(S1 (S (NP (DT The) (JJ Thy-1) (NN gene) (NN promoter)) (VP (VP (VBZ resembles) (NP (NP (DT a) (ADJP (CD ") (NN housekeeping)) (NN ") (NN promoter)) (SBAR (WHPP (IN in) (WHNP (WDT that))) (S (NP (PRP it)) (VP (VBZ is) (VP (VBN located) (PP (IN within) (NP (DT a) (JJ methylation-free) (NN island))))))))) (, ,) (VP (VBZ lacks) (NP (DT a) (JJ canonical) (NNP TATA) (NN box))) (, ,) (CC and) (VP (VBZ displays) (NP (NP (NN heterogeneity)) (PP (IN in) (NP (NP (DT the) (JJ 5'-end) (NNS termini)) (PP (IN of) (NP (DT the) (NN mRNA)))))))) (. .)))
(S1 (S (NP (NP (DT The) (JJ latter) (CD ") (JJ nuclear) (NN factor)) (PP (IN for) (NP (VBN activated) (NN T) (NNS cells)))) (VP (VBZ ") (ADJP (JJ likely) (S (VP (VBZ contributes) (PP (TO to) (NP (NP (DT the) (NN tissue) (NN specificity)) (PP (IN of) (NP (JJ IL-2) (NN gene) (NN expression))))))))) (. .)))
(S1 (S (ADVP (RB Thus)) (, ,) (NP (PRP we)) (VP (VBD postulated) (SBAR (SBAR (IN that) (S (NP (NP (DT the) (JJ circadian) (NN modification)) (PP (IN of) (NP (NNP GR)))) (VP (VBD was) (ADJP (JJ independent) (PP (IN of) (NP (DT the) (JJ diurnal) (NNS fluctuations)))) (PP (IN in) (NP (NP (NN plasma) (JJ cortisol) (NN level)) (CC or) (NP (NP (DT the) (JJ circadian) (NNS variations)) (PP (IN in) (NP (JJ environmental) (NN lighting))))))))) (CC and) (SBAR (IN that) (S (NP (DT the) (NN rhythmicity)) (VP (MD might) (VP (VB be) (VP (VBN regulated) (PP (IN by) (NP (DT the) ('' ') (NP (JJ circadian) (NN pacemaker) (POS ')) (VP (VBN located) (PP (IN in) (NP (DT the) (JJ human) (JJ basal) (NN brain))))))))))))) (. .)))
(S1 (S (NP (JJ Such) (NN transcription) (NNS factors)) (VP (VBP play) (NP (NP (DT a) (JJ key) (NN role)) (PP (IN in) (NP (NP (DT the) (NN development)) (PP (IN of) (NP (NP (DT the) (JJ mature) (JJ T-cell) (NN phenotype)) (PP (IN by) (NP (NP (NN functioning) (RB as) (POS ')) (NN master) (NNS regulators))))) (PP (IN of) (NP (JJ T-cell) (NN differentiation) (POS '))))))) (. .)))
(S1 (S (NP (NP (DT The) (NN conversion)) (PP (IN of) (NP (DT the)))) (VP (VBD TCEd) (PP (TO to) (NP (NP (DT a) ('' ') (JJ perfect) ('' ') (NN NF-kB)) (SBAR (S (NP (JJ binding) (NN site)) (VP (VBZ leads) (PP (TO to) (NP (NP (NP (DT a) (ADJP (RBR tighter) (JJ binding)) (PP (IN of) (NP (NP (NNS NF-kB)) (PP (PP (TO to) (NP (JJ TCEd) (NN DNA))) (CC and) (PP (, ,) (PP (IN as) (NP (DT a) (JJ functional) (NN consequence))) (, ,) (TO to) (NP (NP (DT the) (NN activity)) (PP (IN of) (NP (DT the)))))))) (POS ')) (JJ converted) ('' ') (JJ TCEd) (NNS motifs)) (PP (IN in) (NP (NNP HeLa) (NNS cells))))))))))) (. .)))
