_PIP2SynStim_PIP2Syn" metaid="COPASI39" name="Rate_PIP2SynStim_PIP2Syn" units="unit_2" value="0"/>
      <parameter constant="true" id="kf_IP3PH_IP3_PHGFP" metaid="COPASI40" name="kf_IP3PH_IP3_PHGFP" units="unit_5" value="10"/>
      <parameter constant="true" id="KdIP3PH_IP3_PHGFP" metaid="COPASI41" name="KdIP3PH_IP3_PHGFP" units="unit_6" value="2"/>
      <parameter constant="false" id="kr_IP3PH_IP3_PHGFP" metaid="COPASI42" name="kr_IP3PH_IP3_PHGFP" units="unit_2" value="20"/>
    </listOfParameters>
    <listOfRules>
      <assignmentRule variable="Rate_PIP2SynStim_PIP2Syn">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <piecewise>
            <piece>
              <apply>
                <times/>
                <ci> kStimSynPIP2_PIP2Syn </ci>
                <apply>
                  <exp/>
                  <apply>
                    <minus/>
                    <apply>
                      <times/>
                      <apply>
                        <plus/>
                        <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                        <apply>
                          <minus/>
                          <ci> tauPIP2syn_PIP2Syn </ci>
                        </apply>
                      </apply>
                      <apply>
                        <divide/>
                        <cn> 1 </cn>
                        <ci> PIP2syndecay_PIP2Syn </ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <gt/>
                <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                <ci> tauPIP2syn_PIP2Syn </ci>
              </apply>
            </piece>
            <otherwise>
              <cn> 0 </cn>
            </otherwise>
          </piecewise>
        </math>
            </assignmentRule>
      <assignmentRule variable="signal_PLCact">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <piecewise>
            <piece>
              <apply>
                <exp/>
                <apply>
                  <minus/>
                  <apply>
                    <times/>
                    <apply>
                      <plus/>
                      <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                      <apply>
                        <minus/>
                        <ci> tau0_PLCact </ci>
                      </apply>
                    </apply>
                    <apply>
                      <divide/>
                      <cn> 1 </cn>
                      <ci> stimdecay_PLCact </ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <gt/>
                <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                <ci> tau0_PLCact </ci>
              </apply>
            </piece>
            <otherwise>
              <cn> 0 </cn>
            </otherwise>
          </piecewise>
        </math>
            </assignmentRule>
      <assignmentRule variable="Rate_PIP2Synbasal_PIP2Syn">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <piecewise>
            <piece>
              <apply>
                <times/>
                <cn> 0.581 </cn>
                <ci> kBasalSynPIP2_PIP2Syn </ci>
                <apply>
                  <plus/>
                  <apply>
                    <minus/>
                    <cn> 1 </cn>
                  </apply>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <apply>
                        <plus/>
                        <ci> PIP2_basal_PIP2Syn </ci>
                        <apply>
                          <minus/>
                          <ci> PIP2_PM </ci>
                        </apply>
                      </apply>
                      <apply>
                        <divide/>
                        <cn> 1 </cn>
                        <ci> PIP2_basal_PIP2Syn </ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <lt/>
                <ci> PIP2_PM </ci>
                <ci> PIP2_basal_PIP2Syn </ci>
              </apply>
            </piece>
            <otherwise>
              <cn> 0 </cn>
            </otherwise>
          </piecewise>
        </math>
            </assignmentRule>
      <assignmentRule variable="kr_PIP2PH_PIP2_PH">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <apply>
            <times/>
            <ci> kf_PIP2PH_PIP2_PH </ci>
            <ci> KdPIP2PH_PIP2_PH </ci>
          </apply>
        </math>
            </assignmentRule>
      <assignmentRule variable="kr_IP3PH_IP3_PHGFP">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <apply>
            <times/>
            <ci> kf_IP3PH_IP3_PHGFP </ci>
            <ci> KdIP3PH_IP3_PHGFP </ci>
          </apply>
        </math>
            </assignmentRule>
      <assignmentRule variable="Ratestim_PIPsyn_PIPSyn">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <piecewise>
            <piece>
              <apply>
                <times/>
                <ci> kStimSynPIP_PIPSyn </ci>
                <apply>
                  <exp/>
                  <apply>
                    <minus/>
                    <apply>
                      <times/>
                      <apply>
                        <plus/>
                        <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                        <apply>
                          <minus/>
                          <ci> tauPIPsyn_PIPSyn </ci>
                        </apply>
