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        <div class="dc:title">Proctor2013 - Effect of Aβ immunisation
in Alzheimer's disease (stochastic version)</div>
<div class="dc:description">Extension of a previously published
stochastic model (designed to examine some of the key pathways
involved in the aggregation of amyloid-beta (A
<span style="color: rgb(84, 84, 84); font-family: arial, sans-serif; font-size: small;">β) </span>and
the micro-tubular binding protein tau (
<a href="http://identifiers.org/biomodels.db/BIOMD0000000286">BIOMD0000000286</a>,

<a href="http://identifiers.org/biomodels.db/BIOMD0000000462">BIOMD0000000462</a>))
to include the main processes involved in passive and active
immunisation against A
<span style="color: rgb(84, 84, 84); font-family: arial, sans-serif; font-size: small;">β</span>
and then to demonstrate the effects of this intervention on soluble
A
<span style="color: rgb(84, 84, 84); font-family: arial, sans-serif; font-size: small;">β. </span>This
is the stochastic version of the model, the deterministic version
is
<a href="http://identifiers.org/biomodels.db/BIOMD0000000488">BIOMD0000000488</a>. </div>
<div class="dc:bibliographicCitation">
  <p>This model is described in the article:</p>
  <div class="bibo:title">
    <a href="http://identifiers.org/pubmed/24098635" title="Access to this publication">Investigating interventions
    in Alzheimer's disease with computer simulation models.</a>
  </div>
  <div class="bibo:authorList">Proctor CJ, Boche D, Gray DA, Nicoll
  JA.</div>
  <div class="bibo:Journal">PLoS ONE 2013; 8(9): e73631</div>
  <p>Abstract:</p>
  <div class="bibo:abstract">
    <p>Progress in the development of therapeutic interventions to
    treat or slow the progression of Alzheimer's disease has been
    hampered by lack of efficacy and unforeseen side effects in
    human clinical trials. This setback highlights the need for new
    approaches for pre-clinical testing of possible interventions.
    Systems modelling is becoming increasingly recognised as a
    valuable tool for investigating molecular and cellular
    mechanisms involved in ageing and age-related diseases.
    However, there is still a lack of awareness of modelling
    approaches in many areas of biomedical research. We previously
    developed a stochastic computer model to examine some of the
    key pathways involved in the aggregation of amyloid-beta (Aβ)
    and the micro-tubular binding protein tau. Here we show how we
    extended this model to include the main processes involved in
    passive and active immunisation against Aβ and then demonstrate
    the effects of this intervention on soluble Aβ, plaques,
    phosphorylated tau and tangles. The model predicts that
    immunisation leads to clearance of plaques but only results in
    small reductions in levels of soluble Aβ, phosphorylated tau
    and tangles. The behaviour of this model is supported by
    neuropathological observations in Alzheimer patients immunised
    against Aβ. Since, soluble Aβ, phosphorylated tau and tangles
    more closely correlate with cognitive decline than plaques, our
    model suggests that immunotherapy against Aβ may not be
    effective unless it is performed very early in the disease
    process or combined with other therapies.</p>
  </div>
</div>
<div class="dc:publisher">
  <p>This model is hosted on
  <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a>
  and identified by:
  <a href="http://identifiers.org/biomodels.db/BIOMD0000000634">BIOMD0000000634</a>.</p>
  <p>To cite BioModels Database, please use:
  <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database:
  An enhanced, curated and annotated resource for published
  quantitative kinetic models</a>.</p>
</div>
<div class="dc:license">
  <p>To the extent possible under law, all copyright and related or
  neighbouring rights to this encoded model have been dedicated to
  the public domain worldwide. Please refer to
  <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0
  Public Domain Dedication</a> for more information.</p>
</div>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_p53_Ub3" initialAmount="0" metaid="f766d9c3-fe35-4275-8cd2-35d3b4dc40d6">
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	</rdf:RDF>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_p53_Ub4" initialAmount="0" metaid="_64abf391-d3c8-42f6-a89e-b3b31f905791">
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P1_p53_Ub4" initialAmount="0" metaid="_4cf12b38-6ce4-489d-8225-3a472dd1dc15">
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	</rdf:RDF>
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	</rdf:RDF>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_Ub2" initialAmount="0" metaid="_598edd23-c964-4036-82ff-6996e7be764a">
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	</rdf:RDF>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_Ub3" initialAmount="0" metaid="_44ea822b-5048-4500-8d10-7bc91ab5219c">
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	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_Ub4" initialAmount="0" metaid="bdd6ff23-225a-4cbc-af23-12262016e23e">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#bdd6ff23-225a-4cbc-af23-12262016e23e">
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	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P_Ub" initialAmount="0" metaid="_1c6ab6fd-6e51-4237-a600-9e2ad7ba7d1a">
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	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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	<bqbiol:is>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/pr/PR:000037070"/>
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	</rdf:RDF>
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            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P_Ub2" initialAmount="0" metaid="_2718eb58-0222-4451-bdec-8231f16c64db">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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	<bqbiol:hasPart>
	<rdf:Bag>
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	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P_Ub3" initialAmount="0" metaid="_27ef1f38-9401-42c5-8778-3133be9a6a02">
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	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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	<bqbiol:hasPart>
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	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P_Ub4" initialAmount="0" metaid="_08cf58cd-6626-4358-9e69-9d82d787aa88">
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	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
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	<bqbiol:is>
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	<rdf:li rdf:resource="http://identifiers.org/pr/PR:000037070"/>
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	</rdf:RDF>
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            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="p53_Ub4_Proteasome" initialAmount="0" metaid="_0b6360bd-b5d0-4b11-a59e-b0f1a577ddc3">
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	<rdf:li rdf:resource="http://identifiers.org/go/GO:0000502"/>
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	</rdf:RDF>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_Ub4_Proteasome" initialAmount="0" metaid="_236f389a-5320-4d54-8b35-d226009f0d0f">
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	</rdf:RDF>
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Mdm2_P_Ub4_Proteasome" initialAmount="0" metaid="d79732ef-21e1-41b2-974d-7ff30641b4bf">
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	<bqbiol:is>
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	</rdf:RDF>
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            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GSK3b" initialAmount="500" metaid="_7fff67f9-3266-4f27-8c41-98d534b21cf9">
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	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GSK3b_p53" initialAmount="0" metaid="f6d4e28f-b852-453e-b1fe-9279062d8c54">
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	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GSK3b_p53_P" initialAmount="0" metaid="_62a49d7e-7034-4641-9459-1254d46552e6">
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      <species compartment="cell" hasOnlySubstanceUnits="true" id="Abeta" initialAmount="0" metaid="_09dd609c-ed84-47ca-b3b8-1bc3178301e8">
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	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AggAbeta_Proteasome" initialAmount="0" metaid="_635b86a7-cc19-47a9-ba91-718c9b42f404">
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	<rdf:li rdf:resource="http://identifiers.org/go/GO:0000502"/>
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	<bqbiol:hasProperty>
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	<rdf:li rdf:resource="urn:miriam:sbo:SBO%3A0000543"/>
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	</bqbiol:hasProperty>
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	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AbetaPlaque" initialAmount="0" metaid="f51f0ec4-2bac-46d8-b5a2-1982f5b7fd4c">
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	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="urn:miriam:sbo:SBO%3A0000543"/>
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	</bqbiol:hasProperty>
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	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Tau" initialAmount="0" metaid="b495bca6-e675-4215-898e-b77b043973c4">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#b495bca6-e675-4215-898e-b77b043973c4">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Tau_P1" initialAmount="0" metaid="_7efe7049-7c1d-4b13-ad66-869b82996083">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_7efe7049-7c1d-4b13-ad66-869b82996083">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Tau_P2" initialAmount="0" metaid="_45839dd2-e1c5-43f5-8d25-cb0b3c41d676">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_45839dd2-e1c5-43f5-8d25-cb0b3c41d676">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="MT_Tau" initialAmount="100" metaid="f6f4ed03-710a-4673-8f41-42a78b0dfd79">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#f6f4ed03-710a-4673-8f41-42a78b0dfd79">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AggTau" initialAmount="0" metaid="_4ee816a1-ab48-4b51-95fe-03d93a64765e">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_4ee816a1-ab48-4b51-95fe-03d93a64765e">
              <bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="urn:miriam:sbo:SBO%3A0000543"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AggTau_Proteasome" initialAmount="0" metaid="f4cac7b6-6de0-4dbe-b165-f20dc9b3dce2">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#f4cac7b6-6de0-4dbe-b165-f20dc9b3dce2">
              <bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="urn:miriam:sbo:SBO%3A0000543"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0000502"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Proteasome_Tau" initialAmount="0" metaid="ab9be3a9-8c92-4eda-b698-2af99e25c5e5">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#ab9be3a9-8c92-4eda-b698-2af99e25c5e5">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	<rdf:li rdf:resource="http://identifiers.org/go/GO:0000502"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="PP1" initialAmount="50" metaid="_9d54099f-a1d4-414c-adaf-61e1dcc35c2f">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_9d54099f-a1d4-414c-adaf-61e1dcc35c2f">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P62136"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="NFT" initialAmount="0" metaid="f38327b4-e667-4e48-92d9-4646476cfd23">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#f38327b4-e667-4e48-92d9-4646476cfd23">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/interpro/IPR002955"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species boundaryCondition="true" compartment="cell" constant="true" hasOnlySubstanceUnits="true" id="ATP" initialAmount="10000" metaid="_16380dd6-79ba-4e23-9a29-49103d1468bc">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_16380dd6-79ba-4e23-9a29-49103d1468bc">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:15422"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species boundaryCondition="true" compartment="cell" constant="true" hasOnlySubstanceUnits="true" id="ADP" initialAmount="1000" metaid="_5837a322-65c1-4e8e-873a-e3588f019cfb">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_5837a322-65c1-4e8e-873a-e3588f019cfb">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16761"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species boundaryCondition="true" compartment="cell" constant="true" hasOnlySubstanceUnits="true" id="AMP" initialAmount="1000" metaid="bcf08e1f-7eb6-4c57-bae0-850a6dbba671">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#bcf08e1f-7eb6-4c57-bae0-850a6dbba671">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/chebi/CHEBI:16027"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AbetaDimer" initialAmount="0" metaid="_167fefc7-9513-4d84-b33f-6a49a87d09c1">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_167fefc7-9513-4d84-b33f-6a49a87d09c1">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P05067"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AbetaPlaque_GliaA" initialAmount="0" metaid="_508a5aed-e600-4432-ba9b-1dd650908263">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_508a5aed-e600-4432-ba9b-1dd650908263">
