(TOP (S (NP-SBJ (DT The)  (NN Thy-1)  (NN gene)  (NN promoter) ) (VP (VBZ resembles)  (NP (DT a)  (`` ")  (JJ housekeeping)  ('' ")  (NN promoter) ) (PP (IN in)  (SBAR (IN that)  (S (NP-SBJ-68 (PRP it) ) (VP-COOD (VP (VBZ is)  (ADJP-PRD (JJ located)  (PP (IN within)  (NP (DT a)  (JJ methylation-free)  (NN island) )))) (, ,)  (VP (VBZ lacks)  (NP (DT a)  (JJ canonical)  (NN TATA)  (NN box) )) (, ,)  (CC and)  (VP (VBZ displays)  (NP (NN heterogeneity) ) (PP (IN in)  (NP (NP (DT the)  (JJ 5'-end)  (NNS termini) ) (PP (IN of)  (NP (DT the)  (NN mRNA) )))))))))) (. .) ) )
(TOP (S (NP-SBJ (DT The)  (JJ latter)  (`` ")  (NP (NP (JJ nuclear)  (NN factor) ) (PP (IN for)  (NP (VBN activated)  (NN T)  (NNS cells) ))) ('' ") ) (ADVP (RB likely) ) (VP (VBZ contributes)  (PP (TO to)  (NP (NP (DT the)  (NN tissue)  (NN specificity) ) (PP (IN of)  (NP (NN IL-2)  (NN gene)  (NN expression) ))))) (. .) ) )
(TOP (S (ADVP (RB Thus) ) (, ,)  (NP-SBJ (PRP we) ) (VP (VBD postulated)  (SBAR-COOD (SBAR (IN that)  (S (NP-SBJ (NP (DT the)  (JJ circadian)  (NN modification) ) (PP (IN of)  (NP (NN GR) ))) (VP (VBD was)  (ADJP-PRD (JJ independent)  (PP (IN of)  (NP-COOD (NP (NP (DT the)  (JJ diurnal)  (NNS fluctuations) ) (PP (IN in)  (NP (NN plasma)  (NN cortisol)  (NN level) ))) (CC or)  (NP (NP (DT the)  (JJ circadian)  (NNS variations) ) (PP (IN in)  (NP (JJ environmental)  (NN lighting) ))))))))) (CC and)  (SBAR (IN that)  (S (NP-SBJ-79 (DT the)  (NN rhythmicity) ) (VP (MD might)  (VP (VB be)  (VP (VBN regulated)  (NP (-NONE- *-79) ) (PP (IN by)  (NP-LGS (NP (DT the)  (`` ')  (JJ circadian)  (NN pacemaker)  ('' ') ) (ADJP (JJ located)  (PP (IN in)  (NP (DT the)  (JJ human)  (JJ basal)  (NN brain) )))))))))))) (. .) ) )
(TOP (S (NP-SBJ-70 (JJ Such)  (NN transcription)  (NNS factors) ) (VP (VBP play)  (NP (DT a)  (JJ key)  (NN role) ) (PP (IN in)  (NP (NP (DT the)  (NN development) ) (PP (IN of)  (NP (DT the)  (JJ mature)  (NN T-cell)  (NN phenotype) )))) (PP (IN by)  (S (NP-SBJ (-NONE- *-70) ) (VP (VBG functioning)  (PP (IN as)  (`` ')  (NP (NP (JJ master)  (NNS regulators) ) (PP (IN of)  (NP (NN T-cell)  (NN differentiation) ))) ('' ') ))))) (. .) ) )
(TOP (S (NP-SBJ (NP (DT The)  (NN conversion) ) (PP (IN of)  (NP (DT the)  (NN TCEd) )) (PP (TO to)  (NP (DT a)  (`` ')  (JJ perfect)  ('' ')  (NN NF-kB)  (NN binding)  (NN site) ))) (VP-COOD (VP (VBZ leads)  (PP (TO to)  (NP-19 (NP (DT a)  (JJR tighter)  (NN binding) ) (PP (IN of)  (NP (NN NF-kB) )) (PP (TO to)  (NP (NN TCEd)  (NN DNA) ))))) (CC and)  (, ,)  (VP (PP (IN as)  (NP (DT a)  (JJ functional)  (NN consequence) )) (, ,)  (PP (TO to)  (NP=19 (NP (DT the)  (NN activity) ) (PP (IN of)  (NP (DT the)  (`` ')  (VBN converted)  ('' ')  (NN TCEd)  (NNS motifs) )) (PP (IN in)  (NP (NN HeLa)  (NNS cells) )))))) (. .) ) )