                      </apply>
                      <apply>
                        <divide/>
                        <cn> 1 </cn>
                        <ci> PIPsyndecay_PIPSyn </ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <gt/>
                <csymbol encoding="text" definitionURL="http://www.sbml.org/sbml/symbols/time"> time </csymbol>
                <ci> tauPIPsyn_PIPSyn </ci>
              </apply>
            </piece>
            <otherwise>
              <cn> 0 </cn>
            </otherwise>
          </piecewise>
        </math>
            </assignmentRule>
      <assignmentRule variable="Ratebasal_PIPsyn_PIPSyn">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <piecewise>
            <piece>
              <apply>
                <times/>
                <cn> 0.581 </cn>
                <ci> kBasalSynPIP_PIPSyn </ci>
                <apply>
                  <plus/>
                  <apply>
                    <minus/>
                    <cn> 1 </cn>
                  </apply>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <apply>
                        <plus/>
                        <ci> PIP_basal_PIPSyn </ci>
                        <apply>
                          <minus/>
                          <ci> PIP_PM </ci>
                        </apply>
                      </apply>
                      <apply>
                        <divide/>
                        <cn> 1 </cn>
                        <ci> PIP_basal_PIPSyn </ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <lt/>
                <ci> PIP_PM </ci>
                <ci> PIP_basal_PIPSyn </ci>
              </apply>
            </piece>
            <otherwise>
              <cn> 0 </cn>
            </otherwise>
          </piecewise>
        </math>
            </assignmentRule>
    </listOfRules>
    <listOfReactions>
      <reaction fast="false" id="PIPSyn" metaid="COPASI43" name="PIPSyn" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="Rate_PIPSyn"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI43">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000216"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI43">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000216"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PI_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="PIP_PM" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> PM </ci>
              <apply>
                <ci> Function_for_PIPSyn </ci>
                <ci> PI_PM </ci>
                <ci> Ratebasal_PIPsyn_PIPSyn </ci>
                <ci> Ratestim_PIPsyn_PIPSyn </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction fast="false" id="PIP2_hyd" metaid="COPASI44" name="PIP2_hyd" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="Rate_PIP2_hyd"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI44">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI44">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PIP2_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="DAG_PM" stoichiometry="1"/>
          <speciesReference constant="true" species="IP3_Cyt" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="PLC_act_PM"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <ci> Function_for_PIP2_hyd </ci>
              <ci> PIP2_PM </ci>
              <ci> PLC_act_PM </ci>
              <ci> PM </ci>
              <ci> k_PIP2hyd </ci>
            </apply>
          </math>
                  <listOfLocalParameters>
            <localParameter id="k_PIP2hyd" name="k_PIP2hyd" value="2.4"/>
          </listOfLocalParameters>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="PLCact" metaid="COPASI45" name="PLCact" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="RatePLCact"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI45">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000170"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI45">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000170"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PLC_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="PLC_act_PM" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="stim_PM"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> PM </ci>
              <apply>
                <ci> Function_for_PLCact </ci>
                <ci> KfPLCact </ci>
                <ci> PLC_PM </ci>
                <ci> PLC_act_PM </ci>
                <ci> krPLCact </ci>
                <ci> signal_PLCact </ci>
                <ci> stim_PM </ci>
              </apply>
            </apply>
          </math>
                  <listOfLocalParameters>
            <localParameter id="KfPLCact" name="KfPLCact" value="0.0005"/>
            <localParameter id="krPLCact" name="krPLCact" value="0.1"/>
          </listOfLocalParameters>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="PIP2_PH_hyd" metaid="COPASI46" name="PIP2_PH_hyd" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="RatePIP2_PH_hyd"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI46">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI46">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PIP2_PHGFP_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="PH_GFP_Cyt" stoichiometry="1"/>
          <speciesReference constant="true" species="IP3_Cyt" stoichiometry="1"/>