              <bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P05067"/>
	<rdf:li rdf:resource="http://identifiers.org/cl/CL:0000129"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	
	<bqbiol:hasProperty>
	<rdf:Bag>
	<rdf:li rdf:resource="urn:miriam:sbo:SBO%3A0000543"/>
	</rdf:Bag>
	</bqbiol:hasProperty>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GliaI" initialAmount="100" metaid="fb8b48ab-febc-4889-8cb0-b3a1a9d8d192">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#fb8b48ab-febc-4889-8cb0-b3a1a9d8d192">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/cl/CL:0000129"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GliaM1" initialAmount="0" metaid="_204ed488-3725-4c6d-adc8-0d0ed926d5c0">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_204ed488-3725-4c6d-adc8-0d0ed926d5c0">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/cl/CL:0000129"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GliaM2" initialAmount="0" metaid="_5b28d62b-2925-4de4-9959-37bfb8e6897a">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_5b28d62b-2925-4de4-9959-37bfb8e6897a">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/cl/CL:0000129"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="GliaA" initialAmount="0" metaid="_9561d5e4-20ad-4380-9dd3-a048d1e5c9d6">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_9561d5e4-20ad-4380-9dd3-a048d1e5c9d6">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/cl/CL:0000129"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="antiAb" initialAmount="0" metaid="ef440bdf-0dec-4d33-abb1-f62145ee833f">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#ef440bdf-0dec-4d33-abb1-f62145ee833f">
	<bqbiol:isVersionOf>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/fma/FMA:62871"/>
	</rdf:Bag>
	</bqbiol:isVersionOf>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="Abeta_antiAb" initialAmount="0" metaid="_790b9038-6613-4507-b17a-7db550bd5cef">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#_790b9038-6613-4507-b17a-7db550bd5cef">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P05067"/>
	<rdf:li rdf:resource="http://identifiers.org/fma/FMA:62871"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="AbetaDimer_antiAb" initialAmount="0" metaid="a344899f-a984-403a-8d43-b77c058126e1">
        <annotation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
            <rdf:Description rdf:about="#a344899f-a984-403a-8d43-b77c058126e1">
	<bqbiol:hasPart>
	<rdf:Bag>
	<rdf:li rdf:resource="http://identifiers.org/uniprot/P05067"/>
	<rdf:li rdf:resource="http://identifiers.org/fma/FMA:62871"/>
	</rdf:Bag>
	</bqbiol:hasPart>
	</rdf:Description>
	
	
	
	</rdf:RDF>
	</annotation>
            </species>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="degAbetaGlia" initialAmount="0" metaid="_9f785dcc-067e-4395-abf5-b2712e6a96f1"/>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="disaggPlaque1" initialAmount="0" metaid="_260bf8c8-e1c8-40f6-bc38-f78a0fb2f76d"/>
      <species compartment="cell" hasOnlySubstanceUnits="true" id="disaggPlaque2" initialAmount="0" metaid="_67cee4b9-83cb-4669-b975-68391f009896"/>
      <species boundaryCondition="true" compartment="cell" constant="true" hasOnlySubstanceUnits="true" id="Source" initialAmount="1" metaid="_90841c67-b885-4a47-9809-2c4ed82f8732" sboTerm="SBO:0000291"/>
      <species boundaryCondition="true" compartment="cell" constant="true" hasOnlySubstanceUnits="true" id="Sink" initialAmount="1" metaid="_7f60e31d-7ba6-4252-b36c-eed48e0070c6" sboTerm="SBO:0000291"/>
    </listOfSpecies>
    <listOfParameters>
      <parameter id="ksynp53mRNA" metaid="_87466f05-40a0-466f-b7d4-64c13d6765b8" value="0.001"/>
      <parameter id="kdegp53mRNA" metaid="c77e84b9-8dcb-4fca-a89a-9ac5ec580f11" value="0.0001"/>
      <parameter id="ksynMdm2mRNA" metaid="b4c6c459-c686-48df-80d5-959f8cf4d5df" value="0.0005"/>
      <parameter id="kdegMdm2mRNA" metaid="_383c3e5a-8a6f-4811-930a-a2efe1b142f4" value="0.0005"/>
      <parameter id="ksynMdm2mRNAGSK3bp53" metaid="_2f1abb12-ed8d-4601-97cd-98866442ba57" value="0.0007"/>
      <parameter id="ksynp53" metaid="ef5dc3f8-2850-4779-be10-0e0ad2152e98" value="0.007"/>
      <parameter id="kdegp53" metaid="a04254a6-73ea-47d8-be2c-71bfcfd9a453" value="0.005"/>
      <parameter id="kbinMdm2p53" metaid="_6d2bf7d8-ad9c-4232-96c6-d1a2b584b6e1" value="0.001155"/>
      <parameter id="krelMdm2p53" metaid="_3ed62ed1-6329-4c2a-9882-3b8ee1118ef8" value="1.155E-5"/>
      <parameter id="kbinGSK3bp53" metaid="b06be24a-ff55-4b60-bd81-ae6f5d9bf829" value="2E-6"/>
      <parameter id="krelGSK3bp53" metaid="_9ad92066-32bc-4b8e-878c-70a9f37f7304" value="0.002"/>
      <parameter id="ksynMdm2" metaid="_4291c4ee-c747-4610-b747-1dafa01f1f0a" value="0.000495"/>
      <parameter id="kdegMdm2" metaid="_00701cdd-33eb-4d14-9125-7e0b7e72ee6a" value="0.01"/>
      <parameter id="kbinE1Ub" metaid="a4b81694-2e9f-458d-b291-984845f5ed8e" value="0.0002"/>
      <parameter id="kbinE2Ub" metaid="ad4c8845-b709-4012-8b43-c2083a894e0e" value="0.001"/>
      <parameter id="kp53Ub" metaid="_9fbb69ba-6204-4ae9-8641-6d9e0f4342ab" value="5E-5"/>
      <parameter id="kp53PolyUb" metaid="dc392c84-4dcb-4670-9044-7cdaacecd971" value="0.01"/>
      <parameter id="kbinProt" metaid="_57651427-d248-418b-945f-0524480e52f9" value="2E-6"/>
      <parameter id="kactDUBp53" metaid="_8517b97c-b609-48c1-a799-414aecf91b07" value="1E-7"/>
      <parameter id="kactDUBProtp53" metaid="bd9d6d77-a1c2-4479-84e0-1977bba90272" value="0.0001"/>
      <parameter id="kactDUBMdm2" metaid="_4b108d07-bf14-4462-8914-9c72ce89853c" value="1E-7"/>
      <parameter id="kMdm2Ub" metaid="be92a0bd-5bd0-4bb6-970b-83eb8c78a2b8" value="4.56E-6"/>
      <parameter id="kMdm2PUb" metaid="_9d806149-1262-4e2f-96ca-d30023453eaa" value="6.84E-6"/>
      <parameter id="kMdm2PolyUb" metaid="f0715881-bd9f-4ef3-8f48-e0767601cc6b" value="0.00456"/>
      <parameter id="kdam" metaid="_4552479e-f7b2-440f-aaac-7d19b7f2d519" value="0.08"/>
      <parameter id="krepair" metaid="d0273989-0c37-4b5a-b87b-602501b48266" value="2E-5"/>
      <parameter id="kactATM" metaid="d2bb0cd9-7ce0-495d-bf80-cd29524abe59" value="0.0001"/>
      <parameter id="kinactATM" metaid="_3bd32425-8985-45af-912f-4122f802e367" value="0.0005"/>
      <parameter id="kphosp53" metaid="e02291aa-1b3f-4bd6-bf29-a42986cdbb4b" value="0.0002"/>
      <parameter id="kdephosp53" metaid="_37ae34ea-3dca-43f1-901f-8fb34b83b4e7" value="0.5"/>
      <parameter id="kphosMdm2" metaid="d19429ef-c44f-4a56-8a87-5ad34ea2d242" value="2"/>
      <parameter id="kdephosMdm2" metaid="_067dfb4b-19a5-4b9a-ab65-3aa1bfbf71f1" value="0.5"/>
      <parameter id="kphosMdm2GSK3b" metaid="c31272bd-56eb-43da-b695-594cc8c29dc1" value="0.005"/>
      <parameter id="kphosMdm2GSK3bp53" metaid="_667636c2-05b6-4c63-8a5f-623b693986ee" value="0.5"/>
      <parameter id="kphospTauGSK3bp53" metaid="_062a7918-88d8-4627-a4d1-f8fadbd1bd33" value="0.1"/>
      <parameter id="kphospTauGSK3b" metaid="_71e4e9ff-f6a0-4538-972f-880a9f200e55" value="0.0002"/>
      <parameter id="kdephospTau" metaid="a1d31bc7-9f45-4721-b5ee-b6d5ff2e7312" value="0.01"/>
      <parameter id="kbinMTTau" metaid="_930c4ec9-b877-4853-9728-5237d3132472" value="0.1"/>
      <parameter id="krelMTTau" metaid="_0ddb44a2-1756-450d-987a-e939a9d3521f" value="0.0001"/>
      <parameter id="ksynTau" metaid="bfba878c-49f3-4cfa-a8ea-a140a3624b30" value="8E-5"/>
      <parameter id="kbinTauProt" metaid="f1ac4972-4e1d-436e-86f7-72a1ec7adb37" value="1.925E-7"/>
      <parameter id="kdegTau20SProt" metaid="_477bc3a5-b161-4be8-89ad-4c0c18d9b37b" value="0.01"/>
      <parameter id="kaggTau" metaid="_5a93ff3f-723a-495b-ab53-91a2e41ad5fe" value="1E-8"/>
      <parameter id="kaggTauP1" metaid="_0b0e21da-5298-47c2-8d82-f7b670b95bed" value="1E-8"/>
      <parameter id="kaggTauP2" metaid="a2661641-7d49-4e79-8c41-8d4b8cc55c8f" value="1E-7"/>
      <parameter id="ktangfor" metaid="e5fe07b9-bdef-4de8-84af-2d03658c84ed" value="0.001"/>
      <parameter id="kinhibprot" metaid="_912461eb-32c3-4eac-9053-0c5b82cc34ec" value="1E-7"/>
      <parameter id="ksynp53mRNAAbeta" metaid="_0a394d6d-dd61-48d7-9c89-370e08ef0c14" value="1E-5"/>
      <parameter id="kdamROS" metaid="_7b8c3ac5-7fe9-43f0-91df-daea43b46547" value="1E-5"/>
      <parameter id="kgenROSAbeta" metaid="_7f5ed4a6-eaad-4a07-9713-13f253215b60" value="2E-5"/>
      <parameter id="kgenROSPlaque" metaid="_6b6de022-4b06-48b3-b356-f030ede79362" value="1E-5"/>
      <parameter id="kgenROSGlia" metaid="d8c3357b-993f-4681-9c41-ebcc225da3a4" value="1E-5"/>
      <parameter constant="false" id="kproteff" metaid="f3e4a746-ece0-4a0c-838e-2b157f2a1d5c" value="1"/>
      <parameter id="kremROS" metaid="_5d81c1cd-8f76-4b59-b73c-78db95e9bd35" value="7E-5"/>
      <parameter id="kprodAbeta" metaid="cb9c29a6-18ac-497e-b3fb-a9da5405a785" value="1.86E-5"/>
      <parameter id="kprodAbeta2" metaid="_8c91fdda-ddf3-473a-aecc-05e935592ade" value="1.86E-5"/>
      <parameter id="kdegAbeta" metaid="_612384ea-8e9d-4731-9a1f-f654c7372a79" value="1.5E-5"/>
      <parameter id="kaggAbeta" metaid="b2cb86a2-b1c9-4a80-9b3e-302c124fbe56" value="3E-6"/>
      <parameter id="kdisaggAbeta" metaid="fcad1c96-d917-43ee-899e-189085acb9ff" value="1E-6"/>
      <parameter id="kdisaggAbeta1" metaid="e8bab176-e2d6-4d34-8e9e-8601eb04f81d" value="0.0002"/>
      <parameter id="kdisaggAbeta2" metaid="e64d554b-00ab-4ee3-94da-5dd72950c834" value="1E-6"/>
      <parameter id="kdegAbetaGlia" metaid="e255350f-e909-472d-901d-94e5a74bf5cd" value="0.005"/>
      <parameter id="kpf" metaid="_2b416ed7-ec85-4c75-b0fc-b49fb7363d52" value="0.2"/>
      <parameter id="kpg" metaid="_955a574d-bc79-4099-88e1-a4bb7ce3a389" value="0.15"/>
      <parameter id="kpghalf" metaid="a3997e5a-3dfd-4482-9a04-2077539d14f7" value="10"/>
      <parameter id="kactglia1" metaid="_57a7f5fc-7e1a-48fd-9c31-1fb3babee79c" value="6E-7"/>
      <parameter id="kactglia2" metaid="_9c011719-4599-4c08-9670-1ec60ab3af21" value="6E-7"/>
      <parameter id="kinactglia1" metaid="faad9eea-8d3a-427d-94a7-e60397cd30ee" value="5E-6"/>
      <parameter id="kinactglia2" metaid="_135e0160-848f-462a-9811-5b7475318efd" value="5E-6"/>
      <parameter id="kbinAbetaGlia" metaid="_3723453d-357d-430c-98b4-07f9fb28745f" value="1E-5"/>
      <parameter id="krelAbetaGlia" metaid="_4a671200-0c9d-4895-9250-c44c528884a2" value="5E-5"/>
      <parameter id="kdegAntiAb" metaid="_7ed5e3f0-57b4-47e4-9a17-a3a6d3af0940" value="2.75E-6"/>
      <parameter id="kbinAbantiAb" metaid="_844f31e3-39b0-4c78-a6d9-937b02a97190" value="1E-6"/>
    </listOfParameters>
    <listOfReactions>
      <reaction id="p53mRNASynthesis" metaid="a989b9af-0821-42dd-bec4-c891b15038c7" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_298b2f20-b516-4157-a499-d5fe7b0531fb" species="Source"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_0359301e-3d22-4d81-ab29-8fd6316b4f04" species="p53_mRNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="dca2eeb7-c511-4f7f-80b6-131d80bd4c5b" species="Source"/>
        </listOfModifiers>
        <kineticLaw metaid="_67d8f8a9-bb61-4267-8c59-db246aac9c49">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynp53mRNA </ci>
              <ci> Source </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53mRNADegradation" metaid="_665d8d0d-5108-4a16-83a5-7d374c3dfdd5" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ede18b6c-b638-4ec0-aee9-6e2dc29ea07c" species="p53_mRNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_78a83ff5-affa-40b1-8632-5c54ecdac355" species="Sink"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_03f5fce9-5c11-4449-ba6f-0cbf02a887ab" species="p53_mRNA"/>
        </listOfModifiers>
        <kineticLaw metaid="_956cd51a-974c-4bfc-8720-34de2e57ebca">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegp53mRNA </ci>
              <ci> p53_mRNA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Synthesis" metaid="_14c34032-c98c-4ada-b685-e3c066b3ba24" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_7042ef8c-bb7c-4c48-b650-e98d4fcc32b1" species="Mdm2_mRNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_8b7ec01b-ad33-4575-9709-ddd804352ea1" species="Mdm2_mRNA"/>
          <speciesReference metaid="_73e81e50-2b07-4c40-9c3c-6c0cc5d5fc8f" species="Mdm2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="eaae2c60-0e10-4962-a946-9945d4e0d922" species="Mdm2_mRNA"/>
        </listOfModifiers>
        <kineticLaw metaid="_1572536e-d8c3-4111-a440-02b8cadcacb2">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynMdm2 </ci>
              <ci> Mdm2_mRNA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2mRNASynthesis1" metaid="c360730f-a373-462f-8a67-0d421f61c745" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_10b5cd75-1650-4717-b52b-7f085dff48e6" species="p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="db165bb9-65d7-4175-8921-0a6809fbf775" species="p53"/>
          <speciesReference metaid="_2c57b392-8baf-447b-9a4b-d80e16799a1f" species="Mdm2_mRNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="fa91b082-9a0e-4193-aeb5-a8717bbed94d" species="p53"/>
        </listOfModifiers>
