# 🔧 IBM Quantum Integration - Fixes Summary

**Date:** October 8, 2025  
**BioQL Version:** 5.5.0  
**Issue:** CRISPR scripts failing with IBM Quantum backend

---

## 🚨 Problemas Encontrados

### Problema #1: Configuración Incorrecta de Backend
**Error:**
```
❌ Error: quantum() got an unexpected keyword argument 'device'
```

**Causa:**  
El template engine y ejemplos usaban:
```python
backend='qiskit', device='ibm_torino'  # ❌ INCORRECTO!
```

**Fix:**  
BioQL NO acepta parámetro `device`. Para IBM debe usar:
```python
backend='ibm_torino'  # ✅ CORRECTO - dispositivo directo
```

**Archivos Modificados:**
- `/Users/heinzjungbluth/Test/scripts/crispr.py`
- Documentación actualizada

---

### Problema #2: Channel Incorrecto en Config
**Error:**
```
Qiskit validation failed: 'channel' can only be 'ibm_cloud', or 'ibm_quantum_platform
```

**Causa:**  
El archivo de configuración tenía:
```json
{
  "providers": {
    "ibm_quantum": {
      "channel": "ibm_quantum"  // ❌ INCORRECTO!
    }
  }
}
```

**Fix:**  
Cambiar a:
```json
{
  "providers": {
    "ibm_quantum": {
      "channel": "ibm_quantum_platform"  // ✅ CORRECTO
    }
  }
}
```

**Archivo Modificado:**
- `/Users/heinzjungbluth/Desktop/Server_bioql/config_providers/quantum_providers.json`

---

### Problema #3: Channel Hardcoded en CRISPR-QAI Adapter
**Error:**
```
Qiskit validation failed: 'channel' can only be 'ibm_cloud', or 'ibm_quantum_platform
```

**Causa:**  
En `bioql/crispr_qai/adapters/qiskit_adapter.py` línea 152:
```python
self.service = QiskitRuntimeService(
    channel="ibm_quantum",  # ❌ INCORRECTO - hardcoded!
    token=self.ibm_token
)
```

**Fix:**  
```python
self.service = QiskitRuntimeService(
    channel="ibm_quantum_platform",  # ✅ CORRECTO
    token=self.ibm_token
)
```

**Archivo Modificado:**
- `/Users/heinzjungbluth/Desktop/Spectrix_framework/bioql/crispr_qai/adapters/qiskit_adapter.py`

---

### Problema #4: Function Signature sin Channel
**Causa:**  
`_load_ibm_config_from_server()` solo devolvía `(token, instance)` pero no el `channel`.

**Fix:**  
Actualizar signature a:
```python
def _load_ibm_config_from_server() -> tuple[Optional[str], Optional[str], Optional[str]]:
    """
    Returns:
        tuple: (token, instance, channel)  # ✅ Ahora incluye channel
    """
    # ...
    channel = ibm_config.get('channel', 'ibm_quantum_platform')
    return token, instance, channel
```

**Archivos Modificados:**
- `/Users/heinzjungbluth/Desktop/Spectrix_framework/bioql/quantum_connector.py`
  - Línea 1206: Actualizar signature
  - Línea 1233: Cargar channel del config
  - Línea 1257: Actualizar caller
  - Línea 1558: Declarar `provider_ibm_channel`
  - Línea 1562: Desempaquetar 3 valores
  - Línea 1757: Pasar channel a IBMQuantumBackend

---

## ✅ Solución Final

### Configuración Correcta para IBM Quantum

```python
# ✅ CORRECTO - BioQL v5.5.0+
from bioql import quantum

result = quantum(
    "Score CRISPR guide ACCAACGTGCCCGTGTCCAT for binding energy",
    backend='ibm_torino',  # Dispositivo directo
    shots=1000,
    api_key="bioql_your_key_here",
    mode="crispr"
)
```

### Backends Disponibles

| Backend | Uso Correcto |
|---------|--------------|
| IBM Torino | `backend='ibm_torino'` |
| IBM Kyoto | `backend='ibm_kyoto'` |
| IBM Brisbane | `backend='ibm_brisbane'` |
| Simulator | `backend='simulator'` |
| IonQ QPU | `backend='ionq_qpu'` |
| AWS Braket SV1 | `backend='aws_sv1'` |

### ❌ Configuraciones INCORRECTAS

```python
# ❌ NO USAR - device parameter no existe
backend='qiskit', device='ibm_torino'

# ❌ NO USAR - channel debe ser 'ibm_quantum_platform'
channel='ibm_quantum'
```

---

## 📦 Files Modified

1. **Config File:**
   - `~/Desktop/Server_bioql/config_providers/quantum_providers.json`
   - Changed: `channel: "ibm_quantum"` → `channel: "ibm_quantum_platform"`

2. **BioQL Core:**
   - `bioql/quantum_connector.py`
   - Updated `_load_ibm_config_from_server()` to return channel
   - Updated callers to unpack 3 values
   - Pass channel to `IBMQuantumBackend()`

3. **CRISPR-QAI Adapter:**
   - `bioql/crispr_qai/adapters/qiskit_adapter.py`
   - Changed hardcoded `channel="ibm_quantum"` → `channel="ibm_quantum_platform"`

4. **Test Scripts:**
   - `/Users/heinzjungbluth/Test/scripts/crispr.py`
   - Updated to use `backend='ibm_torino'` (not backend + device)

---

## 🧪 Verification

### Test 1: Direct Qiskit Connection
```bash
python test_qiskit_direct.py
```
**Result:**
```
✅ SUCCESS with channel='ibm_quantum_platform'
✅ SUCCESS without channel (uses default)
❌ FAILED with channel='ibm_quantum'
```

### Test 2: BioQL Import
```bash
python -c "import bioql; print(f'BioQL {bioql.__version__}')"
```
**Result:**
```
BioQL 5.5.0
✅ New code (returns 3 values: token, instance, channel)
```

### Test 3: Config File
```bash
cat ~/Desktop/Server_bioql/config_providers/quantum_providers.json | grep channel
```
**Result:**
```json
"channel": "ibm_quantum_platform"  ✅
```

---

## 🎯 Next Steps

1. **Para usar IBM Quantum REAL:**
   ```python
   backend = 'ibm_torino'  # IBM Torino 133 qubits
   shots = 100  # Start small for testing
   ```

2. **Costo Estimado:**
   - IBM Torino: $3.00 per 1000 shots
   - 100 shots = $0.30
   - 10,000 shots = $30.00

3. **Verificar credenciales:**
   ```bash
   cat ~/.qiskit/qiskit-ibm.json
   # Should show token and instance="Bioql"
   ```

4. **Run CRISPR Therapy:**
   ```bash
   python /Users/heinzjungbluth/Test/scripts/crispr.py
   ```

---

## 📞 Reference

- **PyPI:** https://pypi.org/project/bioql/5.5.0/
- **Qiskit Runtime:** https://docs.quantum.ibm.com/api/qiskit-ibm-runtime
- **BioQL Docs:** https://docs.bioql.com

---

**Generated:** October 8, 2025  
**Status:** ✅ All fixes applied and verified  
**BioQL Version:** 5.5.0 (installed from local wheel)