          <speciesReference constant="true" species="DAG_PM" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="PLC_act_PM"/>
        </listOfModifiers>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <ci> Function_for_PIP2_PH_hyd </ci>
              <ci> PIP2_PHGFP_PM </ci>
              <ci> PLC_act_PM </ci>
              <ci> PM </ci>
              <ci> k_PIP2PHhyd </ci>
            </apply>
          </math>
                  <listOfLocalParameters>
            <localParameter id="k_PIP2PHhyd" name="k_PIP2PHhyd" value="0"/>
          </listOfLocalParameters>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="PIP2_PH" metaid="COPASI47" name="PIP2_PH" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="J"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI47">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI47">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PH_GFP_Cyt" stoichiometry="1"/>
          <speciesReference constant="true" species="PIP2_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="PIP2_PHGFP_PM" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <ci> Function_for_PIP2_PH </ci>
              <ci> PH_GFP_Cyt </ci>
              <ci> PIP2_PHGFP_PM </ci>
              <ci> PIP2_PM </ci>
              <ci> PM </ci>
              <ci> kf_PIP2PH_PIP2_PH </ci>
              <ci> kr_PIP2PH_PIP2_PH </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction fast="false" id="IP3deg" metaid="COPASI48" name="IP3deg" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="Cytosol"/>
            <ReactionRate Name="Rate_IP3deg"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI48">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000179"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI48">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000179"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="IP3_Cyt" stoichiometry="1"/>
        </listOfReactants>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Cytosol </ci>
              <apply>
                <ci> Function_for_IP3deg </ci>
                <ci> IP3_Cyt </ci>
                <ci> IP3_basal </ci>
                <ci> KMOLE </ci>
                <ci> kIP3deg </ci>
              </apply>
            </apply>
          </math>
                  <listOfLocalParameters>
            <localParameter id="IP3_basal" name="IP3_basal" value="0.16"/>
            <localParameter id="kIP3deg" name="kIP3deg" value="0.08"/>
          </listOfLocalParameters>
        </kineticLaw>
      </reaction>
      <reaction fast="false" id="PIP2Syn" metaid="COPASI49" name="PIP2Syn" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="PM"/>
            <ReactionRate Name="Rate_PIP2Syn"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI49">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000216"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI49">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000216"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="PIP_PM" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="PIP2_PM" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> PM </ci>
              <apply>
                <ci> Function_for_PIP2Syn </ci>
                <ci> PIP_PM </ci>
                <ci> Rate_PIP2SynStim_PIP2Syn </ci>
                <ci> Rate_PIP2Synbasal_PIP2Syn </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction fast="false" id="IP3_PHGFP" metaid="COPASI50" name="IP3-PHGFP" reversible="true">
        <annotation>
          <VCellInfo xmlns="http://sourceforge.net/projects/vcell">
            <SimpleReaction Structure="Cytosol"/>
            <ReactionRate Name="J"/>
          </VCellInfo>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:vCard4="http://www.w3.org/2006/vcard/ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#COPASI50">
    <bqbiol:isVersionOf>
    <rdf:Bag>
    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
    </rdf:Bag>
    </bqbiol:isVersionOf>
    </rdf:Description>
    
          </rdf:RDF>
          <COPASI xmlns="http://www.copasi.org/static/sbml">
            <rdf:RDF xmlns:CopasiMT="http://www.copasi.org/RDF/MiriamTerms#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
              <rdf:Description rdf:about="#COPASI50">
                <CopasiMT:isVersionOf>
                  <rdf:Bag>
                    <rdf:li rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000182"/>
                  </rdf:Bag>
                </CopasiMT:isVersionOf>
              </rdf:Description>
            </rdf:RDF>
          </COPASI>
        </annotation>
              <listOfReactants>
          <speciesReference constant="true" species="IP3_Cyt" stoichiometry="1"/>
          <speciesReference constant="true" species="PH_GFP_Cyt" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference constant="true" species="IP3_PHGFP_Cyt" stoichiometry="1"/>
        </listOfProducts>
        <kineticLaw>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <times/>
              <ci> Cytosol </ci>
              <apply>
                <ci> Function_for_IP3_PHGFP </ci>
                <ci> IP3_Cyt </ci>
                <ci> IP3_PHGFP_Cyt </ci>
                <ci> KMOLE </ci>
                <ci> PH_GFP_Cyt </ci>
                <ci> kf_IP3PH_IP3_PHGFP </ci>
                <ci> kr_IP3PH_IP3_PHGFP </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>