        <kineticLaw metaid="_1b8c8a2d-fb8a-4416-b6c7-af325cd95fc7">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynMdm2mRNA </ci>
              <ci> p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2mRNASynthesis2" metaid="_437e4627-82be-4177-834f-c53deb9c68eb" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_7b66fbba-d628-4bc3-8de0-1073175bda35" species="p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_45c2cce1-56cb-4559-b5b5-3fb18432e361" species="p53_P"/>
          <speciesReference metaid="c70ece34-4cba-4ebd-99d1-479d76402791" species="Mdm2_mRNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_1cdcbf84-902e-476d-8419-5cde4163003c" species="p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="afc5baf0-d87a-4d5a-a83e-f5c6c74159a4">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynMdm2mRNA </ci>
              <ci> p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2mRNASynthesis3" metaid="_3136503a-bda1-4ee9-b7b6-99d795c9f88f" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_05462c56-5d5b-42cd-b0c7-285f3963fd7a" species="GSK3b_p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f0afc0db-d9cf-4c44-833a-37c6cdf38328" species="GSK3b_p53"/>
          <speciesReference metaid="ccc9e4c3-5ce9-448e-a765-c4285516e02c" species="Mdm2_mRNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_773cbc60-74c8-4f00-bbad-3bb99a0d4c8f" species="GSK3b_p53"/>
        </listOfModifiers>
        <kineticLaw metaid="eead7865-3657-4fdd-b403-edba4325b421">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynMdm2mRNAGSK3bp53 </ci>
              <ci> GSK3b_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2mRNASynthesis4" metaid="_2d8e8a86-d34b-4e6e-becd-500a42c6c8cb" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_85369ad0-1d78-4525-8d71-3d9d44ee21b2" species="GSK3b_p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_4bf1ca57-c898-4293-9a7e-39bb2d8fbdec" species="GSK3b_p53_P"/>
          <speciesReference metaid="_8a505017-752a-451d-90b3-40bd33ddb224" species="Mdm2_mRNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_4588172c-5111-4e32-a17f-e2aed9fe1343" species="GSK3b_p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="_3f9fa6b6-779a-40bb-9342-31f3619e6361">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynMdm2mRNAGSK3bp53 </ci>
              <ci> GSK3b_p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2mRNADegradation" metaid="ca9fbc30-6e3f-4acc-b982-5a0d66f858c9" reversible="false">
        <listOfReactants>
          <speciesReference metaid="e9828716-394d-468d-992a-0585fa1fe15b" species="Mdm2_mRNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_28765cc7-239f-4ce0-89a8-29efa3e9140d" species="Sink"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_4ce3f804-6b10-4c21-bf19-bc3d83e3c6fa" species="Mdm2_mRNA"/>
        </listOfModifiers>
        <kineticLaw metaid="_25639021-32c5-4d75-a434-bc29bc95b9ea">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegMdm2mRNA </ci>
              <ci> Mdm2_mRNA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="P53Mdm2Binding" metaid="_28e80f88-e140-4fd5-98b3-65007e7d1afd" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a469de77-4fda-4349-9f81-1519c6d429a8" species="p53"/>
          <speciesReference metaid="_10e63fbb-9dfa-418a-8c33-fb7e5b1a04ae" species="Mdm2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_0e7eac9d-ad07-49f2-9751-da0f43b778bc" species="Mdm2_p53"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_522f678d-7010-400e-b3e6-b481a4ec4d37" species="p53"/>
          <modifierSpeciesReference metaid="cb56f6fe-f5a1-435a-b1a8-482d8e19ed6f" species="Mdm2"/>
        </listOfModifiers>
        <kineticLaw metaid="db776c64-995e-4694-a70e-3437661d7a91">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinMdm2p53 </ci>
              <ci> p53 </ci>
              <ci> Mdm2 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="P53Mdm2Release" metaid="_142839f7-2ea9-43d2-9d3f-323accb2fd8b" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_262c0bb6-df9b-48fe-bff4-da8bf0204dab" species="Mdm2_p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_0e585663-339e-4360-bebd-86c161c5dc2b" species="p53"/>
          <speciesReference metaid="_82a36e65-279d-4617-9073-658a4607ed0d" species="Mdm2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="d074219f-ebb5-4dbd-9fde-4914ae387fd1" species="Mdm2_p53"/>
        </listOfModifiers>
        <kineticLaw metaid="_4702c909-8590-4643-bcb6-ff0371c64b21">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krelMdm2p53 </ci>
              <ci> Mdm2_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GSK3p53Binding" metaid="f7e9b467-538f-4180-8acc-7c28ed13208b" reversible="false">
        <listOfReactants>
          <speciesReference metaid="cbe877cc-211a-4409-8f8b-25e882a992e0" species="GSK3b"/>
          <speciesReference metaid="b4939340-1b94-482c-8ad4-0a2d2be69801" species="p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="bf30d6b5-18a7-4723-977f-4d364e1078e0" species="GSK3b_p53"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_9f1dd044-5f0c-48f7-ac7a-2e5a4a1e7df8" species="GSK3b"/>
          <modifierSpeciesReference metaid="_7e6d602e-e095-495e-ad93-24a3286f72bf" species="p53"/>
        </listOfModifiers>
        <kineticLaw metaid="_4b38cfb5-5d19-4511-9ab0-a40b09ad59e9">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinGSK3bp53 </ci>
              <ci> GSK3b </ci>
              <ci> p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GSK3p53Release" metaid="bf83260e-f460-453b-95c4-010de89a3845" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b1da2905-193e-453b-8fb1-b5d4cf6093c8" species="GSK3b_p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_9fd14ee3-6f62-461d-bb2b-d64fe24e2f5c" species="GSK3b"/>
          <speciesReference metaid="f88a4e84-30ec-451f-adeb-91ee4209e5f0" species="p53"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_6178a891-7e9c-482d-b295-92495b2f22cf" species="GSK3b_p53"/>
        </listOfModifiers>
        <kineticLaw metaid="e3752e6b-a559-4ccb-9540-94e04eb731d7">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krelGSK3bp53 </ci>
              <ci> GSK3b_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GSK3p53PBinding" metaid="_64e5df5e-051c-4f4e-a7ed-d8d3828835b2" reversible="false">
        <listOfReactants>
          <speciesReference metaid="bd3b7816-3104-407a-a9a9-83066d945d99" species="GSK3b"/>
          <speciesReference metaid="_6f88fb0b-511e-410e-a630-45f6a0b9030d" species="p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_46db1254-ebd5-41f6-983d-d87c60c77fcf" species="GSK3b_p53_P"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_81fef2c6-5ec3-4848-8fe7-6d36ff9dce74" species="GSK3b"/>
          <modifierSpeciesReference metaid="_8f7b82c4-5a88-4ec0-b543-04ee096cecf6" species="p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="_681983a7-dddc-4f50-b584-60aa84a1537e">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinGSK3bp53 </ci>
              <ci> GSK3b </ci>
              <ci> p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GSK3_p53PRelease" metaid="_87d8fd08-e1a2-421d-b36f-9384d5f3fc76" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_35537283-20cd-4f8e-a4dd-240aeb39e621" species="GSK3b_p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_21627bbc-20c3-4b20-adae-b123dd5c3b24" species="GSK3b"/>
          <speciesReference metaid="_927d30ae-7dd6-4263-a60f-d1174126787d" species="p53_P"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_3c0771a2-d758-4e41-a295-c3d11c87eb90" species="GSK3b_p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="_4e2e0cb4-099a-4b0a-8b78-4e65cb6e3d65">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krelGSK3bp53 </ci>
              <ci> GSK3b_p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="E1UbBinding" metaid="f1cb1773-85d7-48ce-82e5-4cbd8dbe8893" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ce9838fb-212b-499a-b119-af57f00c24b0" species="E1"/>
          <speciesReference metaid="_9a7ab4e7-50be-40e8-98f4-d04d84363ada" species="Ub"/>
          <speciesReference metaid="dc54bb29-5350-44c3-985e-2c362222de61" species="ATP"/>
        </listOfReactants>
        <listOfProducts>
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          <speciesReference metaid="_4491fea3-25f5-4f29-acf5-f2d5b42a8181" species="AMP"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_495518f4-d1eb-43d4-957f-2a9b120f7055" species="E1"/>
          <modifierSpeciesReference metaid="e71f4ff0-9577-4337-a73b-55c288958d82" species="Ub"/>
          <modifierSpeciesReference metaid="_18ca59a1-6133-4f63-8a30-396958bd70d4" species="ATP"/>
        </listOfModifiers>
        <kineticLaw metaid="f1e5845c-7a3e-45b7-a098-c279453c1342">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kbinE1Ub </ci>
                <ci> E1 </ci>
                <ci> Ub </ci>
                <ci> ATP </ci>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 5000 </cn>
                <ci> ATP </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="E2UbBinding" metaid="_5715cd90-53ba-476e-a421-c1dcff295d55" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_191d6fef-5413-4606-8d22-cd58d9004a3e" species="E2"/>
          <speciesReference metaid="_0efbbd64-21b0-4984-b9af-2b8eeba22b5b" species="E1_Ub"/>
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        <listOfProducts>
          <speciesReference metaid="_49e4896e-8bf3-4443-83e7-68caa3ba9c28" species="E2_Ub"/>
          <speciesReference metaid="_0db3edc0-1deb-44d4-b80b-25897ea595f2" species="E1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="d02052d7-abf7-4f4a-9e0f-1b8ca9a788a3" species="E2"/>
          <modifierSpeciesReference metaid="_82d6b292-89e2-4122-abea-0d0db0891b97" species="E1_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_893770b4-eba2-472a-9ded-8cc3d440b088">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinE2Ub </ci>
              <ci> E2 </ci>
              <ci> E1_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Ubiquitination" metaid="_29f7a67f-5d64-4949-8da2-2a8ec6074ae4" reversible="false">
        <listOfReactants>
          <speciesReference metaid="af8c4a8b-1d27-46c9-868b-02c4243d8581" species="Mdm2"/>
          <speciesReference metaid="_70df956d-36e0-4c22-8c47-60bb64bda8ff" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f9145aa4-d725-4e9a-9b47-c15f34d7d518" species="Mdm2_Ub"/>
          <speciesReference metaid="_47729812-ae0b-4788-b85a-006313fa6036" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_2e70c65b-0d56-4c20-82e5-282a6240f7c1" species="Mdm2"/>
          <modifierSpeciesReference metaid="_5be565a7-86c7-47a6-a194-63ed13150f5c" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_33e4373a-4f51-4f4b-a099-57c58d116d86">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2Ub </ci>
              <ci> Mdm2 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2polyUbiquitination1" metaid="e34a2507-8305-4219-83be-f90ec7a84db4" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_88a23313-49c5-43e0-9a79-a6de11088847" species="Mdm2_Ub"/>
          <speciesReference metaid="_1c31d661-df3e-44d6-9329-8054d37e0152" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="aa05d506-b1f2-47d5-a4db-945779455e71" species="Mdm2_Ub2"/>
          <speciesReference metaid="_9e568f68-7a29-4ace-b54f-6f941048d993" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_04c6157b-3673-476a-811e-46e560e2f66d" species="Mdm2_Ub"/>
          <modifierSpeciesReference metaid="_769b8b04-3ceb-4c81-9f45-9cceb66deaba" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="e7408ea5-097e-4667-9bd6-4f1575b398f1">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_Ub </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2polyUbiquitination2" metaid="f14a07af-d38e-4862-bf11-735208412152" reversible="false">
        <listOfReactants>
          <speciesReference metaid="bdceeec4-5d42-45c6-8caa-9510fa4e542c" species="Mdm2_Ub2"/>
          <speciesReference metaid="_9a41c406-7197-4a9c-97b7-ce743f7d1a0d" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_81cc4f9a-a9d1-4551-abd0-842c4f6123c2" species="Mdm2_Ub3"/>
          <speciesReference metaid="bddbe1c6-5055-4b25-9159-9490f0713e83" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_9ed74bea-9632-4d4f-a303-cd2e8ecfe1b8" species="Mdm2_Ub2"/>
          <modifierSpeciesReference metaid="fbce0df2-52f5-4d39-a8b5-a4d8c3390a08" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_9dc22c42-1cd2-4406-95a4-c365c4ce6cc5">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_Ub2 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2polyUbiquitination3" metaid="_9701e341-3d7e-43f4-8317-2cfe6a671a5a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="f6da3779-aad1-43c6-8d83-e59aaf93423e" species="Mdm2_Ub3"/>
          <speciesReference metaid="_06a7e998-8dd2-4691-98ad-bc6e4e4b89e3" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_838c33a2-c432-4f8f-b678-c9632e613798" species="Mdm2_Ub4"/>
          <speciesReference metaid="b8cbb9b2-2b40-45be-8336-0398c9289343" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_175a9407-c7c0-4b64-9f83-df735ff4a54f" species="Mdm2_Ub3"/>
          <modifierSpeciesReference metaid="cee51661-4ef9-4018-b367-c0ab81965e0f" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_74b47238-64e1-4791-b952-60f7f95a0da3">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_Ub3 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Deubiquitination4" metaid="_7f1014f0-3cff-4dbf-a82c-940ac37d4149" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_98929aa9-ed2c-48a7-9393-048781b10ac2" species="Mdm2_Ub4"/>
          <speciesReference metaid="afec95a2-ce61-454c-a539-494118580091" species="Mdm2DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_09707d86-01fd-4be3-9d9a-76d1e6256a5a" species="Mdm2_Ub3"/>
          <speciesReference metaid="a1a2307b-0e42-478b-aa9c-ef2dc805080c" species="Mdm2DUB"/>
          <speciesReference metaid="a28e8a86-832e-4ef3-baa6-0fe6730b718a" species="Ub"/>
        </listOfProducts>
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          <modifierSpeciesReference metaid="_1080c681-3abb-4d4d-b735-96aad96e8bf6" species="Mdm2_Ub4"/>
          <modifierSpeciesReference metaid="b301e1bb-0785-4efd-b01e-f9543ed82638" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="fac77ca9-f603-4c2a-9682-a2c53101bdf3">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_Ub4 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Deubiquitination3" metaid="fc96ea72-faf4-4192-b8c0-e018c546c3ce" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_845ec5de-745c-4c56-a96a-9548095b70f0" species="Mdm2_Ub3"/>
          <speciesReference metaid="_6fb8f5e2-04a7-45fb-a76a-d974352c44e5" species="Mdm2DUB"/>
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        <listOfProducts>
          <speciesReference metaid="_03e1204e-29bf-452d-9c67-24b65a1baf84" species="Mdm2_Ub2"/>
          <speciesReference metaid="_384399b5-ec00-4be3-8772-45ca9895e866" species="Mdm2DUB"/>
          <speciesReference metaid="f11146ae-5ab7-454b-ab15-6d7504b65d6d" species="Ub"/>
        </listOfProducts>
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          <modifierSpeciesReference metaid="_0e4dfaa7-ac48-4fa0-83b5-ba4c1036bb7a" species="Mdm2_Ub3"/>
          <modifierSpeciesReference metaid="fd492fb0-0518-4ee1-9a91-08cd266d0428" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_29a8f94f-bb98-49af-84df-507838ce79a6">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_Ub3 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Deubiquitination2" metaid="_5d864c2a-168a-4fb4-a6ef-29b87ee7d5c5" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_6d026182-0445-4b5f-8aaa-cccb03287fd4" species="Mdm2_Ub2"/>
          <speciesReference metaid="_31f1838c-2168-49a7-99b3-311ef1e66b43" species="Mdm2DUB"/>
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        <listOfProducts>
          <speciesReference metaid="e3ca2416-f712-4c72-8297-6db4043d6464" species="Mdm2_Ub"/>
          <speciesReference metaid="a10572f0-d6d4-4a43-a62e-d924ef4e8d29" species="Mdm2DUB"/>
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          <modifierSpeciesReference metaid="b072ef0f-cea4-4dea-8753-ef164889a52a" species="Mdm2DUB"/>
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        <kineticLaw metaid="_527ae250-4f64-45fd-bbfe-310d2e223137">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_Ub2 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Deubiquitination1" metaid="_21f5c087-0843-45ad-9a82-ce472dbd5e20" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_87539c1a-f201-4695-88d3-63d14e54bac3" species="Mdm2_Ub"/>
          <speciesReference metaid="_52aaad80-7878-4e9a-8528-1106f066450b" species="Mdm2DUB"/>
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        <listOfProducts>
          <speciesReference metaid="_4a79b393-4ff5-47f6-b08f-0b6d14453e5d" species="Mdm2"/>
          <speciesReference metaid="_41dad438-6c09-4693-b136-3beca77d9f10" species="Mdm2DUB"/>
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          <modifierSpeciesReference metaid="_04984f1b-bc85-4a30-8c0e-0bba22c224f0" species="Mdm2_Ub"/>
          <modifierSpeciesReference metaid="fa9ab99b-7cf5-4ee7-8f0d-96e6c6a00bd2" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="f9d5a970-5ae3-4888-8514-36ea3f787418">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_Ub </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2ProteasomeBinding1" metaid="e0399095-273d-4267-bea9-509f9302aaac" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a16db718-b0e4-4f2c-a04a-543c0866b5c9" species="Mdm2_Ub4"/>
          <speciesReference metaid="de04e8ce-1248-488f-98c5-03ce6ab17eb2" species="Proteasome"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="b63bda91-2c7c-42da-a1ac-4d7a43644bc5" species="Mdm2_Ub4_Proteasome"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_6920697f-3bc7-47e5-9768-168e4442e3b4" species="Mdm2_Ub4"/>
          <modifierSpeciesReference metaid="_63769a49-c449-4164-a137-5b14ed96288d" species="Proteasome"/>
        </listOfModifiers>
        <kineticLaw metaid="_20b663d1-b617-49de-9d4a-22d0af123fd7">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinProt </ci>
              <ci> Mdm2_Ub4 </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2Degradation" metaid="_4f96a269-e5b6-4a16-8381-eecb6957c470" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_010d4ebe-d1b8-4ad0-8301-ebca248bcb01" species="Mdm2_Ub4_Proteasome"/>
        </listOfReactants>
        <listOfProducts>
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          <speciesReference metaid="decd804e-737f-4ab9-8591-0a4eeea85d98" species="Ub" stoichiometry="4"/>
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          <modifierSpeciesReference metaid="_811f2ed5-2ed4-4b2f-b4ba-b13c594e3916" species="Mdm2_Ub4_Proteasome"/>
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        <kineticLaw metaid="e18d9fed-87bf-4395-8f39-4d367f8b0c8c">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegMdm2 </ci>
              <ci> Mdm2_Ub4_Proteasome </ci>
              <ci> kproteff </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Synthesis" metaid="_5d9606c4-a46a-4f6d-9736-e412badf9017" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ff059931-95a1-4ed1-b8c0-bddbe3c9f518" species="p53_mRNA"/>
        </listOfReactants>
        <listOfProducts>
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          <speciesReference metaid="a44e1d0b-1af5-478c-b2c2-d0753a4391c6" species="p53_mRNA"/>
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          <modifierSpeciesReference metaid="ddc603e2-142c-4a87-89ea-3360e83f0303" species="p53_mRNA"/>
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        <kineticLaw metaid="_469c653a-fc98-4a16-aa60-b3b033dbedf2">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynp53 </ci>
              <ci> p53_mRNA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Monoubiquitination" metaid="_76285555-adf1-4720-839b-5a2acf1793f7" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_6ef5caa2-b4c6-4811-ad8e-04aa65aed54f" species="E2_Ub"/>
          <speciesReference metaid="b2c4b097-9c14-4d78-b75f-a4971c05205b" species="Mdm2_p53"/>
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        <listOfProducts>
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        </listOfModifiers>
        <kineticLaw metaid="aceeace5-9f61-41bb-add9-e8b19bff0ecd">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kp53Ub </ci>
              <ci> E2_Ub </ci>
              <ci> Mdm2_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Polyubiquitination1" metaid="d0fd6554-0c30-4788-a42f-549faf59191a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_4d18a370-22f6-4383-8b3a-c00da27438a8" species="Mdm2_p53_Ub"/>
          <speciesReference metaid="a56fd3ff-0d49-4469-abf2-4fd5bbb7f398" species="E2_Ub"/>
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        <listOfProducts>
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          <speciesReference metaid="_4f6617c6-2e32-45d9-9af2-f7906ac6cfac" species="E2"/>
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          <modifierSpeciesReference metaid="a210d107-b167-4af3-8316-c6d473ee201b" species="Mdm2_p53_Ub"/>
          <modifierSpeciesReference metaid="bb63ba45-1eee-4339-acc6-fc49cf3cc30b" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_84d82e6c-f503-4795-aa42-5d5b54228cbd">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kp53PolyUb </ci>
              <ci> Mdm2_p53_Ub </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Polyubiquitination2" metaid="_053bc342-e79e-4c47-9935-226e7d8bf4d4" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b86e1e74-77c6-4fef-9819-c2a7767e424c" species="Mdm2_p53_Ub2"/>
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          <speciesReference metaid="_5bd75ab7-a721-4c45-874f-905bafa509c9" species="E2"/>
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          <modifierSpeciesReference metaid="_4ea754ed-0c08-4bfc-8343-7539a44a6998" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_0ebacaf1-7474-4e16-b8d0-5db40f78303e">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kp53PolyUb </ci>
              <ci> Mdm2_p53_Ub2 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Polyubiquitination3" metaid="_5ebbce52-3abc-4286-95a6-2ad18db034b3" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_84322dea-3151-45d3-924a-ab674028ccb5" species="Mdm2_p53_Ub3"/>
          <speciesReference metaid="_1b821fd4-21cd-446f-9360-0ceeb85f2810" species="E2_Ub"/>
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        <listOfProducts>
          <speciesReference metaid="a86cb441-e0a7-4036-853b-5af4468738a5" species="Mdm2_p53_Ub4"/>
          <speciesReference metaid="_3b4c723a-3248-4e02-9f6c-ccffd1ec6ff1" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="ca83b004-ebf4-4663-a8fe-e89cfad834e6" species="Mdm2_p53_Ub3"/>
          <modifierSpeciesReference metaid="_1da0f849-7546-4584-b456-f90de5b7bb11" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_4c80435f-edc7-464a-b813-00778d5082b5">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kp53PolyUb </ci>
              <ci> Mdm2_p53_Ub3 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Deubiqutination4" metaid="a351e74b-1bea-428e-8bd1-5f687339947d" reversible="false">
        <listOfReactants>
          <speciesReference metaid="c5a37d73-a82c-440a-a9b6-2f6e97aa1465" species="Mdm2_p53_Ub4"/>
          <speciesReference metaid="e563034b-4463-4823-802e-4718f8e758d8" species="p53DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_93072bc6-ba94-4e82-b9f5-1bc90d5ae61f" species="Mdm2_p53_Ub3"/>
          <speciesReference metaid="f007fcaa-1995-4cfd-9f8a-e2791dac4cd9" species="p53DUB"/>
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          <modifierSpeciesReference metaid="_8b8c57ce-0dca-4ce1-af1a-93b610870b74" species="Mdm2_p53_Ub4"/>
          <modifierSpeciesReference metaid="_828ec0da-1c90-48bd-a55a-866d2a8c97ae" species="p53DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_60f628ef-df88-405c-ab27-d1c3d26befdc">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBp53 </ci>
              <ci> Mdm2_p53_Ub4 </ci>
              <ci> p53DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Deubiquitination3" metaid="f346e47d-2df2-4833-b0f1-fa0a02520b03" reversible="false">
        <listOfReactants>
          <speciesReference metaid="f4e46c4b-6633-47f2-9da1-cfa4f3c99120" species="Mdm2_p53_Ub3"/>
          <speciesReference metaid="ae023603-8e21-4a50-979a-d9be810a929a" species="p53DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_9c893853-4a55-4826-a28f-f7849cff9a3c" species="Mdm2_p53_Ub2"/>
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        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_5a24cf02-7711-4cb1-aeff-6e5e23b65e51" species="Mdm2_p53_Ub3"/>
          <modifierSpeciesReference metaid="b8ef452b-0f83-4c6b-9ede-f5def1dc45a9" species="p53DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="fb1d710f-6e08-4037-b631-d4e418cd6f69">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBp53 </ci>
              <ci> Mdm2_p53_Ub3 </ci>
              <ci> p53DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Deubiquitination2" metaid="_3345015a-b7fd-4337-abe3-142d547b6e68" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_02cc8513-8941-4ac7-8493-f3d8b94e4872" species="Mdm2_p53_Ub2"/>
          <speciesReference metaid="_500984e8-8294-4a3c-b6ea-3f4b5b93167a" species="p53DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="aeea75d5-ca6c-43ce-ad6c-c61fd1385aa4" species="Mdm2_p53_Ub"/>
          <speciesReference metaid="_9399a1c7-6f21-4e80-ade0-1c05f71ef38e" species="p53DUB"/>
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        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_9f322c1a-4beb-4f11-93bc-89722e0718bb" species="Mdm2_p53_Ub2"/>
          <modifierSpeciesReference metaid="e4b7503c-3f20-442e-9aa9-15a4a37ca49d" species="p53DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_18e61a52-71ec-44ff-8777-fa7c3bd7b88d">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBp53 </ci>
              <ci> Mdm2_p53_Ub2 </ci>
              <ci> p53DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53Deubiquitination1" metaid="_1f7fa612-0d91-4568-98c4-cdef34b636cc" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_7cb3be7c-c231-4bf1-a89a-200a1ec4e68d" species="Mdm2_p53_Ub"/>
          <speciesReference metaid="fbcde846-15a5-4601-89b7-cf6a6f1888f5" species="p53DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f7f68265-b7fb-4dbf-8d96-a221c242e8b1" species="Mdm2_p53"/>
          <speciesReference metaid="_70f9157b-bb3a-445e-839c-75ba5c18d4c1" species="p53DUB"/>
          <speciesReference metaid="fc8c61a2-b40f-439b-a215-27223a0f1565" species="Ub"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_5fb0f15a-119d-4339-8cc7-8dfd70f93532" species="Mdm2_p53_Ub"/>
          <modifierSpeciesReference metaid="_6a10f3ae-63ca-4861-9a1e-2e2ae8a5ff91" species="p53DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_1a792609-2f05-46c0-85d6-79973fc9273f">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBp53 </ci>
              <ci> Mdm2_p53_Ub </ci>
              <ci> p53DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2GSK3phosphorylation1" metaid="a743bc48-6d67-4a9c-baf3-704ba430db08" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b5c7ff4a-f338-4dae-8cb9-03fb6aa61537" species="Mdm2_p53_Ub4"/>
          <speciesReference metaid="_31a247b2-9a23-4157-b5d8-d13377b8e207" species="GSK3b"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_946551a0-0c74-403f-8c2c-641391b0dc9f" species="Mdm2_P1_p53_Ub4"/>
          <speciesReference metaid="_682d2da8-c0b0-4e86-a2ea-21d14ef65a17" species="GSK3b"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_0f5a6564-05ba-43e4-ad45-167ee9ebb969" species="Mdm2_p53_Ub4"/>
          <modifierSpeciesReference metaid="_8facd2c0-8d62-4ee3-9f0c-d376afce4f0a" species="GSK3b"/>
        </listOfModifiers>
        <kineticLaw metaid="f6250301-b406-435a-8e1e-cc7f72e40066">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphosMdm2GSK3b </ci>
              <ci> Mdm2_p53_Ub4 </ci>
              <ci> GSK3b </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2GSK3phosphorylation2" metaid="f4e62ace-3292-4cdf-aef2-eaebd29f9273" reversible="false">
        <listOfReactants>
          <speciesReference metaid="bcaebbfa-97f8-4eb6-a2c8-0ff901222a5a" species="Mdm2_p53_Ub4"/>
          <speciesReference metaid="_32f26e78-b9ca-46ee-bbff-7d298366aa34" species="GSK3b_p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_5edc8028-fb31-48b5-978f-ef92c786952f" species="Mdm2_P1_p53_Ub4"/>
          <speciesReference metaid="_3d365e14-928a-428e-9dba-5f04ebd972c2" species="GSK3b_p53"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_197386d5-095b-469b-9c68-ba0e652c1e84" species="Mdm2_p53_Ub4"/>
          <modifierSpeciesReference metaid="e0343d76-7c1f-434e-989a-1852fa3ae008" species="GSK3b_p53"/>
        </listOfModifiers>
        <kineticLaw metaid="fbadcea3-bcbd-4a94-b37b-7acbd7a41204">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphosMdm2GSK3bp53 </ci>
              <ci> Mdm2_p53_Ub4 </ci>
              <ci> GSK3b_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2GSK3phosphorylation3" metaid="c7df7b96-7116-409c-9f5a-2190abd2d891" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_17bb7b03-2b32-4b86-ad19-ea8b89177e95" species="Mdm2_p53_Ub4"/>
          <speciesReference metaid="_971ffb93-b368-48d4-90f1-722d1c9c2932" species="GSK3b_p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_7ba66355-ed7f-4ded-bf1f-2667e6396c40" species="Mdm2_P1_p53_Ub4"/>
          <speciesReference metaid="_5dc02174-ddeb-4cd9-8617-eb6e577263b9" species="GSK3b_p53_P"/>
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          <modifierSpeciesReference metaid="_84923536-3469-4d09-a658-405a7a4d7521" species="Mdm2_p53_Ub4"/>
          <modifierSpeciesReference metaid="c80ddff1-e650-4e9e-8b21-caafe84442a7" species="GSK3b_p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="_1eebe2fc-7d2b-4590-988f-50c6f9dc7718">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphosMdm2GSK3bp53 </ci>
              <ci> Mdm2_p53_Ub4 </ci>
              <ci> GSK3b_p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53ProteasomeBinding1" metaid="ff49c656-23ea-48d2-8f70-1abb331f52eb" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b1008f68-f8d5-4242-95ee-2426bc477965" species="Mdm2_P1_p53_Ub4"/>
          <speciesReference metaid="f8ba3080-5e63-4c92-ba42-cb3eafa19f5f" species="Proteasome"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_6dad6166-4c91-4258-a1a3-97d426f07d35" species="p53_Ub4_Proteasome"/>
          <speciesReference metaid="b01822f6-a521-40ee-9d76-74ee23126cd3" species="Mdm2"/>
        </listOfProducts>
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        </listOfModifiers>
        <kineticLaw metaid="d34fef50-43cd-4259-abeb-58ef31bd0eae">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinProt </ci>
              <ci> Mdm2_P1_p53_Ub4 </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Degradationp53_Ub4" metaid="dfa05342-393e-47e3-a0da-5a12c96ba384" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_31c300d6-0d9f-4c82-bce9-c872ed39c0c4" species="p53_Ub4_Proteasome"/>
          <speciesReference metaid="af09e91d-2952-4686-85ec-009948a90365" species="ATP"/>
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        <listOfProducts>
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          <speciesReference metaid="f2b33028-c9af-4b95-85a0-de8d9b8e9899" species="Proteasome"/>
          <speciesReference metaid="_38448402-6772-41f0-a063-e6c179866a68" species="ADP"/>
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          <modifierSpeciesReference metaid="cc94da49-a2b1-4a1b-a46e-14488fcf57d2" species="p53_Ub4_Proteasome"/>
          <modifierSpeciesReference metaid="fd10b81d-76a1-489c-84bc-39c7abacbd07" species="ATP"/>
        </listOfModifiers>
        <kineticLaw metaid="_12731a8a-0a6b-4f1a-947e-58af57b7dd1a">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kdegp53 </ci>
                <ci> kproteff </ci>
                <ci> p53_Ub4_Proteasome </ci>
                <ci> ATP </ci>
              </apply>
              <apply>
                <plus/>
                <cn type="integer"> 5000 </cn>
                <ci> ATP </ci>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauMTbinding" metaid="_7f655435-3e88-41ac-9d3c-709ce9f97b0c" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_63ecd1ed-be35-430a-b20e-28ec70fd4d09" species="Tau"/>
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        <listOfProducts>
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        <listOfModifiers>
          <modifierSpeciesReference metaid="eb66b4a2-b084-4c1b-82e2-87f48b9afa26" species="Tau"/>
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        <kineticLaw metaid="_1a2060df-6147-4569-a666-f19fa16ddd5a">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinMTTau </ci>
              <ci> Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauMTrelease" metaid="_90c8b88b-aef1-4cbf-a127-efe7a2f99016" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_10b1b43c-8aac-431c-ad31-06bb2382ec38" species="MT_Tau"/>
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        <kineticLaw metaid="_7b118903-fc6c-440a-8292-0a3e109afc39">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krelMTTau </ci>
              <ci> MT_Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation1" metaid="_4ced4423-284f-4509-901d-c084d091f7e2" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_28ebdb43-ab64-46f0-8506-0e5bec41dcea" species="GSK3b_p53"/>
          <speciesReference metaid="_240716ba-7efa-4ee9-be9e-913c7977f66f" species="Tau"/>
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          <speciesReference metaid="e5c700f2-6486-4d0c-b285-13e007ec63d5" species="Tau_P1"/>
        </listOfProducts>
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          <modifierSpeciesReference metaid="fe213fd8-7d2c-47e5-874e-cf8c057d7bf0" species="GSK3b_p53"/>
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        <kineticLaw metaid="_71061919-e04d-489c-851e-cb8eeec4bcd0">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3bp53 </ci>
              <ci> GSK3b_p53 </ci>
              <ci> Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation2" metaid="_9a23186f-ab22-4025-9651-7d5c5dcb8797" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_6d26a0a9-43cb-4a88-93dd-0b5b17b683d6" species="GSK3b_p53"/>
          <speciesReference metaid="_9d6733c7-d328-4f5e-b70c-4f896b861d71" species="Tau_P1"/>
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        <listOfProducts>
          <speciesReference metaid="e41f2b99-815a-4514-8d5b-9850791759e9" species="GSK3b_p53"/>
          <speciesReference metaid="_07ef5f47-977c-40f3-91b0-2ffc8ec8fe01" species="Tau_P2"/>
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          <modifierSpeciesReference metaid="_92e90b40-ee9b-4356-b8c4-9c9fa86414c5" species="GSK3b_p53"/>
          <modifierSpeciesReference metaid="_538ce580-ef32-4026-b991-0aa98c1fbd04" species="Tau_P1"/>
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        <kineticLaw metaid="_7eb56019-bdfa-436c-86cd-f83e485d40b4">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3bp53 </ci>
              <ci> GSK3b_p53 </ci>
              <ci> Tau_P1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation3" metaid="_8b1637f7-3841-4af2-aaf7-29f2343101c8" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_0755f254-cd6d-443d-ac18-7bb861deb588" species="GSK3b_p53_P"/>
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          <modifierSpeciesReference metaid="_0802c0bb-2279-48a4-93d0-3325da676329" species="Tau"/>
        </listOfModifiers>
        <kineticLaw metaid="_096791a9-fead-495a-9c9b-4eb8096a0640">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3bp53 </ci>
              <ci> GSK3b_p53_P </ci>
              <ci> Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation4" metaid="_4f4c5274-fcbb-4b92-b002-80f59978143a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_630e08f8-811a-486f-8d71-c13e50ac06d7" species="GSK3b_p53_P"/>
          <speciesReference metaid="_43512407-0afe-4f49-9dff-d0a2938b33f0" species="Tau_P1"/>
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        <listOfProducts>
          <speciesReference metaid="d09976ce-5bd3-443f-8678-98eeb4099859" species="GSK3b_p53_P"/>
          <speciesReference metaid="f4c690cd-d7cb-4461-931e-ef4f7e1031de" species="Tau_P2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_31b7ff47-96db-4ede-a6c8-2406e655996f" species="GSK3b_p53_P"/>
          <modifierSpeciesReference metaid="_1c693e2a-d4da-47fc-becb-3c4198981992" species="Tau_P1"/>
        </listOfModifiers>
        <kineticLaw metaid="_43000838-5bee-414f-a010-58be74d1ab7d">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3bp53 </ci>
              <ci> GSK3b_p53_P </ci>
              <ci> Tau_P1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation5" metaid="cded67d8-da30-4b51-a814-27955c8e97fd" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_246a8cb4-4b35-4aef-8413-a3c75b374a68" species="GSK3b"/>
          <speciesReference metaid="_086f969e-319b-4bb4-bde6-3cb8f0b39ba3" species="Tau"/>
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        <listOfProducts>
          <speciesReference metaid="_8d438e85-00b5-48b2-be46-995a897d3154" species="GSK3b"/>
          <speciesReference metaid="_504793ab-38ab-4a00-bbe3-f67a0e484bfc" species="Tau_P1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_3eb16681-7a77-4309-ae46-99acc87bb47f" species="GSK3b"/>
          <modifierSpeciesReference metaid="_0a8b575d-5e38-4d0b-bbbc-956eb4e81af0" species="Tau"/>
        </listOfModifiers>
        <kineticLaw metaid="c7679e06-3e15-4707-bf9d-eb3aaa002219">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3b </ci>
              <ci> GSK3b </ci>
              <ci> Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tauphosphorylation6" metaid="f5dd102e-5457-4bc7-af70-c398227e26ca" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_8525c6c5-a84b-43a6-b8b7-2c63ce71c66f" species="GSK3b"/>
          <speciesReference metaid="_820478f3-3d43-422b-8ad4-f8ff97f5dda3" species="Tau_P1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="cc999cce-7999-4252-8f75-11660b4e8c3a" species="GSK3b"/>
          <speciesReference metaid="ccf91961-e93f-4275-8dcb-81e6d0f8e092" species="Tau_P2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_91bd98df-3880-46f1-b77f-9b2370352473" species="GSK3b"/>
          <modifierSpeciesReference metaid="c1e7934d-74ff-43cf-b00e-28317c599f21" species="Tau_P1"/>
        </listOfModifiers>
        <kineticLaw metaid="febc09ee-225f-412d-bd4a-0c2cb11cc4a5">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphospTauGSK3b </ci>
              <ci> GSK3b </ci>
              <ci> Tau_P1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Taudephosphorylation1" metaid="_481a7311-737d-4d82-9ab7-653b31b926e8" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b878a368-4898-4d20-b50a-d8b43569257f" species="Tau_P2"/>
          <speciesReference metaid="c01336e3-bdec-478d-8b20-2a9b67a7f740" species="PP1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_62ed6caf-ed5d-40a2-b050-d02fe5257c15" species="Tau_P1"/>
          <speciesReference metaid="f31fa7bd-99dc-4856-8e8f-216c6c796458" species="PP1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="e7f0d9fc-f172-4c01-ac2c-1f3f7290a480" species="Tau_P2"/>
          <modifierSpeciesReference metaid="e2d97ca5-00e5-414f-b3c0-698f186fee4f" species="PP1"/>
        </listOfModifiers>
        <kineticLaw metaid="_15ceb9f7-00e0-4f28-b2c5-77bf4a05ea75">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdephospTau </ci>
              <ci> Tau_P2 </ci>
              <ci> PP1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Taudephosphorylation2" metaid="cbb5a63c-0dc4-4807-a7d5-184f97a84b0c" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_58fabe11-29fb-405d-87ae-101589707583" species="Tau_P1"/>
          <speciesReference metaid="dda628a2-b0bb-4622-b3c0-39a828933722" species="PP1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="ad80ba3a-f78d-470f-a37c-211f60daad7b" species="Tau"/>
          <speciesReference metaid="_366d47d3-97ed-4429-a366-b0cff8e19ff0" species="PP1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_690d8d59-f91e-4986-8779-cc1cc832a6b8" species="Tau_P1"/>
          <modifierSpeciesReference metaid="d2a90280-acaf-4d6c-ab5f-cee62140523e" species="PP1"/>
        </listOfModifiers>
        <kineticLaw metaid="_91aa5f7c-1aef-42b5-9eb5-92761fe83ac5">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdephospTau </ci>
              <ci> Tau_P1 </ci>
              <ci> PP1 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauP1Aggregation1" metaid="c7ae246d-2c52-42c1-8b5a-09f74d4531be" reversible="false">
        <listOfReactants>
          <speciesReference metaid="f9a46fd0-b39d-4d24-96e7-1117028a1089" species="Tau_P1" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_655a6b2b-6fc6-460a-9f13-257d4f79d1df" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_08bd5d65-6fe1-4815-942c-2c31b7d1df77" species="Tau_P1"/>
        </listOfModifiers>
        <kineticLaw metaid="bfe3bd1d-16fb-407d-a40b-8b0eeb3ad484">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTauP1 </ci>
              <ci> Tau_P1 </ci>
              <apply>
                <minus/>
                <ci> Tau_P1 </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauP1Aggregation2" metaid="_35966973-944a-4b52-8401-860306d8af83" reversible="false">
        <listOfReactants>
          <speciesReference metaid="c15fcce3-3eb9-4798-97cb-1f185229b5ff" species="Tau_P1"/>
          <speciesReference metaid="_785afb1f-000d-4cb2-b306-478ceb415cbc" species="AggTau"/>
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        <listOfProducts>
          <speciesReference metaid="_7aad97b1-3813-4482-a1c4-c3ea4f38db87" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_05430bf0-f20e-4cec-8021-3181b224c495" species="Tau_P1"/>
          <modifierSpeciesReference metaid="_70070d86-9b22-45f9-aeba-f9cb42e4b7d3" species="AggTau"/>
        </listOfModifiers>
        <kineticLaw metaid="_939fe9d8-8ec8-4064-99ed-648586645ba4">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTauP1 </ci>
              <ci> Tau_P1 </ci>
              <ci> AggTau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauP2Aggregation1" metaid="_3098eb3f-3ba9-49ed-8383-2a478e158790" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ec5884ce-e544-4003-8c06-9d0a9b8b108b" species="Tau_P2" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="c224088a-bcba-43cb-9bb6-632e6c449596" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_598fe461-b812-45bf-b54e-6257d374fdf0" species="Tau_P2"/>
        </listOfModifiers>
        <kineticLaw metaid="_9deef827-58df-46da-bd85-2e8e428fc729">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTauP2 </ci>
              <ci> Tau_P2 </ci>
              <apply>
                <minus/>
                <ci> Tau_P2 </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauP2Aggregation2" metaid="_3e926a09-7397-4bbd-8146-dfdbc3eafa96" reversible="false">
        <listOfReactants>
          <speciesReference metaid="d883bfd7-4529-4178-87df-97df024f3fd3" species="Tau_P2"/>
          <speciesReference metaid="_12233e5b-ecaa-41e7-8d6c-3e242f4ea65e" species="AggTau"/>
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        <listOfProducts>
          <speciesReference metaid="_6c006b6e-f40f-4a36-ae81-d2e68dc7fd04" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_9310ed04-843d-4a77-82b9-66ce87eee04c" species="Tau_P2"/>
          <modifierSpeciesReference metaid="b6f3a523-072d-499d-a436-823c762ed65d" species="AggTau"/>
        </listOfModifiers>
        <kineticLaw metaid="_603ba9b6-f330-47e2-91c6-58c9574a61bf">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTauP2 </ci>
              <ci> Tau_P2 </ci>
              <ci> AggTau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauAggregation1" metaid="c3c9a9d2-b42a-4411-b149-8ddd07c21b31" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ed9d6acf-6d13-489b-850f-4a8b09809b11" species="Tau" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f7b474e3-c15d-4922-8a58-aa2a819944d0" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_86175d79-d40c-433b-ae48-2628de587ec8" species="Tau"/>
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        <kineticLaw metaid="_51f4d2aa-b4b7-40c2-86bd-706f57480a5f">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTau </ci>
              <ci> Tau </ci>
              <apply>
                <minus/>
                <ci> Tau </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauAggregation2" metaid="_2dcfec54-300b-4642-a183-a554ad8d18d8" reversible="false">
        <listOfReactants>
          <speciesReference metaid="e702e1bb-38b5-4fb8-bb4e-9280cb650760" species="Tau"/>
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        <listOfProducts>
          <speciesReference metaid="ef4ee070-4586-4654-9725-4708d9b902d7" species="AggTau" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_5d1cfe63-eba4-43bd-b195-1f026575c9ae" species="Tau"/>
          <modifierSpeciesReference metaid="_60a56185-2f2a-43d2-854b-4a5a67ad7deb" species="AggTau"/>
        </listOfModifiers>
        <kineticLaw metaid="_74ed9425-4dfb-4698-90a2-881c2f640f0b">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggTau </ci>
              <ci> Tau </ci>
              <ci> AggTau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TangleFormation1" metaid="b73b3bb5-609f-4fc0-9284-3d24dbb6ac9f" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_75e661cc-5289-43a2-84ff-545df1a2946c" species="AggTau" stoichiometry="2"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_68b72673-2500-4aa1-af75-1ef2def5dbe3" species="NFT" stoichiometry="2"/>
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          <modifierSpeciesReference metaid="ab6d1f4b-c9ab-45e6-a604-9ece914161dc" species="AggTau"/>
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        <kineticLaw metaid="_252a70ea-f4eb-4c0d-87f7-b4fd1a1192f2">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ktangfor </ci>
              <ci> AggTau </ci>
              <apply>
                <minus/>
                <ci> AggTau </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TangleFormation2" metaid="bc408abb-ed37-49bc-9ec7-6029ed2bbde6" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_1d591fde-a207-429b-a2c8-b76f36afbc31" species="AggTau"/>
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        <listOfProducts>
          <speciesReference metaid="e8bc7afc-9805-428d-9365-6fd93869937d" species="NFT" stoichiometry="2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_29611c1b-8f09-4f6f-bcf1-39937700f6be" species="AggTau"/>
          <modifierSpeciesReference metaid="c2e85993-480e-4cba-b5d8-6626f38e93fe" species="NFT"/>
        </listOfModifiers>
        <kineticLaw metaid="f4913b45-7426-42fa-a199-c640d8d2fbcb">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ktangfor </ci>
              <ci> AggTau </ci>
              <ci> NFT </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="ProteasomeInhibitionAggTau" metaid="_4ce03dc0-277c-4f6b-b111-e989c09d0374" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_3785944d-3223-43ff-971d-6ffa784ba692" species="AggTau"/>
          <speciesReference metaid="f36522ac-3ed0-4cb6-8ca1-d87d7ede6ba4" species="Proteasome"/>
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        <listOfProducts>
          <speciesReference metaid="_6fff082e-e4f7-4341-b964-0fcc3ae06ab1" species="AggTau_Proteasome"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_95179001-d89e-484f-90b9-19ff9854e204" species="AggTau"/>
          <modifierSpeciesReference metaid="_65ccf3d7-5e41-49a9-8e2e-3c0359f76af0" species="Proteasome"/>
        </listOfModifiers>
        <kineticLaw metaid="_1c52a72b-4a38-4673-b013-4b3ee5661b83">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kinhibprot </ci>
              <ci> AggTau </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Abetaproduction1" metaid="a8aabd2d-0c63-4dbc-9066-463e6b1fe4d2" reversible="false">
        <listOfReactants>
          <speciesReference metaid="fd4fe1a9-1f16-4dda-9c81-ad4d3ff70cc7" species="Source"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_90fcdc6f-ad6f-4b2d-8456-46d739f8b82a" species="Abeta"/>
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        </listOfModifiers>
        <kineticLaw metaid="_6c02c95a-476e-48db-859b-1868bfef331d">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kprodAbeta </ci>
              <ci> Source </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Abetaproduction2" metaid="_9d0ffbda-bbf3-490d-ab37-b05e15efc0a8" reversible="false">
        <listOfReactants>
          <speciesReference metaid="f9c9c9af-7de6-4fe8-b1a9-3c863da616a3" species="GSK3b_p53"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="d92ce848-a0ed-4b01-8a0c-a32fe315a7f0" species="Abeta"/>
          <speciesReference metaid="_3aa5ab3b-c582-421d-bb33-8c804fc18b1a" species="GSK3b_p53"/>
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          <modifierSpeciesReference metaid="_7f97dd86-6cda-4c25-a45f-7827feabb159" species="GSK3b_p53"/>
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        <kineticLaw metaid="_52947357-1602-42d4-aaac-427f64477bea">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kprodAbeta2 </ci>
              <ci> GSK3b_p53 </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Abetaproduction3" metaid="bfe1943f-a4ee-4e1c-b928-3ac8f63a1ab6" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_2ceaac1b-f5fe-4717-a598-bb71a2bad36a" species="GSK3b_p53_P"/>
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        <listOfProducts>
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          <speciesReference metaid="_676158b3-014e-4d56-91a4-a956d755a132" species="GSK3b_p53_P"/>
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          <modifierSpeciesReference metaid="_611037f1-2f64-4847-bc4d-b120e07b5e39" species="GSK3b_p53_P"/>
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        <kineticLaw metaid="_863d4bd8-3089-4942-9b14-3f2fc5cc7328">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kprodAbeta2 </ci>
              <ci> GSK3b_p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="ProteasomeInhibitionAbeta" metaid="fb947b84-1876-4a2d-9d52-92f75bfe0dfe" reversible="false">
        <listOfReactants>
          <speciesReference metaid="cc163b56-f1e7-4a42-bf7e-f333aa8571e3" species="AbetaDimer"/>
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        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_41097719-54ed-4b65-ad76-5b14f135c78e" species="AggAbeta_Proteasome"/>
        </listOfProducts>
        <listOfModifiers>
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          <modifierSpeciesReference metaid="_5ed02f69-f4f9-40d9-a62e-5802fcea14a7" species="Proteasome"/>
        </listOfModifiers>
        <kineticLaw metaid="_51772b74-9c03-4830-baad-d993d12a8c27">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kinhibprot </ci>
              <ci> AbetaDimer </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaDegradation" metaid="bae49056-7941-41ea-bb9a-4189b5a1db0a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_66af6566-f5c9-4a79-b08c-026c9b373c12" species="Abeta"/>
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        <listOfProducts>
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        <kineticLaw metaid="fedf871b-9cae-4f8d-a629-cb099ca566a9">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegAbeta </ci>
              <ci> Abeta </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53transcriptionViaAbeta" metaid="_7fbf1bd1-fbdb-40d3-8af2-e9aef28904b3" reversible="false">
        <listOfReactants>
          <speciesReference metaid="f71b5653-b260-4201-a988-d8b149f8053f" species="Abeta"/>
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        <listOfProducts>
          <speciesReference metaid="_1a6f0a24-fefe-465a-a0d2-0da1df3943c6" species="p53_mRNA"/>
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        <kineticLaw metaid="ed2269ee-681f-4d74-97bb-78917c39f0e6">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynp53mRNAAbeta </ci>
              <ci> Abeta </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="DNAdamage" metaid="_0c456e8c-503a-4fb4-8cc2-204b4ac4bb29" reversible="false">
        <listOfReactants>
          <speciesReference metaid="cd50ad41-d5df-4406-a0c5-c926526a9f36" species="IR"/>
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          <speciesReference metaid="_1707369b-7a09-4d29-8b95-5f60d1c30057" species="damDNA"/>
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        <kineticLaw metaid="_5255d4c6-210a-4a64-9670-f7ddf3b3d846">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdam </ci>
              <ci> IR </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="DNArepair" metaid="_71937c4b-4013-42eb-be56-4e41b6ec7108" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_0a351307-92e2-4560-8d60-c8a5a7578e83" species="damDNA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_6202bbb1-5945-4176-85f4-edaf9833d616" species="Sink"/>
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        <listOfModifiers>
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        <kineticLaw metaid="_17953a3b-8361-476d-a320-546fdf18a58d">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krepair </ci>
              <ci> damDNA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="ATMactivation" metaid="d066f932-9ba6-4258-9e64-cbf0b87bb017" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_78e1bf64-a5bc-46f8-990a-a7ab9b1d2fed" species="damDNA"/>
          <speciesReference metaid="c9a823cd-ad85-4f32-9413-7bc9bf95881a" species="ATMI"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_2eda1bbc-b93b-471d-ba60-28149ee9de26" species="damDNA"/>
          <speciesReference metaid="e2780f4d-4905-4783-82d6-b69fb31e7fec" species="ATMA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_6939aa56-d5af-4546-99e2-5260fc61542e" species="damDNA"/>
          <modifierSpeciesReference metaid="_833a00d7-1ca4-41fb-b92f-37b364d03d63" species="ATMI"/>
        </listOfModifiers>
        <kineticLaw metaid="_69ddee5f-e3ec-4c58-8811-5fa2593b6f71">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactATM </ci>
              <ci> damDNA </ci>
              <ci> ATMI </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53phosphorylation" metaid="_48851c58-e325-440c-8330-cdbeb8654d98" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a1e6601d-246e-4e90-918c-298659e5e947" species="p53"/>
          <speciesReference metaid="d4ce1c8d-995a-4ae3-95ee-9c012548f0b0" species="ATMA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_05ac8a9b-5324-47ad-a4a1-9837a834beae" species="p53_P"/>
          <speciesReference metaid="_9bef41e6-0796-4fb3-9951-1dcd3ad1fb9c" species="ATMA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="e818685c-71e5-490e-825b-b0e2308a9079" species="p53"/>
          <modifierSpeciesReference metaid="_11dc60dd-26e5-4654-8b61-00eeda7198e7" species="ATMA"/>
        </listOfModifiers>
        <kineticLaw metaid="b37448a9-841d-4599-ad13-4357383d9965">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphosp53 </ci>
              <ci> p53 </ci>
              <ci> ATMA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="p53dephosphorylation" metaid="_910308c0-6c31-4d70-ad2b-e4b574555a84" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_578d9859-4054-4bec-b842-31a91a0b5485" species="p53_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_5e64a34e-077e-4a0d-bd15-54a521918a11" species="p53"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_179cc591-41d3-49ca-846e-1b2fde39d878" species="p53_P"/>
        </listOfModifiers>
        <kineticLaw metaid="_78ec8895-5081-4a8f-bb2f-777cca04a5fd">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdephosp53 </ci>
              <ci> p53_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2phosphorylation" metaid="_5d079b89-340b-4260-8865-ca594d581a80" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a188b759-d2c2-4765-9d1e-5175d47bb2de" species="Mdm2"/>
          <speciesReference metaid="_2a536301-38ed-4128-8979-90263d836d83" species="ATMA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="b9e168ca-2367-4ce7-8e3f-27cd351681de" species="Mdm2_P"/>
          <speciesReference metaid="_50cd0dc1-909d-4fa6-a115-7ba0eb4d67ff" species="ATMA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_6d7a9dc0-997a-460f-bab9-11197f02bad7" species="Mdm2"/>
          <modifierSpeciesReference metaid="a69ee1c7-8d02-496d-b308-c4a637e9ab0f" species="ATMA"/>
        </listOfModifiers>
        <kineticLaw metaid="_448d38bc-ff23-4cad-af49-7804d24464f9">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kphosMdm2 </ci>
              <ci> Mdm2 </ci>
              <ci> ATMA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2dephosphorylation" metaid="cf80012c-25d1-49e5-b246-45fb50283bed" reversible="false">
        <listOfReactants>
          <speciesReference metaid="abdb1851-da9c-4193-9219-0cf7486172ae" species="Mdm2_P"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_70428cc8-c108-4877-a916-15082e58ca4d" species="Mdm2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_4029fb71-61be-4fe4-848a-d20af26dd159" species="Mdm2_P"/>
        </listOfModifiers>
        <kineticLaw metaid="de31f516-2c13-4b9d-b238-8a0ca040007c">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdephosMdm2 </ci>
              <ci> Mdm2_P </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PUbiquitination" metaid="b675ff44-653a-4675-9a2f-1dd172b8fbe6" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_2f1f1d54-ffcb-4ceb-9fc0-759905603545" species="Mdm2_P"/>
          <speciesReference metaid="d3b3c303-d8de-4b90-9dfb-abe971d43d10" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_91db2e8b-3196-4e87-99ba-1b3bcd442b4b" species="Mdm2_P_Ub"/>
          <speciesReference metaid="_87972789-8051-4300-8ed7-850a08322015" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_51c18f7d-0f14-4334-9a82-afe8abb0119c" species="Mdm2_P"/>
          <modifierSpeciesReference metaid="_2b4a6dfe-c03d-4035-a2d5-f94fd790ad4f" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_6c6b530c-d8b6-4a7c-8af0-e3f9b46daa93">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PUb </ci>
              <ci> Mdm2_P </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PpolyUbiquitination1" metaid="_30f05990-ce31-4155-b507-838f8ec3a56a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="aa60c531-c8f5-4c20-a11a-d4b6d7aff96e" species="Mdm2_P_Ub"/>
          <speciesReference metaid="_85aa38b1-828b-434a-a397-2ca9f1a6c52f" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_3aec8a32-d30f-4b43-86e6-65ef3fb9b581" species="Mdm2_P_Ub2"/>
          <speciesReference metaid="fbabae2d-fc8e-4025-90de-15ec9f343384" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_882500ab-2408-4bc3-9c44-4c8ed3183346" species="Mdm2_P_Ub"/>
          <modifierSpeciesReference metaid="_2fdf90c2-5a15-4cf3-9dd5-c6d30536685d" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_503e57f9-0f8f-43ab-94c0-4bc9c02b38ab">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_P_Ub </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PpolyUbiquitination2" metaid="_17b08f5b-8329-490c-a878-e1d39ada82b5" reversible="false">
        <listOfReactants>
          <speciesReference metaid="d851a255-b1b2-47f9-840a-e33997dea5ac" species="Mdm2_P_Ub2"/>
          <speciesReference metaid="a554affa-0d0b-4af8-915c-d79f983735af" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_1091895c-2c83-431f-a574-97bff8a5c177" species="Mdm2_P_Ub3"/>
          <speciesReference metaid="_48e9f703-405e-4087-bed1-73e6c0c4c323" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="ed79c0be-ebba-40e9-918c-64a4b689a99f" species="Mdm2_P_Ub2"/>
          <modifierSpeciesReference metaid="_434676c0-2112-4351-807d-1d8f5cbc9ccc" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_31669302-5708-4bc6-9070-f7aacea014ac">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_P_Ub2 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PpolyUbiquitination3" metaid="_14da9411-3dff-4ef2-ab5f-17fde93ebdb6" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_66bfe2a4-2f30-46b1-b670-f4b8976a9450" species="Mdm2_P_Ub3"/>
          <speciesReference metaid="_7a56ea40-6471-444c-8a22-0f9a25cfaba3" species="E2_Ub"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_6ca8a483-93f1-40fd-b4cf-00af5d536304" species="Mdm2_P_Ub4"/>
          <speciesReference metaid="_75c636c2-5550-45ba-b169-dd41e8691902" species="E2"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_2f2e4c6d-a4e2-4cdb-80c2-3d2edb1ffef9" species="Mdm2_P_Ub3"/>
          <modifierSpeciesReference metaid="_54a8f3c6-3f7e-4b0d-9ac9-349a3620495c" species="E2_Ub"/>
        </listOfModifiers>
        <kineticLaw metaid="_76dfd67b-3406-4b02-b832-1e22bfb7dded">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kMdm2PolyUb </ci>
              <ci> Mdm2_P_Ub3 </ci>
              <ci> E2_Ub </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PDeubiquitination4" metaid="f2fdbcae-bfdf-463d-8542-15617ef715d6" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ae94c66c-5bdb-4c83-bc6a-732dba37e0dd" species="Mdm2_P_Ub4"/>
          <speciesReference metaid="ddeaf5dd-1c76-47a8-8c0f-65508930ce8d" species="Mdm2DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="ad816061-7e79-4dde-bb7e-ab6289e79e32" species="Mdm2_P_Ub3"/>
          <speciesReference metaid="_2eacc4f7-8017-461e-b03b-0428105854db" species="Mdm2DUB"/>
          <speciesReference metaid="b9fbd985-c138-4b14-8dfb-e41826861ab3" species="Ub"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_8014e24c-9269-4bf1-9b01-30e59d8cf513" species="Mdm2_P_Ub4"/>
          <modifierSpeciesReference metaid="_1c1c88b9-fe8c-41c2-a503-a2ddaa7db375" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_33243bd5-899f-42b4-8e77-a1bd279ec565">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_P_Ub4 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PDeubiquitination3" metaid="f3440c8e-3164-4ac6-8d0c-831fe7673ff4" reversible="false">
        <listOfReactants>
          <speciesReference metaid="ea98db9e-6107-408a-852f-fdfcb13f5c27" species="Mdm2_P_Ub3"/>
          <speciesReference metaid="ea42a556-d38f-41b8-9c29-0f51d170214d" species="Mdm2DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="d873ab57-67a2-4b1c-a086-f2bf99a29152" species="Mdm2_P_Ub2"/>
          <speciesReference metaid="_2df552fc-4fcd-4f83-9981-14ade3b79e92" species="Mdm2DUB"/>
          <speciesReference metaid="_379737c8-7040-43b6-8a0f-7359ebb05bcc" species="Ub"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="a7775c22-366d-4ee0-8e5d-202b31ec9357" species="Mdm2_P_Ub3"/>
          <modifierSpeciesReference metaid="a000af4d-ac39-42e2-9560-2cfa38628fcb" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="c1e187fb-47e0-48df-9918-6d47ff937776">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_P_Ub3 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PDeubiquitination2" metaid="dcf2c7b2-23a7-49c8-a5c0-8a2aced32357" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_7a7ca8a8-686c-45d2-b900-8d6d4f462050" species="Mdm2_P_Ub2"/>
          <speciesReference metaid="_20560723-8f72-45f8-91bf-21063e9600fe" species="Mdm2DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="a486e05f-d069-406d-a9c7-340ec973c2fa" species="Mdm2_P_Ub"/>
          <speciesReference metaid="af2f3229-9c6c-45f3-bbe4-4f70537a168f" species="Mdm2DUB"/>
          <speciesReference metaid="_0c18147a-35e0-4797-83b7-9203674518d1" species="Ub"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_8ea5e153-8871-4db9-9c47-9894dd5258bf" species="Mdm2_P_Ub2"/>
          <modifierSpeciesReference metaid="_24e30d45-298f-4c7d-a53a-45b08f5fa5a6" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_4ed50632-dfcf-4739-a647-c1f9f732fa7f">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_P_Ub2 </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PDeubiquitination1" metaid="bb15f96b-32ce-4932-985d-ee5379c69abc" reversible="false">
        <listOfReactants>
          <speciesReference metaid="b69d9997-b387-4fe0-956f-a950e9fe59dc" species="Mdm2_P_Ub"/>
          <speciesReference metaid="ca924d30-99d8-4629-aba1-c3d26f87e91c" species="Mdm2DUB"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_70f3e0f4-3b28-4c8c-b57a-8806244e1ec9" species="Mdm2_P"/>
          <speciesReference metaid="_6de4b0bb-4ada-4076-9e72-93ef1be9ab66" species="Mdm2DUB"/>
          <speciesReference metaid="dfa49d26-c36e-41f6-9e31-63f49e466a2c" species="Ub"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="a82713e2-74e9-4b99-8c60-f1bd931c3612" species="Mdm2_P_Ub"/>
          <modifierSpeciesReference metaid="_4a1fbe91-3b7c-4be7-a3e0-ee275193c857" species="Mdm2DUB"/>
        </listOfModifiers>
        <kineticLaw metaid="_54b07cba-73a9-47b1-a6e3-0da34e52cb53">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactDUBMdm2 </ci>
              <ci> Mdm2_P_Ub </ci>
              <ci> Mdm2DUB </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PProteasomeBinding1" metaid="cd0fe699-82d8-4c83-b3d5-ab2267713fa1" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_833c3ef3-b5d7-4e75-b8f0-824b8ac26327" species="Mdm2_P_Ub4"/>
          <speciesReference metaid="d67770da-8e1d-46fd-9195-e8b638d12a70" species="Proteasome"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f8d6a665-e4ae-4472-8d44-d37513b2d072" species="Mdm2_P_Ub4_Proteasome"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="_92a49081-3a67-4314-8d42-1d470d3965a7" species="Mdm2_P_Ub4"/>
          <modifierSpeciesReference metaid="c66c499c-4bd3-45c6-8f2f-999e6536f57a" species="Proteasome"/>
        </listOfModifiers>
        <kineticLaw metaid="_58cbad5d-de1b-4b74-b1b8-badf0d7ec720">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinProt </ci>
              <ci> Mdm2_P_Ub4 </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Mdm2PDegradation" metaid="df93ec4d-2dc6-4a06-885f-a9d6e1485e2f" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a502691a-4fbc-438b-b0fc-b3ecd07c8e80" species="Mdm2_P_Ub4_Proteasome"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_1376aa21-2a1e-4e17-86d4-3254fafb12d3" species="Proteasome"/>
          <speciesReference metaid="_4a9feed7-9a61-4477-a7b2-caf8a104a04c" species="Ub" stoichiometry="4"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="dbed1fa4-f766-42d1-954c-90d239feb6de" species="Mdm2_P_Ub4_Proteasome"/>
        </listOfModifiers>
        <kineticLaw metaid="_6e072636-5702-4aa4-bb5a-2fb1de6eb559">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegMdm2 </ci>
              <ci> Mdm2_P_Ub4_Proteasome </ci>
              <ci> kproteff </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="ATMInactivation" metaid="c5bd80a6-d464-48f2-92bc-e938fc57d9aa" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_3d2756b8-6690-47ef-b904-d871972f9af9" species="ATMA"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_5237b932-9794-4eba-a478-b9354b4c9fe8" species="ATMI"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="a0f8568c-4c08-44d6-9d60-c3f768294aed" species="ATMA"/>
        </listOfModifiers>
        <kineticLaw metaid="_50ea182c-e09d-49f6-8c48-cc94a2e30b3f">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kinactATM </ci>
              <ci> ATMA </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaROSproduction1" metaid="f5352506-c8d0-407b-b607-15a694206529" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_54610fe9-f9e0-4249-9487-3af7b969ba61" species="Abeta"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="f01668e0-f743-4a8c-aade-c055bf1fbcd0" species="Abeta"/>
          <speciesReference metaid="_49c42e3e-35e9-478d-b8fa-20fa40b2523e" species="ROS"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="e618b06f-93aa-4a88-8a24-bf91a4598a70" species="Abeta"/>
        </listOfModifiers>
        <kineticLaw metaid="_40f52bba-0b91-460f-90cc-22d4f1dd960b">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kgenROSAbeta </ci>
              <ci> Abeta </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="PlaqueROSproduction" metaid="aef94815-8cff-4701-9206-b5b228b2c0cf" reversible="false">
        <listOfReactants>
          <speciesReference metaid="a013c3fa-11fc-479c-b0a7-5aa28f9dbc62" species="AbetaPlaque"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference metaid="_89f7fea3-2752-4d22-a1fc-d48ce22a898a" species="AbetaPlaque"/>
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        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="cd7e960a-1676-4f91-8e3a-fb857f6cd803" species="AbetaPlaque"/>
        </listOfModifiers>
        <kineticLaw metaid="_3abfff16-13de-4fc0-85db-479cfa205f56">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kgenROSPlaque </ci>
              <ci> AbetaPlaque </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AggAbetaROSproduction2" metaid="_264ef8e3-528f-4e4a-a1bc-64fa5a46ade4" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_00c99172-4999-49d1-b2e0-af7b6b989503" species="AggAbeta_Proteasome"/>
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        <listOfProducts>
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          <modifierSpeciesReference metaid="_34aed171-c5c9-42a0-9f58-ee37117fef61" species="AggAbeta_Proteasome"/>
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        <kineticLaw metaid="_35b0b5a7-137a-4429-bdfe-0b933867ee37">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kgenROSAbeta </ci>
              <ci> AggAbeta_Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="ROSDNAdamage" metaid="_5a744990-26e4-4417-9a31-e2fc610e375a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="d15865c6-cd0a-4e3a-ba26-cc05cf530025" species="ROS"/>
        </listOfReactants>
        <listOfProducts>
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          <speciesReference metaid="_203d8021-6d1b-4a46-913b-90efdc2a3c8f" species="damDNA"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference metaid="dfce1ca7-2772-4e35-8196-4545d47a63da" species="ROS"/>
        </listOfModifiers>
        <kineticLaw metaid="_965b7e71-2d4a-4613-abb6-ebc8639a1ba5">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdamROS </ci>
              <ci> ROS </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauSynthesis" metaid="edaf0968-78ba-4598-9cc5-6cc7e7cdd738" reversible="false">
        <listOfReactants>
          <speciesReference metaid="deeafba4-26ae-43b4-aae6-5d45e8605644" species="Source"/>
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        <listOfProducts>
          <speciesReference metaid="e968882b-e6e1-41be-ac1a-8ed70d36310b" species="Tau"/>
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        <kineticLaw metaid="_93e54272-1edb-427c-bfb2-818919cf876b">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> ksynTau </ci>
              <ci> Source </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="TauProteasomeBinding" metaid="_7c60b2aa-146c-48b3-bc33-0e44984b344d" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_9c509234-5f0a-424c-9905-d386a639ffb4" species="Tau"/>
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        <kineticLaw metaid="_3cd6b7fa-43e4-4953-810d-baea3772e021">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinTauProt </ci>
              <ci> Tau </ci>
              <ci> Proteasome </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Tau20SProteasomeDegradation" metaid="d242c7db-8071-4de9-9ef6-f8b00b598f84" reversible="false">
        <listOfReactants>
          <speciesReference metaid="de61be6f-41f8-40ef-a319-a028ee9072b5" species="Proteasome_Tau"/>
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        <listOfModifiers>
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        <kineticLaw metaid="_7853419e-7e61-49a8-b5fe-15bd29eca871">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegTau20SProt </ci>
              <ci> Proteasome_Tau </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaAggregation1" metaid="_40686767-b0b7-4476-bb05-bdc5044aa51a" reversible="false">
        <listOfReactants>
          <speciesReference metaid="de68a777-0e4f-41bd-a40b-295bd301674c" species="Abeta" stoichiometry="2"/>
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        </listOfModifiers>
        <kineticLaw metaid="_514e4157-8c89-49df-8aea-ab037714484b">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kaggAbeta </ci>
              <ci> Abeta </ci>
              <apply>
                <minus/>
                <ci> Abeta </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaPlaqueFormation1" metaid="_3a92294f-de6b-4329-bfbc-fd5748f128a5" reversible="false">
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          <speciesReference metaid="_69c47950-54e5-4479-9985-59a2d1678dd4" species="AbetaDimer" stoichiometry="2"/>
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        <kineticLaw metaid="_31782608-0f10-44b1-b273-60b2bb1ff5a8">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kpf </ci>
              <ci> AbetaDimer </ci>
              <apply>
                <minus/>
                <ci> AbetaDimer </ci>
                <cn type="integer"> 1 </cn>
              </apply>
              <cn> 0.5 </cn>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaPlaqueGrowth" metaid="_71f28a2e-30fc-4dc8-8251-4df7204b9955" reversible="false">
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          <speciesReference metaid="_372e79f9-0797-4e4c-859b-918e920c6ecb" species="AbetaDimer"/>
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          <modifierSpeciesReference metaid="_3360b0e4-07d4-45d1-b604-5acfa28dea94" species="AbetaPlaque"/>
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        <kineticLaw metaid="_231a4f8f-57ef-4449-a717-549e2d77c1ff">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <divide/>
              <apply>
                <times/>
                <ci> kpg </ci>
                <ci> AbetaDimer </ci>
                <apply>
                  <power/>
                  <ci> AbetaPlaque </ci>
                  <cn type="integer"> 2 </cn>
                </apply>
              </apply>
              <apply>
                <plus/>
                <apply>
                  <power/>
                  <ci> kpghalf </ci>
                  <cn type="integer"> 2 </cn>
                </apply>
                <apply>
                  <power/>
                  <ci> AbetaPlaque </ci>
                  <cn type="integer"> 2 </cn>
                </apply>
              </apply>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
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        <listOfReactants>
          <speciesReference metaid="ff2f91fc-20ce-4949-9a60-14af93be732b" species="AbetaDimer"/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdisaggAbeta </ci>
              <ci> AbetaDimer </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaDisaggregation3" metaid="_50aa9a20-5f60-4717-b5df-8dc4b1609e6e" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_14845598-34fc-4a15-a787-8bce695b3c18" species="AbetaPlaque"/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdisaggAbeta1 </ci>
              <ci> AbetaPlaque </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaDisaggregation4" metaid="_3d0f0be5-d7b3-4b17-b140-83058e8708bc" reversible="false">
        <listOfReactants>
          <speciesReference metaid="_380c42b5-93ac-4d62-91a7-9e1b3f7d1fca" species="AbetaPlaque"/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdisaggAbeta2 </ci>
              <ci> antiAb </ci>
              <ci> AbetaPlaque </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Abeta_antiAbBinding" metaid="_1cc890d3-701c-4158-a3c7-d386bb09468c" reversible="false">
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinAbantiAb </ci>
              <ci> Abeta </ci>
              <ci> antiAb </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kbinAbantiAb </ci>
              <ci> AbetaDimer </ci>
              <ci> antiAb </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="Abeta_antiAbDegredation" metaid="_8b62c9e5-d8e0-4ebf-bd73-033b63f2916d" reversible="false">
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <cn type="integer"> 10 </cn>
              <ci> kdegAbeta </ci>
              <ci> Abeta_antiAb </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="AbetaDimer_antiAbDegredation" metaid="cf5ed34e-2759-42a3-9430-2ba322160d02" reversible="false">
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          <speciesReference metaid="_8cbabd6f-e339-4bae-9746-3b7f90132942" species="AbetaDimer_antiAb"/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <cn type="integer"> 10 </cn>
              <ci> kdegAbeta </ci>
              <ci> AbetaDimer_antiAb </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GliaActivationStep1" metaid="d363f9f4-343b-4abd-84c8-f9904a6d6529" reversible="false">
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          <speciesReference metaid="e8c3a178-aebd-4995-95d7-79a252a053fe" species="GliaI"/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactglia1 </ci>
              <ci> GliaI </ci>
              <ci> AbetaPlaque </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactglia1 </ci>
              <ci> GliaM1 </ci>
              <ci> AbetaPlaque </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GliaActivationStep3" metaid="_24f2e655-4a96-4096-959b-596a11899ed0" reversible="false">
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        <kineticLaw metaid="d21aebef-a18b-4ba5-bd3d-6699a4132942">
          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kactglia2 </ci>
              <ci> GliaM2 </ci>
              <ci> antiAb </ci>
            </apply>
          </math>
                </kineticLaw>
      </reaction>
      <reaction id="GliaInactivationStep1" metaid="_69474972-1470-4f2a-918a-2fdeb7b0a2f2" reversible="false">
        <listOfReactants>
          <speciesReference metaid="c184ae27-7d81-49ce-862e-1f8e200c7bee" species="GliaA"/>
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        <listOfProducts>
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            <apply>
              <times/>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kinactglia2 </ci>
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              <times/>
              <ci> kbinAbetaGlia </ci>
              <ci> AbetaPlaque </ci>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> krelAbetaGlia </ci>
              <ci> AbetaPlaque_GliaA </ci>
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegAbetaGlia </ci>
              <ci> AbetaPlaque_GliaA </ci>
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      <reaction id="ROSgenerationByGlia" metaid="cd2ededa-bcf1-4035-bc5f-680f588ca505" reversible="false">
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kgenROSGlia </ci>
              <ci> AbetaPlaque_GliaA </ci>
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                </kineticLaw>
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      <reaction id="antiAbRemoval" metaid="e7cc451c-14b4-4d28-9f75-061928fe92d4" reversible="false">
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kdegAntiAb </ci>
              <ci> antiAb </ci>
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      <reaction id="ROSremoval" metaid="ec47c0fa-d6f5-4775-8397-edfc74dc13e7" reversible="false">
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          <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
              <times/>
              <ci> kremROS </ci>
              <ci> ROS </ci>
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              <cn type="integer"> 345600 </cn>
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            <math xmlns="http://www.w3.org/1998/Math/MathML">
              <cn type="integer"> 50 </cn>
            </math>
                    </eventAssignment>
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      </event>
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